Clonality of dysplastic epithelium in colorectal adenomas from familial adenomatous polyposis patients

Cancer Research

Volumn 57, Issue 3, 1997, Pages 355-361

  Bjerknes, Matthew ^a   Cheng, Hazel ^a   Kim, Hyeja ^b   Schnitzler, Margaret ^b   Gallinger, Steven ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYP; ARTICLE; CELL CLONE; CLINICAL ARTICLE; COLON ADENOMA; COLON MUCOSA; CONTROLLED STUDY; GENE ISOLATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR GENETICS; PRIORITY JOURNAL;

ADENOMA; ADENOMATOUS POLYPOSIS COLI; COLORECTAL NEOPLASMS; GENES, APC; HUMANS; MUTATION;

EID: 0031059392     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Groden, J., Thliveris, A., Samovitz, W., Calson, M., Gelbert, L., Albertsen, H., Joslyn, G., Stevens, J., Spirio, L., Robertson, M., Sargeant, L., Krapcho, K., Wolff, E., Burt, R., Hughes, J. P., Warrington, J., McPherson, J., Wasmuth, J., Le Paslier, D., Abderrahim, H., Cohen, D., Leppert, M., and While, R. Identification and characterization of the familial adenomatous polyposis coli gene. Cell, 66: 589-600, 1991.
2. Joslyn, G., Carlson, M., Thilveris, A., Albertsen, H., Gelbert, L., Samowitz, W., Groden, J., Stevens, J., Spirio, L., Robert son, M., Sargeant, L., Krapcho, K., Wolff, E., Burt, R., Jughes, J. P., Warrington, J., McPherson, J., Wasmuth, J., Le Paslier, D., Abderrahim, H., Cohen, D., Leppert, M., and White, R. Identification of deletion mutations and three new genes at the familial polyposis locus. Cell, 66: 601-613, 1991.
3. Kinzler, K. W., Nilbert, M. C., Su, L-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechine, D., Finniear, R., Markham, A., Groffen, J., Boguski, M. S., Altschul, S. F., Horii, A., Ando, H., Miyochi, Y., Miki, Y., Nishisho I., and Nakumura, Y. Identification of FAP locus genes from chromosome 5q21. Science (Washington, DC), 253: 661-665, 1991.
4. Nishisho, I., Nakamura, Y., Miyoshi, Y., Miki, Y., Ando, H., Horii, A., Koyama, K., Utsunomiya, J., Baba, S., Hedge, P., Markham, A., Kruch, A. J., Petersen, G., Hamilton, S. R., Nilbert, M. C., Levy, D. B., Bryan, T. M., Preisinger, A. C., Smith, K. J., Su, L-K., Kinzler, K. W., and Vogelstein, B. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (Washington DC), 253: 665-669, 1991.
5. Miyaki, M., Konishi, M., Kikuchi-Yanoshita, R., Enomoto, M., Igari, T., Tanaka, K., Muraoka, M., Takahashi, H., Amada, Y., Fukayama, M., Maeda, Y., Iwama, T., Mishima, Y., Mori, T., and Koike, M. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res., 54: 3011-3020, 1994.
6. Fearon, E. R., Hamilton, S. R., and Vogelstein, B. Clonal analysis of human colorectal tumors. Science (Washington DC), 238: 193-197, 1987.
7. Tsao, J., and Shibata, D. Further evidence that one of the earliest alterations in colorectal carcinogenesis involves APC. Am. J. Pathol., 145: 531-534, 1994.
8. Boland, C. R., Sato, J., Appelman, H. D., Bresalier, R. S., and Feinberg, A. P. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat. Med., 1: 902-909, 1995.
9. Nagel, S., Borisch, B., Thein, S. L., Oestreicher, M., Nothiger, F., Birrer, S., Tobler, A., and Fey, M. F. Somatic mutations detected by mini- and microsatellite DNA markers reveal clonal intratumor heterogeneity in gastrointestinal cancers. Cancer Res., 55: 2866-2870, 1995.
10. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767, 1990.
11. Powell, S. M., Petersen, G. M., Krush, A. J., Booker, S., Jen, J., Giardiello, F. M., Hamilton, S. R., Vogelstein, B., and Kinzler, K. W. Molecular diagnosis of familial adenomatous polyposis. N. Engl. J. Med., 329: 1982-1987, 1993.
12. Smith, K. J., Johnson, K. A., Bryan, T. M., Hill, D. E., Markowitz, S., Willson, J. K. V., Paraskeva, C., Petersen, G. M., Hamilton, S. R., Vogelstein, B., and Kinzler, K. W. The APC gene product in normal and tumor cells. Proc. Natl. Acad. Sci. USA, 90: 2846-2850, 1993.
13. Moser, A. R., Dove, W. F., Roth, K. A., and Gordon, J. I. The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J. Cell Biol., 116: 1517-1526, 1992.
14. Steinberg, M. S., and Takeichi, M. Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. Proc. Natl. Acad. Sci. USA, 91: 206-209, 1994.
15. Su, L-K., Vogelstein, B., and Kinzler, K. W. Association of the APC tumor suppressor protein with catenins. Science, (Washington DC) 262: 1734-1737, 1993.
16. Rubinfeld, B., Souza, B., Albert, I., Muller, O., Chamberlain, S. H., Masiarz, F. R., Munemitsu, S., and Polakis, P. Association of the APC gene product with β-catenin. Science, (Washington DC) 262: 1731-1733, 1993.
17. Miyoshi, Y., Nagase, H., Ando, H., Horii, A., Ichii, S., Nakatsuru, S., Aoki, T., Miki, Y., Mon, T., and Nakamura, Y. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum. Mol. Genet., 1: 229-233, 1992.
18. Griffiths, D. F. R., Davies, S. J., Williams, D., Williams, G. T., and Williams, E. D. Demonstration of somatic mutation and crypt clonality by X-linked enzyme histochemistry. Nature (Lond.), 333: 461-463, 1988.
19. Winton, D. J., Blount, M. A., and Ponder, B. A. J. A clonal marker induced by mutation in mouse intestinal epithelium. Nature, (Lond.) 333: 463-466, 1988.
20. Bjerknes, M. Expansion of mutant stem cell populations in the human colon. J. Theor. Biol., 178: 381-385, 1996.
21. Novelli, M. R., Williamson, J. A., Tomlinson, I. P. M., Elia, G., Hodgson, S. V., Talbot, I. C., Bodmer, W. F., and Wright, N. A. Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. Science (Washington DC), 272: 1187-1190, 1996.
22. Powell, S. M., Zilz, N., Beazer-Barclay, Y., Bryan, T. M., Hamilton, S. R., Thibodeau, S. N., Vogelstein, B., and Kinzler, K. W. APC mutations occur early during colorectal tumorigenesis. Nature, (Lond.) 359: 235-237, 1992.