Molecular mechanism of thymidylate synthase-catalyzed reaction and interaction of the enzyme with 2- and/or 4-substituted analogues of dUMP and 5-fluoro-dUMP

Acta Biochimica Polonica

Volumn 43, Issue 1, 1996, Pages 133-142

  Rode, Wojciech ^a   Leś, Andrzej ^b  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

dUMP analogues; Inhibition specificity; Thymidylate synthase

Indexed keywords

2'-DEOXYURIDYLIC ACID; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; ANTIPROTOZOAL AGENT; ANTIVIRUS AGENT; DEOXYURIDINE PHOSPHATE; FLOXURIDINE PHOSPHATE; THYMIDINE KINASE;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; HYDROGEN BOND; METABOLISM; REVIEW; SYNTHESIS;

ANIMALS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; ANTIPROTOZOAL AGENTS; ANTIVIRAL AGENTS; DEOXYURACIL NUCLEOTIDES; DRUG DESIGN; FLUORODEOXYURIDYLATE; HUMANS; HYDROGEN BONDING; MOLECULAR STRUCTURE; THYMIDINE KINASE;

EID: 0029692780     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.1996_4524     Document Type: Article

References (33)

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