Delivery of oligoribonucleotides to human hepatoma cells using cationic lipid particles conjugated to ferric protoporphyrin IX (Heme)

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 3, 1997, Pages 177-185

  Takle, Garry B ^a   Thierry, Alain R ^b,c   Flynn, Sandra M ^a   Peng, Bo ^b   White, Lisa ^a   Devonish, Wayne ^a   Galbraith, Richard A ^d   Goldberg, Allan R ^a   George, Shaji T ^a  

^a Innovir Laboratories Inc   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c TRANSGENE S A   (France)

^d UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG VEHICLE; HEME; LIPID; LUCIFERASE; OLIGORIBONUCLEOTIDE; PHOSPHATIDYLETHANOLAMINE; PROTOPORPHYRIN; TRIMETHYLAMMONIUM SALT DERIVATIVE;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DRUG CONJUGATION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG TARGETING; DRUG UPTAKE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; PLASMID; PRIORITY JOURNAL; RECEPTOR BINDING;

EID: 0030860334     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.177     Document Type: Article

References (5)

1. AKHTAR, S. (1995). Delivery Strategies for Antisense Oligonucleotide Therapeutics. (CRC Press, Boca Raton, FL).
2. BEAVAN, G.H., CHEN, S.H., D'ALBIS, A., and GRATZER, W.B. (1974). A spectroscopic study of hemin-human serum albumin system. Eur. J. Biochem. 41, 539-546.
3. CANNON, J.B., KUO, F.S., PASTERNACK, R.F., WONG, N.M., and MULLER-EBERHARD, U. (1984). Kinetics of the interaction of hemin liposomes with heme binding proteins. Biochemistry 23, 3715-3721.
4. CAPLEN, N.J., GAO, X., HAYES, P., ELASWARAPU, R., FISHER, G., KINRADE, E., CHAKERA, A., SCHORR, J., HUGHES, B., DORIN, J.R., PORTEOUS, D.J., ALTON, E.W.F.W., GEDDES, D.M., COUTELLE, C., WILLIAMSON, R., HUANG, L., and GILCHRIST, C. (1994). Gene therapy for cystic fibrosis in humans by liposome-mediated DNA transfer: The production of resources and the regulatory process. Gene Therapy 1, 139-147.
5. ZHU, N., LIGGITT, D., LIU, Y., and DEBS, R. (1993). Systemic gene expression after intravenous DNA delivery into adult mice. Science 261, 209-211.