Glucosylceramide synthetase inhibitor, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol exhibits a novel decarcinogenic activity against Shope carcinoma cells

Cancer Letters

Volumn 101, Issue 1, 1996, Pages 25-30

  Kyogashima, Mamoru ^a,c   Inoue, Makoto ^a   Seto, Akira ^a   Inokuchi, Jin Ichi ^b,c  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c SEIKAGAKU CORPORATION   (Japan)

Author keywords

D threo 1 phenyl 2 decanoylamino 3 morpholino 1 propanol; Decarcinogenesis; Glucosylceramide synthase inhibitor; Shope carcinoma

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; GLUCOSYLCERAMIDE SYNTHETASE; SYNTHETASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER TRANSPLANTATION; CARCINOGENICITY; CARCINOMA CELL; CELL DENSITY; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONTACT INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; GROWTH INHIBITION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA; CELL DIVISION; GLUCOSYLTRANSFERASES; MICE; MICE, NUDE; MORPHOLINES; NEOPLASMS, EXPERIMENTAL; RABBITS; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

ANIMALIA;

EID: 0030039399     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(95)04106-0     Document Type: Article

References (14)

1. Hakomori, S. (1989) Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv. Cancer Res., 52, 257-331.
2. Hosoi, J., Abe, E., Suda, T., Colburn, N.H. and Kuroki, T. (1986) Induction of anchorage-independent growth of JB6 mouse epidermal cells by 1α,25-dihydroxyvitamin D3. Cancer Res., 46, 5582-5586.
3. Inokuchi, J. and Radin, N.S. (1987) Preparation of active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibition of murine glucocerebroside synthetase. J. Lipid Res., 38, 565-571.
4. Inokuchi, J., Mason, I. and Radin N.S. (1987) Antitumor activity via inhibition of glycosphingolipid biosynthesis. Cancer Lett., 38, 23-30.
5. Inokuchi, J., Jimbo, M., Momosaki, K., Shimeno, H., Nagamatsu, A. and Radin, N.S. (1990) Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthetase and its possible mechanism of action. Cancer Res., 50, 6731-6737.
6. X antigens. Semin. Cancer Biol., 4, 319-324.
7. Kyogashima, M., Inoue, M., Nakayama, J. and Seto, A. (1992) Aberrant expression of blood group H-antigen in Shope carcinoma cells. Cancer Lett., 66, 175-181.
8. Kyogashima, M., Inoue, M., Isono, T., Nakayama, J. and Seto, A. (1994) Monoclonal antibody recognizes glycolipids as a differentiation antigen in Shope carcinoma cells. Cancer Lett., 81, 221-228.
9. Lee, J.S., Ro, J.Y., Sahin, A.A. Hong, W.K. Brown, B.W., Mountain, C.F. and Hittelman, W.N. (1991) Expression of blood-group antigen A-a favorable prognostic factors in non-small-cell lung cancer. N. Engl. J. Med., 324, 1084-1090.
10. Uemura, K., Sugiyama, E., Tamai, C., Hara, A., Taketomi, T. and Radin, N.S. (1990) Effect of an inhibitor of glucosylceramide synthetase on cultured rabbit skin fibroblast. J. Biochem. (Tokyo), 108, 520-530.
11. Uemura, K., Sugiyama, E. and Taketomi, T. (1991) Effects of an inhibitor of glucosylceramide synthetase on glycosphingolipid synthesis and neurite outgrowth in murine neuroblastoma cell lines. J. Biochem. (Tokyo), 110, 96-102.
12. Schaeffer, W.I. and Friend, K. (1976) Efficient detection of soft agar grown colonies using a tetrazolium salt. Cancer Lett., 1, 259-262.
13. Shin, S.-I., Freedman, V.H., Risser, R. and Pollack, R. (1975) Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc. Natl. Acad. Sci. USA, 72, 4435-4439.
14. Seto, A., Isono, T., Inoue, M., Yamade, I. and Ogawa, K. (1991) Establishment from Shope carcinoma induced in an inbred rabbit of culture cell lines with various potentials for differentiation and tumorigenicity. J. Invest. Dermatol., 97, 327-331.