Application of packed capillary liquid chromatography/mass spectrometry with electrospray ionization to the study of the human biotransformation of the anti-emetic drug dolasetron

Journal of Mass Spectrometry

Volumn 31, Issue 6, 1996, Pages 681-689

  Ackermann, Bradley L ^a   Gillespie, Todd A ^a,b   Regg, Brian T ^a   Austin, Kimberly F ^a   Coutant, John E ^a  

^a SANOFI   (France)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Biotransformation; Dolasetron; Electrospray; Packed capillary liquid chromatography; Tandem mass spectrometry

Indexed keywords

ANTIEMETIC AGENT; CARBON 14; DOLASETRON MESILATE; DRUG METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL;

ANTIEMETICS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; HUMANS; INDOLES; INJECTIONS, INTRAVENOUS; MALE; MASS SPECTROMETRY; QUINOLIZINES; SULFATES;

EID: 0030014284     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9888(199606)31:6<681::AID-JMS344>3.0.CO;2-F     Document Type: Article

References (25)

1. T. Conroy, P. Cappelaere, M. Fabbro, A. A. Fauser, T. A. Splinter, M. Spielmann, M. Schneider, B. Chevallier, A. Goupil and J. Chauvergne, Am. J. Clin. Oncol. 17, 97 (1994).
2. M. G. Kris, S. M. Grunberg, R. J. Gralla, L. Baltzer, S. A. Zaretsky, D. Lifsey, L. B. Tyson, L. Schmidt and W. F. Hahne, J. Clin. Oncol. 12, 1045 (1994).
3. T. L. Hunt, M. Cramer, A. Shah, W. Stewart, C. R. Benedict and W. F. Hahne, J. Clin. Pharmacol. 35, 705 (1995).
4. A. Shah, R. Lanman, V. Bhargava, S. Weir and W. Hahne, Biopharm. Drug Dispos. 16, 177 (1995).
5. J. Darius and F. P. Meyer, J. Chromotogr. 656, 343 (1994).
6. A. J. Tomlinson, L. M. Benson, G. F. Scanlan, K. L. Johnson and S. Naylor, Electrophoresis 15, 62 (1994).
7. H. Fouda, M. Nocerini, R. Schneider and C. Gedutis, J. Am. Soc. Mass Spectrom. 2, 164 (1991).
8. T. M. Chen, K. Y. Chan, J. E. Coutant and R. A. Okerholm, J. Pharm. Biomed. Anal. 9, 929 (1991).
9. P. Rossato, M. Scandola, F. Pugnaghi and P. Grossi, Org. Mass Spectrom. 27, 1261 (1992).
10. P. J. Swart, G. M. Bronner, A. P. Bruins, K. Ensing, P. G. Tepper and R. A. DeZeeuw, Toxicol. Methods 3, 279 (1993).
11. T. R. Covey, E. D. Lee, A. P. Bruins and J. D. Henion, Anal. Chem. 58, 1451A (1986).
12. K. B. Tomer and C. E. Parker, J. Chromatogr. 492, 189 (1989).
13. R. D. Smith, J. H. Wahl, D. R. Goodlett and S. A. Hofstadler, Anal. Chem. 65, 574A (1993).
14. G. Hopfgartner, K. Bean, J. Henion and R. Henry, J. Chromatogr. 647, 51 (1993).
15. T. A. Gillespie, J. A. Eckstein, P. Nardella and J. E. Coutant, J. Pharm. Biomed. Anal. 11, 955 (1993).
16. J. E. Coutant, T. M. Chen and B. L. Ackermann, J. Chromatogr. 529, 265 (1990).
17. J. Gluckman, A. Hirose, V. McGuffin and M. Novotny, Chromatographia 17, 303 (1983).
18. H. J. Cortes, C. D. Pfeiffer, B. E. Richter and T. S. Stevens, J. High Resolut. Chromatogr. Chromatogr. Commun. 10, 446 (1987).
19. J. B. Fenn, M. Mann, C. K. Meng, S. F. Wong and C. M. Whitehouse, Science 246, 64 (1989).
20. J. Dow and C. Berg, Chirality 7, 342 (1995).
21. M. K. Reith, G. D. Sproles and L. K. Cheng, Drug Metab. Dispos. 23, 806 (1995).
22. M. Bigaud, J. Elands, P. R. Kastner, R. A. Bohnke, L. W. Emmert and M. Galvan, Drug Dev. Res. 34, 289 (1995).
23. K. M. Straub, P. Rudewicz and C. Garvie, Xenobiotica 17, 413 (1983).
24. H. G. Fouda, M. Avery and K. Navetta, in Proceedings of the 41st ASMS Conference on Mass Spectrometry and Allied Topics, San Francisco, CA, 1993, p. 49a.
25. R. P. Schneider, K. M. Davis, P. B. Inskeep and H. G. Fouda, in Proceedings of the 42nd ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, IL, 1994, p. 345.