Racial differences in the distribution of a low density lipoprotein receptor-related protein (LRP) polymorphism and its association with serum lipoprotein, lipid and apolipoprotein levels

Atherosclerosis

Volumn 137, Issue 1, 1998, Pages 187-195

  Harris, Meagan R ^a   Bunker, Clareann H ^a   Hamman, Richard F ^b   Sanghera, Dharambir K ^a   Aston, Christopher E ^a   Kamboh, M Ilyas ^a  

^a GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Apolipoproteins; Blacks; Hispanics; Lipoprotein lipids; LRP; Non Hispanic whites; Polymorphism

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN B; LIPOPROTEIN A; LIPOPROTEIN RECEPTOR;

ADULT; ARTICLE; CAUCASIAN; DNA POLYMORPHISM; ETHNIC GROUP; FEMALE; GENE FREQUENCY; HUMAN; HUMAN EXPERIMENT; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; MALE; NEGRO; NORMAL HUMAN; PRIORITY JOURNAL; RACE DIFFERENCE;

AFRICAN CONTINENTAL ANCESTRY GROUP; AGE FACTORS; ALLELES; APOLIPOPROTEINS; BODY MASS INDEX; DATA INTERPRETATION, STATISTICAL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HISPANIC AMERICANS; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; LIPIDS; LIPOPROTEINS; MALE; MENOPAUSE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LDL; SEX FACTORS;

EID: 0032478227     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(97)00230-X     Document Type: Article

References (25)

1. Strickland D.K., Kounnas M.Z., Argraves W.S. LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism. FASEB J. 9:1995;890-898.
2. Strickland D.K., Ashcom J.D., Williams S., Burgess W.H., Miglioni M., Argraves W.S. Sequence identity between the α2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem. 265:1990;17401-17404.
3. Nykaer A., Petersen C.M., Moller B., Jensen P.H., Moestrup S.K., Holte T.L., Etzerodt M., Thogersen H.C., Munch M., Andreasen P.A., Gliemann J. Purified α2 -macroglobulin receptor/LDL receptor-related protein binds urokinase-plasminogen activator inhibitor type-1 complexes. Evidence that the α2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J Biol Chem. 267:1992;14543-14546.
4. Brown M.S., Herz J., Kowal R.C., Goldstein J.L. The low-density lipoprotein receptor-related protein: double agent or decoy? Curr Opin Lipidol. 2:1991;65-72.
5. Herz J. The LDL-receptor-related protein-portrait of a multifunctional receptor. Curr Opin Lipidol. 4:1993;107-113.
6. Herz J., Hamann U., Rogne S., Myklebost O., Gausephohl H., Stanley K.K. Surface location and high affinity for calcium of a 500-kD liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 7:1988;4119-4127.
7. Myklebost O., Arheden K., Rogne S., Van Kessel A.G., Mandahl N., Herz J., Stanley K., Heim S., Mitelman F. The gene for the human putative apo E receptor is on chromosome 12 in the segment q13-14. Genomics. 5:1989;65-69.
8. Van Leuven F., Stas L., Hilliker C., Lorent K., Umans L., Serneels L., Overbergh L., Torrekens S., Moechars D., De Strooper B., Van Den Berge H. Structure of the gene (LRP1) coding for the human α2-macroglobulin receptor lipoprotein receptor-related protein. Genomics. 24:1994;78-89.
9. Herz J., Kowal R.C., Goldstein J.L., Brown M.S. Proteolytic processing of the 600 kD low density lipoprotein receptor related protein (LRP) occurs in a trans-golgi compartment. EMBO J. 9:1990;1769-1776.
10. Brown M.S., Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science. 232:1986;34-37.
11. Zuliani G., Hobbs H.H. Tetranucleotide length polymorphism 5′ of the α2-macroglobulin receptor (α2MR)/LDL receptor-related protein (LRP) gene. Hum Mol Genet. 3:1994;205.
12. Hamman R.F., Marshall J.A., Baxter J., Kahn LR, Mayer EJ, Orleans M, Murphy JR, Lezotte DC Methods and prevalence of non-insulin dependent diabetes mellitus in a biethnic Colorado population. The San Luis Valley Diabetes Study. Am J Epidemiol. 129:1989;295-311.
13. Rewers M., Shetterly S.M., Hoag S., Baxter J., Marshall J., Hamman R.F. Is the risk of coronary heart disease lower in Hispanics than in non-Hispanic whites? The San Luis Valley Diabetes Study. Ethnicity Dis. 3:1993;44-54.
14. Bunker C.H., Ukoli F.A., Okoro F.I., Olumu A.B., Kriska A.M., Huston S.L., Markovic N., Kuller L.H. Correlates of serum lipids in a lean black population. Atherosclerosis. 123:1996;215-225.
15. Richmond W. Preparation and properties of a cholesterol oxidase from Nocardia wp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem. 19:1973;1350-1356.
16. Warnick G.R., Benderson J.M., Albers J.J. Quantitation of high density lipoprotein subclasses after separation by dextran sulfate and magnesium precipitation. Clin Chem. 28:1982;1574.
17. Stavropolous W.S., Crouch R.D. A new colorimetric procedure for the determination of serum triglycerides. Clin Chem. 20:1974;957.
18. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 18:1972;499-503.
19. Kanji GK. 100 Statistical Tests. London: SAGE Publications, 1993.
20. Shapiro S.S., Wilk M.B. An analysis of variance test for normality (complete samples). Biometrika. 52:1965;591-611.
21. Boerwinkle E., Chakraborty R., Sing C.F. The use of measured genotype information in the analysis of quantitative phenotypes in man I. Models and analytical methods. Ann Hum Genet. 50:1986;181-194.
22. Boerwinkle E., Sing C.F. Bias of the contribution of single-locus effects to the variance of a quantitative trait. Am J Hum Genet. 39:1986;137-144.
23. Boerwinkle E., Sing C.F. The use of measured genotype information in the analysis of quantitative phenotypes in man III. Simultaneous estimation of the frequencies and effects of the apolipoprotein E polymorphism and residual polygenic effect on cholesterol, betalipoprotein and triglyceride levels. Ann Hum Genet. 51:1987;211-226.
24. Harris M., Sanghera D.K., Kamboh M.I. Two new alleles in the tetranucleotide repeat polymorphism in the LDL-receptor related protein (LRP) gene. Clin Genet. 50:1996;54-55.
25. Beisiegel U., Krapp A., Weber W., Olivecrona G. The role of α2M receptor/LRP in chylomicron remnant metabolism. Ann NY Acad Sci. 737:1994;53-69.