Evaluation of the chronic toxicity and oncogenicity of N,N-diethyl-m- toluamide (DEET)

Toxicological Sciences

Volumn 47, Issue 1, 1999, Pages 99-109

  Schoenig, Gerald P ^a   Osimitz, Thomas G ^b   Gabriel, Karl L ^c   Hartnagel, Ralph ^d   Gill, Michael W ^a   Goldenthal, Edwin I ^e  

^a Toxicology/Regulatory Services Inc   (United States)

^b S C Johnson & Son Inc   (United States)

^c ConTox Ltd ^*  (United States)

^d MPI Research ^*  (United States)

^e MPI RESEARCH   (United States)

Author keywords

Chronic toxicity; Dog; Insect repellent; Mouse; N N diethyl m toluamide (DEET); Oncogenicity; Rat

Indexed keywords

ALKALINE PHOSPHATASE; CHOLESTEROL; DIETHYLTOLUAMIDE; HEMOGLOBIN; POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CARCINOGENICITY; CHOLESTEROL BLOOD LEVEL; CHRONIC TOXICITY; CONTROLLED STUDY; CONVULSION; DOG; FEMALE; FOOD INTAKE; HEAD MOVEMENT; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HYPERSALIVATION; MALE; MOUSE; NONHUMAN; POTASSIUM BLOOD LEVEL; RAT; RODENT; SEX DIFFERENCE; TREMOR; VOMITING; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; CARCINOGENICITY TESTS; CARCINOGENS; DEET; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEMALE; INSECT REPELLENTS; MALE; MICE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0032961352     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/47.1.99     Document Type: Article

References (20)

1. Ambrose, A. M., Huffman, D. K., and Salamone, R. T. (1959). Pharmacologic and toxicologic studies on N,N-diethyltoluamide. Toxicol. Appl. Pharmacol. 1, 97-115.
2. Conover, W. J., and Iman, R. L. (1981). Rank transformations as a bridge between parametric and nonparametric statistics. Am. Stat. 35, 124-133.
3. Curren, R. D. (1989). Unscheduled DNA synthesis assay in rat primary hepatocytes with a confirmatory assay - DEET. Microbiological Associates, Inc. final report of Study # T8728.380009.
4. Dunnett, C. W. (1964). New tables for multiple comparisons with a control. Biometrics 20, 482-491.
5. Ficsor, G., and Nu Lo Piccolo, G. (1972). Survey of pesticides for mutagenicity by the bacterial plate assay method. Environ. Mutagen. Soc. Newsletter 6, 6-8.
6. Huff, J. E. et al. (1988). Carcinogenesis studies: Results of 398 experiments on 104 chemicals from the U.S. National Toxicology Program. Ann. N. Y. Acad. Sci. 534, 1-30.
7. Neter, J., and Wasserman, W. (1974). Applied Linear Statistical Models. pp. 582-584. Richard D. Irwin, Homewood, IL.
8. Organization for Economic Cooperation and Development (OECD) 1981. OECD Guidelines for Testing of Chemicals (Nos. 451, 452, 453).
9. Osimitz, T. G., Gill, M. W., Gabriel, K. L., Ouellette, R. E., and Schoenig, G. P. (1997). DEET blood level studies in humans following dermal application and in dogs following oral administration. Toxicologist 36, 1744.
10. Putman, D. L., and Morris, M. J. (1989). Chromosome aberrations in Chinese hamster ovary (CHO) cells - DEET. Microbiological Associates, Inc. final report of Study # T8728.337.
11. San, R. H. C., and Schadly, M. B. (1989). Salmonella/mammalian-microsome plate incorporation mutagenicity assay (Ames test) with a confirmatory assay -DEET. Microbiological Associates, Inc. final report of Study # T8728.501014.
12. Schoenig, G. P., Hartnagel, R. E., Osimitz, T. G., and Llanso, S. (1996). Absorption, distribution, metabolism and excretion of N,N-diethyl-m-toluamide (DEET) in the rat. Drug Metab. Disp. 24, 156-163.
13. Schoenig, G. P., Hartnagel, Jr., R. E., Schardein, J. L., and Voorhees, C. V. (1993) Neurotoxicity evaluation of N,N-Diethyl-m-toluamide (DEET) in rats. Fundam. Appl. Toxicol. 21, 355-365.
14. Steel, R. G. D., and Torrie, J. H. (1960). Principles and Procedures of Statistics. McGraw-Hill, New York.
15. Stenbaeck, F. (1977). Local and systemic effects of commonly used cutaneous agents: Lifetime studies of 16 compounds in mice and rabbits. Acta Pharmacol. Toxicol. 41, 417-431.
16. Swentzel, K. C. (1977). Investigation of N,N-diethyl-m-toluamide (m-DET) for dominant lethal effects in the mouse: U.S. Army Environmental Hygiene Agency, Aberdeen Proving Ground, Md., Study 51-0034-78.
17. U.S. EPA (Environmental Protection Agency). (1980). N,N-Diethyl-m-toluamide (DEET): Pesticide registration standard. U.S. Environmental Protection Agency, Office of Pesticide and Toxic Substances, Washington, D.C.
18. U.S. EPA (Environmental Protection Agency) (1984). Pesticide Assessment Guidelines Subdivision F. Hazard Evaluation: Human and Domestic Animals (Revised).
19. U.S. EPA (Environmental Protection Agency) (1989). Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) Good Laboratory Practice Standards (40 CFR 160).
20. Welch, B. L. (1938). The significance of the difference between two means when the population variances are unequal. Biometrica 29, 350-362.