Inhibition of MAP kinase by sphingosine and its methylated derivative, N,N-dimethylsphingosine: A correlation with induction of apoptosis in solid tumor cells

International Journal of Oncology

Volumn 11, Issue 1, 1997, Pages 31-39

  Sakakura, Chouhei ^a   Sweeney, Elizabeth A ^a,d   Shirahama, Tsutomu ^a   Ruan, Fuquiang ^a   Solca, Flavio ^b   Kohno, Michiaki ^c   Hakomori, Sen Itiroh ^a,e   Fischer, Edmond H ^b   Igarashi, Yasuyuki ^a,d  

^a The Biomembrane Institute   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^d Fred Hutchinson Cancer Research Center   (United States)

^e PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

Author keywords

Apoptosis; Epidermal growth factor; Mitogen activated protein kinase; N; N dimethylsphingosine; Phosphatase; Sphingosine

Indexed keywords

CERAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; N,N DIMETHYLSPHINGOSINE; SPHINGOSINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SOLID TUMOR;

EID: 0030854629     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Seger R and Krebs EG: The MAPK signaling cascade. FASEB J 9: 726-736, 1995.
2. Sun H, Charles CH, Lau LF and Tonks NK: MKP-1(3CH134), an immediate early gene product, is a dual specificity phasphatase that dephosphorylates MAP kinase in vivo. Cell 75: 487-493, 1993.
3. Gille H, Sharrocks AD and Shaw PE: Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358: 414-417, 1992.
4. Sturgill TW, Ray CB, Erickson E and Maller JL: Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature 334: 715-718, 1988.
5. Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N and Lawrence JC: PHAS-1 as a link between mitogen-activated protein kinase and translation initiation. Science 266: 653-656, 1994.