An on-line physiological state recognition system for the lysine fermentation process based on a metabolic reaction model

Biotechnology and Bioengineering

Volumn 55, Issue 1, 1997, Pages 170-181

  Takiguchi, Noboru ^a   Shimizu, Hiroshi ^a   Shioya, Suteaki ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Corynebacterium glutamicum; Lysine fermentation; Metabolic reaction model; Physiological state recognition

Indexed keywords

BACTERIA; BATCH CELL CULTURE; CELLS; ESTIMATION; FERMENTATION; GLUCOSE; MATHEMATICAL MODELS; METABOLISM; PHYSIOLOGY;

CORYNEBACTERIUM GLUTAMICUM; KALMAN FILTER; LYSINE; METABOLIC REACTION MODEL; PHYSIOLOGICAL STATE RECOGNITION SYSTEM;

AMINO ACIDS;

GLUCOSE; LYSINE;

ARTICLE; BIOENGINEERING; CORYNEBACTERIUM GLUTAMICUM; FERMENTATION; METABOLISM; MODEL; NONHUMAN;

EID: 0031554630     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19970705)55:1<170::AID-BIT18>3.0.CO;2-Q     Document Type: Article

References (34)

1. Bailey, J. E. 1991. Toward a science of metabolic engineering. Science 252: 1668-1675.
2. Barford, J. P. 1990a. A general model for aerobic yeast growth: batch growth. Biotechnol. Bioeng. 35: 907-920.
3. Barford, J. P. 1990b. A general model for aerobic yeast growth: continuous culture. Biotechnol. Bioeng. 35: 921-927.
4. Cooney, C. R., Wang, H. Y., Wang, D. I. C. 1977. Computer-aided material balancing for prediction of fermentation parameters. Biotechnol. Bioeng. 19: 55-67.
5. Delgado, J. P., Liao, J. 1991. Identifying rate-controlling enzymes in metabolic pathways without kinetic parameters. Biotechnol. Prog. 7: 15-20.
6. Erickson, L. E. 1979. Application of mass-energy balance in on-line data analysis. Biotechnol. Bioeng. Symp. 9: 48-60.
7. Groz, R., Stephanopoulos, G. 1990. Physiological biochemical and mathematical studies of micro-aerobic continuous ethanol fermentation by S. cerevisiae: I. Hysteresis, oscillations, and maximum specific ethanol productivities in chemostat culture. Biotechnol. Bioeng. 36: 1006-1019.
8. 13C-enriched L-lysine by Brevibacterium flavum. Eur. J. Biochem. 162: 621-633.
9. Jørgensen, H., Nielsen, J., Villadsen, J. 1995. Metabolic flux distributions in Penicillicum chrysogenum during fed-batch cultivations. Biotechnol. Bioeng. 46: 117-131.
10. Kacser, H., Acerenza, L. 1993. A universal method for achieving increases in metabolite production. Eur. J. Biochem. 216: 361-367.
11. Marx, A., de Graaf, A. A., Wiechert, W., Eggeling, L., Sahm, H. 1996. Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing. Biotechnol. Bioeng. 49: 111-129.
12. Mavrovouniotis, M. L., Stephanopoulos, G., Stephanopoulos, G. 1990. Computer-aided synthesis of biochemical pathways. Biotechnol. Bioeng. 36: 1119-1132.
13. Noorman, H. J., Romein, B., Luyben, K. C. A. M., Heijnen, J. J. 1996. Classification, error detection, and reconciliation of process information in complex biochemical systems. Biotechnol. Bioeng. 49: 365-376.
14. Papoutsakis, E. T. 1984. Equations and calculations for fermentations of butyric acid bacteria. Biotechnol. Bioeng. 26: 174-187.
15. Papoutsakis, E. T., Meyer, C. L. 1985a. Equation and calculations of product yield and preferred pathways for butanediol and mixed-acid fermentations. Biotechnol. Bioeng. 27: 50-66.
16. Papoutsakis, E. T., Meyer, C. L. 1985b. Fermentation equations for propionic-acid bacteria and production of assorted oxychemicals from various sugars. Biotechnol. Bioeng. 27: 67-80.
17. Reardon, K. F., Scheper, T. E., Bailey, J. E. 1987. Metabolic pathway rates and culture fluorescence in batch fermentations of Clostridium acetobutylicum. Biotechnol. Prog. 3: 153-167.
18. Schlosser, P. M., Holcomb, T., Bailey, J. E. 1993. Determining metabolic sensitivity coefficients directly from experimental data. Biotechnol. Bioeng. 41: 1027-1038.
19. Schlosser, P. M., Riedy, G., Bailey, J. E. 1994. Ethanol production in baker's yeast: application of experiment perturbation techniques for model development and resultant changes in flux control analysis. Biotechnol. Prog. 10: 141-154.
20. Shimizu, H., Miura, K., Takiguchi, N., Shioya, S. 1996. Comparison of estimation techniques for a time-varying parameter in a metabolic reaction model. J. Ferment. Bioeng. 81:363-365.
21. Shioya, S., Yang, Y. K., Omasa, T., Suga, K. 1992. Maximizing a lysine production in fed-batch culture by controlling the specific growth rate under leucine-limited conditions, pp. 669-672. In: S. Furusaki, I. Endo, and R. Matsuno (eds.), Biochemical engineering for 2001. Proceedings of Asia-Pacific Biochemical Engineering Conference 1992. Springer, Tokyo.
22. Stephanopoulos, G., San, K. Y. 1984. Studies on on-line bioreactor identification. I. Theory. Biotechnol. Bioeng. 26: 1176-1188.
23. Stephanopoulos, G., Vallino, J. J. 1991. Network rigidity and metabolic engineering in metabolite overproduction. Science 252: 1675-1681.
24. Tosaka, O., Hirakawa, H., Takinami, K., Hirose, Y. 1978. Regulation of lysine biosynthesis by leucine in Brevibacterium lactofermentum. Agric. Biol. Chem. 42: 1501-1506.
25. Tosaka, O., Ishihara, M., Morinaga, Y., Takinami, K. 1979. Mode of conversion of asparto β-semialdehyde to L-threonine and L-lysine in Brevibacterium lactofermentum. Agric. Biol. Chem. 43: 265-270.
26. Vallino, J. J., Stephanopoulos, G. 1993. Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Biotechnol. Bioeng. 41: 633-646.
27. Vallino, J. J., Stephanopoulos, G. 1994a. Carbon flux distributions at the pyruvate branch point in Corynebacterium glutamicum during lysine overproduction. Biotechnol. Prog. 10: 320-326.
28. Vallino, J. J., Stephanopoulos, G. 1994b. Carbon flux distributions at the glucose 6-phosphate branch point in Corynebacterium glutamicum during lysine overproduction. Biotechnol. Prog. 10: 327-334.
29. van Gulik, W. M., Heijnen, J. J. 1995. A metabolic network stoichiometry analysis of microbial growth and product formation. Biotechnol. Bioeng. 48: 681-698.
30. Varma, A., Boesch, S. W., Palsson, B. O. 1993. Biochemical production capabilities of Escherichia coli. Biotechnol. Bioeng. 42: 59-73.
31. Wang, N. S., Stephanopoulos, G. 1983. Application of macroscopic balances to the identification of gross measurement errors. Biotechnol. Bioeng. 25: 2177-2208.
32. 13C NMR studies of lysine fermentation with a Corynebacterium glutamicum mutant. Agric. Biol. Chem. 50: 2453-2459.
33. Zupke, C., Stephanopoulos, G. 1994. Modeling of isotope distributions and intracellular fluxes in metabolic networks using atom mapping matrices. Biotechnol. Prog. 10: 489-498.
34. 13C NMR. Biotechnol. Bioeng. 45: 292-303.