Inhibition of αβ epithelial sodium channels by external protons indicates that the second hydrophobic domain contains structural elements for closing the pore

Biophysical Journal

Volumn 77, Issue 6, 1999, Pages 3043-3051

  Zhang, Ping ^a   Fyfe, Gregor K ^a   Grichtchenko, Irina I ^a   Canessa, Cecilia M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; SODIUM CHANNEL; PROTON; RECOMBINANT PROTEIN; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ARTICLE; CELL MEMBRANE POTENTIAL; CELL PH; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EPITHELIUM; FEMALE; HYDROPHOBICITY; NONHUMAN; OOCYTE; PKA; PROTON TRANSPORT; XENOPUS LAEVIS; ANIMAL; BINDING SITE; BIOPHYSICS; CHEMISTRY; DRUG ANTAGONISM; GENETICS; IN VITRO STUDY; KINETICS; METABOLISM; PH; PROTEIN TERTIARY STRUCTURE; RAT;

ANIMALS; BINDING SITES; BIOPHYSICS; EPITHELIUM; FEMALE; HYDROGEN-ION CONCENTRATION; KINETICS; OOCYTES; PROTEIN STRUCTURE, TERTIARY; PROTONS; RATS; RECOMBINANT PROTEINS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; XENOPUS LAEVIS;

EID: 0032585999     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(99)77135-3     Document Type: Article

References (20)

1. Abriel, H., and J.-D. Horisberger. 1999. Feedback inhibition of rat amiloride-sensitive epithelial sodium channels expressed in Xenopus laevis oocytes. J. Physiol. (Lond.). 516:31-43.
2. Adams, C. M., M. G. Anderson, D. G. Motto, M. P. Price, W. A. Anderson, and M. J. Welsh. 1998. Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. J. Cell. Biol. 140:143-152.
3. Canessa, C. M., A.-M. Merillat, and B. C. Rossier. 1994. Membrane topology of the epithelial sodium channel α-subunit: identification of N-linked glycosylation sites and of start and stop transfer signals used in intact cells. Am. J. Physiol. 267:C1682-C1690.
4. + channel. Am. J. Physiol. 276:C477-C486.
5. Chraïbi, A., V. Vallet, D. Firsov, S. Kharoubi Hess, and J.-D. Horisberger. 1998. Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes. J. Gen. Physiol. 111:127-138.
6. + channel. Biochemistry. 37:3229-3236.
7. + conduction and selectivity. Science. 280:69-77.
8. Driscoll, M., and M. Chalfie. 1991. The mec-4 gene is member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. Nature. 349:588-593.
9. Fyfe, G. K., and C. M. Canessa. 1998. Subunit composition determines the single channel kinetics of the epithelial sodium channel. J. Gen. Physiol. 112:423-432.
10. García-Añoveros, J., C. Ma, and M. Chalfie. 1995. Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain. Curr. Biol. 5:441-448.
11. Huang, M., and M. Chalfie. 1994. Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans. Nature. 367:467-470.
12. + channel changes ion selectivity by modifying molecular sieving. Proc. Natl. Acad. Sci. USA. 96: 4170-4175.
13. Lingueglia, E. L., G. Champigny, M. Lazdunski, and P. Barbry. 1995. Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature. 378:730-733.
14. Palmer, L. G., and G. Frindt. 1987. Effects of cell Ca and pH on Na channels from rat cortical collecting tubule. Am. J. Physiol. 253: F333-F339.
15. + channel studied by EPR spectroscopy. Nature Struct. Biol. 5:459-469.
16. + channel. J. Biol. Chem. 269:12981-12986.
17. Siebens, A. W., and W. F. Boron. 1987. Effect of electroneutral luminal and basolateral lactate transport on intracellular pH in salamander proximal tubules. J. Gen. Physiol. 90:799-831.
18. Vallet, V., A. Chraibi, H-P. Gaeggeler, J.-D. Horisberger, and B. C. Rossier. 1998. An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature. 389:607-610.
19. + channel function. J. Biol. Chem. 270:11735-11737.
20. +-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels. Curr. Opin. Neurobiol. 8:418-424.