The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes

EMBO Journal

Volumn 15, Issue 15, 1996, Pages 4069-4077

  Rubio, Justin P ^a   Thompson, Jennifer K ^a   Cowman, Alan F ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Plasmodium falciparum; Telomere; Var genes

Indexed keywords

PROTOZOAL DNA; PROTOZOAL PROTEIN;

ANTIGENIC VARIATION; ANTIGENICITY; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 12; CONTROLLED STUDY; DNA SEQUENCE; ENDOTHELIUM CELL; ERYTHROCYTE; GENE CLUSTER; GENE LOCATION; GENETIC RECOMBINATION; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RECEPTOR BINDING; TELOMERE; YEAST ARTIFICIAL CHROMOSOME;

PLASMODIUM FALCIPARUM;

EID: 0029739905     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00780.x     Document Type: Article

References (56)

1. Adams, J.H., Sim, K.L., Dolan, S.A., Fang, X., Kaslow, D.C. and Miller, L.H. (1992) A family of erythrocyte binding proteins of malaria parasites. Prof. Natl Acad. Sci. USA, 89, 7085-7089.
2. Barnwell, J.W., Ockenhouse, C.F. and Knowles, D.M. (1985) Monoclonal antibody OKM5 inhibits the in vitro binding of Plasmadium falciparum-infected erythrocytes to monocytes, endothelial, and C32 melanoma cells. J. Immunol., 135, 3494-3497.
3. Baruch, D.I., Pasloske, B.L., Singh, H.B., Bi, X., Ma, X.C., Feldman, M., Taraschi, T.F. and Howard, R.J. (1995) Cloning the P.falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell, 82, 77-87.
4. Berendt, A.R., Simmons, D.L., Tansey, J., Newbold, C.I. and Marsh, K. (1989) Intercellular adhesion molecule 1 is an endothelial cell adhesion molecule for Plasmodium falciparum. Nature, 341, 57-59.
5. Burd, C.G., Matunis, E.L. and Dreyfuss, G. (1991) The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities. Mol Cell. Biol., 11, 3419-3424.
6. Burke, D.K., Carle, G.F. and Olson, M.V. (1987) Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science, 236, 806-812.
7. Busch, H. (1990) The final common pathway of cancer. Cancer Res., 50, 4830-4838.
8. Cappai, R., van Schravendijk, M.R., Anders, R.F., Peterson, M.G., Thomas, L.M., Cowman, A.F. and Kemp, D.J. (1989) Expression of the RESA gene in Plasmodium falciparum isolate FCR3 is prevented by a subtelomeric deletion. Mol. Cell. Biol., 9, 3584-3587.
9. Chen, X., Sullivan, D.S. and Huffaker, T.C. (1994) Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo. Proc. Natl Acad. Sci. USA, 91, 9111-9115.
10. Chu, G., Vollrath, D. and Davis, R. (1986) Separation of large DNA molecules by contour clamped homogeneous electric fields. Science, 234, 1582-1585.
11. Corcoran, L.M., Forsyth, K.P., Bianco, A.E., Brown, G.V. and Kemp, D.J. (1986) Chromosome size polymorphisms in Plasmodium falciparum can involve deletions and are frequent in natural parasite populations. Cell, 44, 87-95.
12. Corcoran, L.M., Thompson, J.K., Walliker, D. and Kemp, D.J. (1988) Homologous recombination within subtelomeric repeat sequences generates chromosome size polymorphisms in P.falciparum. Cell, 53, 807-813.
13. de Bruin, D., Lanzer, M. and Ravetch, J.V. (1994) The polymorphic subtelomeric regions of Plasmodium falciparum chromosomes contain arrays of repetitive sequence elements. Proc. Natl Acad. Sci. USA, 91, 619-623.
14. Foster, J. and Thompson, J. (1995) The Plasmodium falciparum genome project: a resource for researchers. Parasitol. Today, 11, 1-4.
15. Green, E.D. and Olson, M.V. (1990) Systemic screening of yeast artificial-chromosome libraries by use of the polymerase chain reaction. Proc. Natl Acad. Sci. USA, 87, 1213-1217.
16. Guelin, E., Rep, M. and Grivell, L.A. (1994) Sequence of the AFG3 gene encoding a new member of the FtsH/Yme1/Tma subfamily of the AAA-protein family. Yeast, 10, 1389-1394.
17. Hinterberg, K., Mattei, D., Wellems, T.E. and Scherf, A. (1994) Interchromosomal exchange of a large subtelomeric segment in a Plasmodium falciparum cross. EMBO J., 13, 4174-4189.
18. Holloway, S.P., Min, W. and Inselburg, J.W. (1994) Isolation and characterization of a chaperonin-60 gene of the human malaria parasite Plasmodium falciparum. Mol. Biochem. Parasitol., 64, 25-32.
19. Kellerman, K.A. and Miller, K.G. (1992) An unconventional myosin heavy chain gene from Drosophila melanogaster. J. Cell Biol., 119, 823-834.
20. Kemp, D.J., Corcoran, L.M., Coppel, R.L., Stahl, H.D., Bianco, A.E., Brown, G.V. and Anders, R.F. (1985) Size variation in chromosomes from independent cultured isolates of Plasmodium falciparum. Nature, 315, 347-350.
21. Kemp, D.J., Cowman, A.F. and Walliker, D. (1990) Genetic diversity in Plasmodium falciparum. Adv. Parasitol., 29, 75-149.
22. r=8,000 and 11,000 outer arm dynein light chains from Chlamydomonas flagella have cytoplasmic homologues. J. Biol. Chem., 270, 11445-11452.
23. Lanzer, M., De Bruin, D. and Ravetch, J.V. (1993) Transcriptional differences in polymorphic and conserved domains of a complete cloned P. falciparum chromosome. Nature, 361, 654-657.
24. Lanzer, M., Fischer, K. and Le Blancq, S.M. (1995) Parasitism and chromosome dynamics in protozoan parasites: is there a connection? Mol. Biochem. Parasitol., 70, 1-8.
25. Lazard, M. and Mirande, M. (1993) Cloning and analysis of a cDNA encoding mammalian arginyl-tRNA synthetase, a component of the multisynthetase complex with a hydrophobic N-terminal extension. Gene, 132, 237-245.
26. Leech, J.H., Barnwell, J.W., Miller, L.H. and Howard, R.J. (1984) Identification of a strain-specific malarial antigen exposed on the surface of Plasmodium falciparum-infected erythrocytes. J. Exp. Med., 159, 1567-1575.
27. MacPherson, .G.G., Warrell, M.J., White, N.J., Looareesuwan, S. and Warrell, D.A. (1985) Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am. J. Pathol., 119, 385-401.
28. Mutzel, R., Lacombe, M.L., Simon, M.N., de Gunzburg, J. and Veron, M. (1987) Cloning and cDNA sequence of the regulatory subunit of cAMP-dependent protein kinase from Dictyostelium discoideum. Proc. Natl Acad. Sci. USA, 84, 6-10.
29. Ockenhouse, C.F., Tandon, N.N., Magowan, C., Jamieson, G.A. and Chulay, J.D. (1989) Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptor. Science, 243, 1469-1471.
30. Ockenhouse, C.F et al. (1992) Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. J. Exp. Med., 176, 1183-1189.
31. Ogasawara, N. and Yoshikawa, H. (1992) Genes and their organization in the replication origin region of the bacterial chromosome. Mol Microbiol., 6, 629-634.
32. Olson, M., Hood, L., Cantor, C. and Botstein, D. (1989) A common language for physical mapping of the human genome. Science, 245, 1434-1435.
33. Oquendo, P., Goman, M., Mackay, M., Langsley, G., Walliker, D. and Scaife, J. (1986) Characterisation of a repetitive DNA sequence from the malaria parasite, Plasmodium falciparum. Mol. Biochem. Parasitol., 18, 89-101.
34. Oquendo, P., Hundt, E., Lawler, J. and Seed, B. (1989) CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Cell, 58, 95-101.
35. Pace, T., Ponzi, M., Dore, E. and Frontali, C. (1987) Telomeric motifs are present in a highly repetitive element in the Plasmodium berghei genome. Mol. Biochem. Parasitol., 24, 193-202.
36. Pace, T., Ponzi, M, Scotti, R. and Frontali, C. (1995) Structure and superstructure of Plasmodium falciparum subtelomeric regions. Mol. Biochem. Parasitol., 69, 257-268.
37. Parales, R.E. and Harwood, C.S. (1990) Nucleotide sequences of the GYRB gene of Pseudomonas putida. Nucleic Acids Res., 18, 5880.
38. Peterson, D.S., Miller, L.H. and Wellems, T.E. (1995) Isolation of multiple sequences from the Plasmodium falciparum genome that encode conserved domains homologous to those in erythrocyte-binding proteins. Proc. Natl Acad. Sci. USA, 92, 7100-7104.
39. Pologe, L.G. and Ravetch, J.V. (1988) Large deletions result from breakage and healing of Plasmodium falciparum chromosomes. Cell, 55, 869-874.
40. Ponzi, M., Pace, T., Dore, E. and Frontali, C. (1985) Identification of a telomeric DNA sequence in Plasmodium berghei. EMBO J., 4, 2991-2995.
41. Roberts, D.D., Sherwood, J.A., Spitalnik, S.L., Panton, L.J., Howard, R.J., Dixit, V.M., Frazier, W.A., Miller, L.H. and Ginsburg, V. (1985) Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature, 318, 64-66.
42. Rogerson, S.J., Chaiyaroj, S.C., Ng, K., Reeder, J.C. and Brown, G.V. (1995) Chondroitin sulfate A is a cell surface receptor for Plasmodium falciparum-infected erythrocytes. J. Exp. Med., 182, 15-20.
43. Rubio, J.P., Triglia, T., Kemp, D.J., de Bruin, D., Ravetch, J.V. and Cowman, A.F. (1995) A YAC contig map of Plasmodium falciparum chromosome 4: characterization of a DNA amplification between two recently separated isolates. Genomics, 26, 192-198.
44. Saiki, R.K., Gelfand, D.H., Stoffel, S., Scharf, S.J., Higuchi,R ., Horn, G.T., Mullis, K.B. and Erlich, H.A. (1988) Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science, 239, 487-491.
45. Schwartz, D.C. and Cantor, C.R. (1984) Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. Cell, 37, 67-75.
46. Sinnis, P. and Wellems, T.E. (1988) Long-range restriction maps of Plasmodium falciparum chromosomes: crossing over and size variation among geographically distant isolates. Genomics, 3, 287-295.
47. Smith, J.D., Chitnis, C.E., Craig, A.G., Roberts, D.J., Hudson-Taylor, D.E., Peterson, D.S., Pinches, R., Newbold, C.I. and Miller, L.H. (1995) Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell, 82, 101-110.
48. Stahl, H.D., Bianco, A.E., Crewther, P.E., Burkot, T., Coppel, R.L., Brown, G.V., Anders, R.F. and Kemp, D.J. (1986) An asparagine-rich protein from blood stages of Plasmodium falciparum shares determinants with sporozoites. Nucleic Acids Res., 14, 3089-3102.
49. Su, X., Heatwole, V.M., Wertheimer, S.P., Guinet, F., Herrfeldt, J.A., Peterson, D.S., Ravetch, J.A. and Wellems, T.E. (1995) The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparam-infected erythrocytes. Cell, 82, 89-100.
50. Triglia, T. and Kemp, D.J. (1991) Large fragments of Plasmodium falciparum DNA can be stable when cloned in yeast artificial chromosomes. Mol. Biochem. Parasitol., 44, 207-212.
51. Trottein, F. and Cowman, A.F. (1995) Molecular cloning and sequence of two novel P-type adenosine triphosphatases from Plasmodium falciparum. Eur. J. Biochem., 227, 214-225.
52. 2+-ATPases. Gene, 158, 133-137.
53. Van de Ploeg, L.H.T., Gottesdiener, K. and Leem, M.G.-S. (1992) Antigenic variation in African trypanosomes. Trends Genet., 8, 452-456.
54. White, N.J. and Ho, M. (1992) The pathophysiology of malaria. Adv. Parasitol., 31, 83-173.
55. Wilson, R. et al. (1994) 2.2mb of contiguous nucleotide sequence from chromosoma III of C.elegans. Nature, 368, 32-38.
56. Zickler, D., Moreau, P.J.F., Huynh, A.D. and Slezec, A.-M. (1992) Correlation between pairing initiation sites, recombination nodules and meiotic recombination in Sordaria macrospora. Genetics, 132, 135-148.