Patterns of A(2A) extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A(2A) receptor monoclonal antibodies

Molecular Pharmacology

Volumn 55, Issue 3, 1999, Pages 614-624

  Koshiba, Masahiro ^a,c   Rosin, Diane L ^b   Hayashi, Nobuhide ^b,c   Linden, Joel ^b   Sitkovsky, Michail V ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2 RECEPTOR; MONOCLONAL ANTIBODY; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR; CD20 ANTIGEN; CD3 ANTIGEN; CYTOKINE;

ARTICLE; CYTOKINE PRODUCTION; FLOW CYTOMETRY; GROWTH REGULATION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; B LYMPHOCYTE; BIOSYNTHESIS; CELL SEPARATION; CLASSIFICATION; COMPARATIVE STUDY; CYTOLOGY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; METHODOLOGY; TH1 CELL; TH2 CELL;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD20; ANTIGENS, CD3; B-LYMPHOCYTES; CELL SEPARATION; CYTOKINES; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE ACTIVATION; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS;

EID: 0032586888     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Alberola-Ila J, Takaki S, Kerner JD and Perlmutter RM (1997) Differential signaling by lymphocyte antigen receptors. Annu Rev Immunol 15:125-154.
2. Apasov SG, Koshiba M, Chused TM and Sitkovsky MV (1997) Effects of extracellular ATP and adenosine on different thymocyte subsets: Possible role of ATP-gated channels and G protein-coupled purinergic receptors. J Immunol 158:5095-5105.
3. Apasov S, Koshiba M, Redegeld F and Sitkovsky M (1995) Role of extracellular ATP and P1 and P2 classes of purinergic receptors in T cell development and cytotoxic T lymphocyte effector functions. Immunol Rev 146:5-19.
4. Berrebi G, Takayama H and Sitkovsky MV (1987) Antigen-receptor interaction requirement for conjugate formation and lethal-hit triggering by cytotoxic T lymphocytes can be bypassed by protein kinase C activators and Ca++ ionophores. Proc Natl Acad Sci USA 84:1364-1368.
5. Berridge MJ (1997) Lymphocyte activation in health and disease. Crit Rev Immunol 17:155-78.
6. Bowers K, Pitcher C and Marsh M (1997) CD4: A co-receptor in the immune response and HIV infection. J Biochem Cell Biol 29:871-875.
7. Chused TM, Apasov S and Sitkovsky MV (1996) Murine T lymphocytes modulate activity of an ATP-activated p2z-type purinoreceptor during differentiation. J Immunol 157:1371-1380
8. Eppell BA, Newell AM and Brown EJ (1989) Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis. J Immunol 143:4141-4145.
9. Himmelmann A, Riva A, Wilson GL, Lucas BP, Thevenin C and Kehrl JH (1997) PU.1/Pip and basic helix loop helix zipper transcription factors interact with binding sites in the CD20 promoter to help confer lineage-and stage-specific expression of CD20 in B lymphocytes. Blood 90:3984-95.
10. Holgate ST, Lewis RA and Austen KF (1980) Role of adenylate cyclase in immunologie release of mediators from rat mast cells: Agonist and antagonist effects of purine-and bose-modified adenosine analogs. Proc Natl Acad Sci USA 77:6800-6804.
11. Huang S, Koshiba M, Apasov S and Sitkovsky M (1997) Role of A2a adenosine receptor-mediated signaling in inhibition of T cell activation and expansion. Blood 90:1600-1610.
12. Jacobson KA, von Lubitz DK, Daly JW and Fredholm BB (1996) Adenosine receptor ligands: Differences with acute versus chronic treatment. Trends Pharmacol Sci 17:108-113.
13. Jin X, Shepherd RK, Duling BR and Linden J (1997) Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J Clin Invest 100:2849-2857.
14. Jung T, Schauer U, Heusser C, Neumann C and Rieger C (1993) Detection of intracellular cytokines by flow cytometry. J Immunol Methods 159:197-207.
15. Kammer GM (1988) The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. Immunol Today 9:222-229.
16. Kappes DJ, Alarcon B and Regueiro JR (1995) T lymphocyte receptor deficiencies. Curr Opin Immunol 7:441-447.
17. Keenan C, Long A and Kelleher D (1997) Protein kinase C and T cell function. Biochim Biophys Acta 1358:113-126.
18. Klein SA, Dobmeyer JM, Dobmeyer TS, Pape M, Ottmann OG, Helm EB, Hoelzer D and Rossol R (1997) Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry. AIDS 11:1111-1118.
19. Koshiba M, Apasov S, Sverdlov V, Chen P, Erb L, Turner JT, Weisman GA and Sitkovsky MV (1997) Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes. Proc Natl Acad Sci USA 94:831-836.
20. Koshiba M, Kojima H, Huang S, Apasov S and Sitkovsky MV (1997) Memory of extracellular adenosine/A2a purinergic receptor-mediated signalling in murine T cells. J Biol Chem 272:25881.
21. Laxminarayana D and Kammer GM (1996) Activation of type I protein kinase A during receptor-mediated human T lymphocyte activation. J Immunol 156:497-506.
22. Martin PL, Barrett RJ, Linden J and Abraham WM (1997) 2-cyclohexylmethylidene-hydrazinoadenosine (WRC-0470), a novel, short-acting adenosine A(2A) Receptor agonist that produces selective coronary vasodilation. Drug Dev Res 40:313-324.
23. Mosmann TR and Sad S (1996) The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17:138-146.
24. Olah ME and Stiles GL (1995) Adenosine receptor subtypes: Characterization and therapeutic regulation. Annu Rev Pharmacol Toxicol 35:581-606.
25. Philippe J, Louagie H, Thierens H, Vral A, Cornelissen M and DeRidder L (1997) Quantification of apoptosis in lymphocyte subsets and effect of apoptosis on apparent expression of membrane antigens. Cytometry 29:242-249.
26. Poucher SM, Keddie JR, Singh P, Stoggal SM, Caulkett PWR, Jones G and Collis MG (1995) The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist. Br J Pharmacol 116:1096-1102.
27. Qian D and Weiss A (1997) T cell antigen receptor signal transduction. Curr Opin Cell Biol 9:205-212
28. Ravichandran KS, Pratt JC, Sawasdikosol S, Irie HY and Burakoff SJ (1995) Coreceptors and adapter proteins in T-cell signaling, Ann NY Acad Sci 766:117-133.
29. Robeva AS, Woodard R, Jin X, Gao Z, Bhattacharya S, Taylor HE, Rosin DL and Linden J (1996) Molecular characterization of recombinant human adenosine receptors. Drug Dev Res 39:243-252.
30. Robeva AS, Woodard R, Luthin DR, Taylor HE and Linden J (1996) Double tagging recombinant A1-and A2A-adenosine receptors with hexahistidine and the FLAG epitope. Development of an efficient generic protein purification procedure. Biochem Pharmacol 4:545-555.
31. Rosin DL, Robeva AS, Woodard RL, Guyenet PG and Linden J (1998) Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system. J Comp Neurol 401:163-186.
32. Steinberg T, Newman AS, Swanson JA and Silveratein SC (1987) ATP4-permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes. J Biol Chem 262:8884-8888.
33. Strohmeier GR, Reppert SM, Lencer WI and Madara JL (1996) The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia. J Biol Chem 270:2387-2394.
34. Sugiyama H, Apasov S, Redegled F and Sitkovsky MV (1993) Identification of protein kinases and protein phosphatoses involved in CTL effector functions. "On" and "off" signalling and immunopharmacological implications. in: Cytotoxic Cells (Sitkovsky M and Henkart P eds) Birkhauser, Boston-Basel-Berlin, pp 331-340.
35. Sugiyama H, Chen P, Hunter M and Sitkovsky M (1997) Perturbation of the expression of the catalytic subunit Cα of cyclic AMP-dependent protein kinase inhibits TCR-triggered secretion of IL-2 by T-helper cells. J Immunol 158:171-179
36. Sugiyama H, Chen P, Hunter M, Taffs R and Sitkovsky M (1992) The dual role of the cAMP-dependent protein kinase C alpha subunit in T-cell receptor-triggered T-lympocytes effector functions. J Biol Chem 26:25256-25263.
37. Sullivan GW, Carper HT and Mandell GL (1995) The specific type IV phosphodiesterase inhibitor rolipram combined with adenosine reduces tumor necrosis factor-a-primed neutrophil oxidative activity. Int J Immunopharmacol 17:793-803.
38. Surprenant A, Buell G and North RA (1995) P2X receptors bring new structure to ligand-gated ion channels. Trends Neurosci 18:324-229.
39. Takayama H and Sitkovsky MV (1987) Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes. J Exp Med 166:725-743.
40. Takayama H, Trenn G and Sitkovsky MV (1988) Locus of inhibitory action of cAMP-dependent protein kinase in the antigen-receptor triggered cytotoxic T-lymphocyte activation pathway. J Biol Chem 263:2330-2336
41. Varani K, Gessi S, Dalpiaz A and Borea PA (1996) Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. Br J Pharmacol 117:1693-1701.
42. Werfel T, Boeker M and Kapp A (1997) Rapid expression of the CD69 antigen on T cells and natural killer cells upon antigenic stimulation of peripheral blood mononuclear cell suspensions. Allergy 52:465-469.