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Volumn 2, Issue 6, 1999, Pages 651-656

Genes involved in phenotypic and antigenic variation in african trypanosomes and malaria

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN TRYPANOSOMIASIS; ANTIGENIC VARIATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REARRANGEMENT; HOST PARASITE INTERACTION; MALARIA; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PLASMODIUM; REVIEW; TRYPANOSOMA BRUCEI;

EID: 0032693050     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(99)00039-9     Document Type: Review
Times cited : (14)

References (67)
  • 2
    • 0032029361 scopus 로고    scopus 로고
    • Regulation of vsg expression site transcription and switching in Trypanosoma brucei
    • Cross G.A.M., Wirtz L.E., Navarro M. Regulation of vsg expression site transcription and switching in Trypanosoma brucei. Mol Biochem Parasitol. 91:1998;77-91.
    • (1998) Mol Biochem Parasitol , vol.91 , pp. 77-91
    • Cross, G.A.M.1    Wirtz, L.E.2    Navarro, M.3
  • 3
    • 0032029245 scopus 로고    scopus 로고
    • Expression and function of surface proteins in Trypanosoma brucei
    • Pays E., Nolan D.P. Expression and function of surface proteins in Trypanosoma brucei. Mol Biochem Parasitol. 91:1998;3-36.
    • (1998) Mol Biochem Parasitol , vol.91 , pp. 3-36
    • Pays, E.1    Nolan, D.P.2
  • 4
    • 0030900089 scopus 로고    scopus 로고
    • The relative significance of mechanisms of antigenic variation in African trypanosomes
    • Barry J.D. The relative significance of mechanisms of antigenic variation in African trypanosomes. Parasitol Today. 13:1997;212-218.
    • (1997) Parasitol Today , vol.13 , pp. 212-218
    • Barry, J.D.1
  • 5
  • 6
    • 0031890605 scopus 로고    scopus 로고
    • Changing the end: Antigenic variation orchestrated at the telomeres of African trypanosomes
    • Rudenko G., Cross M., Borst P. Changing the end: antigenic variation orchestrated at the telomeres of African trypanosomes. Trends Microbiol. 6:1998;113-117.
    • (1998) Trends Microbiol , vol.6 , pp. 113-117
    • Rudenko, G.1    Cross, M.2    Borst, P.3
  • 7
    • 0031726222 scopus 로고    scopus 로고
    • Surface receptors and transporters of Trypanosoma brucei
    • Borst P., Fairlamb A.H. Surface receptors and transporters of Trypanosoma brucei. Annu Rev Microbiol. 52:1998;745-778.
    • (1998) Annu Rev Microbiol , vol.52 , pp. 745-778
    • Borst, P.1    Fairlamb, A.H.2
  • 8
    • 0032576751 scopus 로고    scopus 로고
    • The role of transferrin-receptor variation in the host range of Trypanosoma brucei
    • A clever explanation for why African trypanosomes have twenty VSG expression sites instead of just one. The polymorphic transferrin receptor subunit genes present in different expression sites appear to encode receptors with different affinities for the variable transferrin proteins present in different mammalian host species. The authors propose that the polymorphic nature of expression site associated genes plays a role in host adaptation.
    • Bitter W., Gerrits H., Kieft R., Borst P. The role of transferrin-receptor variation in the host range of Trypanosoma brucei. Nature. 391:1998;499-502. A clever explanation for why African trypanosomes have twenty VSG expression sites instead of just one. The polymorphic transferrin receptor subunit genes present in different expression sites appear to encode receptors with different affinities for the variable transferrin proteins present in different mammalian host species. The authors propose that the polymorphic nature of expression site associated genes plays a role in host adaptation.
    • (1998) Nature , vol.391 , pp. 499-502
    • Bitter, W.1    Gerrits, H.2    Kieft, R.3    Borst, P.4
  • 9
    • 0032784058 scopus 로고    scopus 로고
    • Predominance of duplicative VSG gene conversion in antigenic variation in African trypanosomes
    • Robinson N.P., Burman N., Melville S.E., Barry J.D. Predominance of duplicative VSG gene conversion in antigenic variation in African trypanosomes. Mol Cell Biol. 19:1999;5839-5846.
    • (1999) Mol Cell Biol , vol.19 , pp. 5839-5846
    • Robinson, N.P.1    Burman, N.2    Melville, S.E.3    Barry, J.D.4
  • 10
    • 0031053120 scopus 로고    scopus 로고
    • Gene conversions mediating antigenic variation in Trypanosoma brucei can occur in variant surface glycoprotein expression sites lacking 70-base-pair repeat sequences
    • McCulloch R., Rudenko G., Borst P. Gene conversions mediating antigenic variation in Trypanosoma brucei can occur in variant surface glycoprotein expression sites lacking 70-base-pair repeat sequences. Mol Cell Biol. 17:1997;833-843.
    • (1997) Mol Cell Biol , vol.17 , pp. 833-843
    • McCulloch, R.1    Rudenko, G.2    Borst, P.3
  • 11
    • 0030037305 scopus 로고    scopus 로고
    • Stable expression of mosaic coats of variant surface glycoproteins in Trypanosoma brucei
    • Mùoz-Jordan J.L., Davies K.P., Cross G.A.M. Stable expression of mosaic coats of variant surface glycoproteins in Trypanosoma brucei. Science. 272:1996;1795-1797.
    • (1996) Science , vol.272 , pp. 1795-1797
    • Mùoz-Jordan, J.L.1    Davies, K.P.2    Cross, G.A.M.3
  • 12
    • 0033199568 scopus 로고    scopus 로고
    • Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei
    • Chaves I., Rudenko G., Dirks-Mulder A., Cross M., Borst P. Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei. EMBO J. 18:1999;4846-4855.
    • (1999) EMBO J , vol.18 , pp. 4846-4855
    • Chaves, I.1    Rudenko, G.2    Dirks-Mulder, A.3    Cross, M.4    Borst, P.5
  • 13
    • 0033065275 scopus 로고    scopus 로고
    • Mono-allelic expression of genes in simple eukaryotes
    • Borst P., Chaves I. Mono-allelic expression of genes in simple eukaryotes. Trends Genet. 15:1999;95-96.
    • (1999) Trends Genet , vol.15 , pp. 95-96
    • Borst, P.1    Chaves, I.2
  • 14
    • 0033062624 scopus 로고    scopus 로고
    • Transcription of 'inactive' expression sites in African trypanosomes leads to expression of multiple transferrin receptor RNAs in bloodstream forms
    • Ansorge I., Steverding D., Melville S., Hartmann C., Clayton C. Transcription of 'inactive' expression sites in African trypanosomes leads to expression of multiple transferrin receptor RNAs in bloodstream forms. Mol Biochem Parasitol. 101:1999;81-94.
    • (1999) Mol Biochem Parasitol , vol.101 , pp. 81-94
    • Ansorge, I.1    Steverding, D.2    Melville, S.3    Hartmann, C.4    Clayton, C.5
  • 15
    • 0028050668 scopus 로고
    • VSG gene expression site control in insect form Trypanosoma brucei
    • Rudenko G., Blundell P.A., Taylor M.C., Kieft R., Borst P. VSG gene expression site control in insect form Trypanosoma brucei. EMBO J. 13:1994;5470-5482.
    • (1994) EMBO J , vol.13 , pp. 5470-5482
    • Rudenko, G.1    Blundell, P.A.2    Taylor, M.C.3    Kieft, R.4    Borst, P.5
  • 16
    • 0029951447 scopus 로고    scopus 로고
    • DNA rearrangements associated with multiple consecutive directed antigenic switches in Trypanosoma brucei
    • Navarro M., Cross G.A.M. DNA rearrangements associated with multiple consecutive directed antigenic switches in Trypanosoma brucei. Mol Cell Biol. 16:1996;3615-3625.
    • (1996) Mol Cell Biol , vol.16 , pp. 3615-3625
    • Navarro, M.1    Cross, G.A.M.2
  • 17
    • 0032128354 scopus 로고    scopus 로고
    • In situ analysis of a variant surface glycoprotein expression-site promoter region in Trypanosoma brucei
    • Navarro M., Cross G.A.M. In situ analysis of a variant surface glycoprotein expression-site promoter region in Trypanosoma brucei. Mol Biochem Parasitol. 94:1998;53-66.
    • (1998) Mol Biochem Parasitol , vol.94 , pp. 53-66
    • Navarro, M.1    Cross, G.A.M.2
  • 18
    • 0002539276 scopus 로고
    • Telomere position effects and transcriptional silencing in the yeast Saccharomyces cerevisiae
    • E.H. Blackburn, & C.W. Greider. Cold Spring Harbour: Cold Spring Harbour Laboratory Press
    • Shore D. Telomere position effects and transcriptional silencing in the yeast Saccharomyces cerevisiae. Blackburn E.H., Greider C.W. Telomeres. 1995;139-191 Cold Spring Harbour Laboratory Press, Cold Spring Harbour.
    • (1995) Telomeres , pp. 139-191
    • Shore, D.1
  • 19
    • 0028809565 scopus 로고
    • A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei
    • Rudenko G., Blundell P.A., Dirks-Mulder A., Kieft R., Borst P. A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei. Cell. 83:1995;547-553.
    • (1995) Cell , vol.83 , pp. 547-553
    • Rudenko, G.1    Blundell, P.A.2    Dirks-Mulder, A.3    Kieft, R.4    Borst, P.5
  • 20
    • 0028881923 scopus 로고
    • A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei
    • Horn D., Cross G. A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei. Cell. 83:1995;555-561.
    • (1995) Cell , vol.83 , pp. 555-561
    • Horn, D.1    Cross, G.2
  • 21
    • 0033561049 scopus 로고    scopus 로고
    • Trypanosoma brucei variant surface glycoprotein regulation involves coupled activation/inactivation and chromatin remodeling of expression sites
    • Navarro M., Cross G.A.M., Wirtz E. Trypanosoma brucei variant surface glycoprotein regulation involves coupled activation/inactivation and chromatin remodeling of expression sites. EMBO J. 18:1999;2265-2272.
    • (1999) EMBO J , vol.18 , pp. 2265-2272
    • Navarro, M.1    Cross, G.A.M.2    Wirtz, E.3
  • 22
    • 0030722989 scopus 로고    scopus 로고
    • Localization of the modified base J in telomeric VSG gene expression sites of Trypanosoma brucei
    • Van Leeuwen F., Wijsman E.R., Kieft R., van der Marel G.A., van Boom J.H., Borst P. Localization of the modified base J in telomeric VSG gene expression sites of Trypanosoma brucei. Genes Dev. 11:1997;3232-3241.
    • (1997) Genes Dev , vol.11 , pp. 3232-3241
    • Van Leeuwen, F.1    Wijsman, E.R.2    Kieft, R.3    Van Der Marel, G.A.4    Van Boom, J.H.5    Borst, P.6
  • 23
    • 0031657236 scopus 로고    scopus 로고
    • Biosynthesis and function of the modified DNA base β-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei
    • Van Leeuwen F., Kieft R., Cross M., Borst P. Biosynthesis and function of the modified DNA base β-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei. Mol Cell Biol. 18:1998;5643-5651.
    • (1998) Mol Cell Biol , vol.18 , pp. 5643-5651
    • Van Leeuwen, F.1    Kieft, R.2    Cross, M.3    Borst, P.4
  • 25
    • 0028246436 scopus 로고
    • A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. brucei
    • Salmon D., Geuskens M., Hanocq F., Hanocq-Quertier J., Nolan D., Ruben L., Pays E. A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. brucei. Cell. 78:1994;75-86.
    • (1994) Cell , vol.78 , pp. 75-86
    • Salmon, D.1    Geuskens, M.2    Hanocq, F.3    Hanocq-Quertier, J.4    Nolan, D.5    Ruben, L.6    Pays, E.7
  • 26
    • 0032423741 scopus 로고    scopus 로고
    • A VSG expression-site associated gene confers resistance to human serum in Trypanosoma rhodesiense
    • A gene mediating human serum resistance in bloodstream form T. brucei rhodesiense is shown to be encoded in an expression site. This explains the reversible and unstable nature of this phenotype, and is additional evidence for the polymorphic nature of VSG expression sites playing a role in host adaptation.
    • Van Hong H., Vanhamme L., Chamekh M., Chimfwembe C.E., van den Abbeele J., Pays A., van Meirvenne N., Hamers R., de Baetselier P., Pays E. A VSG expression-site associated gene confers resistance to human serum in Trypanosoma rhodesiense. Cell. 95:1998;839-846. A gene mediating human serum resistance in bloodstream form T. brucei rhodesiense is shown to be encoded in an expression site. This explains the reversible and unstable nature of this phenotype, and is additional evidence for the polymorphic nature of VSG expression sites playing a role in host adaptation.
    • (1998) Cell , vol.95 , pp. 839-846
    • Van Hong, H.1    Vanhamme, L.2    Chamekh, M.3    Chimfwembe, C.E.4    Van Den Abbeele, J.5    Pays, A.6    Van Meirvenne, N.7    Hamers, R.8    De Baetselier, P.9    Pays, E.10
  • 28
    • 0033178482 scopus 로고    scopus 로고
    • Antigenic variation in Plasmodium falciparum: Mechanisms and consequences
    • Newbold C.I. Antigenic variation in Plasmodium falciparum: mechanisms and consequences. Curr Opin Microbiol. 2:1999;420-425.
    • (1999) Curr Opin Microbiol , vol.2 , pp. 420-425
    • Newbold, C.I.1
  • 30
    • 0029864180 scopus 로고    scopus 로고
    • Membrane modifications in erythrocytes parasitized by Plasmodium falciparum
    • Deitsch K.W., Wellems T.E. Membrane modifications in erythrocytes parasitized by Plasmodium falciparum. Mol Biochem Parasitol. 76:1996;1-10.
    • (1996) Mol Biochem Parasitol , vol.76 , pp. 1-10
    • Deitsch, K.W.1    Wellems, T.E.2
  • 31
    • 0033560274 scopus 로고    scopus 로고
    • A new escape and evasion tactic
    • Barnwell J.W. A new escape and evasion tactic. Nature. 398:1999;562-563.
    • (1999) Nature , vol.398 , pp. 562-563
    • Barnwell, J.W.1
  • 33
    • 0033526976 scopus 로고    scopus 로고
    • A blueprint of 'bad air'
    • Wahlgren M., Bejarano M.T. A blueprint of 'bad air'. Nature. 400:1999;506-507.
    • (1999) Nature , vol.400 , pp. 506-507
    • Wahlgren, M.1    Bejarano, M.T.2
  • 35
    • 0028982168 scopus 로고
    • Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
    • Smith J.D., Chitnis C.E., Craig A.G., Roberts D.J., Hudson-Taylor D.E., Peterson D.S., Pinches R., Newbold C.I., Miller L.H. Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell. 82:1995;101-110.
    • (1995) Cell , vol.82 , pp. 101-110
    • Smith, J.D.1    Chitnis, C.E.2    Craig, A.G.3    Roberts, D.J.4    Hudson-Taylor, D.E.5    Peterson, D.S.6    Pinches, R.7    Newbold, C.I.8    Miller, L.H.9
  • 36
    • 0029070914 scopus 로고
    • The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes
    • Su X., Heatwole V.M., Wertheimer S.P., Guinet F., Herrfeldt J.A., Peterson D.S., Ravetch J.A., Wellems T.E. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell. 82:1995;89-100.
    • (1995) Cell , vol.82 , pp. 89-100
    • Su, X.1    Heatwole, V.M.2    Wertheimer, S.P.3    Guinet, F.4    Herrfeldt, J.A.5    Peterson, D.S.6    Ravetch, J.A.7    Wellems, T.E.8
  • 37
    • 0029052741 scopus 로고
    • Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
    • Baruch D.I., Pasloske B.L., Singh H.B., Bi X., Ma X.C., Feldman M., Taraschi T.F., Howard R.J. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell. 82:1995;77-87.
    • (1995) Cell , vol.82 , pp. 77-87
    • Baruch, D.I.1    Pasloske, B.L.2    Singh, H.B.3    Bi, X.4    Ma, X.C.5    Feldman, M.6    Taraschi, T.F.7    Howard, R.J.8
  • 40
    • 0030904788 scopus 로고    scopus 로고
    • Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress
    • The authors disrupt the KAHRP gene necessary for knob formation. Parasites with parasite-derived endothelial cell receptors concentrated in knobs appear better able to adhere to endothelium under flow conditions typical of capillaries.
    • Crabb B.S., Cooke B.M., Reeder J.C., Waller R.F., Caruana S.R., Davern K.M., Wickham M.E., Brown G.V., Coppel R.L., Cowman A.F. Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Cell. 89:1997;287-296. The authors disrupt the KAHRP gene necessary for knob formation. Parasites with parasite-derived endothelial cell receptors concentrated in knobs appear better able to adhere to endothelium under flow conditions typical of capillaries.
    • (1997) Cell , vol.89 , pp. 287-296
    • Crabb, B.S.1    Cooke, B.M.2    Reeder, J.C.3    Waller, R.F.4    Caruana, S.R.5    Davern, K.M.6    Wickham, M.E.7    Brown, G.V.8    Coppel, R.L.9    Cowman, A.F.10
  • 41
    • 0033609079 scopus 로고    scopus 로고
    • The adhesion of Plasmodium falciparum infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1
    • Reeder J.C., Cowman A.F., Davern K.M., Beeson J.G., Thompson J.K., Rogerson S.J., Brown G.V. The adhesion of Plasmodium falciparum infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1. Proc Natl Acad Sci USA. 96:1999;5198-5202.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5198-5202
    • Reeder, J.C.1    Cowman, A.F.2    Davern, K.M.3    Beeson, J.G.4    Thompson, J.K.5    Rogerson, S.J.6    Brown, G.V.7
  • 42
    • 0032583103 scopus 로고    scopus 로고
    • Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain
    • Analysis of the adhesive properties conferred by different domains of a VAR protein using transfections in mammalian cells and ligand coupled to beads. A4VAR was shown to bind to CD36, but binding to ICAM-1 couldn't be reconstructed using this method.
    • Smith J.D., Kyes S., Craig A.G., Fagan T., Hudson-Taylor D., Miller L.H., Baruch D.I., Newbold C.I. Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain. Mol Biochem Parasitol. 97:1998;133-148. Analysis of the adhesive properties conferred by different domains of a VAR protein using transfections in mammalian cells and ligand coupled to beads. A4VAR was shown to bind to CD36, but binding to ICAM-1 couldn't be reconstructed using this method.
    • (1998) Mol Biochem Parasitol , vol.97 , pp. 133-148
    • Smith, J.D.1    Kyes, S.2    Craig, A.G.3    Fagan, T.4    Hudson-Taylor, D.5    Miller, L.H.6    Baruch, D.I.7    Newbold, C.I.8
  • 43
    • 0032791203 scopus 로고    scopus 로고
    • Cytoadherence, pathogenesis and the infected red cell surface in Plasmodium falciparum
    • Newbold C., Craig A., Kyes S., Rowe A., Fernandez-Reyes D., Fagan T. Cytoadherence, pathogenesis and the infected red cell surface in Plasmodium falciparum. Int J Para. 29:1999;1-11.
    • (1999) Int J para , vol.29 , pp. 1-11
    • Newbold, C.1    Craig, A.2    Kyes, S.3    Rowe, A.4    Fernandez-Reyes, D.5    Fagan, T.6
  • 44
    • 0029739905 scopus 로고    scopus 로고
    • The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes
    • Rubio J.P., Thompson J.K., Cowman A.F. The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes. EMBO J. 15:1996;4069-4077.
    • (1996) EMBO J , vol.15 , pp. 4069-4077
    • Rubio, J.P.1    Thompson, J.K.2    Cowman, A.F.3
  • 47
    • 0030927168 scopus 로고    scopus 로고
    • Expression of var genes located within polymorphic subtelomeric domains of Plasmodium falciparum chromosomes
    • Fischer K., Horrocks P., Preuâ M., Wiesner J., Wünsch S., Camargo A.A., Lanzer M. Expression of var genes located within polymorphic subtelomeric domains of Plasmodium falciparum chromosomes. Mol Cell Biol. 17:1997;3679-3686.
    • (1997) Mol Cell Biol , vol.17 , pp. 3679-3686
    • Fischer, K.1    Horrocks, P.2    Preuâ, M.3    Wiesner, J.4    Wünsch, S.5    Camargo, A.A.6    Lanzer, M.7
  • 48
    • 0032805381 scopus 로고    scopus 로고
    • Analysis of Plasmodium falciparum PfEMP-1/var genes suggests that recombination rearranges constrained sequences
    • Ward C.P., Clottey G.T., Dorris M., Ji D.D., Arnot D.E. Analysis of Plasmodium falciparum PfEMP-1/var genes suggests that recombination rearranges constrained sequences. Mol Biochem Parasitol. 102:1999;167-177.
    • (1999) Mol Biochem Parasitol , vol.102 , pp. 167-177
    • Ward, C.P.1    Clottey, G.T.2    Dorris, M.3    Ji, D.D.4    Arnot, D.E.5
  • 49
    • 0029892854 scopus 로고    scopus 로고
    • Compartmentalization of genes coding for immunodominant antigens to fragile chromosome ends leads to dispersed subtelomeric gene families and rapid gene evolution in Plasmodium falciparum
    • Hernandez-Rivas R., Hinterberg K., Scherf A. Compartmentalization of genes coding for immunodominant antigens to fragile chromosome ends leads to dispersed subtelomeric gene families and rapid gene evolution in Plasmodium falciparum. Mol Biochem Parasitol. 78:1996;137-148.
    • (1996) Mol Biochem Parasitol , vol.78 , pp. 137-148
    • Hernandez-Rivas, R.1    Hinterberg, K.2    Scherf, A.3
  • 51
    • 0032530397 scopus 로고    scopus 로고
    • Antigenic variation in malaria: In situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum
    • •] the authors show that multiple VAR genes are transcribed in the early ring stages. Using nuclear run-on experiments, the authors show that mutually exclusive transcription in the trophozoite is mediated at the level of transcription initiation.
    • •] the authors show that multiple VAR genes are transcribed in the early ring stages. Using nuclear run-on experiments, the authors show that mutually exclusive transcription in the trophozoite is mediated at the level of transcription initiation.
    • (1998) EMBO J , vol.17 , pp. 5418-5426
    • Scherf, A.1    Hernandez-Rivas, R.2    Buffet, P.3    Bottius, E.4    Benatar, C.5    Pouvelle, B.6    Gysin, J.7    Lanzer, M.8
  • 52
  • 53
    • 0033551215 scopus 로고    scopus 로고
    • Virulence and transmission success of the malarial parasite Plasmodium falciparum
    • Hayward R.E., Tiwari B., Piper K.P., Baruch D.I., Day K.P. Virulence and transmission success of the malarial parasite Plasmodium falciparum. Proc Natl Acad Sci USA. 96:1999;4563-4568.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4563-4568
    • Hayward, R.E.1    Tiwari, B.2    Piper, K.P.3    Baruch, D.I.4    Day, K.P.5
  • 54
    • 0033062625 scopus 로고    scopus 로고
    • Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum
    • Deitsch K.W., del Pinal A., Wellems T.E. Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum. Mol Biochem Parasitol. 101:1999;107-116.
    • (1999) Mol Biochem Parasitol , vol.101 , pp. 107-116
    • Deitsch, K.W.1    Del Pinal, A.2    Wellems, T.E.3
  • 55
    • 0025994368 scopus 로고
    • Alpha-amanitin-resistant transcription units in trypanosomes: A comparison of promoter sequences for a VSG gene expression site and for the ribosomal RNA genes
    • Zomerdijk J.C.B.M., Kieft R., Shiels P.G., Borst P. Alpha-amanitin-resistant transcription units in trypanosomes: a comparison of promoter sequences for a VSG gene expression site and for the ribosomal RNA genes. Nucleic Acids Res. 19:1991;5153-5158.
    • (1991) Nucleic Acids Res , vol.19 , pp. 5153-5158
    • Zomerdijk, J.C.B.M.1    Kieft, R.2    Shiels, P.G.3    Borst, P.4
  • 56
    • 0026085421 scopus 로고
    • Transient activity assays of the Trypanosoma brucei variant surface glycoprotein gene promoter: Control of the gene expression at the posttranscriptional level
    • Jeffries D., Tebabi P., Pays E. Transient activity assays of the Trypanosoma brucei variant surface glycoprotein gene promoter: control of the gene expression at the posttranscriptional level. Mol Cell Biol. 11:1991;338-343.
    • (1991) Mol Cell Biol , vol.11 , pp. 338-343
    • Jeffries, D.1    Tebabi, P.2    Pays, E.3
  • 57
    • 0031464010 scopus 로고    scopus 로고
    • Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei
    • Horn D., Cross G.A.M. Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei. EMBO J. 16:1997;7422-7431.
    • (1997) EMBO J , vol.16 , pp. 7422-7431
    • Horn, D.1    Cross, G.A.M.2
  • 58
    • 0033083101 scopus 로고    scopus 로고
    • Antigenic variation in malaria: A 3′ genomic alteration associated with the expression of a P. knowlesi variant antigen
    • Al-Khedery B., Barnwell J.W., Galinski M.R. Antigenic variation in malaria: a 3′ genomic alteration associated with the expression of a P. knowlesi variant antigen. Mol Cell. 3:1999;131-141.
    • (1999) Mol Cell , vol.3 , pp. 131-141
    • Al-Khedery, B.1    Barnwell, J.W.2    Galinski, M.R.3
  • 59
    • 0027472596 scopus 로고
    • Rosetting Plasmodium falciparum-infected erythrocytes express unique strain-specific antigens on their surface
    • Helmby H., Cavelier L., Pettersson U., Wahlgren M. Rosetting Plasmodium falciparum-infected erythrocytes express unique strain-specific antigens on their surface. Infect Immun. 61:1993;284-288.
    • (1993) Infect Immun , vol.61 , pp. 284-288
    • Helmby, H.1    Cavelier, L.2    Pettersson, U.3    Wahlgren, M.4
  • 60
    • 0031982752 scopus 로고    scopus 로고
    • The role of rosetting in the multiplication of Plasmodium falciparum: Rosette formation neither enhances nor targets parasite invasion into uninfected red cells
    • Clough B., Atilola F.A., Pasvol G. The role of rosetting in the multiplication of Plasmodium falciparum: rosette formation neither enhances nor targets parasite invasion into uninfected red cells. Brit J Haem. 100:1998;99-104.
    • (1998) Brit J Haem , vol.100 , pp. 99-104
    • Clough, B.1    Atilola, F.A.2    Pasvol, G.3
  • 61
    • 1842403514 scopus 로고    scopus 로고
    • P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    • Rowe J.A., Moulds J.M., Newbold C.I., Miller L.H. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature. 388:1997;292-295.
    • (1997) Nature , vol.388 , pp. 292-295
    • Rowe, J.A.1    Moulds, J.M.2    Newbold, C.I.3    Miller, L.H.4
  • 62
    • 0031963302 scopus 로고    scopus 로고
    • Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum
    • Chen Q., Barragan A., Fernandez V., Sundström A., Schlichtherle M., Sahlén A., Carlson J., Datta S., Wahlgren M. Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum. J Exp Med. 187:1998;15-23.
    • (1998) J Exp Med , vol.187 , pp. 15-23
    • Chen, Q.1    Barragan, A.2    Fernandez, V.3    Sundström, A.4    Schlichtherle, M.5    Sahlén, A.6    Carlson, J.7    Datta, S.8    Wahlgren, M.9
  • 63
    • 0033529973 scopus 로고    scopus 로고
    • Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum
    • Kyes S.A., Rowe J.A., Kriek N., Newbold C.I. Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum. Proc Natl Acad Sci USA. 96:1999;9333-9338.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9333-9338
    • Kyes, S.A.1    Rowe, J.A.2    Kriek, N.3    Newbold, C.I.4
  • 65
    • 0032583111 scopus 로고    scopus 로고
    • Stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens
    • Cheng Q., Cloonan N., Fischer K., Thompson J., Waine G., Lanzer M., Saul A. stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Mol Biochem Parasitol. 97:1998;161-176.
    • (1998) Mol Biochem Parasitol , vol.97 , pp. 161-176
    • Cheng, Q.1    Cloonan, N.2    Fischer, K.3    Thompson, J.4    Waine, G.5    Lanzer, M.6    Saul, A.7
  • 66
    • 0033561460 scopus 로고    scopus 로고
    • A rhoptry-protein associated mechanism of clonal phenotypic variation in rodent malaria
    • The authors use micromanipulation of P. yoelii parasites in order to show that these undergo clonal phenotypic variation of proteins thought to be involved in host invasion. Different parasites can therefore invade different subsets of host erythrocyte.
    • Preiser P.R., Jarra W., Capiod T., Snounou G. A rhoptry-protein associated mechanism of clonal phenotypic variation in rodent malaria. Nature. 398:1999;618-622. The authors use micromanipulation of P. yoelii parasites in order to show that these undergo clonal phenotypic variation of proteins thought to be involved in host invasion. Different parasites can therefore invade different subsets of host erythrocyte.
    • (1999) Nature , vol.398 , pp. 618-622
    • Preiser, P.R.1    Jarra, W.2    Capiod, T.3    Snounou, G.4
  • 67
    • 0033560274 scopus 로고    scopus 로고
    • A new escape and evasion tactic
    • Barnwell J.W. A new escape and evasion tactic. Nature. 398:1999;562-563.
    • (1999) Nature , vol.398 , pp. 562-563
    • Barnwell, J.W.1


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