The x-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water- mediated hydrogen bond to corepressor specificity and binding affinity

Journal of Biological Chemistry

Volumn 272, Issue 36, 1997, Pages 22648-22653

  Schumacher, Maria A ^a   Glasfeld, Arthur ^a,b   Zalkin, Howard ^c   Brennan, Richard G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b REED COLLEGE   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CRYSTAL STRUCTURE; DNA BINDING; ELECTRICITY; GENE REPRESSION; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DNA BINDING;

BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ESCHERICHIA COLI PROTEINS; GUANINE; HYDROGEN BONDING; MOLECULAR SEQUENCE DATA; OPERATOR REGIONS (GENETICS); PROTEIN BINDING; REPRESSOR PROTEINS; WATER;

ESCHERICHIA COLI;

EID: 0030967745     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.36.22648     Document Type: Article

References (40)

1. Zalkin, H., and Dixon, J. E. (1992) Prog. Nucleic Acid Res. Mol. Biol. 42, 259-286
2. Steiert, J. G., Rolfes, R., Zalkin, H., and Stauffer, G. V. (1990) J. Bacteriol. 172, 3799-3803
3. He, B., Choi, K. Y., and Zalkin, H. (1993) J. Bacteriol. 175, 3598-3606
4. Rolfes, R. J., and Zalkin, H. (1990) J. Bacteriol. 172, 5758-5766
5. Meng, L., Kilstrup, M., and Nygaard, P. (1990) Eur. J. Biochem. 187, 373-379
6. Weickert, M. J., and Adhya, S. (1992) J. Biol. Chem. 267, 15869-15874
7. Ngyuen, C. C., and Saier, M. H., Jr. (1995) FEBS Lett. 377, 98-102
8. Choi, K. Y., and Zalkin, H. (1992) J. Bacteriol. 174, 6207-6214
9. Schumacher, M. A., Choi, K. Y., Zalkin, H., and Brennan, R. G. ( 1994) Science 266, 763-770
10. Müller-Hill, B. (1983) Nature 302, 163-164
11. Bowie, J. V., Lüthy, R., and Eisenberg, D. (1991) Science 253, 164-170
12. Quiocho, F. A. (1991) Curr. Opin. Struct. Biol. 1, 922-933
13. Schumacher, M. A., Choi, K. Y., Zalkin, H., and Brennan, R. G. (1995) Cell 83, 147-155
14. Rolfes, R., and Zalkin, H. (1990) J. Bacteriol. 172, 5637-5642
15. Schumacher, M. A., Choi, K. Y., Zalkin, H., and Brennan, R. G. (1994) J. Mol. Biol. 242, 302-305
16. Xuong, N., Nielsen, C., Hamlin, R., and Andersen, D. (1985) J. Appl. Crystallogr. 18, 342-350
17. Tronrud, D. E., TenEyck, L. J., and Matthews, B. W. (1987) Acta Crystallogr. Sect. A 43, 498-501
18. Laskowski, R. A., MacArthur, M. W., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
19. Lavory, R., and Sklenar, H. (1990) J. Biomol. Struct. & Dyn. 6, 215-235
20. Glasfeld, A., Schumacher, M. A., Choi, K. Y., Zalkin, H., and Brennan, R. G. (1996) J. Am. Chem. Soc. 118, 13073-13074
21. Quiocho, F. A., Wilson, D. A., and Vyas, N. K. (1989) Nature 340, 404-407
22. Vyas, N. K., Vyas, M. N., and Quiocho, F. A. (1991) J. Biol. Chem. 266, 5226-5237
23. Yao, N., Trakhanov, S., and Quiocho, F. A. (1994) Biochemistry 33, 4769-4779
24. Tame, J. R. H., Sleigh, S. H., Wilkinson, A. J., and Ladbury, J. E. (1996) Nat. Struct. Biol. 3, 998-1001
25. Fujinaga, M., Sielecki, A. P., Read, R. J., Ardelt, W., Laskowski, M., and James, M. N. G. (1987) J. Mol. Biol. 195, 397-418
26. Otwinowski, Z., Schevitz, R. W., Zhang, R.-G., Lawson, C. L., Joachimiak, A., Marmorstein, R. Q., Luisi, B. F., and Sigler, P. B. (1988) Nature 334, 321-329
27. Joachimiak, A., Haran, T. E., and Sigler, P. B. (1994) EMBO J. 13, 367-372
28. Greasley, S. E., Jhoti, H., Teahan, C., Solan, R., Fensome, A., Thomas, G. M. H., Cockcroft, S., and Bax, B. (1995) Nat. Struct. Biol. 2, 797-806
29. Getzoff, E. D., Tainer, J. A., Weiner, P. K., Kollman, P. A., Richardson, J. S., and Richardson, D. C. (1983) Nature 306, 287-290
30. Klapper, I., Hagstrom, R., Fine, R., Sharp, K., and Honig, B. (1986) Proteins Struct. Funct. Genet. 1, 47-59
31. Schevitz, R. W., Otwinowski, Z., Joachimiak, A., Lawson, C. L., and Sigler, P. B. (1985) Nature 317, 782-786
32. Zhang, R.-G., Joachimiak, A., Lawson, C. L., Schevitz, R. W., Otwinowski, Z. O., and Sigler, P. B. (1987) Nature 327, 591-597
33. Lawson, C. L., and Carey J. (1993) Nature 366, 178-182
34. Rafferty, J. B., Somers, W. S., Saint-Girons, I., and Phillips, S. E. V. (1989) Nature 341, 705-710
35. Somers, W. S., and Phillips, S. E. V. (1992) Nature 359, 387-393
36. Phillips, K., and Phillips, S. E. V. (1994) Structure 2, 309-316
37. Spolar, K. S., and Record, M. T. (1994) Science 263, 777-784
38. Nagadoi, A., Morikawa, S., Nakamura, H., Enari, M., Kobagashi, K., Yamamoto, H., Sampei, G., Mizobuchi, K., Schumacher, M. A., Brennan, R. G., and Nishimura, Y. (1995) Structure 3, 1217-1224
39. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
40. Honig, B., and Nicholls, A. (1995) Science 268, 1144-1149