A recombinant minigene vaccine containing a nonameric cytotoxic-T-lymphocyte epitope confers limited protection against listeria monocytogenes infection

Infection and Immunity

Volumn 64, Issue 5, 1996, Pages 1685-1693

  An, Ling Ling ^a   Pamer, Eric ^b   Lindsay Whitton, J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LISTERIOLYSIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; IMMUNIZATION; INFECTION PREVENTION; LISTERIA MONOCYTOGENES; LISTERIOSIS; MALE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINIA VIRUS; VIRUS RECOMBINANT;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; BASE SEQUENCE; COLONY COUNT, MICROBIAL; DNA PRIMERS; DNA, BACTERIAL; EPITOPES; FEMALE; GENES, BACTERIAL; HUMANS; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; LIVER; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS; VACCINES, SYNTHETIC; VACCINIA VIRUS;

EID: 0029936490     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.5.1685-1693.1996     Document Type: Article

References (46)

1. Bancroft, G. J., R. D. Schreiber, and E. R. Unanue. 1991. Natural immunity: a T-cell-independent pathway of macrophage activation, defined in the scid mouse. Immunol Rev 124:5-24.
2. Berche, P., J. L. Gaillard, C. Geoffroy, and J. E. Alouf. 1987. T cell recognition of listeriolysin O is induced during infection with Listeria monocytogenes. J. Immunol. 139:3813-3821
3. Berche, P., J. L. Gaillard, and P. J. Sansonetti. 1987. Intracellular growth of Listeria monocytogenes as a prerequisite for in vivo induction of T cell-mediated immunity. J. Immunol 138:2266-2271
4. Bouwer, H. G., B. L. Gibbins, S. Jones, and D. J. Hinrichs. 1994. Antilisterial immunity includes specificity to listeriolysin O (LLO) and non-LLO-derived determinants. Infect Immun. 62:1039-1045
5. Bouwer, H. G., C. S. Nelson, B. L. Gibbins, D. A. Portnoy, and D. J. Hinrichs. 1992 Listeriolysin O is a target of the immune response to Listeria monocytogenes. J. Exp. Med. 175:1467-1471
6. Chakrabarti, S., K. Brechling, and B. Moss. 1985 Vaccinia virus expression vector, coexpression of β-galactosidase provides visual screening of recombinant virus plaques. Mol. Cell Biol. 5:3403-3409.
7. Chakraborty, T., F. Ebel, J. Wehland, J. Dufrenne, and S. Notermans. 1994. Naturally occurring virulence-attenuated isolates of Listeria monocytogenes capable of inducing long term protection against infection by virulent strains of homologous and heterologous serotypes. FEMS Immunol. Med. Microbiol. 10:1-9.
8. Conlan, J. W., and R. J. North. 1991 Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium. J. Exp. Med. 174:741-744.
9. - cytolytic T lymphocytes from mice infected with the intracellular bacterium Listeria monocytogenes J. Immunol. 137:2688-2694
10. Farber, J. M., and P. I. Peterkin. 1991. Listeria monocytogenes, a food-borne pathogen. Microbiol. Rev 55:476-511.
11. Ferrick, D. A., M. D. Schrenzel, T. Mulvania, B. Hsieh, W. G. Ferlin, and H. Lepper. 1995, Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature (London) 373:255-257
12. Fluit, A. C., R. Torensma, M. J. Visser, C. J. Aarsman, M. J. Poppelier, B. H. Keller, P. Klapwijk, and J. Verhoef. 1993 Detection of Listeria monocytogenes in cheese with the magnetic immuno-polymerase chain reaction assay. Appl Environ Microbiol 59:1289-1293
13. Gaillard, J. L., P. Berche, J. Mounier, S. Richard, and P. J. Sansonetti. 1987. In vitro model of penetration and intracellular growth of Listeria monocytogenes in the human enterocyte-like cell line Caco-2. Infect. Immun. 55: 2822-2829
14. Gaillard, J. L., P. Berche, and P. J. Sansonetti. 1986. Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of Listeria monocytogenes. Infect. Immun. 52:50-55.
15. + T cell subset: a study with Listeria-specific T lymphocytes recovered from murine infected liver. Int. Immunol. 4:591-598.
16. + T lymphocytes by an attenuated Listeria monocytogenes actA mutant. Int. Immunol. 4:1413-1418.
17. + T cells in vivo - a study with the nuclcoprotein of the lymphocytic choriomeningitis virus. Int. Immunol. 7:797-805.
18. + T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo. J. Exp. Med. 175:1531-1538.
19. Harty, J. T., and E. G. Pamer. 1995. CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection J. Immunol. 154:4642-4650.
20. Harty, J. T., R. D. Schreiber, and M. J. Bevan. 1992. CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion. Proc. Natl. Acad. Sci. USA 89:11612-11616
21. + T lymphocytes in coxsackievirus B3-induced myocarditis. J. Virol. 69: 6720-6728
22. + T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur. J. Immunol. 24:3068-3072
23. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature (London) 369:31-37.
24. Kaufmann, S. H. 1993. Immunity to intracellular bacteria. Annu. Rev Immunol. 11:129-163.
25. Klavinskis, L. S., J. L. Whitton, E. Joly, and M. B. A. Oldstone. 1990. Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope Virology 178:393-400.
26. Klavinskis, L. S., J. L. Whitton, and M. B. A. Oldstone. 1989 Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection. J. Virol. 63:4311-4316.
27. Lane, F. C., and E. R. Unanue. 1972. Requirement of thymus (T) lymphocytes for resistance to listeriosis J. Exp. Med. 135:1104-1112
28. + cytolytic T cells and confers protection to infection. Immunol Lett 40:101-104.
29. + T cell-mediated protection against listeriosis. Protection correlates with phagocyte depletion but not with IFN-gamma production. J. Immunol. 142:2879-2886.
30. Mackaness, G. B., and W. C. Hill. 1969. The effect of anti-lymphocyte globulin on cell-mediated resistance to infection. J. Exp. Med. 129:993-1012.
31. Mengaud, J., M. F. Vicente, J. Chenevert, J. M. Pereira, C. Geoffroy, B. Gicquel-Sanzey, F. Baquero, J. C. Perez-Diaz, and P. Cossart. 1988. Expression in Escherichia coli and sequence analysis of the listenolysin O determinant of Listeria monocytogenes. Infect. Immun 56:766-772.
32. Oldstone, M. B. A., J. L. Whitton, H. Lewicki, and A. Tishon. 1988. Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes J. Exp. Med. 168:559-570.
33. Pamer, E. G. 1994. Direct sequence identification and kinetic analysis of an MHC class I-restnctcd Listeria monocytogenes CTL epitope. J Immunol 152:686-694.
34. Pamer, E. G., J. T. Harty, and M. J. Bevan. 1991. Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature (London) 353:852-855.
35. + T cells in adoptive immunity to Listeria monocytogenes in the liver. Immunology 82: 249-254.
36. Reed, L. J., and H. A. Muench. 1938. A simple method of estimating fifty percent end points. Am. J. Hyg 27:493
37. Schafer, R., D. A. Portnoy, S. A. Brassell, and Y. Paterson. 1992. Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine. J Immunol. 149:53-59.
38. Shen, H., M. K. Slifka, M. Matloubian, E. R. Jensen, R. Ahmed, and J. F. Miller. 1995. Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity Proc Natl. Acad. Sci. USA 92:3987-3991
39. Sheng, N., J. Zhang, T. A. McKee, and J. L. Whitton. 1993. A rapid and simple method for determining the DNA sequences of fragments inserted into recombinant vaccinia viruses. Biotechniques 14:781-784
40. Verma, N. K., H. K. Ziegler, M. Wilson, M. Khan, S. Safley, B. A. Stocker, and G. K. Schoolnik. 1995. Delivery of class I and class II MHC-restricted T-cell epitopes of listeriolysin of Listeria monocytogenes by attenuated Salmonella. Vaccine 13:142-150.
41. Weidt, G., W. Deppert, O. Utermohlen, J. Heukeshoven, and F. Lehmaan-Grube. 1995 Emergence of virus escape mutants after immunization with epitope vaccine. J. Virol. 69:7147-7151.
42. Whitton, J. L. 1994. Induction of protective immunity using minigenes Ann. N. Y. Acad. Sci. 730:107-117.
43. 42a.Whitton, J. L. Unpublished data.
44. Whitton, J. L., N. Sheng, M. B. A. Oldstone, and T. A. McKee. 1993 A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge. J. Virol. 67:348-352.
45. Whitton, J. L., P. J. Southern, and M. B. A. Oldstone. 1988 Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus. Virology 162:321-327.
46. Whitton, J. L., A. Tishon, H. Lewicki, J. R. Gebhard, T. Cook, M. S. Salvato, E. Joly, and M. B. A. Oldstone. 1989. Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity. J. Virol. 63:4303-4310.