Human cytomegalovirus protease complexes its substrate recognition sequences in an extended peptide conformation

Biochemistry

Volumn 37, Issue 27, 1998, Pages 9793-9801

  LaPlante, Steven R ^a   Aubry, Norman ^a   Bonneau, Pierre R ^a   Cameron, Dale R ^a   Lagacé, Lisette ^a   Massariol, Marie Josée ^a   Montpetit, Hélène ^a   Plouffe, Céline ^a   Kawai, Stephen H ^a   Fulton, Bruce D ^b   Chen, Zhigang ^b   Ni, Feng ^b  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; VIRUS ENZYME;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; CYTOMEGALOVIRUS; ENZYME STRUCTURE; HYDROLYSIS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN CONFORMATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SUBSTITUTION; BINDING SITES; CYTOMEGALOVIRUS; ENDOPEPTIDASES; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; MAGNETIC RESONANCE SPECTROSCOPY; OLIGOPEPTIDES; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

CYTOMEGALOVIRUS; FELIS CATUS; HUMAN HERPESVIRUS 5; MIRIDAE; RNA VIRUSES;

EID: 0032493329     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980555v     Document Type: Article

References (42)

1. Mocarski, E. S., Jr. (1995) in Virology 2 (Fields, B. N., Ed.) pp 2447-2492, Lippincott-Raven, Philadelphia, PA.
2. Britt, W. J., and Alford, C. A. (1995) in Virology 2 (Fields, B. N., Ed.) pp 2493-2525, Lippincott-Raven, Philadelphia, PA.
3. Gibson, W., Welch, A. R., and Hall, M. R. T. (1994) Perspect. Drug Discov. Des. 2, 413-426.
4. Gao, M., Matusick-Kumar, L., Hurlburt, W., DiTusa, S. F., Newcomb, W. W., Brown, J. C., McCann, P. J., III, Deckman, I., and Colonno, R. J. (1994) J. Virol. 68, 3702-3712.
5. Preston, V. G., Coates, J. A. V., and Rixon, F. J. (1983) J. Virol. 45, 1056-1064.
6. Matusick-Kumar, L., McCann, P. J., III, Robertson, B. J., Newcomb, W. W., Brown, J. C., and Gao, M. (1995) J. Virol. 69, 7113-7121.
7. Casjens, S., and King, J. (1975) Annu. Rev. Biochem. 44, 555.
8. Tong, L., Qian, C., Massariol, M.-J., Bonneau, P. R., Cordingley, M. G., and Lagacé, L. (1996) Nature 383, 272-275.
9. Qiu, X., Culp, J. S., DiLella, A. G., Hellmig, B., Hoog, S. S., Janson, C. A., Smith, W. W., and Abdel-Meguid, S. S. (1996) Nature 383, 275-279.
10. Shieh, H.-S., Kurumbail, R. G., Stevens, A. M., Stegeman, R. A., Sturman, E. J., Pak, J. Y., Wittwer, A. J., Palmier, M. O., Wiegand, R. C., Holwerda, B. C., and Stallings, W. C. (1996) Nature 383, 279-282.
11. Chen, P., Tsuge, H., Almassy, R. J., Gribskov, C. L., Katoh, S., Vanderpool, D. L., Margosiak, S. A., Pinko, C., Matthews, D. A., and Kan, C.-C. (1996) Cell 86, 835-843.
12. Margosiak, S. A., Vanderpool, D. L., Sisson, W., Pinko, C., and Kan, C.-C. (1996) Biochemistry 35, 5300-5307.
13. Darke, P. L., Cole, J. L., Waxman, L., Hall, D. L., Sardana, M. K., and Kuo, L. C. (1996) J. Biol. Chem. 271, 7445-7449.
14. Bonneau, P. R., Grand-Maître, C., Greenwood, D. J., Lagacé, L., LaPlante, S. R., Massariol, M.-J., Ogilvie, W. W., O'Meara, J. A., and Kawai, S. H. (1997) Biochemistry 36, 12644-12652.
15. Schlechter, J. and Berger, A. (1970) Philos. Trans. R. Soc. London, Ser. B 257, 249-264.
16. Fields, G. B., and Noble, R. L. (1990) Int. J. Pept. Protein Res. 35, 161-214.
17. Pinko, C., Margosiak, S. A., Vanderpool, D., Gutowski, J. C., Condon, B., and Kan. C.-C. (1995) J. Biol. Chem. 270, 23634-23640.
18. Bonneau, P. R., Plouffe, C., Pelletier, A., Wernic, D., and Poupart, M.-A. (1998) Anal. Biochem. 255, 59-65.
19. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
20. Holwerda, B. C. (1997) Antiviral Res. 35, 1-21.
21. Piotto, M., Saudek, V., and Sklenar, V. (1992) J. Biomol. NMR 2, 661-665.
22. Marion, D. and Wuthrich, K. (1983) Biochem. Biophys. Res. Commun. 113, 967-974.
23. Ernst, R. R., Bodenhausen, G., and Wokaun, A. (1987) Principles of Nuclear Magnetic Resonance in One and Two Dimensions, pp 494-496, Clarendon Press, Oxford, England.
24. Bax, A., and Davis, D. G. (1985) J. Magn. Reson. 65, 355-360.
25. Ni, F. (1994) Prog. NMR Spectrosc. 26, 517-606.
26. Sklenar, V., Piotto, M., Leppik, R., and Saudek, V. (1993) J. Magn. Reson. A 102, 241-245.
27. Lippens, G., Dhalliun, C., and Wieruszeski, J.-M. (1995) J. Biomol. NMR 5, 327-331.
28. Baleja, J. D., Moult, J., and Sykes, B. D. (1990) J. Magn. Reson. 87, 375-384.
29. Moseley, H. N. B., Curto, E. V., and Krishna, N. R. (1995) J. Magn. Reson., Ser. B 108, 243-261.
30. Meyer, E. F., Clore, G. M., Gronenborn, A. M., and Hansen, H. A. S. (1988) Biochemistry 27, 725-730.
31. Polgar, L., Ed. Mechanisms of Protease Action, CRC Press, Roca Baton, FL.
32. Sardana, V. V., Wolfgang, J. A., Veloski, C. A., Long, W. J., Legrow, K., Wolanski, B., Emini, E. A., and LaFemina, R. L. (1994) J. Biol. Chem. 269, 14337-14340.
33. LaFemina, R. L., Bakshi, K., Long, W. J., Pramanik, B., Veloski, C. A., Wolanski, B. S., Marcy, A. I., and Hazuda, D. J. (1996) J. Virol. 70, 4819-4824.
34. Ogilvie, W., Bailey, M., Poupart, M.-A., Abraham, A., Bhavsar, A., Bonneau, P. R., Bordeleau, J., Bousquet, Y., Chabot, C., Duceppe, J.-S., Fazal, G., Goulet, S., Grand-Maître, C., Guse, I., Halmos, T., Lavallée, P., Leach, M., Malenfant, E., O'Meara, J. A., Plante, R., Plouffe, C., Poirier, M., Soucy, F., Yoakim, C., and Déziel, R. (1998) J. Med. Chem. 40, 4113-4135.
35. Stevens, J. T., Mapelli, C., Tsao, J., Hail, M., O'Boyle, D., II, Weinheimer, S. P., and Diianni, C. L. (1994) Eur. J. Biochem. 226, 361-367.
36. Wüthrich, K., Billeter, M., and Braun, W. (1984) J. Mol. Biol. 180, 715-740.
37. Nicotra, M., Paci, M., Sette, M., Oakley, A. J., Parker, M. W., Lo Bello, M., Caccuri, A. M., Federici, G., and Ricci, G. (1998) Biochemistry 37, 3020-3027.
38. Jones, T. R., Sun, L., Bebernitz, G. A., Muzithras, V. P., Kim, H.-J., Johnston, S. H., and Baum, E. Z. (1994) J. Virol. 68, 3742-3752.
39. Welch, A. R., McNally, L. M., Hall, M. R. T., and Gibson, W. (1993) J. Virol. 67, 7360-7372.
40. Burck, P. J., Berg, D. H., Luk, T. P., Sassmannshausen, L. M., Wakulchik, M., Smith, D. P., Hsiung, H. M., Becker, G. W., Gibson, W., and Villarreal, E. C. (1994) J. Virol. 68, 2937-2946.
41. Holwerda, B. C., Wittwer, A. J., Duffin, K. L., Smith, C., Toth, M. V., Carr, L. S., Wiegang, R. C., and Bryant, M. L. (1994) J. Biol. Chem. 269, 25911-25915.
42. McCann, P. J., III, O'Boyle, D. R., II, and Deckman, I. C. (1994) J. Virol. 68, 526-529.