The intestinal epithelium and its neoplasms: Genetic, cellular and tissue interactions

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 353, Issue 1370, 1998, Pages 915-923

  Dove, William F ^a,b   Cormier, Robert T ^a   Gould, Karen A ^a,b   Halberg, Richard B ^a   Merritt, Anita J ^a   Newton, Michael A ^c   Shoemaker, Alexander R ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

Author keywords

APC Apc; Cancer genetics; Clonality; Knudson hypothesis; Min mouse; Mom1 modifier locus

Indexed keywords

ANIMALIA;

EID: 0032577987     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.1998.0256     Document Type: Article

References (53)

1. Bjerknes, M., Cheng, H., Kim, H., Schnitzler, M. & Gallinger, S. 1997 Clonality of dysplastic epithelium in colorectal adenomas from familial adenomatous polyposis patients. Cancer Res. 57, 355-361.
2. Cahill, D. P., Lengauer, G., Yu, J., Riggins, G. J., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W. & Vogelstein, B. 1998 Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303.
3. Cormier, R., Hong, K., Halberg, R., Hawkins, T. L., Richardson, R., Mulherkar, R., Dove, W. F. & Lander, E. S. 1997 Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat. Genet. 17, 88-91.
4. Cutler, S. J., Scotto, J., Devesa, S. S. & Connelly, R. R. 1974 Third national cancer survey - an overview of available information. J. Natn. Cancer Inst. 53, 1565-1575.
5. Dexter, M. 1986 Growth factors. From the laboratory to the clinic. Nature 321, 198.
6. Dexter, M. & Allen, T. 1992 Haematopoiesis. Multi-talented stem cells? Nature 360, 709-710.
7. Dietrich, W., Lander, E., Smith, J. S., Moser, A. R., Gould, K. A., Luongo, G., Borenstein, N. & Dove, W. F. 1993 Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 75, 631-639.
8. Dove, W. F. 1987 Perspectives: molecular genetics of Mus musculus: point mutagenesis and millimorgans. Genetics 116, 5-8.
9. Dove, W. F. 1995 Mammalian development and human cancer: from the phage group to the genetics of intestinal cancer. In The DMA provirus: Howard Temin's scientific legacy (ed. G. Cooper, R. Greenberg Temin & B. Sugden), chap. 8, pp. 95-107. Washington, DC: American Society of Microbiology.
10. Dove, W. F., Luongo, C., Connelly, C. S., Gould, K. A., Shoemaker, A. R., Moser, A. R. & Gardner, R. L. 1994 The adenomatous polyposis coli gene of the mouse in development and neoplasia. Cold Spring Harb. Symp. Quant. Biol. 59, 501-508.
11. Dove, W. F., Gould, K. A., Luongo, C., Moser, A. R. & Shoemaker, A. R. 1995 Emergent issues in the genetics of intestinal neoplasia. Cancer Surv. 25, 335-355.
12. Falconer, D. S. & Mackay, T. F. C. 1996 Introduction to quantitative genetics, 4th edn, p. 375. Harlow, UK: Longman Group Ltd.
13. Gardner, R. L. 1993 Extrinsic factors in cellular differentiation. Int. J. Devl Biol. 37, 47-50.
14. Garrod, A. E. 1927 The Huxley lecture on diathesis. Br. Med. J. 2, 967-971.
15. Gehring, W. 1967 Clonal analysis of determination dynamics in cultures of imaginai disks in Drosophila melanogasler. Devl Biol. 16, 438-456.
16. Gould, K. A. & Dove, W. F. 1996 Action of Min and Moml on neoplasia in ectopic intestinal grafts. Cell Growth Differ. 7, 1361-1368.
17. Gould, K. A. & Dove, W. F. 1997 Localized action of Apc and Moml in intestinal neoplasia. Proc. Main. Acad. Sci. USA 94, 5848-5853.
18. Gould, K. A., Dietrich, W. F., Borenstein, N., Lander, E. S. & Dove, W. F. 1996a Moml is a semi-dominant modifier of the size and multiplicity of intestinal adenomas in Min mice. Genetics 144, 1769-1776.
19. Gould, K. A., Luongo, G., Moser, A. R., McNeley, M. K., Borenstein, N., Shedlovsky, A., Dove, W. F., Hong, K., Dietrich, W. F. & Lander, E. S. 1996b Genetic evaluation of candidate genes for the Moml modifier of intestinal neoplasia in mice. Genetics 144, 1777-1785.
20. Griffiths, D. F. R., Sacco, P., Williams, D., Williams, G. T. & Williams, E. D. 1989 The clonal origin of experimental large bowel tumours. Br. J. Cancer 59, 385-387.
21. Gurdon, J. B., Lemaire, P. & Kato, K. 1993 Community effects and related phenomena in development. Cell 75, 831-834.
22. Haber, D. A., Buckler, A. J., Glaser, T., Call, K. M., Pelletier, J., Sohn, R. L., Douglass, E. C. & Housman, D. E. 1990 An internal deletion within an 11pl3 zinc finger gene contributes to the development of Wilms' tumor. Cell 61, 1257-1269.
23. Hiltunen, M. O., Alhonen, L., Koistinaho, J., Myöhänen, S., Pääkkönen, M., Marin, S., Kosma, V.-M. & Jänne, J. 1997 Hypermethylation of the APC (adenomatous poljposis coli) gene promoter region in human colorectal carcinoma. Int. J. Cancer 70, 644-648.
24. Jacks, T. 1996 Tumor suppressor gene mutations in mice. A. Rev. Genet. 30, 603-636.
25. Kinzler, K. W. & Vogelstein, B. 1996 Lessons from hereditary colorectal cancer. Cell 87, 159-170.
26. Knudson, A. G. Jr 1971 Mutation and cancer: statistical study of retinoblastoma. Proc. Natn. Acad. Sci. USA 68, 820-823.
27. Lengauer, C., Kinzler, K. W. & Vogelstein, B. 1997 Genetic instability in colorectal cancers. Nature 386, 623-627.
28. Luongo, C. & Dove, W. F. 1996 Somatic genetic events linked to the Ape locus in intestinal adenomas of the Min mouse. Genes, Chromosomes, Cancer 17, 194-198.
29. + in intestinal adenomas from Alin mice. Cancer Res. 54, 5947-5952.
30. Min-induced intestinal neoplasia. Cell 81, 957-966.
31. + from all tumor lineages. Proc. Natn. Acad. Sci. USA 94, 13927-13931.
32. Midgley, C. A., White, S., Howitt, R., Save, V., Dunlop, M. G., Hall, P. A., Lane, D. P., Wyllie, A. H. & Bubb, V. J. 1997 Ape expression in normal human tissues. J. Pathol. 181, 426-433.
33. Moser, A. R., Pilot, H. C. & Dove,W. F. 1990 A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322-324.
34. Moser, A. R., Dove, W. F., Roth, K. A. & Gordon, J. I. 1992 The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J. Cell Biol. 116, 1517-1526.
35. Moser, A. R., Shoemaker, A. R., Connelly, C. S., Clipson, L., Gould, K. A., Luongo, C., Dove, W. F., Siggers, P. H. & Gardner, R. L. 1995 Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation. Devl Dyn. 203, 422-433. New York Times 1996 Editorial page. August 18.
36. Novelli, M. R., Williamson, J. A., Tomlinson, I. P. M., Elia, G., Hodgson, S. V., Talbot, I. C., Bodmer, W. F. & Wright, N. A. 1996 Polyclonal origin of colonie adenomas in an XO/XY patient with FAR Science 272, 1187-1190.
37. 716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803-809.
38. Peto, R., Roe, F. J. C., Lee, P. N., Levy, L. & Clack, J. 1975 Cancer ageing in mice and man. Br. J. Cancer 32, 411-426.
39. Polakis, P. 1995 Mutations in the APC gene and their implications for protein structure and function. Curr. Opin. Genet. Dev. 5, 66-71.
40. Ponder, B. A. J. & Wilkinson, M. M. 1986 Direct examination of the clonality of carcinogen-induced colonie epithelial dysplasia in chimeric mice. J. Natn. Cancer Inst. 77, 967-973.
41. Riggins, G. J., Markowitz, S., Wilson, J. K., Vogelstein, B. & Kinzler, K. W. 1995 Absence of secretory phospholipase A2 gene alterations in human colorectal cancer. Cancer Res. 55, 5184-5186.
42. Rous, P. & Kidd, J. G. 1941 Conditional neoplasms and subthreshold neoplastic states, J. Exp. Med. 73, 365.
43. Schmidt, G. H., Winton, D. J. & Ponder, B. A. J. 1988 Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine. Development 103, 785-790.
44. Shoemaker, A. R., Moser, A. R. & Dove, W. F. 1995 ENU treatment of Min mice: age-related effects on the formation of intestinal adenomas, cystic crypts, and epidermoid cysts. Cancer Res. 55, 4479-4485.
45. Shoemaker, A. R., Gould, K. A., Luongo, C., Moser, A. R. & Dove, W. F. 1997a Studies of neoplasia in the Min mouse. BBA Rev. Cancer 1332, F25-F48.
46. Shoemaker, A. R., Luongo, C., Moser, A. R., Marion, L.-J. & Dove, W. F. 1997b Somatic mutational mechanisms involved in intestinal tumor formation in Min mice. Cancer Res. 57, 1999-2006.
47. Solomon, E., Voss, R., Hall, V., Bodnier, W. F., Jass, J. R., Jeffreys, A. J., Lucibello, F. C., Patel, I. & Rider, S. H. 1987 Chromosome 5 allele loss in human colorectal carcinomas. Nature 328, 616-619.
48. Spirio, L. N. (and 11 others) 1996 Three secretory phospholipase A2 genes that map to human chromosome 1P35-36 are not mutated in individuals with attenuated adenomatous polyposis coli. Cancer Res. 56, 955-958.
49. Su, L.-K., Kinzler, K. W., Yogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A. & Dove, W. F. 1992 A germline mutation of the murine homolog of the APC gene causes multiple intestinal neoplasia. Science 256, 668-670.
50. Tomlinson, I. P. M., Neale, K., Talbot, I. C., Spigelman, A. D., Williams, C. B., Phillips, R. K. S. & Bodmer, W. F. 1996a A modifying locus for familial adenomatous polyposis may be present on chromosome Ip35-p36. J. Med. Genet. 33, 268-273.
51. Tomlinson, I. P., Beck, N. E., Neale, K. & Bodmer, W. F. 1996b Variants at the secretory phospholipase A2 (PLA2G2a) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumors. Ann. Hum. Genet. 60, 369-376.
52. Wong, M. H., Hermiston, M. L., Syder, A. J. & Gordon, J. I. 1996 Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium. Proc. Juin. Acad. Sci. USA 93, 9588-9593.
53. Zambrowicz, B. P., Imamoto, A., Fiering, S., Herzenberg, L. A., Kerr,W. G. & Soriano, P. 1997 Disruption of overlapping transcripts in the ROSA βgeo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells. Proc. Natn. Acad. Sci. USA 94, 3789-3794.