Ethanol selectively interferes with the trophic action of NMDA and carbachol on cultured cerebellar granule neurons undergoing apoptosis

Developmental Brain Research

Volumn 111, Issue 2, 1998, Pages 279-289

  Castoldi, Anna F ^a,b   Barni, Sergio ^a   Randine, Giovanna ^a,b   Costa, Lucio G ^c   Manzo, Luigi ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b IRCCS   (Italy)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Apoptosis; Carbachol; Cerebellar granule cells; Ethanol; GABA; NMDA

Indexed keywords

4 AMINOBUTYRIC ACID; ALCOHOL; CARBACHOL; FORSKOLIN; N METHYL DEXTRO ASPARTIC ACID; POTASSIUM ION;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GRANULE CELL; NEUROPROTECTION; NEUROTOXICITY; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CARBACHOL; CELL SURVIVAL; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBELLUM; DRUG INTERACTIONS; ETHANOL; EXCITATORY AMINO ACID AGONISTS; FORSKOLIN; GAMMA-AMINOBUTYRIC ACID; MICROSCOPY, ELECTRON; MUSCARINIC AGONISTS; N-METHYLASPARTATE; NEURONS; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0032495008     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(98)00135-7     Document Type: Article

References (57)

1. 3 muscarinic receptor subtypes on cerebellar granule cells in primary culture J. Neurochem. 55:1990;334-337.
2. Ankarkrona M., Dypbukt J.M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S.A., Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15:1995;961-973.
3. Balazs R., Jørgensen O.S., Hack N. N-methyl-D-aspartate promotes the survival of cerebellar granule cells in culture. Neuroscience. 27:1988;437-451.
4. Balduini W., Costa L.G. Effects of ethanol on muscarinic receptor-stimulated phosphoinositide metabolism during brain development. J. Pharmacol. Exp. Ther. 250:1989;541-547.
5. Balduini W., Costa L.G. Developmental neurotoxicity of ethanol: in vitro inhibition of muscarinic receptor-stimulated phosphoinositide metabolism in brain from neonatal but not adult rats. Brain Res. 512:1990;248-252.
6. Balduini W., Candura S.M., Manzo L., Cattabeni F., Costa L.G. Time-, concentration- and age-dependent inhibition of muscarinic receptor-stimulated phosphoinositide metabolism by ethanol in the developing rat brain. Neurochem. Res. 16:1991;1235-1240.
7. Balduini W., Reno F., Costa L.G., Cattabeni F. Developmental neurotoxicity of ethanol: further evidence for an involvement of muscarinic receptor-stimulated phosphoinositide hydrolysis. Eur. J. Pharmacol. Mol. Pharmacol. 266:1994;283-289.
8. Bhave S.V., Hoffman P.L. Ethanol promotes apoptosis in cerebellar granule cells by inhibiting the trophic effect of NMDA. J. Neurochem. 68:1997;578-586.
9. Bhave S.V., Snell L.D., Tabakoff B., Hoffman P.L. Mechanisms of ethanol inhibition of NMDA receptor function in primary cultures of cerebral cortical cells. Alcohol. Clin. Exp. Res. 20:1996;934-941.
10. 2+ flux in cultured neurons following chronic EtOH exposure. Neurosci. Lett. 200:1995;214-218.
11. A receptor function and expression, and their relevance to behavior. Alcohol. Clin. Exp. Res. 20:1996;198A-202A.
12. Cavallaro S., Copani A., D'Agata V., Musco S., Petralia S., Ventra C., Stivala F., Travali S., Canonico P.L. Pituitary adenylate cyclase activating polypeptide prevents apoptosis in cultured cerebellar granule neurons. Mol. Pharmacol. 50:1996;60-66.
13. Chandler L.J., Newson H., Sumners C., Crews F. Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortex neurons. J. Neurochem. 60:1993;1578-1581.
14. Chang J.Y., Korolev V.V., Wang J.-Z. Cyclic AMP and pituitary adenylate cyclase-activating polypeptide (PACAP) prevent programmed cell death of cultured rat cerebellar granule cells. Neurosci. Lett. 206:1996;181-184.
15. Copani A., Bruno V.M., Barresi V., Battaglia G., Condorelli D.F., Nicoletti F. Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture. J. Neurochem. 64:1995;101-108.
16. Crews F.T., Morrow A.L., Criswell H., Breese G. Effects of ethanol on ion channels. Int. Rev. Neurobiol. 39:1996;283-367.
17. Cui S.-J., Tewari M., Schneider T., Rubin R. Ethanol promotes cell death by inhibition of the insulin-like growth factor I receptor. Alcohol. Clin. Exp. Res. 21:1997;1121-1127.
18. Du Y., Dodel R.C., Bales K.R., Jemmerson R., Hamilton-Byrd E., Paul S.M. Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons. J. Neurochem. 69:1997;1382-1388.
19. D'Mello S.R., Galli C., Ciotti T., Calissano P. Induction of apoptosis in cerebellar granule cells neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA. 90:1993;10989-10993.
20. Freund G. Apoptosis and gene expression: perspectives on alcohol-induced brain damage. Alcohol. 11:1994;385-387.
21. Fukamauchi F., Saunders P.L., Hough C., Chuang D.-M. Agonist-induced down regulation and antagonist-induced up-regulation of m2 and m3 muscarinic acetylcholine receptor mRNA and protein in cultured cerebellar granule cells. Mol. Pharmacol. 44:1993;940-949.
22. Galli C., Meucci O., Scorziello A., Werge T.M., Calissano P., Schettini G. Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-I through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J. Neurosci. 15:1995;1172-1179.
23. Gallo V., Kingsbury A., Balasz R., Jørgensen O.S. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7:1987;2203-2213.
24. Goodlett C.R., Marcussen B.L., West J.R. A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss. Alcohol. 7:1990;107-114.
25. Gordon A.S. Ethanol-induced translocation of the catalytic subunit of the protein kinase A. Alcohol. Clin. Exp. Res. 20:1996;160A.
26. Gruol D.L., Parsons K.L. Chronic alcohol reduces calcium signaling elicited by glutamate receptor stimulation in developing cerebellar neurons. Brain Res. 728:1996;166-174.
27. Guizzetti M., Costa L.G. Inhibition of muscarinic receptor-stimulated glial cell proliferation by ethanol. J. Neurochem. 67:1996;2236-2245.
28. Hoffman P.L., Bhave S.V., Kumar K.N., Iorio K.R., Snell L.D., Tabakoff B., Michaelis E.K. The 71 kDa glutamate-binding protein is increased in cerebellar granule cells after chronic ethanol treatment. Mol. Brain Res. 39:1996;167-176.
29. Iorio K.R., Reinlib L., Tabakoff B., Hoffmann P.L. Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function. Mol. Pharmacol. 41:1992;1142-1148.
30. M. Ito, Granule cells, in: M. Ito (Ed.), The Cerebellum and Neural Control, Raven Press, New York, 1984, pp. 74-85.
31. M. Ito, Mossy Fiber System, in: M. Ito (Ed.), The Cerebellum and Neural Control, Raven Press, New York, 1984, pp. 235-255.
32. Johnson E.M., Deckwerth T.L. Molecular mechanisms of developmental neuronal death. Annu. Rev. Neurosci. 16:1993;31-46.
33. Kharlamov E., Cagnoli C.M., Atabay C., Ikonomovic S., Grayson D.R., Manev H. Opposite effects of protein synthesis inhibitors on potassium deficiency-induced apoptotic cell death in immature and mature neuronal cultures. J. Neurochem. 65:1995;1395-1398.
34. Kovacs K.A., Kavanagh T.J., Costa L.G. Ethanol inhibits muscarinic receptor-stimulated phosphoinositide metabolism and calcium mobilization in rat primary cortical cultures. Neurochem. Res. 20:1995;939-949.
35. Kubo T., Nonomura T., Enokido Y., Hatanaka H. Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule cells in culture. Dev. Brain Res. 85:1995;249-258.
36. Lin T.-A., Navidi M., James W., Lin T.-N., Sun G.Y. Effects of acute ethanol administration on polyphosphoinositide turnover and levels of inositol 1,4,5-trisphosphate in mouse cerebrum and cerebellum. Alcohol. Clin. Exp. Res. 17:1993;401-405.
37. Masood K., Wu C., Brauneis U., Weight F.F. Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol. Pharmacol. 45:1994;324-329.
38. Miller T.M., Johnson E.M. Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells. J. Neurosci. 16:1996;7487-7495.
39. A receptor a1 and a2 subunit mRNA levels in rat cerebellum. J. Mol. Cell. Neurosci. 3:1992;251-258.
40. Mosmann T.R. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 65:1983;55-63.
41. Mount H.T.J., Dreyfus C.F., Black I.B. Muscarinic stimulation promotes cultured Purkinje cell survival: a role for acetylcholine in cerebellar development? J. Neurochem. 63:1994;2065-2073.
42. Okamoto K., Sekiguchi M. Synaptic receptors and intracellular signal transduction in the cerebellum. Neurosci. Res. 9:1991;213-237.
43. 3H -cytisine binding to nicotinic cholinergic receptors in brain Mol. Pharmacol. 39:1991;9-12.
44. Pantazis N.J., Dohrman D.P., Goodlett C.R., Cook R.T., West J.R. Vulnerability of cerebellar granule cells to alcohol-induced cell death diminishes with time in culture. Alcohol. Clin. Exp. Res. 17:1993;1014-1021.
45. Pierce D.R., Goodlett C.R., West J.R. Differential neuronal loss following postnatal alcohol exposure. Teratology. 40:1989;113-126.
46. 2+ signals, triggers apoptosis and potentiates NMDA toxicity in cerebellar granule neurons. Cell Death Diff. 4:1997;317-324.
47. Schulz J.B., Weller M., Klockgether T. Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity and reactive oxygen species. J. Neurosci. 16:1996;4696-4706.
48. Slater S.J., Cow K.J., Lombardi J.V., Ho C., Kelly M.B., Rubin E., Stubbs C.D. Inhibition of protein kinase C by alcohols and anaesthetics. Nature. 364:1993;82-84.
49. Urso T., Gavaleret T.J., Van Thiel D.H. Blood ethanol levels in sober alcohol users seen in an emergency room. Life Sci. 28:1981;1053-1056.
50. 2 subunits. FEBS Lett. 313:1992;113-117.
51. Wakade A.R., Bhave S.V., Malhotra K., Wakade T.D. Forskolin mediates the survival of nerve growth factor-dependent sympathetic neurons of chick embryo by a cyclic AMP-independent mechanism. J. Neurochem. 54:1990;1281-1287.
52. Walker D.W., Heaton M.B., Lee N., King M.A., Hunter B.E. Effect of chronic ethanol on the septohippocampal system: a role for neurotrophic factors? Alcohol. Clin. Exp. Res. 17:1993;12-18.
53. Wegelius K., Korpi E.R. Ethanol inhibits NMDA-induced toxicity and trophism in cultured cerebellar granule cells. Acta Physiol. Scand. 154:1995;25-34.
54. West J.R., Goodlett C.R. Teratogenic effects of alcohol on brain development. Ann. Med. 22:1990;319-325.
55. Wetts R., Herrup K. Direct correlation between Purkinje and granule cell number in the cerebella of lurcher chimeras and wild-type mice. Dev. Brain Res. 10:1983;41-47.
56. Williams R.W., Herrup K. The control of neuron number. Annu. Rev. Neurosci. 11:1988;423-453.
57. Yan G.-M., Lin S.-Z., Irwin R.P., Paul S.M. Activation of muscarinic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol. Pharmacol. 47:1995;248-257.