Structure elucidation of three isomeric metabolites of SYN-2836, a novel antifungal agent, in dogs via liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry methodologies

Journal of Mass Spectrometry

Volumn 34, Issue 11, 1999, Pages 1185-1194

  Bu, Hai Zhi ^a   Poglod, Marzena ^a   Micetich, Ronald G ^a   Khan, Jehangir K ^a  

^a NAEJA Pharmaceuticals Inc   (Canada)

Author keywords

Antifungal agent; Biotransformation; Drug metabolism; Electrospray ionization; Liquid chromatography mass spectrometry

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 3 [4 [4 [2 (4 TRIFLUOROMETHOXYBENZYL) 2H 1,2,4 TRIAZOL 3 ONE 4 YL]PHENYL]PIPERAZIN 1 YL] 1 (1H 1,2,4 TRIAZOL 1 YL)BUTAN 2 OL; 4 [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 1 PIPERAZINYL]PHENYL] 2,4 DIHYDRO 2 [[4 (TRIFLUOROMETHYL)PHENYL]METHYL] 3H 1,2,4 TRIAZOL 3 ONE; ACETONITRILE; ANTIFUNGAL AGENT; DRUG METABOLITE; FORMIC ACID; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOG; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTIFUNGAL AGENTS; BENZENE DERIVATIVES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; ISOMERISM; MALE; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PIPERAZINES; TRIAZOLES;

ANIMALIA; CANIS FAMILIARIS;

EID: 0032706643     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9888(199911)34:11<1185::AID-JMS879>3.0.CO;2-R     Document Type: Article

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