Site-specific immune regulation in the brain: Differential modulation of major histocompatibility complex (MHC) proteins in brainstem vs. hippocampus

Journal of Comparative Neurology

Volumn 405, Issue 3, 1999, Pages 322-333

  Phillips, Lynnette M ^a,b   Simon, Peter J ^a   Lampson, Lois A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Experimental autoimmune encephalomyelitis (EAE); Interferon gamma (IFN ); Microglia; Neuroimmunology; Rat

Indexed keywords

GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; BRAIN STEM; CELLULAR IMMUNITY; COMPUTER ANALYSIS; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOREGULATION; IMMUNOTHERAPY; MALE; MICROGLIA; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN; BRAIN STEM; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNE SYSTEM; INJECTIONS; INTERFERON TYPE II; MALE; NEURONS; RATS; RATS, INBRED F344; STAINING AND LABELING;

EID: 0033559014     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19990315)405:3<322::AID-CNE3>3.0.CO;2-S     Document Type: Article

References (54)

1. Adams CWM. 1989. Color atlas of multiple sclerosis and other myelin disorders. Dobbs Ferry, NY: Sheridan Medical Books.
2. Aihara, N, Hall JJ, Pitta LH, Fukuda K, Noble LJ. 1995. Altered immunoexpression of microglia and macrophages after mild head injury. J Neurotrauma 12:53-63.
3. Barker CF, Billingham RE. 1977. Immunologically privileged sites. Adv Immunol 25:1-54.
4. Berger T, Weerth S, Kojima K, Linington C, Wekerle H, Lassman H. 1997. Experimental autoimmune encephalomyelitis: The antigen specificity of T lymphocytes determines the topography of lesiona in the central and peripheral nervous system. Lab Invest 76:355-364.
5. Besedovsky HO, del Rey A. 1996. Immune-neuro-endocrine interactions: Facts and hypotheses. Endocr Rev 17:64-102.
6. Blalock JE. 1989. A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol Rev 69: 1-32.
7. Bost KL. 1988. Hormone and neuropeptide receptors on mononuclear leukocytes. Prog Allerg 43:68-83.
8. Bozic CR, Lu B, Hopken UE, Gerard C, Gerard NP.1996. Neurogenic amplification of immune complex inflammation. Science 273:1722-1725.
9. Breder CD, Hazuka C, Ghayur T, Klug C, Huginin M, Yasuda K, Teng M, Saper CB. 1994. Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration. Proc Natl Acad Sci 91:11393-11397.
10. Brownell B, Hughes JT. 1962. The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatr 25:315-320.
11. Cras P, Kawai M, Siedlak S, Mulvihill P, Gambetti P, Lowery D, Gonzalez-DeWitt P, Greenberg B, Perry G 1990. Neuronal and microglial involvement in β-amyloid protein deposition in Alzheimer's disease. Am J Pathol 137:241-246.
12. Cuello AC, Kanazawa I. 1978. The distribution of substance P immunoreactive fibers in the rat central nervous system. J Comp Neurol 178:129-156.
13. del Rio-Hortega P. 1932. Microglia. In: Penfield W, editor. Cytology and cellular pathology of the nervous system. New York: Hoeber, Inc. p 483-534.
14. Emmett CJ, Lawrence JM, Raisman G, Seeley PJ. 1991. Cultured epitheloid astrocytes migrate after transplantation into the adult rat brain. J Comp Neurol 311:330-341.
15. Ericsson A, Hart RD, Sawchenko PE. 1995. Type I interleukin-1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL-1 induced cellular activation. J Comp Neurol 361:681-698.
16. Ferguson TA, Griffith TS. 1997. A vision of cell death: Insights into immune privilege. Immunol Rev 156:167-184.
17. Frohman EM. 1988. Norepinephrine inhibits gamma-interferon-induced MHC class II(Ia) antigen expression on cultured brain astrocytes. J Neuroimmunol 17:89-101.
18. Hafler DA, Weiner HL. 1987. T cells in multiple sclerosis and inflammatory CNS diseases. Immunol Rev 100:307-332.
19. Horwitz MS, Evans CF, McGavern DB, Rodriguez M, Oldstone MBA. 1997. Primary demyelination in transgenic mice expressing interferon-γ. Nature Med 3:1037-1041.
20. Irani DN, Lin KI, Griffin DE. 1997. Regulation of brain-derived T cells during acute central nervous system inflammation. J Immunol 158: 2318-2326.
21. Johns LD, Babcock G, Green D, Freedman M, Sriram S, Ransahoff RM. 1992. Transforming growth factor-β differentially regulates proliferation and MHC class II antigen expression in forebrain and brainstem astrocyte primary cultures. Brain Res 585:229-236.
22. Kato H, Kogure K, Araki T, Itoyama Y. 1995. Graded expression of immunomolecules on activated microglia in the hippocampus following ischemia in a rat model of ischemic tolerance. Brain Res 694:85-93.
23. Laerum OD, Bjerkvig R, Steinsvag SK, Ridder LD.1984. Invasiveness of primary brain tumors. Cancer Met Revs 3:223-236.
24. Lampson LA. 1995. Interpreting MHC class I expression and class I/II reciprocity in the CNS: Reconciling divergent findings. Micros Res Tech 32:267-285.
25. Lampson LA. 1997. Immunobiology of brain tumors: Antigens, effectors, and delivery to sites of microscopic tumor in the brain. In Black P McL, Loeffler JS, editors. Cancer of the nervous system. Boston: Blackwell Science, Inc. p 874-906.
26. Lampson LA. 1998. Beyond inflammation: Site-directed immunotherapy. Immunol Today 19:17-22.
27. Lampson LA, Levy R. 1980. Two populations of Ia-like molecules on a human B cell line. J Immunol 125:293-299.
28. Lampson LA, Lampson MA, Dunne AD. 1993. Exploiting the lacZ reporter gene for quantitative analysis of disseminated tumor growth within the brain: Use of the lacZ gene product as a tumor antigen, for evaluation of antigenic modulation, and to facilitate image analysis of tumor growth in situ. Cancer Res 53:176-182.
29. Lampson LA, Chen A, Vortmeyer AO, Sloan AE, Ghogawala Z, Kim L. 1994. Enhanced T cell migration to sites of microscopic CNS disease: Complementary treatments evaluated by 2-and 3-D image analysis. Brain Pathol 4:125-134.
30. Lawson LJ, Perry VH, Dri P, Gordon S. 1990. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39:151-170.
31. Lee N, Collins M, Vanguri P, Shin ML. 1992. Glutamate differentially inhibits the expression of class II MHC antigens on astrocytes and microglia. J Immunol 148:3391-3397.
32. Levine JD, Clark R, Devor M, Helms C, Moskowitz MA, Basbaum AI. 1984. Intraneuronal substance P contributes to the severity of experimental arthritis. Science 226:547-549.
33. Meeson AP, Piddlesden S, Morgan BP, Reynolds R. 1994. The distribution of inflammatory demyelinated lesions in the central nervous system of rats with antibody-augmented demyelinating experimental allergic encephalomyelitis. Exp Neurol 129: 299-310.
34. Moore TC. 1984. Modification of lymphocyte traffic by vasoactive neurotransmitter substances. Immunology 52:511-518.
35. Neumann H, Schmidt H, Cavalie A, Jenne D, Wekerle H. 1997. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: Differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. J Exp Med 185:305-316.
36. Paxinos G, Watson C. 1986. The rat brain in stereotaxic coordinates. 2nd edition. Sydney: Academic Press.
37. Payan DG, Goetzl EJ. 1985. Modulation of lymphocyte function by sensory neuropeptides. J Immunol 135:783s-786s.
38. Payan DG, Brewster DR, Goetzl EJ. 1983. Specific stimulation of human T lymphocytes by substance P. J Immunol 131:1613-1615.
39. Payan DG, McGillis JP, Goetzl EJ. 1986. Neuroimmunology. Adv Immunol 39:299-323.
40. Phillips LM, Simon PJ, Lampson LA. 1998. Site specific regulation in the CNS revealed by low dose IFN-γ (Abstract). J Neuroimmunol 90:51.
41. Planz O, Bilzer T, Sobbe M, Stitz L. 1993. Lysis of major histocompatibility complex class I-bearing cells in Borna disease virus-induced degenerative encephalopathy. J Exp Med 178:163-174.
42. Romanic AM, Madri JA. 1994. Extracellular matrix-degrading proteinases in the nervous system. Brain Pathol 4:145-156.
43. Santoni G, Perfumi M, Bressan AM, and Piccoli M. 1996. Capsaicin-induced inhibition of mitogen and interleukin-2-stimulated T cell proliferation: Its reversal by in vivo substance P administration. J Neuroimmunol 68:131-138.
44. Serra MC, Bazzoni F, Della Bianca V, Greskowiak M, Rossi F. 1988. Activation of human neutrophils by substance P. J Immunol 141:2118-2124.
45. Sethna MP, Lampson LA. 1991. Immune modulation within the brain: Recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-g. J Neuroimmunol 34:121-132.
46. Soares HD, Hicks RR, Smith D, McIntosh TK. 1995. Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury. J Neurosci 15:8223-8233.
47. Streilein JW. 1993. Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments. Curr Opinion Immunol 5:428-432.
48. Streit WJ, Graeber MB, Kreutzberg GW. 1988. Functional plasticity of microglia: Areview. Glia 1:301-307.
49. Tang SC, Braunsteiner H, Wiedermann CJ. 1992. Regulation of human T lymphoblast growth by sensory neuropeptides: Augmentation of CCK-induced inhibition of Molt-4 proliferation by somatostatin and VIP in vitro. Immunol Lett 34:237-242.
50. Tani M, Ransahoff RM. 1994. Do chemokines mediate inflammatory cell invasion of the central nervous system parenchyma? Brain Pathol 4:135-144.
51. Traugott U, Lebon P. 1988. Multiple sclerosis: Involvement of interferons in lesion pathogenesis. Ann Neurol 24:243-251.
52. Valtschanoff JG, Weinberg RJ, Kharazia VN, Nakane M, Schmidt HHHW. 1993. Neurons in rat hippocampus that synthesize nitric oxide. J Comp Neurol 331:111-121.
53. Williams KC, Ulvestad E, Hickey WF. 1994. Immunology of multiple sclerosis. Clinical Neurosci. 2:229-245.
54. Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. 1994. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 179:973-984.