Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils

American Journal of Respiratory and Critical Care Medicine

Volumn 159, Issue 6, 1999, Pages 1903-1909

  Sano, Akiko ^a   Muñoz, Nilda M ^a   Sano, Hiroyuki ^a   Choi, John ^a   Zhu, Xiangdong ^a   Jacobs, Benjamin ^a   Leff, Alan R ^a,b  

^a Departments of Medicine and Pharmacology   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; FLUTICASONE PROPIONATE; LEUKOTRIENE C4; LIPOCORTIN 1; PHOSPHOLIPASE A2; ANDROSTANE DERIVATIVE; ANNEXIN; ANTIINFLAMMATORY AGENT; FLUTICASONE; GLUCOCORTICOID; PHOSPHOLIPASE A;

APOPTOSIS; ARTICLE; ATOPY; CELL ACTIVATION; CELL NUCLEUS MEMBRANE; CELL VIABILITY; CYTOTOXICITY; DRUG EFFECT; EOSINOPHIL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; CELL SURVIVAL; CYTOSOL; DRUG ANTAGONISM; ENZYMOLOGY; INTRACELLULAR MEMBRANE; METABOLISM; PHYSIOLOGY; TOPICAL DRUG ADMINISTRATION; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, TOPICAL; ANDROSTADIENES; ANNEXINS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; ARACHIDONIC ACID; BIOLOGICAL TRANSPORT; CELL SURVIVAL; CYTOSOL; EOSINOPHILS; GLUCOCORTICOIDS; HUMANS; INTRACELLULAR MEMBRANES; LEUKOTRIENE C4; PHOSPHOLIPASES A;

EID: 0032587256     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.159.6.9810005     Document Type: Article

References (33)

1. 1. Laviolette, M., C. Ferland, I., Trepanier, H. Rocheleau, A. Dakhama, and L. P. Boulet. 1994. Effects of inhaled steroids on blood eosinophils in moderate asthma. Ann. N.Y. Acad. Sci. 725:288-297.
2. 2. Pincus, D. J., S. J. Szefler, L. M. Ackerson, and R. J. Martin. 1995. Chronotherapy of asthma with inhaled steroids: the effect of dosage liming on drug efficacy. J. Allergy Clin. Immunol. 95:1172-1178.
3. 3. Duddridge, M., C. Ward, D. J. Hendrick, and E. H. Walters. 1993. Changes in bronchoalveolar lavage inflammatory cells in asthmatic patients treated with high dose inhaled beclomethasone dipropionate. Eur. Respir. J. 6:489-497.
4. 4. Zimmerman, B., A. Lanner, I. Enander, R. S. Zimmerman, C. G. Peterson, and S. Ahlstedt. 1993. Total blood eosinophils, serum eosinophil cationic protein and eosinophil protein X in childhood asthma: relation to disease status and therapy. Clin. Exp. Allergy 23:564-570.
5. 5. Wedi, B., U. Raap, H. Lewrick, and A. Kapp. 1997. Delayed eosinophil programmed cell death in vitro: a common feature of inhalant allergy and extrinsic and intrinsic atopic dermatitis. J. Allergy Clin. Immunol. 100:536-543.
6. 6. Weiler, C. R., H. Kita, M. Hukee, and G. J. Gleich. 1996. Eosinophil viability during immunoglobulin-induced degranulation. J. Leuko. Biol. 60:493-501.
7. 7. Woolley, K. L., P. G. Gibson, K. Carty, A. J. Wilson, S. H. Twaddell, and M. J. Woolley. 1996. Eosinophil apoptosis and the resolution of airway inflammation in asthma. Am. J. Respir. Crit. Care Med. 154:237-243.
8. 8. Meagher, L. C., J. M. Cousin, J. R. Seckl, and C. Haslett. 1996. Opposing effects of glucocorticoids on the rate of apoplosis in neutrophilic and eosinophilic granulocytes. J. Immunol. 156:4422-4428.
9. 2 antibodies. Life Sci. 61:127-134.
10. 10. Crocker, I. C., C. Y. Zhou, A. K. Bewtra, W. Kreutner, and R. G. Townley. 1997. Glucocorticosteroids inhibit leukotriene production. Ann. Allergy Asthma Immunol. 78:497-505.
11. 2. Biochem. 35:3712-3721.
12. 2 to the nuclear envelopes elicits topographically localized phospholipid hydrolysis. Biochem. J. 318:797-803.
13. 13. Hamilton, A. L., R. M. Watson, G. Wyile, and P. M. O'Byrne. 1997. Attenuation of early and late phase allergen-induced bronchoconstriction in asthmatic subjects by a 5-lipoxygenase activating protein antagonist, BAYx 1005. Thorax 52:348-354.
14. 4 production in asthma of different severities. Eur. Respir. J. 8:1465-1472.
15. 15. Drazen, J. M. 1997. Pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors in the management of asthma. Pharmacotherapy 17:22S-30S.
16. 16. Leff, A. R., A. Herrnreiter, R. M. Naclerio, F. M. Baroody, D. A. Handley, and N. M. Muñoz. 1997. Effect of enantiomerie forms of albuterol on stimulated secretion of granular protein from human eosinophils. Pulm. Pharmacol. 10:97-104.
17. 17. Adachi, T., S. Motojima, A. Hirata, T. Fukuda, N. Kihara, A. Kosaku, H. Ohtake, and S. Makino. 1996. Eosinophil apoptosis caused by theophylline, glucocorticoids, and macrolides alter stimulation with IL-5. J. Allergy Clin. Immunol. 98:S207-S215.
18. 18. Tsuyuki, S., C. Bertrand, F. Erard, A. Trifilieff, J. Tsuyuki, M. Wesp, G. P. Anderson, and A. J. Coyle. 1995. Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways. J. Clin. Invest. 96:2924-2931.
19. 19. Altman, S. A., L. Randers, and G. Rao. 1993. Comparison of trypan blue dye exclusion and fluorometric assays for mammalian cell viability determinations. Biotech. Prog. 9:671-674.
20. 20. Fuller, R., M. Johnson, and A. Bye. 1995. Fluticasone propionate - an update on preclinical and clinical experience. Respir. Med. 89:3-18.
21. 2: probing the role of histidine, aspartic acid, cysteine, and arginine. J. Biol. Chem. 271:19225-19231.
22. 22. Hansel, T. T., J. M. DeVries, T. HT, S. Rihs, M. Wandzilak, S. Betz, K. Blaser, and C. Walker. 1991. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J. Immunol. Methods 145:105-110.
23. 23. Chihara, J., D. Kurachi, T. Yamamoto, H. Yamada, T. Wada, A. Yasukawa, and S. Nakajima. 1995. A comparative study of eosinophil isolation by different procedures of CD16-negative depletion. Allergy 50:11-24.
24. 24. Muñoz, N. M., A. J. Vita, S. P. Neeley, K. McAllister, S. M. Spaethe, S. White, and A. R. Leff. 1994. Beta adrenergic modulation of formyl-methionine-leucine-phenytalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4. J. Pharmacol. Exp. Ther. 268:139-143.
25. 25. Nagata, M., J. B. Sedgwick, and W. W. Busse. 1995. Differential effects of granulocyte-macrophage colony-stimulating factor on eosinophil and neutrophil superoxide anion generation. J. Immunol. 155:4948-4954.
26. 26. Muñoz, N. M., and A. R. Leff. 1995. Blockade of eosinophil migration by 5-lipoxygenase and cyclooxygenase inhibition in explanted guinea pig trachealis. Am. J. Physiol. 268:L446-L454.
27. 27. Muñoz, N. M., I. Douglas, D. Mayer, A. Herrnreiter, X. Zhu, and A. R. Leff. 1997. Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. Am. J. Respir. Crit. Care Med. 155:1398-1403.
28. 28. Muñoz, N. M., K. J. Hamann, A. Vita, P. J. Cozzi, S. Baranowski, J. Solway, and A. R. Leff. 1993. Activation of tracheal smooth muscle responsiveness by fMI.P-treated HL-60 cells and neutrophils. Am. J. Physiol. 264:L222-L228.
29. 29. Rabe, K. F., N. M. Muñoz, A. J. Vita, B. Morton, H. Magnussen, and A. R. Leff. 1994. Contraction of human bronchial smooth muscle caused by activated human eosinophils. Am. J. Physiol. (Lung Cell Mol. Physiol.) 267:L326-L334.
30. 30. Yasui, K., B. Hu, T. Nakazawa, K. Agematsu, and A. Komiyama. 1997. Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition. J. Clin. Invest. 100:1677-1684.
31. 31. Jarjour, N. N., and W. W. Busse. 1995. Cytokines in bronchoalveolar lavage fluid of patients with nocturnal asthma. Am. J. Respir. Crit. Care Med. 152:1474-1477.
32. 2. J. Biol. Chem. 272:16709-16712.
33. 33. Fischer, A. R., C. A. MeFadden, R. Frantz, W. M. Awni, J. Cohn, J. M. Drazen, and E. Israel. 1995. Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects. Am. J. Respir. Crit. Care Med. 152:1203-1207.