Mutational analysis of the interacting cell death regulators CED-9 and CED-4

Cell Death and Differentiation

Volumn 4, Issue 7, 1997, Pages 526-533

  Ottilie, Sabine ^a   Wang, Yan ^a   Banks, Sean ^a   Chang, Julia ^a   Vigna, Nicole J ^a   Weeks, Suzanne ^a   Armstrong, Robert C ^a   Fritz, Lawrence C ^a   Oltersdorf, Tilman ^a  

^a PFIZER INC   (United States)

Author keywords

Apoptosis; Bcl 2; Bcl xL; BH 3 peptide; Ced 4; Ced 9; Cell death

Indexed keywords

EID: 0000606378     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400288     Document Type: Article

References (21)

1. Armstrong RC, Aja T, Xiang J, Gaur S, Krebs JF, Hoang K, Bai X, Korsmeyer SJ, Karanewsky DS, Fritz LC and Tomaselli K (1996) Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and ICE family protease inhibitors. J. Biol. Chem. 271: 16850-16855
2. Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, Lenardo MJ, Tomaselli KJ and Cohen JI (1997) Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas-and TNFR1-induced apoptosis. Proc. Natl. Acad. Sci. 94: 1172-1176
3. Chang BS, Minn AJ, Muchmore SW, Fesik SW and Thompson CB (1977) Identification of a novel regulatory domain in Bcl-xl and Bcl-2. EMBO J 16: 968-977
4. L function upstream of the CED-3-like apoptotic proteases. J. Biol. Chem. 271: 4573-4576
5. Chinnaiyan AM, O'Rourke K, Lane BR and Dixit VM (1997) Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death. Science 275: 1122-1126
6. Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G and Lutz RJ (1995) A conserved domain in Bax, distinct from BH1 and BH2 mediates cell death and protein binding functions. EMBO J. 14: 5589-5596
7. Diaz JL, Oltersdorf T, Home W, McConnell M, Wilson G, Weeks S, Garcia T and Fritz LC (1997) A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members. J. Biol. Chem. 272: 11350
8. Gyuris J, Golemis E, Chertkov H and Brent R (1993) Cdi, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 75: 791-803
9. Hengartner MO, Ellis RE and Horvitz HR (1992) Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356: 494-499
10. Hengartner MO and Horvitz HR (1994) C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian protooncogene bcl-2 Cell 76: 665-676
11. Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SC and Fesik SW (1996) X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381: 335-341
12. Sato T, Hanada M, Bodrug S, Irie S, Iwama N, Boise LH, Thompson CB, Golemis E, Fong L, Wang HG and Reed JC (1994) Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad. Sci. 91: 9238-9242
13. L-Bak peptide complex: recognition between regulators of apoptosis. Science 275: 983-986
14. Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB and Korsmeyer SJ (1995) Multiple Bcl-2 family members demonstrate selective dimerization with Bax. Proc. Natl. Acad. Sci. USA 92: 7834-7838
15. Shaham S and Horvitz HR (1996) An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Cell 86: 201-208
16. Spector MS, Desnoyers S, Hoeppner DJ and Hengartner MO (1997) Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature 385: 653-656
17. Wu D, Wallen HD and Nunez G (1977) Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275: 1126-1129
18. Yin XM, Oltvai ZN and Korsmeyer SJ (1994) BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369: 321-323
19. Yuan J and Horvitz HR (1992) The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 116: 309-320
20. Yuan J, Shaham S, Ledoux S, Ellis HM and Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75: 641-652
21. Zha H, Aime-Sempe C, Sato T and Reed JC (1996) Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J. Biol. Chem. 271: 7440-7444