Treatment of homozygous protein C deficiency with subcutaneous protein C concentrate

British Journal of Haematology

Volumn 93, Issue 1, 1996, Pages 215-216

  Minford, A M B ^a   Parapia, L A ^a   Stainforth, C ^a   Lee, D ^a  

^a ST LUKE S HOSPITAL   (United Kingdom)

Author keywords

protein C deficiency; subcutaneous protein C concentrate

Indexed keywords

PROTEIN C; PROTEIN C CONCENTRATE; UNCLASSIFIED DRUG;

ARTICLE; CASE REPORT; FEMALE; HOMOZYGOTE; HUMAN; INFANT; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; SUBCUTANEOUS DRUG ADMINISTRATION;

FEMALE; HUMANS; INFANT, NEWBORN; INJECTIONS, SUBCUTANEOUS; PROTEIN C; PROTEIN C DEFICIENCY; THROMBOSIS;

EID: 0029968541     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.4691021.x     Document Type: Article

References (7)

1. Baliga, V., Thwaites, R., Tillyer, M.L., Minford, A., Parapia, L. & Allgrove, J. (1995) Homozygous protein C deficiency: management with protein C concentrate. European Journal of Paediatrics, 154, 534-538.
2. Branson, H.E., Katz, J., Marble, R. & Griffin, J.H. (1983) Inherited protein C deficiency and coumarin: responsive chronic relapsing purpura fulminans in a newborn infant. Lancet. ii. 1165-1168.
3. De Stefano, V., Mastrangelo, S., Schwarz, H.P., Pola, P., Flore, R., Bizzi, B. & Leone, G. (1993) Replacement therapy with a purified protein C concentrate during initiation of oral anticoagulation in severe protein C congenital deficiency. Thrombosis and Haemostasis, 70, 247-249.
4. Dreyfus, M., Magny, J.F., Britley, F., Schwarz, H.P., Planche, C., Dehan, M. & Tchernia, G. (1991) Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. New England Journal of Medicine, 325, 1565-1568.
5. Dreyfus, M., Masterson, M., David, M., Rivard, G.F., Muller, F-M., Kreuz, W., Beeg, T., Minford, A., Allgrove, J., Cohen, J.D., Christoph, J., Bergmann, F., Mitchell, V.E., Haworth, C., Nelson, K. & Schwartz, H.P. (1995) Replacement therapy with a monoclonal antibody purified protein C concentrate in newborns with severe congenital protein C deficiency. Seminars in Thrombosis and Haemostasis, 21, 571-581.
6. Marlar, R.A., Montgomery, R.R. & Broekmans. A.W. (1989) Diagnosis and treatment of homozygous protein C deficiency. Report of the working party on homozygous protein C deficiency of the subcommittee on protein C and protein S. international committee on thrombosis and haemostasis. Journal of Paediatrics, 114, 528-534.
7. Mitchell, L.G., Massicotte, M.P. & Andrew, M. (1995) A single subcutaneous (SQ) injection of protein C concentrate can maintain therapeutic levels for up to 77 hours. Thrombosis and Haemostasis, 73, 1294.