Development and evaluation of lipodeet, a new long-acting formulation of N, N-diethyl-m-toluamide (DEET) for the revention of schistosomiasis

American Journal of Tropical Medicine and Hygiene

Volumn 61, Issue 5, 1999, Pages 743-750

  Salafsky, B ^a   Ramaswamy, Kalyanasundaram ^a   He, Yi Xun ^a   Li, Jing ^a   Shibuya, Takeshi ^b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLTOLUAMIDE; DRUG CARRIER; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG ABSORPTION; DRUG FORMULATION; DRUG SAFETY; MALE; MOUSE; NONHUMAN; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SKIN;

ANIMALIA; INSECTA; SCHISTOSOMA MANSONI; TREMATODA;

EID: 0032709748     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1999.61.743     Document Type: Article

References (29)

1. Goodyer L, Behrens RH, 1998. Short report: the safety and toxicity of insect repellents. Am J Trop Med Hyg 59: 323-324.
2. Qiu H, Jun HW, McCall JW, 1998. Pharmacokinetics, formulation, and safety of insect repellent N,N-diethyl-3-methyl-benzamide (deet): a review. J Am Mosq Control Assoc 14: 12-27.
3. Suryanarayana MV, Pandey KS, Prakash S, Raghuveeran CD, Dangi RS, Swamy RV, Rao KM, 1991. Structure-activity relationship studies with mosquito repellent amides. J Pharm Sci 80: 1055-1057.
4. Braverman Y, Chizov-Ginzburg A, 1998. Duration of repellency of various synthetic and plant-derived preparations for Culicoides imicola, the vector of African horse sickness virus. Arch Virol (suppl) 14: 165-174.
5. Cockcroft A, Cosgrove JB, Wood RJ, 1998. Comparative repellency of commercial formulations of deet, permethrin and citronellal against the mosquito Aedes aegypti, using a collagen membrane technique compared with human arm tests. Med Vet Entomol 12: 289-294.
6. Salafsky B, Ramaswamy K, He YX, Anderson GL, Nowicki DK, Shibuya T, 1998. Evaluation of N,N-diethyl-m-toluamide (DEET) as a topical agent for preventing skin penetration by cercariae of Schistosoma mansoni. Am J Trop Med Hyg 58: 828-834.
7. Schoenig GP, Hartnagel Jr RE, Osimitz TG, Llanso S, 1996. Absorption, distribution, metabolism, and excretion of N,N-diethyl-M-toluamide in the rat. Drug Metab Dispos 24: 156-163.
8. Moody RP, Benoit FM, Riedel D, Ritter L, 1989. Dermal absorption of the insect repellent DEET (N,N-diethyl-m-toluamide) in rats and monkeys: effect of anatomical site and multiple exposure. J Toxicol Environ Health 26: 137-147.
9. 35S-labeling of cercariae of Schistosoma mansoni: a less expensive tool for tracing in vivo migration of schistosomula in mice. Parasitol Int 46: 55-65.
10. Qiu H, Jun HW, 1996. Solid-phase extraction and liquid chromatographic quantitation of insect repellent N,N-diethyl-m-toluamide in plasma. J Pharm Biomed Anal 15: 241-250.
11. Ramaswamy K, He YX, Salafsky B, 1997. ICAM-1 and iNOS expression increased in the skin of mice after vaccination with γ-irradiated cercariae of Schistosoma mansoni. Exp Parasitol 86: 118-132.
12. Mouritsen OG, Jorgensen K, 1998. A new look at lipid-membrane structure in relation to drug research. Pharm Res 15: 1507-1519.
13. Banghain AD, 1972. Lipid bilayers and biomembranes. Annu Rev Biochem 41: 753-776.
14. Allen TM, 1998. Liposomal drug formulations. Rationale for development and what we can expect for the future. Drugs 56: 747-756.
15. Desonneaux A, Bergeron MG, 1998. Liposomes as drug delivery system: a strategic approach for the treatment of HIV infection. J Drug Target 6: 1-15.
16. Lasic DD, 1998. Novel applications of liposomes. Trends Biotechnol 16: 307-321.
17. Sharata HH, Katz KH, 1996. Liposomes. Int J Dermatol 35: 761-769.
18. Schoenig GP, Osimitz TG, Gabriel KL, Hartnagel R, Gill MW, Goldenthal EI, 1999. Evaluation of the chronic toxicity and oncogenicity of N,N-diethyl-m-toluamide (DEET) Toxicol Sci 47: 99-109.
19. Hardell L, Nasman A, Ohlson CG, Fredrikson M, 1998. Case-control study on risk factors for testicular cancer. Int J Oncol 13: 1299-1303.
20. Kurt TL, 1998. Epidemiological association in US veterans between Gulf War illness and exposures to anticholinesterases. Toxicol Lett 102-103: 523-526.
21. Robbins PJ, Cherniack MG, 1986. Review of the biodistribution and toxicity of the insect repellent N,N-diethyl-m-toluamide (DEET). J Toxicol Environ Health 18: 503-525.
22. Veltri JC, Osimitz TG, Bradford DC, Page BC, 1994. Retrospective analysis of calls to poison control centers resulting from exposure to the insect repellent N,N-diethyl-mtoluamide (DEET) from 1985-1989. J Toxicol Clin Toxicol 32: 1-16.
23. Lipscomb JW, Kramer JE, Leikin JB, 1992. Seizure following brief exposure to the insect repellent N,N-diethyl-m-toluamide. Ann Emerg Med 21: 315-317.
24. Stinecipher J, Shah J, 1997. Percutaneous permeation of N,N-diethyl-m-toluamide (DEET) from commercial mosquito repellents and the effect of solvent. J Toxicol Environ Health 52: 119-135.
25. Rutledge LC, Gupta RK, Mehr ZA, Buescher MD, Reifenrath WG, 1996. Evaluation of controlled-release mosquito repellent formulations. J Am Mosq Control Assoc 12: 39-44.
26. Qiu H, Jun HW, Dzimianski M, McCall J, 1997. Reduced transdermal absorption of N,N-diethyl-m-toluamide from a new topical insect repellent formulation. Pharm Dev Technol 2: 33-42.
27. Domb AJ, Marlinsky A, Maniar M, Teomim L, 1995. Insect repellent formulations of N,N-diethyl-m-toluamide (deet) in a liposphere system: efficacy and skin uptake. J Am Mosq Control Assoc 11: 29-34.
28. Schreck CE, Kline DL, 1989. Repellency of two controlled-release formulations of deet against Anopheles quadrimaculatus and Aedes taeniorhynchus mosquitoes. J Am Mosq Control Assoc 5: 91-94.
29. Selim S, Hartnagel Jr RE, Osimitz TG, Gabriel KL, Schoenig GP, 1995. Absorption, metabolism, and excretion of N,N-diethyl-m-toluamide following dermal application to human volunteers. Fundam Appl Toxicol 25: 95-100.