Inhibition of diabetic nephropathy by a GH antagonist: A molecular analysis

Kidney International

Volumn 50, Issue 2, 1996, Pages 506-514

  Esposito, Ciro ^b   Liu, Zhi Hong ^b   Striker, Gary E ^b   Phillips, Carrie ^b   Chen, Nian Yi ^b   Chen, Wen Y ^b   Kopchick, John J ^b   Striker, Liliane J ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; GROWTH HORMONE; GROWTH HORMONE DERIVATIVE; LAMININ; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FEMALE; GROWTH HORMONE RELEASE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0029832429     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1996.342     Document Type: Article

References (46)

1. DOI T, STRIKER LJ, QUAIFE C, CONTI FG, PALMITER R, BEHRINGER R, BRINSTER R, STRIKER GE: Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor hut not in those expressing insulin like growth factor-1. Am J Pathol 131:398-403, 1988
2. YANG CW, STRIKER LJ, PESCE C, CHEN WY, PETEN EP, ELLIOT SJ, DOI T, KOPCHICK JJ, STRIKER GE: Glomerulosclerosis and body growth are mediated by different portions of bovine growth hormone: Studies in transgenic mice. Lab Invest 68:62-70, 1993
3. EL NAHAS AM, BASSET AH, COPE GH, LE CARPENTIER JE: Role of growth hormone in the development of experimental scarring. Kidney Int 40:29-34, 1991
4. CHEN WY, WIGHT DC, MEHTA BV, WAGNER TE, KOPCHICK JJ: Glycine 119 of bovine growth hormone is critical for growth-promoting activity. Mol Endocrinol 5:1845-1852, 1991
5. CHEN WY, WIGHT DC, WAGNER TE, KOPCHICK JJ: Expression of a mutated bovine growth hormone gene suppresses growth of transgenic mice. Proc Natl Acad Sci USA 87:5061-5065, 1990
6. PLUMB M, NATH K, SEAQUIST ER: Hypopituitarism stabilizes the renal and retinal complications of diabetes mellitus. Am J Nephrol 12:265-267, 1992
7. NICKELS D, SCHWAB N, POTH M: Effects of somatostatin and captopril on glomerular prostaglandin E2 production in normal and diabetic rats. Prostaglandins 46:61-73, 1993
8. CHEN NY, CHEN WY, BELLUSH L, YANG CW, STRIKER LJ, STRIKER GE, KOPCHICK JJ: Effects of streptozotocin treatment in growth hormone (GH) and GH antagonist transgenic mice. Endocrinology 136:660-667, 1995
9. CHEN WY, CHEN NY, YUN J, WAGNER T, KOPCHICK JJ: In vitro and in vivo studies of antagonistic effects of human growth hormone analogs. J Biol Chem 269:15892-15897, 1994
10. YANG CW, HATTORI M, VLASSARA H, HE CJ, CAROME MA, YAMATO E, ELLIOT S, STRIKER GE, STRIKER LJ: Overexpression of transforming growth factor-β1 mRNA is associated with up-regulation of glomerular tenascin and laminin gene expression in nonobese diabetic mice. J Am Soc Nephrol 5:1610-1617, 1995
11. PETEN EP, GARCIA-PEREZ A, TERADA Y, WOODROW D, MARTIN BM, STRIKER GE, STRIKER LJ: Age-related changes in alpha 1- and alpha 2-chain type IV collagen mRNA in adult mouse glomeruli: Competitive PCR. Am J Physiol 263:F951-F957, 1992
12. PETEN EP, STRIKER LJ, GARCTA-PEREZ A, STRIKER GE: Studies by competitive PCR of glomerulosclerosis in growth hormone transgenic mice. Kidney Int 43(Suppl 39):S55-S58, 1993
13. YANG CW, VLASSARA H, PETEN EP, HE CJ, STRIKER GE, STRIKER JL: Advanced glycation end products upregulate gene expression found in diabetic glomerular disease. Proc Natl Acad Sci USA 91:9436-9440, 1994
14. LIKE AA, ROSSINI AA: Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus. Science 193:415-417, 1976
15. LIU ZH, STRIKER LJ, PHILLIPS C, CHEN NY, CHEN WY, KOPCHICK JJ, STRIKER GE: Growth hormone expression is required for the development of diabetic glomerulosclerosis in mice. Kidney Int 48(Suppl 51):S37-S38, 1995
16. MCKAY K, STRIKER LJ, PINKERT C, BRINSTER RA, STRIKER GE: Glomerulosclerosis and renal cysts in mice transgenic for the early region of SV40. Kidney Int 32:827-837, 1987
17. HE CJ, ZALUPS RK, HENDERSON DA, STRIKER GE, STRIKER LJ: Molecular analysis of spontaneous glomerulosclerosis in the Os+ mice, a model with reduced nephron mass. Am J Physiol 269:F266-F273, 1995
18. HORIKOSHI S, MCCUNE B, RAY PE, KOPP JB, SPORN MB, KLOTMANN PE: Water deprivation stimulates growth factor accumulation in the juxta-glomerular apparatus. J Clin Invest 88:2117-2122, 1991
19. SMITH WC, KUNIYOSHI J, TALAMANTES F: Mouse serum growth hormone binding protein (GH) has GH receptor extracellular and substituted transmembrane domains. Mol Endocrinol 3:984-990, 1989
20. PRESS M, TAMBORLANE WV, SHERWIN RS: Importance of raised growth hormone levels in mediating the metabolic derangements in diabetes. N Engl J Med 310:810-815, 1984
21. GERICH JE: Rationale for inhibition of growth hormone in the management of the diabetic patient. Scand J Gastroenterol 21(Suppl 119):154-157, 1988
22. HOLLY JMP, AMIEL SA, SANDHU RR, REES LH, WASS JAH: The role of growth hormone in diabetes mellitus. J Endocrinol 118:353-364, 1988
23. GERICH JE: Role of growth hormone in diabetes mellitus. N Engl J Med 310:848-849, 1984
24. MUCHANETA-KUBARA EC, SAYED-AHMED N, BESBAS N, ZHANG G, COPE GH, EL NAHAS AM: Experimental diabetic renal growth: Role of growth hormone and insulin-like growth factor I. Nephrol Dial Transplant 9:1395-1401, 1994
25. FLYVBERG A, FRYSTYK J, OSTERBY R, ORSKOV H: Kidney IGF-I and renal hypertrophy in GH-deficient diabetic dwarf rats. Am J Physiol 262:E956-E962, 1992
26. HE CJ, STRIKER LJ, TSOKOS M, YANG CW, STRIKER GE: Relationships between mesangial cell proliferation and types I and IV collagen mRNA levels in vitro. Am J Physiol 269:C554-C562, 1995
27. HE CJ, ESPOSITO C, PHILLIPS C, ZALUPS RK, HENDERSON DA, STRIKER GE, STRIKER LJ: Dissociation of glomerular hypertrophy, cell proliferation and glomerulosclerosis in mouse strains heterozygous for a mutation (Os) which induces a 50% reduction in nephron number. J Clin Invest 97:1-8, 1996
28. COUCHMAN JR, BEAVAN LA, MCCARTHY KJ: Glomerular matrix: Synthesis, turnover and role in mesangial expansion. Kidney Int 45:328-335, 1994
29. FUKUI M, NAKAMURA T, EBIHARA I, SHIRATO I, TOMINO Y, KOIDE H: ECM gene expression and its modulation by insulin in diabetes. Diabetes 41:1520-1527, 1992
30. ZIYADEH FN: The extracellular matrix in diabetic nephropathy. Am J Kidney Dis 22:736-744, 1993
31. ADLER S: Structure-function relationships associated with extracellular matrix alterations in diabetic glomerulopathy. J Am Soc Nephrol 51:1165-1172, 1994
32. NAKAMURA T, FUKUI M, EBIHARA I, OSADA S, TOMINO Y, KOIDE H: Abnormal gene expression of matrix metalloproteinases and their inhibitor in glomeruli from diabetic rats. Renal Physiol Biochem 17:316-325, 1994
33. RECKELHOFF JF, TYGART VL, MITIAS MM, WALCOTT JL: STZ-induced diabetes results in decreased activity of glomerular cathepsin and metalloprotease in rats. Diabetes 42:1425-1432, 1993
34. GLICK AD, JACOBSON HR. HARALSON MA: Mesangial deposition of type I collagen in human glomerulosclerosis. Hum Pathol 23:1373-1379, 1992
35. CAROME MA, STRIKER LJ, PETEN EP, STETLER-STEVENSON WG, REPONEN P, TRYGGVASON K, STRIKER GE: Assessment of 72-kd gelatinase and TIMP-1 gene expression in normal and sclerotic murine glomeruli. J Am Soc Nephrol 5:1391-1399, 1994
36. APTE SS, HAYASHI K, SELDIN MF, MATTEI MG, HAYASHI M, OLSEN BJ: Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10. Develop Dynamics 200:177-197, 1994
37. YOSHIOKA K, TAKEMURA T, MURAKAMI K, OKADA M, MIYAMOTO H, HINO S, MAKI S: Transforming growth factor-β protein and mRNA in glomeruli in normal and diseased human kidney. Lab Invest 68:154-163, 1993
38. YAMAMOTO T, NAKAMURA T, NOBLE NA, RUOSLAHTI E, BORDER WA: Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 90:1814-1818, 1993
39. NAKAMURA T, FUKUI M, EBIHARA I, OSADA S, NAGAOKA I, TOMINO Y, KOIDE H: mRNA expression of growth factors in glomeruli from diabetic rats. Diabetes 42:450-456, 1993
40. SHARMA K, ZIYADEH FN: Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mice. Am J Physiol 267:F1094-F1101, 1994
41. WAHL SM, ALLEN JB, WEEKA BS, WONG HL, KLOTMAN PE: Transforming growth factor β enhances integrin expression and type IV collagenase secretion in human monocytes. Proc Natl Acad Sci USA 90:4577-4581, 1993
42. TIONG TS, HERINGTON AC: Tissue distribution, characterization, and regulation of messenger ribonucleic acid for growth hormone receptor and serum binding protein in the rat. Endocrinology 129:1628-1634, 1991
43. LOBIE PE, GARCIA-ARAGON J, WANG BS, BAUMBACH WR, WATERS MJ: Cellular localization of the growth hormone binding protein in the rat. Endocrinology 130:3057-3065, 1992
44. BAUMANN G: Editorial: Growth hormone binding protein-errant receptor or active player? Endocrinology 136:377-378, 1995
45. MENON RK, STEPHAN DA, RAO RH, SHEN-ORR Z, DOWNS LS JR, ROBERTS CT, LEROITH D, SPERLING MA: Tissue-specific regulation of the growth hormone receptor gene in streptozotocin-induced diabetes in the rat. J Endocrinol 142:453-462, 1994
46. CHIN E, ZHOU J, BONDY CA: Renal growth hormone receptor gene expression: Relationship to renal insulin-like growth factor system. Endocrinology 131:3061-3066, 1992