Programming the Rous sarcoma virus protease to cleave new substrate sequences

Journal of Biological Chemistry

Volumn 271, Issue 18, 1996, Pages 10538-10544

  Ridky, Todd W ^a   Bizub Bender, Diane ^b   Cameron, Craig E ^a,e   Weber, Irene T ^c   Wlodawer, Alexander ^d   Copeland, Terry ^b   Skalka, Anna Marie ^b   Leis, Jonathan ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KYNOSTATIN 272; PROTEINASE; PROTEINASE INHIBITOR; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; ROUS SARCOMA ONCOVIRUS;

ASPARTIC ENDOPEPTIDASES; BASE SEQUENCE; CLONING, MOLECULAR; ESCHERICHIA COLI; HIV PROTEASE INHIBITORS; HIV-1; HYDROLYSIS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; SUBSTRATE SPECIFICITY;

EID: 17544378583     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.18.10538     Document Type: Article

References (15)

1. Jaskolski, M., Miller, M., Rao, J. K. M., Leis, J., and Wlodawer, A. (1990) Biochemistry 29, 5889-5898
2. Wlodawer, A., Miller, M., Jaskolski, M., Sathyanarayana, B. K., Baldwin, E., Weber, I. T., Selk, L. M., Clawson, L., Schneider, J., and Kent, S. B. H. (1989) Science 245, 616-621
3. Cameron, C., Grinde, B., Jacques, P., Jentoft, J., Leis, J., Wlodawer, A., and Weber, I. (1993) J. Biol. Chem. 268, 11711-11720
4. Cameron, C., Ridky, T., Shulenin, S., Leis, J., Weber, I., Copeland, T., Wlodawer, A., Burstein, H., Bizub-Bender, D., and Skalka, A. (1994) J. Biol. Chem. 269, 11170-11177
5. Grinde, B., Cameron, C., Leis, J., Weber, I., Wlodawer, A., Burstein, H., Bizub, D., and Skalka, A. (1992) J. Biol. Chem. 267, 9481-9490
6. Grinde, B., Cameron., C., Leis, J., Weber, I., Wlodawer, A., Burstein, H., and Skalka, A. (1992) J. Biol. Chem. 267, 9491-9498
7. Sedlacek, J., Fabry, M., Coward, J., Horejsi, M., Strop, P., and Luftig, R. (1993) Virology 192, 667-672
8. Condra, J., Schleif, W., Blahy, O., Gabryelski, L., Graham, D., Quintero, J., Rhodes, A., Robbins, H., Roth, E., Shivaprakash, M., Titus, D., Yang, T., Teppler, H., Squires, K., Deutsch, P., and Emmini, E. (1995) Nature 374, 569-571
9. Ridky, T., and Leis, J. (1995) J. Biol. Chem. 270, 29621-29623
10. Alexander, F., Leis, J., Soltis, D., Crowl, R., Danho, W., Poonian, M., Pan, Y., and Skalka, A. (1987) J. Virol. 61, 534-542
11. Ridky, T. W., Cameron, C. E., Cameron, J., Leis, J., Copeland, T., Wlodawer, A., Weber, I., and Harrison, R. (1996) J. Biol. Chem. 271, 4709-4717
12. Bizub, D., Weber, I., Cameron, C., Leis, J., and Skalka, A. (1991) J. Biol. Chem. 266, 4951-4958
13. Fitzgerald, P., McKeever, B., VanMiddlesworth, J., Springer, J., Heimbach, J., Leu, C., Herber, W., Dixon, R., and Darke, P. (1991) J. Biol. Chem. 265, 14209-14219
14. Gulnik, S. V., Suvorov, L., Liu, B., Yu, B., Anderson, B., Mitsuya, H., and Erickson, J. W. (1995) Biochemistry 34, 9282-9287
15. Kraulis, P. (1991) J. Appl. Crystallogr. 24, 946-950