Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats

Hepatology

Volumn 24, Issue 4 I, 1996, Pages 947-951

  Niederberger, Michel ^a,c   Ginès, Pere ^a,d   Martin, Pierre Yves ^a   Tsai, Phoebe ^a   Morris, Kenneth ^a   Mcmurtry, Ivan ^a   Schrier, Robert W ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF BERN   (Switzerland)

^d HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTERY DILATATION; ARTICLE; IMMUNOBLOTTING; LIVER BLOOD FLOW; LIVER CIRRHOSIS; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; NONHUMAN; OXIDATION REDUCTION REACTION; PATHOGENESIS; PORTAL HYPERTENSION; PRIORITY JOURNAL; RAT;

EID: 0029786248     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v24.pm0008855203     Document Type: Article

References (43)

1. Schrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, Rodés J. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. HEPATOLOGY 1988;8: 1151-1157.
2. Arroyo V, Ginès P, Jiménez W, Rodés J. Ascites, renal failure, and electrolyte disorders in cirrhosis. Pathogenesis, diagnosis, and treatment. In: McIntyre N, Benhamou JP, Bircher J, Rizetto M, Rodés J, eds. Oxford textbook of clinical hepatology. Oxford: Oxford Medical Press, 1991:429-470.
3. Groszmann RJ. Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences. HEPATOLOGY 1994;20:1359-1363.
4. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-142.
5. Pizcueta MP, Piqué JM, Bosch J, Whittle BJ, Moncada S. Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension. Br J Pharmacol 1992;105:184-190.
6. Clària J, Jiménez W, Ros J, Asbert M, Castro A, Arroyo V, Rivera F, et al. Pathogenesis of arterial hypotension in cirrhotic rats with ascites: role of endogenous nitric oxide. HEPATOLOGY 1992;15:343-349.
7. Iwata F, Joh T, Kawai T, Itoh M. Role of EDRF in splanchnic blood flow of normal and chronic portal hypertensive rats. Am J Physiol 1992;263: G149-G154.
8. Lee FY, Albillos A, Colombato LA, Groszmann RJ. The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats. HEPATOLOGY 1992;16:1043-1048.
9. Lee FY, Colombato LA, Albillos A, Groszmann RJ. Nw-nitro-L-arginine administration corrects peripheral vasodilation and systemic capillary hypotension and ameliorates plasma volume expansion and sodium retention in portal hypertensive rats. HEPATOLOGY 1993;17:84-90.
10. Castro A, Jiménez W, Clària J, Ros J, Martínez JM, Bosch M, Arroyo V, et al. Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide. HEPATOLOGY 1993;18:367-372.
11. Vorobioff J, Bredfeldt JE, Groszmann RJ. Increased blood flow through the portal system in cirrhotic rats. Gastroenterology 1984:1120-1126.
12. Jiménez W, Clària J, Arroyo V, Rodés J. Carbon tetrachloride induced cirrhosis in rats: a useful tool for investigating the pathogenesis of ascites in chronic liver disease. Eur J Gastroenterol Hepatol 1992; :90-97.
13. Bomzon A, Blendis LM. Animal models of liver disease. In: Bomzon A, Blendis LM, eds. Cardiovascular complications of liver disease. Boca Raton: CRC Press, 1990:10-28.
14. López C, Jiménez W, Arroyo V, Clària J, La Villa G, Asbert M, Gaya J, et al. Temporal relationship between the decrease in arterial pressure and sodium retention in conscious spontaneously hypertensive rats with carbon tetrachloride-induced cirrhosis. HEPATOLOGY 1991;13:585-589.
15. Arnal JF, Warin L, Michel JB. Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J Clin Invest 1992;90:647-652.
16. Niederberger M, Ginès P, Tsai P, Martin PY, Weigert A, Schrier RW. Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. HEPATOLOGY 1995;21:1625-1631.
17. Niederberger M, Martin PY, Ginès P, Morris K, Tsai P, Xu DL, McMurtry IF, et al. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in rats with cirrhosis and ascites. Gastroenterology 1995;109:1624-1630.
18. Chojkier M, Groszmann RJ. Measurement of portal-systemic shunting in the rats by using gamma-labeled microspheres. Am J Physiol 1981;240: G371-G375.
19. Sikuler E, Kravetz D, Groszmann RJ. Evolution of portal hypertension and mechanisms involved in its maintenance in a rat model. Am J Physiol 1985;248:G618-625.
20. Coleman TG. Cardiac output by dye dilution in the conscious rat. J Appl Physiol 1974;37:452-455.
21. Stevens T, Morris K, McMurtry I, Zamora M, Tucker A. Pulmonary and systemic vascular responsiveness to TNF-α in conscious rats. J Appl Physiol 1993;74:1905-1910.
22. Kim JK, Summer SN, Howard RL, Schrier RW. Vasopressin gene expression in rats with experimental cirrhosis. HEPATOLOGY 1993;17:143-147.
23. Burnette WN. Western blotting: electrophoretic transfer of proteins from SDS-polyacrylamide to unmodified nitrocellulose and radiographic detection with antibody and radiolabelled protein A. Anal Biochem 1981;112: 195-203.
24. Martin PY, Xu DL, Niederberger M, Weigert A, Tsai P, St. John J, Ginès P, et al. Upregulation of the endothelial constitutive NOS: a major role in the increased NO production in cirrhotic rats. Am J Physiol 1996;270 (Renal and Fluid Electrolyte Physiol.39):F494-F499.
25. Arnal JF, El Amrani AI, Michel JB. Atrial natriuretic factor influences in vivo plasma, lung and aortic wall cGMP concentrations differently. Eur J Pharmacol 1993;237:265-273.
26. Ros J, Jiménez W, Lamas S, Clària J, Arroyo V, River F, Rodés J. Nitric oxide production in arterial vessels of cirrhotic rats. HEPATOLOGY 1995; 21:554-560.
27. Guarner C, Soriano G, Tomas A, Bulbena O, Novella MT, Balanzo J, Vilardell F, et al. Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. HEPATOLOGY 1993;18:1139-1143.
28. Albillos A, Rossi I, Cacho G, Martínez MV, Millán I, Abreu L, Barrios C, et al. Enhanced endothelium-dependent vasodilation in patients with cirrhosis. Am J Physiol 1995;31:G459-G464.
29. Matsumoto A, Ogura K, Hirata Y, Kakoki M, Watanabe F, Takenaka K, Shiratori Y, et al. Increased nitric oxide in the exhaled air of patients with decompensated liver cirrhosis. Ann Intern Med 1995;123:110-113.
30. Sogni P, Garnier P, Gadano A, Moreau R, Dall'Ava-Santucci J, Dinh-Xuan AT, Lebrec D. Endogenous pulmonary nitric oxide production measured from exhaled air is increased in patients with severe cirrhosis. J Hepatol 1995;23:471-473.
31. Sieber CC, Groszmann RJ. Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats. Gastroenterology 1992;103:235-239.
32. Garcia-Pagán JC, Fernández M, Bernadich C, Pizcueta P, Piqué JM, Bosch J, Rodés J. Effects of continued NO inhibition on portal hypertensive syndrome after portal vein stenosis in rat. Am J Physiol 1994;267:G984-G990.
33. Noris M, Morigi M, Donadelli S, Aiello M, Foppolo M, Todeschini S, Orisio G, et al. Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ Res 1995;76:536-543.
34. Sogni P, Moreau R, Gadano A, Lebrec D. The role of nitric oxide in the hyperdynamic circulatory syndrome associated with portal hypertension. J Hepatol 1995;23:218-224.
35. Bendtsen F, Schifter S, Henriksen JH, Increased circulating calcitonin gene-related peptide (CGRP) in cirrhosis. J Hepatol 1991;12:118-123.
36. Fernández-Rodríguez CM, Prieto J, Quiroga J, Zozaya JM, Andrade A, Núñez M, Sangro B, et al. Plasma levels of substance P in liver cirrhosis: relationship to the activation of vasopressor systems and urinary sodium excretion. HEPATOLOGY 1995;21:35-40.
37. Muller MJ, Wilmann O, Rieger A, Fenk A, Selberg O, Lautz HU, Burger M, et al. Mechanism of insulin resistance associated with liver cirrhosis. Gastroenterology 1992;102:2033-2041.
38. Bourgoignie JJ, Valle GA. Endotoxin and renal dysfunction in liver disease. In: Epstein M, ed. The kidney in liver disease. Ed 3. Baltimore: Williams & Wilkins, 1988:486-507.
39. Runyon BA, Squier S, Borzio M. Translocation of gut bacteria in rats with cirrhosis to mesenteric lymph nodes partially explains the pathogenesis of spontaneous bacterial peritonitis. J Hepatol 1994;21:792-796.
40. Llovet JM, Bartoli R, Planas R, Cabré E, Urban A, Ojanguren J, Giménez M, et al. Bacterial translocation in cirrhotic rats. Its role on the development of spontaneous bacterial peritonitis. Gut 1994;35:1648-1652.
41. Mehta R, Gottstein J, Zeller WP, Lichtenberg R, Blei AT. Endotoxin and the hyperdynamic circulation of portal vein-ligated rats. HEPATOLOGY 1990;12:1152-1156.
42. Garcia-Tsao G, Albillos A, Barden GE, West AB. Bacterial translocation in acute and chronic portal hypertension. HEPATOLOGY 1993;17:1081-1085.
43. Vallance P, Moncada S. Hyperdynamic circulation in cirrhosis: a role for nitric oxide? Lancet 1991;337:776-778.