Design of benzamidine-type inhibitors of factor Xa

Journal of Medicinal Chemistry

Volumn 41, Issue 22, 1998, Pages 4240-4250

  Gabriel, Bernhard ^a   Stubbs, Milton T ^a,b   Bergner, Andreas ^a   Hauptmann, Jörg ^c   Bode, Wolfram ^a   Stürzebecher, Jörg ^c   Moroder, Luis ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; [N [4 [(1 ACETIMIDOYL 4 PIPERIDYL)OXY]PHENYL] N [(7 AMIDINO 2 NAPHTHYL)METHYL]SULFAMOYL]ACETIC ACID; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A INHIBITOR; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICOAGULANT THERAPY; ARTICLE; DRUG DESIGN; DRUG ELIMINATION; DRUG STRUCTURE; NONHUMAN; RAT; THROMBOSIS; X RAY ANALYSIS;

ANIMALS; BENZAMIDINES; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; FACTOR XA; HUMANS; HYDROGEN BONDING; RATS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032561224     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980227t     Document Type: Article

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