메뉴 건너뛰기




Volumn 5, Issue 3, 1996, Pages 265-274

Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Author keywords

1,2,3,4 tetrahydroisoquinoline; 1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine 1 methyl 4 phenylpyridinium; Isoquinoline derivatives; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; 6,7 DIMETHOXY 1 STYRYL 3,4 DIHYDROISOQUINOLINE; AMPHETAMINE; APOMORPHINE; DOPAMINE; HOMOVANILLIC ACID; ISOQUINOLINE DERIVATIVE; N METHYL 6,7 DIMETHOXYISOQUINOLINIUM; N,N PROPYLISOQUINOLINE; NEUROTOXIN; TETRAHYDROISOQUINOLINE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 0030249938     PISSN: 10558330     EISSN: None     Source Type: Journal    
DOI: 10.1006/neur.1996.0035     Document Type: Article
Times cited : (23)

References (49)
  • 3
    • 0026598930 scopus 로고
    • Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium-evidence for free radical involvement
    • Cleeter MJW, Cooper JM, Schapira AHV (1992) Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium-evidence for free radical involvement. J Neurochem 58:786-789
    • (1992) J Neurochem , vol.58 , pp. 786-789
    • Cleeter, M.J.W.1    Cooper, J.M.2    Schapira, A.H.V.3
  • 4
    • 0018852663 scopus 로고
    • Biogenic amine-aldehyde condensation products: Tetrahydroisoquinolines and tryptolines (β-carbolines)
    • Deitrich R, Erwin V (1980) Biogenic amine-aldehyde condensation products: tetrahydroisoquinolines and tryptolines (β-carbolines). Annu Rev Pharmacol Toxicol 20:55-80
    • (1980) Annu Rev Pharmacol Toxicol , vol.20 , pp. 55-80
    • Deitrich, R.1    Erwin, V.2
  • 5
    • 0023185105 scopus 로고
    • A dopaminergic cell line variant resistant to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Denton T, Howard BD (1987) A dopaminergic cell line variant resistant to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurochem 49:622-630
    • (1987) J Neurochem , vol.49 , pp. 622-630
    • Denton, T.1    Howard, B.D.2
  • 6
    • 0025821265 scopus 로고
    • Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia
    • Dexter DT, Carayon A, Javoy-Agid F, Agid Y, Wells FR, Daniel SE, Jenner P, Marsden CD (1991) Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114:1953-1975
    • (1991) Brain , vol.114 , pp. 1953-1975
    • Dexter, D.T.1    Carayon, A.2    Javoy-Agid, F.3    Agid, Y.4    Wells, F.R.5    Daniel, S.E.6    Jenner, P.7    Marsden, C.D.8
  • 9
    • 0002647295 scopus 로고
    • MPTP and Parkinson's disease
    • Harvey AL (ed), Academic Press
    • Irwin I, Langston JW (1993) MPTP and Parkinson's disease. In: Harvey AL (ed), Natural and Synthetic Neurotoxins, Academic Press, pp 225-256
    • (1993) Natural and Synthetic Neurotoxins , pp. 225-256
    • Irwin, I.1    Langston, J.W.2
  • 10
    • 0027185713 scopus 로고
    • Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease
    • Jenner P (1993) Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease. Acta Neurol Scand 87 (suppl 146):6-13
    • (1993) Acta Neurol Scand , vol.87 , Issue.SUPPL. 146 , pp. 6-13
    • Jenner, P.1
  • 12
    • 0026073997 scopus 로고
    • Metabolism and penetration through the blood-brain barrier of parkinsonism-related compounds: 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline
    • Kikuchi K, Nagatsu Y, Makino Y, Mashino T, Ohta S, Hirobe M (1991) Metabolism and penetration through the blood-brain barrier of parkinsonism-related compounds: 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline. Drug Metab Dispos 19:257-262
    • (1991) Drug Metab Dispos , vol.19 , pp. 257-262
    • Kikuchi, K.1    Nagatsu, Y.2    Makino, Y.3    Mashino, T.4    Ohta, S.5    Hirobe, M.6
  • 13
    • 0002776118 scopus 로고
    • Methods for the counting of neurons
    • Nauta WJH, Ebbesson SOE (eds). Springer, New York
    • Konigsmark BW (1970) Methods for the counting of neurons. In Nauta WJH, Ebbesson SOE (eds), Contemporary Research Methods in Neuroanatomy. Springer, New York, pp. 315-340
    • (1970) Contemporary Research Methods in Neuroanatomy , pp. 315-340
    • Konigsmark, B.W.1
  • 14
    • 0029019124 scopus 로고
    • N-methyl(R)salsolinol produces hydroxyl radicals: Involvement to neurotoxicity
    • Maruyama W, Dostert P, Matsubara K, Naoi M (1995b) N-methyl(R)salsolinol produces hydroxyl radicals: involvement to neurotoxicity. Free Rad Biol Med 19:67-75
    • (1995) Free Rad Biol Med , vol.19 , pp. 67-75
    • Maruyama, W.1    Dostert, P.2    Matsubara, K.3    Naoi, M.4
  • 15
    • 0028988538 scopus 로고
    • Dopamine-derived 1-methyl-6,7-dihydroxyisoquinoline as hydroxyl radical promoters and scavengers: In vivo and in vitro studies
    • Maruyama W, Dostert W, Naoi M (1995a) Dopamine-derived 1-methyl-6,7-dihydroxyisoquinoline as hydroxyl radical promoters and scavengers: In vivo and in vitro studies. J Neurochem 64:2635-2643
    • (1995) J Neurochem , vol.64 , pp. 2635-2643
    • Maruyama, W.1    Dostert, W.2    Naoi, M.3
  • 16
    • 0026753805 scopus 로고
    • N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: In vivo microdialysis study
    • Maruyama W, Nakahara D, Ota M, Takahashi T, Takahashi A, Nagatsu T, Naoi M (1992) N-Methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: In vivo microdialysis study. J Neurochem 59:395-400
    • (1992) J Neurochem , vol.59 , pp. 395-400
    • Maruyama, W.1    Nakahara, D.2    Ota, M.3    Takahashi, T.4    Takahashi, A.5    Nagatsu, T.6    Naoi, M.7
  • 17
    • 0027343649 scopus 로고
    • Cytotoxicity of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines
    • Narabayashi H, Nagatsu T, Yanagisawa N, Mizuno Y (eds). Raven Press Ltd., New York
    • Maruyama W, Takahashi T, Minami M, Takahashi A, Dostert P, Nagatsu T, Naoi M (1993) Cytotoxicity of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, in Narabayashi H, Nagatsu T, Yanagisawa N, Mizuno Y (eds), Advances in Neurology, Vol. 60. Raven Press Ltd., New York pp 224-230
    • (1993) Advances in Neurology , vol.60 , pp. 224-230
    • Maruyama, W.1    Takahashi, T.2    Minami, M.3    Takahashi, A.4    Dostert, P.5    Nagatsu, T.6    Naoi, M.7
  • 19
    • 0028989810 scopus 로고
    • Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • McNaught KSt.P, Altomare C, Cellamare S, Carotti A, Thull U, Carrupt PA, Testa B, Jenner P, Marsden CD (1995b) Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuroreport 6:1105-1108
    • (1995) Neuroreport , vol.6 , pp. 1105-1108
    • McNaught, K.St.P.1    Altomare, C.2    Cellamare, S.3    Carotti, A.4    Thull, U.5    Carrupt, P.A.6    Testa, B.7    Jenner, P.8    Marsden, C.D.9
  • 23
    • 0028176592 scopus 로고
    • A immunohistochemical study on α-ketoglutarate dehydrogenase complex in Parkinson's disease
    • Mizuno Y, Matuda S, Yoshino H, Mori H, Hattori N, Ikebe S (1994) A immunohistochemical study on α-ketoglutarate dehydrogenase complex in Parkinson's disease. Ann Neurol 35:204-210
    • (1994) Ann Neurol , vol.35 , pp. 204-210
    • Mizuno, Y.1    Matuda, S.2    Yoshino, H.3    Mori, H.4    Hattori, N.5    Ikebe, S.6
  • 24
    • 0023111239 scopus 로고
    • Inhibition of mitochondrial α-ketoglutarate dehydrogenase by 1-methyl-4-phenylpyridinium ion
    • Mizuno Y, Saitoh T, Sone N (1987) Inhibition of mitochondrial α-ketoglutarate dehydrogenase by 1-methyl-4-phenylpyridinium ion. Biochem Biophys Res Commun 143:971-976
    • (1987) Biochem Biophys Res Commun , vol.143 , pp. 971-976
    • Mizuno, Y.1    Saitoh, T.2    Sone, N.3
  • 25
    • 0023935663 scopus 로고
    • An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions
    • Nagatsu T, Yoshida M (1987) An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions. Neurosci Lett 87:178-182
    • (1987) Neurosci Lett , vol.87 , pp. 178-182
    • Nagatsu, T.1    Yoshida, M.2
  • 26
    • 0024492782 scopus 로고
    • Oxidation of N-methyl-1,2,3,4-tetrahydroisoquinoline into the N-methyl-isoquinolinium ion by monoamine oxidase
    • Naoi M, Matsurra S, Parvez H, Takahashi T, Hirata Y, Minami M, Nagatsu T (1989a) Oxidation of N-methyl-1,2,3,4-tetrahydroisoquinoline into the N-methyl-isoquinolinium ion by monoamine oxidase. J Neurochem 52:653-655
    • (1989) J Neurochem , vol.52 , pp. 653-655
    • Naoi, M.1    Matsurra, S.2    Parvez, H.3    Takahashi, T.4    Hirata, Y.5    Minami, M.6    Nagatsu, T.7
  • 27
    • 0024359987 scopus 로고
    • A N-methyl-transferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neutrotoxin, N-methylisoquinolinium ion
    • Naoi M, Matsuura S, Takahashi T, Nagatsu T (1989b) A N-methyl-transferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neutrotoxin, N-methylisoquinolinium ion. Biochem Biophys Res Commun 161:1213-1219
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 1213-1219
    • Naoi, M.1    Matsuura, S.2    Takahashi, T.3    Nagatsu, T.4
  • 28
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridinium, a metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Nicklas WJ, Vyas I, Heikkila RE (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridinium, a metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life Sci 36:2503-2508
    • (1985) Life Sci , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 30
    • 0001831890 scopus 로고
    • +) and tetrahydroisoquinoline derivatives on dopaminergic neurons in ventral mesencephalic striatal co-culture
    • +) and tetrahydroisoquinoline derivatives on dopaminergic neurons in ventral mesencephalic striatal co-culture. Neurodegeneration 3:33-42
    • (1994) Neurodegeneration , vol.3 , pp. 33-42
    • Nishi, K.1    Mochizuki, H.2    Furukawa, Y.3    Mizuno, Y.4    Yoshida, M.5
  • 31
    • 0024413468 scopus 로고
    • Detection of tetrahydroisoquinoline in parkinsonism as an endogenous amine by use of gas-chromatography-mass spectrometry
    • Niwa T, Takeda N, Sasaoka T, Kaneda N, Hashizume Y, Yoshizumi H, Tatematsu A, Nagatsu T (1989) Detection of tetrahydroisoquinoline in parkinsonism as an endogenous amine by use of gas-chromatography-mass spectrometry. J Chromatogr 491:397-403
    • (1989) J Chromatogr , vol.491 , pp. 397-403
    • Niwa, T.1    Takeda, N.2    Sasaoka, T.3    Kaneda, N.4    Hashizume, Y.5    Yoshizumi, H.6    Tatematsu, A.7    Nagatsu, T.8
  • 32
    • 0023698218 scopus 로고
    • Migration of tetrahydroisoquinoline, a possible parkinsonian neurotoxin, into monkey brain from blood as proved by gas chromatography-mass spectrometry
    • Niwa T, Takeda N, Tatematsu A, Matsuura S, Yoshida M, Nagatsu T (1988) Migration of tetrahydroisoquinoline, a possible parkinsonian neurotoxin, into monkey brain from blood as proved by gas chromatography-mass spectrometry. J Chromatogr 452:85-91
    • (1988) J Chromatogr , vol.452 , pp. 85-91
    • Niwa, T.1    Takeda, N.2    Tatematsu, A.3    Matsuura, S.4    Yoshida, M.5    Nagatsu, T.6
  • 33
    • 0024376611 scopus 로고
    • The effects of 1,2,3,4-tetrahydroisoquinolines (TIQ) on mesencephalic dopaminergic neurones in C57BL/6J mice: Immunohistochemical studies-tyrosine hydroxylase
    • Ogawa M, Araki M, Nagatsu I, Nagatsu T, Yoshida M (1989) The effects of 1,2,3,4-tetrahydroisoquinolines (TIQ) on mesencephalic dopaminergic neurones in C57BL/6J mice: Immunohistochemical studies-tyrosine hydroxylase. Biogenic Amines 6:427-436
    • (1989) Biogenic Amines , vol.6 , pp. 427-436
    • Ogawa, M.1    Araki, M.2    Nagatsu, I.3    Nagatsu, T.4    Yoshida, M.5
  • 34
    • 0019797396 scopus 로고
    • Rat brain salsolinol and blood-brain barrier
    • Origitano T, Hannigan J, Collins MA (1981) Rat brain salsolinol and blood-brain barrier. Brain Res 224:446-451
    • (1981) Brain Res , vol.224 , pp. 446-451
    • Origitano, T.1    Hannigan, J.2    Collins, M.A.3
  • 36
    • 0023867458 scopus 로고
    • Tetrahydroisoquinoline lacks dopaminergic nigrostriatal neurotoxicity in mice
    • Perry TL, Jones K, Hansen S (1988) Tetrahydroisoquinoline lacks dopaminergic nigrostriatal neurotoxicity in mice. Neurosci Lett 85:101-104
    • (1988) Neurosci Lett , vol.85 , pp. 101-104
    • Perry, T.L.1    Jones, K.2    Hansen, S.3
  • 37
    • 0023001744 scopus 로고
    • Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria
    • Ramsay RR, Singer TP (1986) Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria. J Biol Chem 261:7585-7587
    • (1986) J Biol Chem , vol.261 , pp. 7585-7587
    • Ramsay, R.R.1    Singer, T.P.2
  • 38
    • 0024321178 scopus 로고
    • A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra
    • Saggu H, Cooksey J, Dexter D, Wells FR, Lees A, Jenner P, Marsden CD (1989) A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra. J Neurochem 53:692-697
    • (1989) J Neurochem , vol.53 , pp. 692-697
    • Saggu, H.1    Cooksey, J.2    Dexter, D.3    Wells, F.R.4    Lees, A.5    Jenner, P.6    Marsden, C.D.7
  • 39
    • 0000232034 scopus 로고
    • A marker of oxyradical-mediated DNA damage (8-hydroxy-2′-deoxyguanosine) is increased in the nigro-striatum in Parkinson's disease brain
    • Sanchez-Ramos JR, Overvik E, Ames BN (1994) A marker of oxyradical-mediated DNA damage (8-hydroxy-2′-deoxyguanosine) is increased in the nigro-striatum in Parkinson's disease brain. Neurodegeneration 3:197-204
    • (1994) Neurodegeneration , vol.3 , pp. 197-204
    • Sanchez-Ramos, J.R.1    Overvik, E.2    Ames, B.N.3
  • 40
    • 0026754078 scopus 로고
    • Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: Relationship to the dopamine uptake system and inhibition of mitochondrial respiration
    • Saporito M, Heikkila RE, Youngster SK, Nicklas WJ, Geller HM (1992) Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. J Pharmacol Exper Therapeut 260:1400-1409
    • (1992) J Pharmacol Exper Therapeut , vol.260 , pp. 1400-1409
    • Saporito, M.1    Heikkila, R.E.2    Youngster, S.K.3    Nicklas, W.J.4    Geller, H.M.5
  • 41
    • 0025747972 scopus 로고
    • Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances
    • Sayre LM, Wang F, Arora PK, Riachi NJ, Harik SI, Hoppel CL (1991) Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances. J Neurochem 57:2106-2115
    • (1991) J Neurochem , vol.57 , pp. 2106-2115
    • Sayre, L.M.1    Wang, F.2    Arora, P.K.3    Riachi, N.J.4    Harik, S.I.5    Hoppel, C.L.6
  • 43
    • 0028075410 scopus 로고
    • Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
    • Sian J, Dexter DT, Lees AJ, Daniel S, Agid Y, Javoy-Agid F, Jenner P, Marsden CD (1994) Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol 36:348-355
    • (1994) Ann Neurol , vol.36 , pp. 348-355
    • Sian, J.1    Dexter, D.T.2    Lees, A.J.3    Daniel, S.4    Agid, Y.5    Javoy-Agid, F.6    Jenner, P.7    Marsden, C.D.8
  • 45
    • 0026654844 scopus 로고
    • Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain
    • Suzuki K, Mizuno Y, Yasuhiro Y, Nagatsu T, Mitsuo Y (1992) Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain. J Neurol Sci 109:219-223
    • (1992) J Neurol Sci , vol.109 , pp. 219-223
    • Suzuki, K.1    Mizuno, Y.2    Yasuhiro, Y.3    Nagatsu, T.4    Mitsuo, Y.5
  • 46
    • 0024317786 scopus 로고
    • Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinoline
    • Suzuki K, Mizuno Y, Yoshida M (1989) Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinoline. Biochem Biophys Res Commun 162:1541-1545
    • (1989) Biochem Biophys Res Commun , vol.162 , pp. 1541-1545
    • Suzuki, K.1    Mizuno, Y.2    Yoshida, M.3
  • 47
    • 0025308554 scopus 로고
    • Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain
    • Suzuki K, Mizuno Y, Yoshida M (1990) Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain. Neurochem Res 7:705-710
    • (1990) Neurochem Res , vol.7 , pp. 705-710
    • Suzuki, K.1    Mizuno, Y.2    Yoshida, M.3
  • 48
    • 0024993985 scopus 로고
    • Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: The behavioural and biochemical changes
    • Yoshida M, Niwa T, Nagatsu T (1990) Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: the behavioural and biochemical changes. Neurosci Lett 119:109-113
    • (1990) Neurosci Lett , vol.119 , pp. 109-113
    • Yoshida, M.1    Niwa, T.2    Nagatsu, T.3
  • 49
    • 0027354221 scopus 로고
    • Parkinsonism produced by tetrahydroisoquinoline (TIQ) or the analogues
    • Narabayashi H, Yanagisawa, Mizuno Y (eds). Raven Press Ltd., New York
    • Yoshida M, Ogawa M, Suzuki K, Nagatsu T (1993) Parkinsonism produced by tetrahydroisoquinoline (TIQ) or the analogues. In Narabayashi H, Yanagisawa, Mizuno Y (eds), Advances in Neurology, Vol. 60. Raven Press Ltd., New York, pp 207-211
    • (1993) Advances in Neurology , vol.60 , pp. 207-211
    • Yoshida, M.1    Ogawa, M.2    Suzuki, K.3    Nagatsu, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.