Epidemiological association in US veterans between Gulf War illness and exposures to anticholinesterases

Toxicology Letters

Volumn 102-103, Issue , 1998, Pages 523-526

  Kurt, Thomas L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cholinesterases; Epidemiology; Gulf War

Indexed keywords

CHEMICAL WARFARE AGENT; CHOLINESTERASE; DIETHYLTOLUAMIDE; INSECT REPELLENT; PYRIDOSTIGMINE; SARIN;

ATAXIA; CLINICAL TRIAL; COGNITIVE DEFECT; CONFERENCE PAPER; CONFUSION; ENVIRONMENTAL EXPOSURE; FEVER; HUMAN; INCONTINENCE; INFORMATION PROCESSING; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALE; MUSCLE WEAKNESS; MYALGIA; NEUROPATHIC JOINT DISEASE; PERSIAN GULF SYNDROME; PHENOTYPE; PHOBIA; PRIORITY JOURNAL; SOLDIER;

CASE-CONTROL STUDIES; CHOLINESTERASE INHIBITORS; HUMANS; MALE; PERSIAN GULF SYNDROME; VETERANS;

ACARI; ANIMALIA; ATAXIA; INSECTA; SIPHONAPTERA (FLEAS);

EID: 0032421617     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00259-8     Document Type: Conference Paper

References (27)

1. Abou-Donia, M.B., Lapadula, D.M., 1990. Mechanisms of organophosphorus ester-induced delayed polyneuropathy. Annu. Rev. Pharmacol. Toxicol. 30, 405-440.
2. Abou-Donia, M.B., Wilmarth, K.W., Jensen, K.F., Oehme, F.W., Kurt, T.L., 1996. Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET and permethrin. FASEB J. 10, A719; J. Toxicol. Environ. Health 48, 36-56.
3. Abou-Donia, M.B., Wilmarth, K.W., Jensen, K.F., Oehme, F.W., Kurt, T.L., 1996. Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET and permethrin. FASEB J. 10, A719; J. Toxicol. Environ. Health 48, 36-56.
4. Abou-Donia, M.B., Wilmarth, K.R., Abdel-Rahman, A.A., Jensen, K.F., Oehme, F.W., Kurt, T.L., 1996. Increased neurotoxicity following simultaneous exposure in pyridostigmine bromide (PB), DEET and chlorpyrifos. FASEB J. 10, A1285; Fund. Appl. Toxicol. 34, 201-222.
5. Abou-Donia, M.B., Wilmarth, K.R., Abdel-Rahman, A.A., Jensen, K.F., Oehme, F.W., Kurt, T.L., 1996. Increased neurotoxicity following simultaneous exposure in pyridostigmine bromide (PB), DEET and chlorpyrifos. FASEB J. 10, A1285; Fund. Appl. Toxicol. 34, 201-222.
6. Amato, A., McVey, A., Cha, C., et al., 1997. Evaluation of neuromuscular symptoms in veterans of the Persian Gulf War. Neurology 49, 4-18.
7. Cattell, R.B., 1978. The Scientific Use of Factor Analysis in Behavioral and Life Sciences. Plenum Press, New York, NY.
8. Cook, J.E., Kolka, M.A., 1992. Chronic pyridostigmine bromide administration: Side effects among soldiers working in a desert environment. Mil. Med. 157, 250-254.
9. Friedman, A., Kaufer, D., Shenier, J., Hendler, I., Soreq, H., Tur-Kaspa, I., 1966. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nature Med. 2, 1382-1385.
10. Gorsuch, R.L., 1983. Factor Analysis, 2nd ed. Lawrence Erlbaum Associations Publishers, Hillsdale, NJ.
11. Haley, R.W., Kurt, T.L., 1997. Exposure to neurotoxic chemical combinations in the Gulf War: cross sectional epidemiologic study. J. Am. Med. Assess. 277, 231-237.
12. Haley, R.W., Kurt, T.L., Horn, J., 1997a. Is there a Gulf War syndrome? Searching for syndromes by factor analysis of symptoms. J. Am. Med. Assess. 277, 215-222.
13. Haley, R.W., Horn, J., Roland, P.S., et al., 1997b. Evaluation of neurologic function in Gulf War veterans: a blinded case-control study. J. Am. Med. Assess. 277, 223-230.
14. Harp, P., Tanaka, D., Jr., Pope, C.N., 1997. Potentiation of organophosphorus-induced delayed neurotoxicity following phenyl saligenin phosphate exposures in 2-, 5- and 8-week-old chickens. Fund. Appl. Toxicol. 37, 64-70.
15. Hom, J., Haley, R.W., Ku, Kurt, T.L., 1997. Neuropsychological correlates of Gulf War syndrome. Arch. Clin. Neuropsychol. 12, 531-544.
16. Horan, J.M., Kurt, T.L., Landrigan, P.J., Melius, J.M., Singal, M., 1985. Neurologic dysfunction from exposure to 2-t-butyl-2-hydroxy-5-methylhexane: a new occupational neuropathy. Am. J. Public Health 75, 513-517.
17. Jamal, G.A., Hassen, S., Apartopoulos, F., Peden, A., 1996. The 'Gulf War syndrome': is there evidence of dysfunction to the nervous system? J. Neurol. Neurosurg. Psychiatry 60, 441-449.
18. Kaplan, J.G., Kessler, J., Rosenberg, N., Schaumburg, H.H., 1998. Sensory neuropathy associated with Dursban (chlorpyrifos) exposure. Neurology 43, 2193-2196.
19. Kiser, K.W., Joseph, S., Moll, M., Rankin, J.T., 1995. Unexplained illness among Persian Gulf War veterans in an Air National Guard unit. J. Am. Med. Assess. 274, 16-17.
20. Lotti, M., 1991. The pathogenesis of organophosphate polyneuropathy. Crit. Rev. Toxicol. 212, 465-487.
21. NIH Technology Assessment Workshop Panel1994. The Persian Gulf experience and health. J. Am. Med. Assess. 272, 391-396.
22. Polhuijs, M., Langenberg, J.P., Benschop, H.P., 1997. New method for retrospective detection of exposure to organophosphorus anticholinesterases: application to alleged sarin victims of Japanese terrorists. Toxicol. Appl. Pharmacol. 146, 156-161.
23. Pope, C.N., Padilla, S., 1990. Potentiation of organophosphorus-induced delayed neurotoxicity by phenylmethylsulfonyl fluoride (PMFS). J. Toxicol. Environ. Health 31, 261-273.
24. Spencer, P.S., Beaubernard, C.M., Bischoff-Fenton, N.C., Kurt, T.L., 1985. Clinical and experimental neurotoxicity of 2-t-butylazo-2-hydroxy-5-methylhexane. Ann. Neurol. 17, 28-37.
25. The Iowa Persian Gulf Study Group 1997. Self-reported illness and health status among Gulf War veterans: a population-based study. J. Am. Med. Assess. 277, 238-245.
26. Tucker, J.B., 1997. Evidence Iraq used chemical weapons during the 1991 Persian Gulf War. The Nonproliferation Review Spring-Summer, 114-122.
27. Wenger, C.B., Latzka, W.A., 1992. Effects of pyridostigmine bromide on physiological responses to heat, exercise and hypohydration. Aviat. Space Environ. Med. 63, 37-45.