Characterization of the efflux of the organic cation MPP+ in cultured rat hepatocytes

European Journal of Pharmacology

Volumn 379, Issue 2-3, 1999, Pages 211-218

  Martel, Fátima ^a   Ribeiro, Laura ^a   Calhau, Conceição ^a   Azevedo, Isabel ^a  

^a Inst of Pharmacol and Therapeutics   (Portugal)

Author keywords

Hepatocytes, rat; MPP+ (1 methyl 4 phenylpyridinium); P glycoprotein; rOCT1 (rat Organic Cation Transporter 1); Transport

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ANTIPORTER; CARRIER PROTEIN; CATION; CYCLOSPORIN A; DAUNORUBICIN; GLYCOPROTEIN P; RHODAMINE 123; VANADIC ACID; VERAPAMIL; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; ION TRANSPORT; LIVER CELL; LIVER METABOLISM; MALE; METABOLIC INHIBITION; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TEMPERATURE;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; DOPAMINE AGENTS; ION PUMPS; LIVER; MALE; MEMBRANE PROTEINS; ORGANIC CATION TRANSPORTER 1; RATS; RATS, WISTAR;

EID: 0032701388     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00501-4     Document Type: Article

References (39)

1. Bradford M. A rapid method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
2. Busch A.E., Quester S., Ulzheimer J.C., Waldegger S., Gorboulev V., Arndt P., Lang F., Koepsell H. Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J. Biol. Chem. 271:1996;32599-32604.
3. Cavet M.E., West M., Simmons N.L. Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells. Br. J. Pharmacol. 121:1997;1567-1578.
4. Gatmaitan Z.C., Arias I.M. ATP-dependent transport systems in the canalicular membrane of the hepatocyte. Physiol. Rev. 75:1995;261-275.
5. Gorboulev V., Ulzheimer J.C., Akhoundova A., Ulzheimer-Teuber I., Karbach U., Quester S., Baumann C., Lang F., Busch A.E., Koepsell H. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 16:1997;871-881.
6. Gottesman M.M., Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:1993;385-427.
7. Gründemann D., Gorboulev V., Gambaryan S., Veyhl M., Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 372:1994;549-552.
8. Jakob I., Hauser I.A., Thevenod F., Lindemann B. MDR1 in taste buds of rat vallate pappila: functional, immunohistochemical, and biochemical evidence. Am. J. Physiol. 274:1998;C182-C191.
9. Kamimoto Y., Gatmaitan Z., Hsu J., Arias I.M. The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J. Biol. Chem. 264:1989;11693-11698.
10. Klaassen C.D., Watkins J. III Mechanisms of bile formation, hepatic uptake, and biliary excretion. Pharmacol. Rev. 36:1984;1-67.
11. + in freshly isolated rat hepatocytes: evidence for interaction with catecholamines Naunyn-Schmiedeberg's Arch. Pharmacol. 354:1996;305-311.
12. 3H ]-1-methyl-4-phenylpyridinium in rat isolated hepatocytes: putative involvement of a P-glycoprotein transporter Br. J. Pharmacol. 119:1996;1519-1524.
13. Martel F., Vetter T., Russ H., Gründemann D., Azevedo I., Koepsell H., Schömig E. Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn-Schmiedeberg's Arch. Pharmacol. 354:1996;320-326.
14. Martel F., Calhau C., Hipólito-Reis C. Effect of bile duct obstruction on hepatic uptake of 1-methyl-4-phenylpyridinium in the rat. Pharmacol. Res. 37:1998;497-504.
15. 2 and OCT1: effects of catecholamines, metanephrines and corticosterone. Naunyn-Schmiedeberg's Arch. Pharmacol. 359:1999;303-309.
16. Mechetner E.B., Roninson I.B. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc. Natl. Acad. Sci. U.S.A. 89:1992;5824-5828.
17. Meijer D.K.F., Mol W., Muller M., Kurz G. Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations. J. Pharmacokinet. Biopharm. 18:1990;35-70.
18. Miller D.S. Daunomycin secretion by killifish renal proximal tubules. Am. J. Physiol. 269:1995;R370-R379. Regulatory Integrative Comp. Physiol.
19. Moseley R.H., Jarose S.M., Permoad P. Organic cation transport by rat liver plasma membrane vesicles: studies with tetraethlyammonium. Am. J. Physiol. 263:1992;G775-G785. Gastrointest. Liver Physiol.
20. + exchanger. J. Pharmacol. Exp. Ther. 281:1997;34-40.
21. Motulsky, H.J., Spannard, P., Neubig, R., 1994. Graphpad Prism (version 1.0). Graphpad Prism Software, San Diego.
22. Muller M., Mayer R., Hero U., Keppler D. ATP-dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by the mdr1 P-glycoprotein. FEBS Lett. 343:1994;168-172.
23. Oude Elferink R.P.J., Meijer D.K.F., Kuipers F., Jansen P.L.M., Groen A.K., Groothuis G.M.M. Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim. Biophys. Acta. 1241:1995;215-268.
24. Sayre L.M. Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicol. Lett. 48:1989;121-149.
25. Schinkel A.H., Arceci R.J., Smit J.J., Wagenaar E., Baas F., Dolle M., Tsuruo T., Mechetner E.B., Roninson I.B., Borst P. Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein. Int. J. Cancer. 55:1993;478-484.
26. Schramm U., Fricker G., Wenger R., Miller D.S. P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules. Am. J. Physiol. 268:1995;F46-F52. Renal Fluid Electrolyte Physiol.
27. Schweifer N., Barlow D.P. The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mamm. Genome. 7:1996;735-740.
28. Smit J.W., Duin E., Steen H., Oosting R., Roggeveld J., Meijer D.K.F. Interactions between P-glycoprotein substrates and other cationic drugs at the hepatic excretory level. Br. J. Pharmacol. 123:1998;361-370.
29. Smit J.W., Schinkel A.H., Muller M., Weert B., Meijer D.K.F. Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption. Hepatology. 27:1998;1056-1063.
30. Smit J.W., Weert B., Schinkel A.H., Meijer D.K.F. Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs. J. Pharmacol. Exp. Ther. 286:1998;321-327.
31. 1 cells. Br. J. Pharmacol. 123:1998;13-22.
32. Terashita S., Dresser M.J., Zhang L., Gray A.T., Yost S.C., Giacomini K.M. Molecular cloning and functional expression of a rabbit renal organic cation transporter. Biochim. Biophys. Acta. 1369:1998;1-6.
33. Thalhammer T., Stapf V., Gajdzik L., Graf J. Bile canalicular cationic dye secretion as a model for P-glycoprotein mediated transport. Eur. J. Pharmacol. 270:1994;213-220.
34. Trendelenburg, U., 1988. The extraneuronal uptake and metabolism of catecholamines. In: Trendelenburg, U., Weiner, N. (Eds.), Catecholamines I, Handb Exp. Pharmacol, Vol. 90/I. Springer-Verlag, Berlin, pp. 279-319.
35. Tsuji A., Tamai I., Sakata A., Tenda Y., Terasaki T. Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem. Pharmacol. 46:1993;1096-1099.
36. Watanabe T., Miyauchi S., Sawada Y., Iga T., Hanano M., Inaba M., Sugiyama Y. Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine. J. Hepatol. 16:1992;77-88.
37. Zhang L., Dresser M.J., Gray A.T., Yost S.C., Terashita S., Giacomini K.M. Cloning and functional expression of a human liver organic cation transporter. Mol. Pharmacol. 51:1997;913-921.
38. Zhang L., Brett C.M., Giacomini K.M. Role of organic cation transporters in drug absorption and elimination. Annu. Rev. Pharmacol. Toxicol. 38:1998;431-460.
39. Zhang L., Schaner M.E., Giacomini K.M. Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J. Pharmacol. Exp. Ther. 286:1998;354-361.