Relationships between neuropsychological and oculomotor measures in schizophrenia patients and normal controls

Biological Psychiatry

Volumn 42, Issue 9, 1997, Pages 797-805

  Radant, Allen D ^a,c   Claypoole, Keith ^a   Wingerson, Dane K ^a,b   Cowley, Deborah S ^a,b   Roy Byrne, Peter P ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Antisaccades; Eye tracking; Neuropsychological; Oculomotor; Schizophrenia; Wisconsin card son test

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; EYE MOVEMENT CONTROL; FEMALE; HUMAN; LEARNING; MALE; NEUROPSYCHOLOGICAL TEST; PHENOTYPE; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; SMOOTH PURSUIT EYE MOVEMENT; TASK PERFORMANCE;

ADULT; ATTENTION; ELECTROOCULOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OCULAR MOTILITY DISORDERS; PSYCHOMETRICS; PURSUIT, SMOOTH; REACTION TIME; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SACCADES; SCHIZOPHRENIA; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 0030772211     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(96)00464-7     Document Type: Article

References (67)

1. Anderson TJ, Jenkins IH, Brooks DJ, Hawken MB, Frackowiak RS, Kennard C. Cortical control of saccades and fixation in man. A PET study. Brain. 117:1994;1073-1084.
2. Arnett PA, Rao SM, Bernardin L, Grafman J, Yetkin FZ, Lobeck L. Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis. Neurology. 44:1994;420-425.
3. Bahill AT, Clark MT, Stork L. The main sequence A tool for studying human eye movements . Math Biosci. 24:1975;191-204.
4. Bartfai A, Levander S, Nyback H, Berggren BM, Schalling D. Smooth pursuit eye tracking, neuropsychological test performance, and computed tomography in schizophrenia. Psychiatry Res. 15:1985;49-62.
5. Bartfai A, Wirs'en A, Levander S, Schalling D. Smooth pursuit eye tracking and neuro-psychological performance in healthy volunteers. Exploring a possible genetic marker for vulnerability to schizophrenia. Acta Psychiatr Scand. 80:1989;479-489.
6. Becker W, Fuchs A. Prediction in the oculomotor system Smooth pursuit during transient disappearance of a visual target . Exp Brain Res. 57:1985;562-575.
7. Blanchard JJ, Neale JM. The neuropsychological signature of schizophrenia Generalized or differential deficit? Am J Psychiatry. 151:1994;40-48.
8. Braff DL, Heaton R, Kuck J, et al. The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting Test results. Arch Gen Psychiatry. 48:1991;891-898.
9. Clementz BA, McDowell JE. Smooth pursuit in schizophrenia Abnormalities of open- and closed-loop responses . Psychophysiology. 31:1994;79-86.
10. Clementz BA, Grove WM, Iacono WG, Sweeney JA. Smooth-pursuit eye movement dysfunction and liability for schizophrenia Implications for genetic modeling . J Abnorm Psychol. 101:1992;117-129.
11. Clementz BA, McDowell JE, Zisook S. Saccadic system functioning among schizophrenia patients and their first-degree biological relatives. J Abnorm Psychol. 103:1994;277-287.
12. Crawford TJ, Haeger B, Kennard C, Reveley MA, Henderson L. Saccadic abnormalities in psychotic patients I. Neuroleptic-free psychotic patients . Psychol Med. 25:1995;461-471.
13. Crawford TJ, Haeger B, Kennard C, Reveley MA, Henderson L. Saccadic abnormalities in psychotic patients II. The role of neuroleptic treatment . Psychol Med. 25:1995;473-483.
14. Deicken RF, Merrin EL, Floyd TC, Weiner MW. Correlation between left frontal phospholipids and Wisconsin Card Sort Test performance in schizophrenia. Schizophr Res. 14:1995;177-181.
15. Friedman L, Jesberger JA, Meltzer HY. A model of smooth pursuit performance illustrates the relationship between gain, catch-up saccade rate, and catch-up saccade amplitude in normal controls and patients with schizophrenia. Biol Psychiatry. 30:1991;537-556.
16. Friedman L, Jesberger JA, Abel LA, Meltzer HY. Catch-up saccade amplitude is related to square wave jerk rate. Invest Ophthalmol Vis Sci. 33:1992;228-233.
17. Friedman L, Kenny JT, Jesberger JA, Choy MM, Meltzer HY. Relationship between smooth pursuit eye-tracking and cognitive performance in schizophrenia. Biol Psychiatry. 37:1995;265-272.
18. Frith CD, Firston KJ, Liddle PF, Frackowiak RS. A PET study of word finding. Neuropsychologia. 29:1991;1137-1148.
19. Fukushima J, Fukushima K, Morita N, Yamashita I. Further analysis of the control of voluntary saccadic eye movements in schizophrenic patients. Biol Psychiatry. 28:1990;943-958.
20. Fukushima J, Fukushima K, Miyasaka K, Yamashita I. Voluntary control of saccadic eye movement in patients with frontal cortical lesions and parkinsonian patients in comparison with that in schizophrenics. Biol Psychiatry. 36:1994;21-30.
21. Gambini O, Scarone S. Smooth pursuit eye movements and neuropsychological tests in schizophrenic patients Possible involvement of attentional components . Eur Arch Psychiatry Clin Neurosci. 241:1992;333-336.
22. Grawe RW, Levander S. Smooth pursuit eye movements and neuropsychological impairments in schizophrenia. Acta Psychiatr Scand. 92:1995;108-114.
23. Heaton RK (1993): Wisconsin Card Sorting Test: Computer Version-2. Research Edition. Odessa. Psychological Assessment Resources, Inc.
24. Holzman PS. The role of psychological probes in genetic studies of schizophrenia. Schizophr Res. 13:1994;1-9.
25. Iacono WG, Clementz BA. A strategy for elucidating genetic influences on complex psychopathological syndromes (with special reference to ocular motor functioning and schizophrenia). Prog Exp Pers Psychopathol Res. 16:1993;11-65.
26. Iacono WG, Tuason VB, Johnson RA. Dissociation of smooth-pursuit and saccadic eye tracking in remitted schizophrenics An ocular reaction time task that schizophrenics perform wells . Arch Gen Psychiatry. 38:1981;991-996.
27. Katsanis J, Iacono WG. Clinical, neuropsychological, and brain structural correlates of smooth-pursuit eye tracking performance in chronic schizophrenia. J Abnorm Psychol. 100:1991;526-534.
28. Keating EG. Lesions of the frontal eye field impair pursuit eye movements, but preserve the predictions driving them. Behav Brain Res. 53:1993;91-104.
29. Keefe RS. The contribution of neuropsychology to psychiatry. Am J Psychiatry. 152:1995;6-15.
30. Kremen WS, Seidman LJ, Pepple JR, Lyons MJ, Tsuang MT, Faraone SV. Neuropsychological risk indicators for schizophrenia A review of family studies . Schizophr Bull. 20:1994;103-119.
31. Leigh RJ, Zee DS. The Neurology of Eye Movements. 2nd ed. 1991;F.A. Davis Company, Philadelphia.
32. Levin S, Holzman PS, Rothenberg SJ, Lipton RB. Saccadic eye movements in psychotic patients. Psychiatry Res. 5:1981;47-58.
33. Levin S, Jones A, Stark L, Merrin EL, Holzman PS. Saccadic eye movements of schizophrenic patients measured by reflected light technique. Biol Psychiatry. 17:1982;1277-1287.
34. Levin S, Luebke A, Zee DS, Hain TC, Robinson DA, Holzman PS. Smooth pursuit eye movements in schizophrenics Quantitative measurements with the search-coil technique . J Psychiatr Res. 22:1988;195-206.
35. Levy DL, Holzman PS, Matthysse S, Mendell NR. Eye tracking dysfunction and schizophrenia A critical perspective . Schizophr Bull. 19:1993;461-536.
36. Litman RE, Hommer DW, Clem T, Ornsteen ML, Ollo C, Pickar D. Correlation of Wisconsin Card Sorting Test performance with eye tracking in schizophrenia. Am J Psychiatry. 148:1991;1580-1582.
37. Litman RE, Hommer DW, Radant A, Clem T, Pickar D. Quantitative effects of typical and atypical neuroleptics on smooth pursuit eye tracking in schizophrenia. Schizophr Res. 12:1994;107-120.
38. MacAvoy MG, Bruce CJ. Comparison of the smooth eye tracking disorder of schizophrenics with that of nonhuman primates with specific brain lesions. Int J Neurosci. 80:1995;117-151.
39. Marenco S, Coppola R, Daniel DG, Zigun JR, Weinberger DR. Regional cerebral blood flow during the Wisconsin Cart Sorting Test in normal subjects studied by Xenon-133 dynamic SPECT Comparison of absolute values, percent distribution values, and covariance analysis . Psychiatry Res Neuroimaging. 50:1994;177-192.
40. Matsue Y, Okuma T, Saito H, et al. Saccadic eye movements in tracking, fixation, and rest in schizophrenic and normal subjects. Biol Psychiatry. 21:1986;382-389.
41. Matsue Y, Saito H, Osakabe K, et al. Smooth pursuit eye movements and voluntary control of saccades in the antisaccade task in schizophrenic patients. Jpn J Psychiatry Neurol. 48:1994;13-22.
42. Mirsky AF. Research on schizophrenia in the NIMH laboratory of psychology and psychopathology, 1954-1987. Schizophr Bull. 14:1988;151-156.
43. O'Driscoll GA, Alpert NM, Matthysse SW, Levy DL, Rauch SL, Holzman PS. Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography. Proc Natl Acad Sci USA. 92:1995;925-929.
44. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry. 49:1992;975-982.
45. Park S, Holzman PS. Association of working memory deficit and eye tracking dysfunction in schizophrenia. Schizophr Res. 11:1993;55-61.
46. Park S, Holzman PS, Goldman-Rakic PS. Spatial working memory deficits in the relatives of schizophrenic patients. Arch Gen Psychiatry. 52:1995;821-828.
47. Paus T. Two modes of central gaze fixation maintenance and oculomotor distractibility in schizophrenics. Schizophr Res. 5:1991;145-152.
48. Radant AD, Hommer DW. A quantitative analysis of saccades and smooth pursuit during visual pursuit tracking A comparison of schizophrenics with normals and substance abusing controls . Schizophr Res. 6:1992;225-235.
49. Rashbass C. The relationship between saccadic and smooth pursuit tracking eye movements. J Physiol (Lond). 159:1961;326-338.
50. Reitan RM, Wolfson D. Category Test and Trail Making Test as measures of frontal lobe functions. Clin Neuropsychol. 9:1995;50-56.
51. Ross DE, Ochs AL, Hill MR, Goldberg SC, Pandurangi AK, Winfrey CJ. Erratic eye tracking in schizophrenic patients as revealed by high-resolution techniques. Biol Psychiatry. 24:1988;675-688.
52. Ross RG, Hommer D, Breiger D, Varley C, Radant A. Eye movement task related to frontal lobe functioning in children with attention deficit disorder. J Am Acad Child Adolesc Psychiatry. 33:1994;869-874.
53. Ross DE, Thaker GK, Holcomb HH, Cascella NG, Medoff DR, Tamminga CA. Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions. Psychiatry Res. 58:1995;53-67.
54. Rosse RB, Schwartz BL, Kim SY, Deutsch SI. Correlation between antisaccade and Wisconsin Card Sorting Test performance in schizophrenia. Am J Psychiatry. 150:1993;333-335.
55. Roy-Byrne P, Radant A, Wingerson D, Cowley DS. Human oculomotor function Reliability and diurnal variation . Biol Psychiatry. 38:1995;2-7.
56. Saykin AJ, Gur RC, Gur RE, et al. Neuropsychological function in schizophrenia Selective impairment in learning and memory . Arch Gen Psychiatry. 48:1991;618-624.
57. Saykin AJ, Shtasel DL, Gur RE, et al. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch Gen Psychiatry. 51:1994;124-131.
58. Schlenker R, Cohen R, Berg P, et al. Smooth-pursuit eye movement dysfunction in schizophrenia The role of attention and general psychomotor dysfunctions . Eur Arch Psychiatry Clin Neurosci. 244:1994;153-160.
59. Seidman LJ, Yurgelun-Todd D, Kremen WS, et al. Relationship of prefrontal and temporal lobe MRI measures to neuropsychological performance in chronic schizophrenia. Biol Psychiatry. 35:1994;235-246.
60. Sereno AB, Holzman PS. Antisaccades and smooth pursuit eye movements in schizophrenia. Biol Psychiatry. 37:1995;394-401.
61. Spitzer RL, Williams JBW, Gibbon M, First MB. Structured Clinical Interview for DSM-IV. 1990;American Psychiatric Press, Washington, DC.
62. Spreen O, Strauss E. A Compendium of Neuropsychological Tests Administration, Norms and Commentary . 1991;Oxford University Press, New York.
63. Sweeney JA, Clementz BA, Escobar MD, Li S, Pauler DK, Haas GL. Mixture analysis of pursuit eye-tracking dysfunction in schizophrenia. Biol Psychiatry. 34:1993;331-340.
64. Sweeney JA, Haas GL, Li S, Weiden PJ. Selective effects of antipsychotic medications on eye-tracking performance in schizophrenia. Psychiatry Res. 54:1994;185-198.
65. Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia I. Regional cerebral blood flow evidence . Arch Gen Psychiatry. 43:1986;114-124.
66. Yee RD, Baloh RW, Marder SR, Levy DL, Sakala SM, Honrubia V. Eye movement in schizophrenia. Invest Ophthalmol Vis Sci. 28:1987;366-374.
67. Yurgelun-Todd DA, Kinney DK. Patterns of neuropsychological deficits that discriminate schizophrenic individuals from siblings and control subjects. J Neuropsychiatry Clin Neurosci. 5:1993;294-300.