HIV-1 RNA in plasma and genital tract secretions in women infected with HIV-1

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 22, Issue 2, 1999, Pages 124-131

  Kovacs, Andrea ^a   Chan, Linda S ^a   Chen, Zhi Chun ^a   Meyer III, William A ^b   Muderspach, Laila ^c   Young, Mary ^d   Anastos, Kathryn ^e   Levine, Alexandra M ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b QUEST DIAGNOSTICS NICHOLS INSTITUTE   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^e ST VINCENT S HOSPITAL   (United States)

Author keywords

Genital tract; HIV; RNA; Women

Indexed keywords

VIRUS RNA;

ADULT; ARTICLE; CELL FREE SYSTEM; FEMALE; GENITAL SYSTEM; GENITAL TRACT INFECTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; NONHUMAN; PLASMA; PRIORITY JOURNAL; VAGINA SECRETION; VIRUS DETECTION; VIRUS EXPRESSION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0032707669     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00126334-199910010-00003     Document Type: Article

References (42)

1. Centers for Disease Control. Update: AIDS among women -United States, 1994. MMWR Morb Mortal Wkly Rep 1995;44:81-4 [published erratum appears in MMWR Morb Mortal Wkly Rep 1995;44:135].
2. U.S. Centers for Disease Control and Prevention. Estimated incidence of AIDS and deaths of persons with AIDS, adjusted for delays in reporting, by quarter-year of diagnosis/death, United States, January 1985 through June 1997. HIV/AIDS Surveill Rep 1997;9:1-43.
3. Zhu T, Wang N, Carr A, et al. Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission. J Virol 1996;70:3098-3107.
4. Kiessling AA, Fitzgerald LM, Zhang D, et al. Human immunodeficiency virus in semen arises from a genetically distinct virus reservoir. AIDS Res Hum Retroviruses 1998;14(Suppl 1):S33-41.
5. Overbaugh J, Anderson RJ, Ndinya-Achola JO, Kreiss JK. Distinct but related human immunodeficiency virus type 1 variant populations in genital secretions and blood. AIDS Res Hum Retroviruses 1996;12:107-15.
6. Poss M, Martin HL, Kreiss JK, et al. Diversity in virus populations from genital secretions and peripheral blood from women recently infected with human immunodeficiency virus type 1. J Virol 1995; 69:8118-22.
7. Weiser B, Philpott S, Anastos K, et al. Quantitation and cloning of the HIV-1 RNA genome from the genital tract of women [abstract]. Presented at NIH-sponsored meetings on HIV in Genital Secretions, Bethesda, MD, U.S.A., 1997.
8. Byrn RA, Zhang D, Eyre R, McGowan K, Kiessling AA. HIV-1 in semen: an isolated virus reservoir [letter]. Lancet 1997;350:1141.
9. Fang G, Burger H, Anastos K, et al. Sequence analysis of the complete HIV pol gene from virions in plasma and genital tract of women: genital tract reservoir and differential drug resistance [abstract]. Presented at the Keystone Symposia on Molecular and Cellular Biology: HIV Pathogenesis and Treatment, Keystone, Colorado, 1998.
10. Clemetson DB, Moss GB, Willerford DM, et al. Detection of HIV DNA in cervical and vaginal secretions. Prevalence and correlates among women in Nairobi, Kenya. JAMA 1993;269:2860-4.
11. John GC, Nduati RW, Mbori-Ngacha D, et al. Genital shedding of human immunodeficiency virus type 1 DNA during pregnancy: association with immunosuppression, abnormal cervical or vaginal discharge, and severe vitamin A deficiency. J Infect Dis 1997;175: 57-62.
12. Schacker T, Ryncarz AJ, Goddard J, Diem K, Shaughnessy M, Corey L. Frequent recovery of HIV-1 from genital herpes simplex virus lesions in HIV-1-infected men. JAMA 1998;280:61-6.
13. Plummer FA. Heterosexual transmission of human immunodeficiency virus type 1 (HIV): interactions of conventional sexually transmitted diseases, hormonal contraception and HIV-1. AIDS Res Hum Retroviruses 1998;14(Suppl 1):S5-10.
14. Augenbraun M, Feldman J, Chirgwin K, et al. Increased genital shedding of herpes simplex virus type 2 in HIV-seropositive women. Ann Intern Med 1995;123:845-7.
15. Barkan SE, Melnick SL, Preston-Martin S, et al. The Women's Interagency HIV Study. Epidemiology 1998;9:117-125.
16. Lew J, Reichelderfer P, Fowler M, et al. Determinations of levels of human immunodeficiency virus type 1 RNA in plasma: reassessment of parameters affecting assay outcome. TUBE Meeting Workshop attendees: Technology Utilization for HIV-1 Blood Evaluation and Standardization in Pediatrics. J Clin Microbiol 1998;36:1471-9.
17. Anderson DJ, Politch JA, Tucker LD, et al. Quantitation of mediators of inflammation and immunity in genital tract secretions and their relevance to HIV type 1 transmission. AIDS Res Hum Retroviruses 1998;14(Suppl 1):S43-9
18. van Gemen B, Kievits T, Schukkink R, et al. Quantification of HIV-1 RNA in plasma using NASBA during HIV-1 primary infection. J Virol Methods 1993;43:177-87.
19. Mayaux MJ, Dussaix E, Isopet J, et al. Maternal virus load during pregnancy and mother-to-child transmission of human immunodeficiency virus type 1: the French perinatal cohort studies. SERO-GEST Cohort Group. J Infect Dis 1997;175:172-5.
20. Cao Y, Krogstad P, Korber BT, et al. Maternal HIV-1 viral load and vertical transmission of infection: the Ariel Project for the prevention of HIV transmission from mother to infant. Nat Med 1997;3:549-52.
21. Sperling RS, Shapiro DE, Coombs RW, et al. Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group [see comments]. N Engl J Med 1996;335:1621-9.
22. Hart CE, Lennox JL, Pratt-Palmore M, et al. Correlation of human immunodeficiency virus type 1 RNA levels in blood and the female genital tract. J Infect Dis 1999;179:871-82.
23. Goulston C, McFarland W, Katzenstein D. Human immunodeficiency virus type 1 RNA shedding in the female genital tract. J Infect Dis 1998;177:1100-3.
24. Iversen AK, Larsen AR, Jensen T, et al. Distinct determinants of human immunodeficiency virus type 1 RNA and DNA loads in vaginal and cervical secretions. J Infect Dis 1998;177:1214-20.
25. Kreiss J, Willerford DM, Hensel M, et al. Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA. J Infect Dis 1994;170:1597-1601.
26. Loussert-Ajaka I, Mandelbrot L, Delmas MC, et al. HIV-1 detection in cervicovaginal secretions during pregnancy. AIDS 1997;11: 1575-81.
27. Mostad SB, Overbaugh J, DeVange DM, et al. Hormonal contraception, vitamin A deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina. Lancet 1997; 350:922-7.
28. Mostad SB. Prevalence and correlates of HIV type 1 shedding in the female genital tract. AIDS Res Hum Retroviruses 1998; 14(Suppl 1):S11-15.
29. Henin Y, Mandelbrot L, Henrion R, Pradinaud R, Coulaud JP, Montagnier L. Virus excretion in the cervicovaginal secretions of pregnant and nonpregnant HIV-infected women [see comments]. J Acquir Immune Defic Syndr 1993;6:72-5.
30. Cu-Uvin S, Caliendo AM, Reinert SE, Mayer KH, Flanigan TP, Carpenter CC. HIV-1 in the female genital tract and the effect of antiretroviral therapy [letter]. AIDS 1998;12:826-7.
31. Cu-Uvin S, Caliendo AM. Cervicovaginal human immunodeficiency virus secretion and plasma viral load in human immunodeficiency virus-seropositive women. Obstet Gynecol 1997;90:739-43.
32. Rasheed S, Li Z, Xu D, Kovacs A. Presence of cell-free human immunodeficiency virus in cervicovaginal secretions is independent of viral load in the blood of human immunodeficiency virus-infected women. Am J Obstet Gynecol 1996;175:122-9.
33. Iversen AK, Fugger L, Eugen-Olsen J, et al. Cervical human immunodeficiency virus type 1 shedding is associated with genital beta-chemokine secretion. J Infect Dis 1998;178:1334-42.
34. al-Harthi L, Spear GT, Hashemi FB, Landay A, Sha BE, Roebuck KA. A human immunodeficiency virus (HIV)-inducing factor from the female genital tract activates HIV-1 gene expression through the kappaB enhancer. J Infect Dis 1998;178:1343-51.
35. Hill JA, Anderson DJ. Human vaginal leukocytes and the effects of vaginal fluid on lymphocyte and macrophage defense functions. Am J Obstet Gynecol 1992;166:720-6.
36. Howell AL, Edkins RD, Rier SE, et al. Human immunodeficiency virus type 1 infection of cells and tissues from the upper and lower human female reproductive tract. J Virol 1997;71:3498-3506.
37. Palacio J, Souberbielle BE, Shattock RJ, Robinson G, Manyonda I, Griffin GE. In vitro HIV 1 infection of human cervical tissue. Res Virol 1994;145:155-61.
38. Yeaman GR, White HD, Howell A, Prabhala R, Wira CR. The mucosal immune system in the human female reproductive tract: potential insights into the heterosexual transmission of HIV. AIDS Res Hum Retroviruses 1998;14(Suppl 1):S57-62.
39. Soto-Ramirez LE, Renjifo B, McLane MF, et al. HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV. Science 1996;271:1291-3.
40. Phillips DM, Tan X, Pearce-Pratt R, Zacharopoulos VR. An assay for HIV infection of cultured human cervix-derived cells. J Virol Methods 1995;52:1-13.
41. Boom R, Sol CJ, Salimans MM, Jansen CL, Wertheim-van Dillen PM, van der Noordaa J. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 1990;28:495-503.
42. Kievits T, van Gemen B, van Strijp D, et al. NASBA isothermal enzymatic in vitro nucleic acid amplification optimized for the diagnosis of HIV-1 infection. J Virol Methods 1991;35:273-286.