Chimeras containing influenza NS1 and HIV-1 rev protein sequences: Mechanism of their inhibition of nuclear export of Rev protein-RNA complexes

Virology

Volumn 241, Issue 2, 1998, Pages 234-250

  Chen, Zhongying ^a   Li, Yongzhong ^a   Krug, Robert M ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CHIMERIC PROTEIN; MUTANT PROTEIN; NUCLEOPORIN; REV PROTEIN; RNA BINDING PROTEIN; VIRUS RNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL STRAIN 3T3; CIS TRANS ISOMERISM; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLUENZA VIRUS A; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN RNA BINDING; RNA TRANSPORT;

ANIMALIA; DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN INFLUENZA VIRUS; INFLUENZA A VIRUS; INFLUENZA VIRUS; RNA VIRUSES;

EID: 0032519893     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8949     Document Type: Article

References (58)

1. Alonso-Caplen F. V., Nemeroff M. E., Qiu Y., Krug R. M. Nucleocytoplasmic transport: The influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA. Genes Dev. 6:1992;255-267.
2. Alzhanova-Ericsson A. T., Sun X., Visa N., Kiseleva E., Wurtz T., Daneholt B. A protein of the SR family of splicing factors binds extensively to exonic Balbiani ring pre-mRNA and accompanies the RNA from the gene to the nuclear pore. Genes Dev. 10:1996;2881-2893.
3. Bevec D., Dobrovnik M., Hauber J., Bohnlein E. Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator. Proc. Natl. Acad. Sci. USA. 89:1992;9870-9874.
4. Bevec D., Jaksche H., Oft M., Wohl T., Himmerlspach M., Pacher A., Schebesta A., Koettnitz K., Dobrovnik M., Csonga R., Lottspeich F., Hauber J. Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5a. Science. 271:1996;1858-1860.
5. Bogerd H., Greene W. C. Dominant negative mutants of human T-cell leukemia virus type 1 Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo. J. Virol. 67:1993;2496-2502.
6. Bogerd H. P., Fridell R. A., Madore S., Cullen B. R. Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell. 82:1995;485-494.
7. Borer R. A., Lehner C. F., Eppenberger H. M., Nigg E. A. Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell. 56:1989;379-390.
8. Bridges S. H., Sarver N. Gene therapy and immune restoration for HIV disease. Lancet. 345:1995;427-432.
9. Chien C., Tejero R., Huang Y., Zimmerman D. E., Rios C. B., Krug R. M., Montelione G. T. A novel RNA-binding motif in influenza A virus non-structural protein 1. Nature Struct. Biol. 4:1997;890-895.
10. Cole J. L., Gehman J. D., Shafer J. A., Kuo L. C. Solution oligomerization of the Rev protein of HIV-1: Implications for function. Biochemistry. 32:1993;11769-11775.
11. Cullen B. R. Regulation of HIV gene expression. AIDS. 9:1995;S19-S32.
12. Daly T. J., Cook K. S., Gray G. S., Malone T. E., Rusche J. R. Specific binding of the HIV-1 recombinant Rev protein to the Rev-responsive element in vitro. Nature. 342:1989;816-819.
13. Emerman M., Vazeux R., Peden K. The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization. Cell. 57:1989;1155-1165.
14. Felber B. K., Hadzopoulou-Cladaras M., Cladaras C., Copeland T., Pavlakis G. N. Rev protein of human immunodeficiency virus type 1 affects the stability and transport of viral mRNA. Proc. Natl. Acad. Sci. USA. 86:1989;1495-1499.
15. Fields S., Song O.-K. A novel genetic system to detect protein-protein interactions. Nature. 340:1989;245-246.
16. Fischer U., Huber J., Boeiens W. C., Mattaj I. W., Luhrmann R. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell. 82:1995;475-483.
17. Fischer U., Michael W. M., Luhrmann R., Dreyfuss G. Signal-mediated nuclear export pathways of proteins and RNAs. Trends Cell Biol. 6:1996;290-293.
18. Fornerod M., Ohno M., Yoshida M., Mattaj I. W. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell. 90:1997;1051-1060.
19. Fortes P., Beloso A., Ortin J. Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J. 13:1994;704-712.
20. Fritz C. C., Zapp M. L., Green M. R. A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature. 376:1995;530-533.
21. Gerace L. Nuclear export signals and the fast track to the cytoplasm. Cell. 82:1995;341-344.
22. Gorlich D., Mattaj I. W. Nucleocytoplasmic transport. Science. 271:1996;1513-1518.
23. Guiochon-Mantel A., Delabre K., Lescop P., Milgrom E. Nuclear localization signals also mediate the outward movement of proteins from the nucleus. Proc. Natl. Acad. Sci. USA. 91:1994;7179-7183.
24. Hammarskjold M. L., Heimer J., Hammarskjold B., Sangwan I., Albert L., Rekosh D. Regulation of human immunodeficiency virus env expression by therev. J. Virol. 63:1989;1959-1966.
25. Hope T. J., Klein N. P., Elder M. E., Parslow T. G. Trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes. J. Virol. 66:1992;1849-1855.
26. Izaurralde E., Mattaj I. W. RNA export. Cell. 81:1995;153-159.
27. Kalland K.-H., Szilvay A. M., Brokstad K. A., Saetrevik W., Haukenes G. The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments. Mol. Cell. Biol. 14:1994;7436-7444.
28. Liu J., Lynch P. A., Chien C.-Y., Montelione G. T., Krug R. M., Berman H. M. Crystal structure of the unique multifunctional RNA-binding domain of the influenza virus NS1 protein. Nature Struct. Biol. 4:1997;896-899.
29. Lu Y., Qian X.-Y., Krug R. M. The influenza virus NS1 protein: A novel inhibitor of pre-mRNA splicing. Genes Dev. 8:1994;1817-1828.
30. Madore S. J., Tiley L. S., Malim M. H., Cullen B. R. Sequence requirements for rev multimerization in vivo. Virology. 202:1994;186-194.
31. Malim M. H., Hauber J., Lee S.-Y., Maizel J. V., Cullen B. R. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature. 338:1989a;254-257.
32. Malim M. H., Bohnlein S., Hauber J., Cullen B. R. Functional dissection of the HIV-1 Rev trans-activator-derivation of a trans-dominant repressor of Rev function. Cell. 58:1989b;205-214.
33. Malim M. H., Cullen B. R. HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latency. Cell. 65:1991;241-248.
34. Malim M. H., McCarn D. F., Tiley L. S., Cullen B. R. Mutational definition of the human immunodeficiency virus type 1 Rev activation domain. J. Virol. 65:1991;4248-4254.
35. Malim M. H., Freimuth W. W., Liu J., T. J. B., Lyerly H. K., Cullen B. R., Nabel G. J. Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. J. Exp. Med. 176:1992;1197-1201.
36. Mermer B., Felber B. K., Campbell M., Pavlakis G. N. Identification oftrans. Nucleic Acids Res. 18:1990;2937-2044.
37. Meyer B., Malim M. H. The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev. 8:1994;1538-1547.
38. Meyer B. E., Meinkoth J. L., Malim M. H. Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: Identification of a family of transferable nuclear export signals. J. Virol. 70:1996;2350-2359.
39. Miller J. H. Experiments in Molecular Genetics. 1972;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
40. Nemeroff M. E., Qian X., Krug R. M. The influenza virus NS1 protein forms multimersin vitroin vivo. Virology. 212:1995;422-428.
41. Olsen H. S., Cochrane A. W., Dillon P. J., Nalin C. M., Rosen C. A. Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids. Genes Dev. 4:1990;1357-1364.
42. Ossareh-Nazari B., Bachelerie F., Dargemont C. Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science. 278:1997;141-143.
43. Pinol-Roma S., Dreyfuss G. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature. 355:1992;730-732.
44. Qian X., Chien C., Lu Y., Montelione G. T., Krug R. M. An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA binding activity and largely helical backbone structure. RNA. 1:1995;948-956.
45. Qian X. Y., Chen Z. Y., Zhang J., Rabson A. B., Krug R. M. New approach for inhibiting Rev function and HIV-1 production using the influenza virus NS1 protein. Proc. Natl. Acad. Sci. USA. 93:1996;8873-8877.
46. Qian X. Y., Alonso-Caplen F., Krug R. M. Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA. J. Virol. 68:1994;2433-2441.
47. Qiu Y., Krug R. M. The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A). J. Virol. 68:1994;2425-2432.
48. Qiu Y., Nemeroff M., Krug R. M. The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing. RNA. 1:1995;304-316.
49. Rexach M., Blobel G. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell. 83:1995;683-692.
50. Richard N., Iacampo S., Cochrane A. HIV-1 Rev is capable of shuttling between the nucleus and cytoplasm. Virology. 204:1994;123-131.
51. Ruhl M., Himmelspach M., Bahr G. M., Hammerschmid F., Jaksche H., Wolff B., Aschauer H., Farrington G. K., Probst H., Bevec D., Hauber J. Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation. J. Cell Biol. 123:1993;1309-1320.
52. Stade K., Ford C. S., Guthrie C., Weis K. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell. 90:1997;1041-1050.
53. Stauber R., Gaitanaris G. A., Pavlakis G. N. Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: Transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm. Virology. 213:1995;439-449.
54. Stutz F., Izaurralde E., Mattaj I. W., Rosbash M. A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Mol. Cell Biol. 16:1996;7144-7150.
55. Stutz F., Neville M., Rosbash M. Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 rev protein in yeast. Cell. 82:1995;495-506.
56. Venkatesh L. K., Chinnadurai G. Mutants in a conserved region near the carboxy terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype. Virology. 178:1990;327-330.
57. Wen W., Meinkoth J. L., Tsien R. Y., Taylor S. S. Identification of a signal for rapid export of proteins from the nucleus. Cell. 82:1995;463-473.
58. Zapp M. L., Green M. R. Sequence-specific RNA binding by the HIV-1 Rev protein. Nature. 342:1989;714-716.