Mechanism of ethanol inhibition of NMDA receptor function in primary cultures of cerebral cortical cells

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 5, 1996, Pages 934-941

  Bhave, Sanjiv V ^a   Snell, Lawrence D ^a   Tabakoff, Boris ^a   Hoffman, Paula L ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Cerebral Cortical Cells; Ethanol; Glycine; Intracellular Ca2+; NMDA Receptor

Indexed keywords

ALCOHOL; GLUTAMATE RECEPTOR; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE C;

ALCOHOLISM; ANIMAL CELL; ARTICLE; BRAIN CORTEX; CALCIUM CELL LEVEL; CEREBELLUM; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0029787119     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb05274.x     Document Type: Article

References (47)

1. Collingridge GL, Lester RAJ: Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 40:143-210, 1989
2. Kleckner NW, Dingledine R: Requirement for glycine in activation of NMDA receptors expressed in Xenopus oocytes. Science 241:835-837, 1988
3. Hoffman PL: Effects of alcohol on excitatory amino acid receptor function, in Kranzler H (ed): Handbook of Experimental Pharmacology, vol 114. The Pharmacology of Alcohol Abuse. Heidelberg, Springer, 1995, pp 75-102
4. Rabe CS, Tabakoff B: Glycine site directed agonists reverse ethanol's actions at the NMDA receptor. Mol Pharmacol 38:753-757, 1990
5. Snell LD, Tabakoff B, Hoffman PL: Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells. Alcohol Clin Exp Res 18:81-85, 1994
6. Snell LD, Iorio KR, Tabakoff B, Hoffman PL: Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells. J Neurochem 62:1783-1789, 1994
7. 3H]-norepinephrine release from rat cortical slices. J Pharmacol Exp Ther 252:1138-1144, 1990
8. Woodward JJ: A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices. J Neurochem 62:987-991, 1994
9. Peoples RW, Weight FF: Ethanol inhibition of N-methyl-D-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine. Brain Res 571:342-344, 1992
10. Markram H, Segal M: Activation of protein kinase C suppresses responses to NMDA in rat CA1 hippocampal neurones. J Physiol 457:491-501, 1992
11. Courtney MJ, Nicholls DG: Interactions between phospholipase C-coupled and N-methyl-D-aspartate receptors in cultured cerebellar granule cells: Protein kinase C mediated inhibition of N-methyl-D-aspartate responses. J Neurochem 59:983-992, 1992
12. Chen L, Huang LYM: Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a mu opioid. Neuron 7:319-326, 1991
13. 2+ in mouse striatal neurons? Bur J Neurosci 6:854-860, 1994
14. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, Mishina M: Molecular diversity of the NMDA receptor channel. Nature 358:36-41, 1992
15. Urushihara H, Tohda M, Nomura Y: Selective potentiation of N-methyl-D-aspartate-induced current by protein kinase C in Xenopus oocytes injected with rat brain RNA. J Biol Chem 267:11697-11700, 1992
16. Brewer JG, Cotman CW: Survival and growth of hippocampal neurons in defined medium at low density: Advantages of a sandwich culture technique or low oxygen. Brain Res 494:65-74, 1989
17. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450, 1985
18. Dildy-Mayfield JE, Harris RA: Acute and chronic ethanol exposure alters the function of hippocampal kainate receptors expressed in Xenopus oocytes. J Neurochem 58:1569-1572, 1992
19. Hollmann M, Heinemann S: Cloned glutamate receptors. Annu Rev Neurosci 17:31-108, 1994
20. Lovinger DM: Developmental decreases in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: Relation to the actions of ifenprodil. J Pharmacol Exp Ther 274:164-172, 1995
21. Lustig HS, von Brauchitsch KL, Chan J, Greenberg DA: Ethanol and excitotoxicity in cultured cortical neurons: Differential sensitivity of N-methyl-D-aspartate and sodium nitroprusside toxicity. J Neurochem 59:2293-2200, 1992
22. Hoffman PL, Rabe CS, Moses F, Tabakoff B: N-methyl-D-aspartate receptors and ethanol: Inhibition of calcium influx and cyclic GMP production. J Neurochem 52:1937-1940, 1989
23. Simson PE, Criswell HE, Johnson KB, Hicks RE, Breese GR: Ethanol inhibits NMDA-evoked electrophysiological activity in vivo. J Pharmacol Exp Ther 257:225-231, 1991
24. Iorio KR, Reinlib L, Tabakoff B, Hoffman PL: Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function. Mol Pharmacol 41:1142-1148, 1992
25. 2+ responses to N-methyl-D-aspartate and depolarization in cerebellar granule cells. J Neurochem 61:760-763, 1993
26. 2+ concentration by ethanol. J Neurochem 56:1536-1543, 1991
27. Woodward JJ, Gonzales RA: Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from striatal slices: Reversal by glycine. J Neurochem 54:712-715, 1990
28. Chandler JL, Guzman NJ, Sumners C, Crews FT: Magnesium and zinc potentiate ethanol inhibition of N-methyl-D-aspartate-stimulated nitric oxide synthase in cortical neurons. J Pharmacol Exp Ther 271:67-75, 1994
29. Persson MG, Gustafsson LE: Ethanol can inhibit nitric oxide production. Eur J Pharmacol 224:99-100, 1992
30. Huettner JE, Bean BP: Block of N-methyl-D-aspartate-activated current by anticonvulsant MK-801: Selective binding to open channels. Proc Natl Acad Sci USA 85:1307-1311, 1988
31. Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH: Developmental and functional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529-540, 1994
32. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH: Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science 256:1217-1221, 1992
33. Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa C, Shigemoto R, Mizuno N, Masu M, Nakanishi S: Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem 268:2836-2843, 1993
34. Sugihara H, Moriyoshi K, Ishii T, Masu M, Nakanishi S: Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing. Biochem Biophys Res Commun 185:826-832, 1992
35. Hollmann M, Boulter J, Maron C, Beasley L, Sullivan J, Pecht G, Heinemann S: Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor. Neuron 10:943-954, 1993
36. Zhong J, Russell SL, Pritchett DB, Molinoff PB, Williams K: Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. Mol Pharmacol 45:846-853, 1994
37. +-induced depolarization and NMDA treatment. Neuron 12:87-95, 1994
38. +-induced depolarization and NMDA exposure. J Neurochem 64:558-565, 1995
39. Hoffman PL, Tabakoff B, Bhave SV, Kumar KN, Iorio KR, Snell LD, Michaelis EK: The 71 kDa glutamate binding protein is increased in cerebellar granule cells after chronic ethanol treatment. Mol Brain Res (in press), 1996
40. Buller AL, Larson HC, Morrisett RA, Monaghan DT: Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Mol Pharmacol 48:717-723, 1995
41. Koltchine B, Anantharam V, Wilson W, Bayley H, Treistman SN: Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol. Neurosci Lett 152:13-16, 1993
42. Kuner T, Schoepfer R, Korpi ER: Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. NeuroReport 5:297-300, 1993
43. Masood K, Wu C, Brauneis U, Weight FF: Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol Pharmacol 45:324-329, 1994
44. Lovinger DM, White G, Weight FF: Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243:1721-1724, 1989
45. Dildy-Mayfield JE, Harris RA: Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 262:487-494, 1992
46. Lovinger DM: High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells. Neurosci Letters 159:83-87, 1993
47. Sokal RR, Rohlf FJ: Biometry, ed 2. San Francisco, W. H. Freeman, 1981