2, 3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 20, 1998, Pages 2849-2854

  Collado, Iván ^a   Ezquerra, Jesús ^a   Mazón, Angel ^a   Pedregal, Concepción ^a   Yruretagoyena, Belén ^a   Kingston, Anne E ^b   Tomlinson, Rosemary ^b   Wright, Rebecca A ^b   Johnson, Bryan G ^b   Schoepp, Darryle D ^b  

^a ELI LILLY AND COMPANY   (Spain)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2' CARBOXY 3' METHOXYMETHYLCYCLOPROPYL)GLYCINE; 2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM; COMPLEX FORMATION; DRUG POTENCY; DRUG SYNTHESIS; HYDROLYSIS; LIGAND BINDING; NEUROTRANSMITTER RELEASE; NONHUMAN;

ANIMALS; CELL LINE; CYCLOPROPANES; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; HUMANS; INHIBITORY CONCENTRATION 50; NEURONS; PROSENCEPHALON; RATS; RECEPTORS, GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032552933     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00510-1     Document Type: Article

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