Haemodynamic and hormonal responses to long-term inhibition of nitric oxide synthesis in rats with portal hypertension

European Journal of Pharmacology

Volumn 312, Issue 1, 1996, Pages 63-68

  Pilette, Christophe ^a,b   Moreau, Richard ^a   Sogni, Philippe ^a   Kirstetter, Philippe ^a   Cailmail, Stéphane ^a   Pussard, Eric ^c   Lebrec, Didier ^a  

^a BEAUJON HOSPITAL   (France)

^b ANGERS UNIVERSITY HOSPITAL   (France)

^c BICÊTRE HOSPITAL   (France)

Author keywords

Baseline vascular tone; EDRF (endothelium derived relaxing factor); Portal hypertension

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CYCLIC GMP; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; HEMODYNAMICS; LIVER BLOOD FLOW; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PORTAL HYPERTENSION; PRIORITY JOURNAL; RAT; VASCULAR RESISTANCE;

EID: 0030593752     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00448-7     Document Type: Article

References (24)

1. Albillos, A., L.A. Colombato and R.J. Groszmann, 1992, Vasodilation and sodium retention in prehepatic portal hypertension, Gastroenterology 102, 931.
2. Baylis, C., B. Mitruka and A. Deng, 1985, Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage, J. Clin. Invest. 90, 278.
3. Chinkers, M. and D.L. Garbers, 1991, Signal transduction by guanylyl cyclases, Annu. Rev. Biochem. 60, 553.
4. Claria, J., W. Jimenez, J. Ros, M. Asbert, A. Castro, V. Arroyo, F. Rivera and J. Rodes, 1992, Pathogenesis of arterial hypotension in cirrhotic rats with ascites: role of endogenous nitric oxide, Hepatology 15, 343.
5. De Nicola, L., R.C. Blantz and F.B. Gabbai, 1992, Nitric oxide and angiotensin II, J. Clin. Invest. 89, 1248.
6. Garcia-Pagan, J.C., M. Fernandez, C. Bernadich, P. Pizcueta, J.M. Pique, J. Bosch and J. Rodes, 1994, Effects of continued NO inhibition on portal hypertensive syndrome after portal vein stenosis in rat, Am. J. Physiol. 267, G984.
7. Gardes, J., M.F. Gonzales, F. Alhenc-Gelas and J. Menard, 1994, Influence of sodium diet on L-NAME effects on renin release and renal vasoconstriction, Am. J. Physiol. 267, F798.
8. Lauster, F., J.M. Heim, C. Drummer, H.J. Fülle, R. Gerzer and H. Schiffl, 1993, Plasma cGMP level aa a marker of the hydration state in renal replacement therapy, Kidney Int. 43 (Suppl. 41), S57.
9. Lee, F.Y., L.A. Colombato, A. Albillos and R.J. Groszmann, 1993a, Nω-Nitro-L-arginine administration corrects peripheral vasodilation and systemic capillary hypotension and ameliorates plasma volume expansion and sodium retention in portal hypertensive rats, Hepatology 17, 84.
10. Lee, F.Y., L.A. Colombato, A. Albillos and R.J. Groszmann, 1993b, Administration of Nω-nitro-L-arginine ameliorates portal-systemic shunting in portal-hypertensive rats, Gastroenterology 105, 1464.
11. Lee, S.S., C. Girod, D. Valla, P. Geoffroy and D. Lebrec, 1985, Effects of pentobarbital sodium anesthesia on splanchnic hemodynamics of normal and portal-hypertensive rats, Am. J. Physiol. 249, G528.
12. Moncada, S., R.J.M. Palmer and E.A. Higgs, 1991, Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacol. Rev. 43, 109.
13. + channels by glibenclamide reduces portal pressure and hyperdynamic circulation in portal hypertensive rats, J. Hepatol. 16, 215.
14. Mosca, P., F.Y. Lee, A.J. Kaumann and R.J. Groszmann, 1992, Pharmacology of portal-systemic collaterals in portal hypertensive rats: role of the endothelium, Am. J. Physiol. 263, G544.
15. Niederberger, M., P. Gines, P. Tasi, P.Y. Martin, K. Morris, A. Weigert, I. McMurtry and R.W. Schrier, 1995, Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis, Hepatology 21, 1625.
16. Pizcueta, M.P., J.M. Piqué, M. Fernadez, J. Bosch, J. Rodes, B.J.R. Whittle and S. Moncada, 1992, Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition, Gastroenterology 103, 1909.
17. Ros, J., J. Claria, W. Jimenez, M. Bosch-Marce, P. Angeli, V. Arroyo, F. Rivera and J. Rodes, 1995, Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis, Hepatology 22, 915.
18. Sessa, W.C., K. Pritchard, N. Seyedi, J. Wang and T.H. Hintze, 1994, Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression, Circ. Res. 74, 349.
19. Sieber, C.C., J.C. Lopez-Talavera and R.J. Groszmann, 1993, Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats, Gastroenterology 104, 1750.
20. Sogni, P., R. Moreau, M. Ohsuga, S. Cailmail, F. Oberti, A. Hadengue, E. Pussard and D. Lebrec, 1992, Evidence for normal nitric oxide-mediated vasodilator tone in conscious rats with cirrhosis, Hepatology 16, 980.
21. Sogni, P., R. Moreau, A. Gadano and D. Lebrec, 1995, The role of nitric oxide in the hyperdynamic circulatory syndrome associated with portal hypertension, J. Hepatol. 23, 218.
22. Stasch, J.P., S. Kazda and D. Neuser, 1989, Different effects of ANP and nitroprusside on cGMP extrusion of isolated aorta. Eur. J. Pharmacol. 174, 279.
23. Stoss, B.A., O.A. Carretero, R.D. Farhy, G. Scicli and J.L. Garvin, 1992, Endothelium-derived relaxing factor inhibits transport and increases cGMP content in cultured mouse cortical collecting duct cells, J. Clin. Invest. 89, 761.
24. Wu, Y., R. Burns and J.V. Sitzmann, 1993, Effects of nitric oxide and cyclooxygenase inhibition on splanchnic hemodynamics in portal hypertension, Hepatology 18, 1416.