메뉴 건너뛰기




Volumn 422, Issue 2, 1998, Pages 255-269

Alkylation-induced frameshift mutagenesis during in vitro DNA synthesis by DNA polymerases α and β

Author keywords

Alkylating agent; Frameshift mutation; Herpes simplex virus thymidine kinase; Polymerase alpha; Polymerase beta; Repetitive DNA

Indexed keywords

ALKYLATING AGENT; DNA POLYMERASE; ETHYLNITROSOUREA; REPETITIVE DNA; THYMIDINE KINASE;

EID: 0032480954     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00206-1     Document Type: Article
Times cited : (13)

References (49)
  • 1
    • 0023762467 scopus 로고
    • Chemical carcinogenesis: From animal models to molecular models in one decade
    • Yuspa S.H., Poirer M.C. Chemical carcinogenesis: from animal models to molecular models in one decade. Adv. Cancer Res. 50:1991;25-70.
    • (1991) Adv. Cancer Res. , vol.50 , pp. 25-70
    • Yuspa, S.H.1    Poirer, M.C.2
  • 2
    • 0025335561 scopus 로고
    • Study of mutational specificity in the lacI gene of Escherichia coli as a window on the mechanisms of mutation
    • Glickman B.W. Study of mutational specificity in the lacI gene of Escherichia coli as a window on the mechanisms of mutation. Environmental and Molecular Mutagenesis. 16:1990;48-54.
    • (1990) Environmental and Molecular Mutagenesis , vol.16 , pp. 48-54
    • Glickman, B.W.1
  • 3
    • 0020987951 scopus 로고
    • Mutational specificity in bacteria
    • Miller J.H. Mutational specificity in bacteria. Annu. Rev. Genet. 17:1983;215-238.
    • (1983) Annu. Rev. Genet. , vol.17 , pp. 215-238
    • Miller, J.H.1
  • 4
    • 0025831694 scopus 로고
    • Site-specific mutagenesis: Retrospective and prospective
    • Singer B., Essigmann J.M. Site-specific mutagenesis: retrospective and prospective. Carcinogenesis. 12:1991;949-955.
    • (1991) Carcinogenesis , vol.12 , pp. 949-955
    • Singer, B.1    Essigmann, J.M.2
  • 5
    • 0029938649 scopus 로고    scopus 로고
    • The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: Perspective, prospects and problems
    • Loechler E. The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective, prospects and problems. Carcinogenesis. 17:1996;895-902.
    • (1996) Carcinogenesis , vol.17 , pp. 895-902
    • Loechler, E.1
  • 6
    • 0030738503 scopus 로고    scopus 로고
    • Development and use of an in vitro HSV-tk forward mutation assay to study eukayotic DNA polymerase processing of DNA alkyl lesions
    • Eckert K.A., Hile S.E., Vargo P.L. Development and use of an in vitro HSV-tk forward mutation assay to study eukayotic DNA polymerase processing of DNA alkyl lesions. Nucleic Acids Res. 25:1997;1450-1457.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 1450-1457
    • Eckert, K.A.1    Hile, S.E.2    Vargo, P.L.3
  • 7
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clue to cancer etiology and molecular pathogenesis
    • Greenblatt M.S., Bennett W.P., Hollstein M., Harris C.C. Mutations in the p53 tumor suppressor gene: clue to cancer etiology and molecular pathogenesis. Cancer Res. 54:1994;4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 8
    • 0029996282 scopus 로고    scopus 로고
    • Deletions and insertions in the p53 tumor suppressor gene in human cancers: Confirmation of the DNA polymerase slippage/misalignment model
    • Greenblatt M.S., Grollman A.P., Harris C.C. Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model. Cancer Res. 56:1996;2130-2136.
    • (1996) Cancer Res. , vol.56 , pp. 2130-2136
    • Greenblatt, M.S.1    Grollman, A.P.2    Harris, C.C.3
  • 9
    • 0018358626 scopus 로고
    • N-Nitroso alkylating agents: Formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis
    • Singer B. N-Nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis. J. Natl. Cancer Inst. 62:1979;1329-1339.
    • (1979) J. Natl. Cancer Inst. , vol.62 , pp. 1329-1339
    • Singer, B.1
  • 11
    • 0022807809 scopus 로고
    • Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis
    • Preston B., Singer B., Loeb L.A. Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis. Proc. Natl. Acad. Sci. U.S.A. 83:1986;8501-8505.
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 8501-8505
    • Preston, B.1    Singer, B.2    Loeb, L.A.3
  • 12
    • 0021505055 scopus 로고
    • In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome
    • Loechler E., Green C., Essigmann J. In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome. Proc. Natl. Acad. Sci. U.S.A. 81:1984;6271-6275.
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 6271-6275
    • Loechler, E.1    Green, C.2    Essigmann, J.3
  • 13
    • 0026528038 scopus 로고
    • Base alterations in yeast induced by alkylating agents with differing swain-scott substrate constants
    • Lee G.S.-F., Blonsky K.S., On D.L.V., Savage E.A., Morgan A.R., Borstel R.C.v. Base alterations in yeast induced by alkylating agents with differing swain-scott substrate constants. J. Mol. Biol. 223:1992;617-626.
    • (1992) J. Mol. Biol. , vol.223 , pp. 617-626
    • Lee, G.S.-F.1    Blonsky, K.S.2    On, D.L.V.3    Savage, E.A.4    Morgan, A.R.5    Borstel, R.C.V.6
  • 14
    • 0024726367 scopus 로고
    • Sequence analysis of N-ethyl-N-nitrosourea-induced vermilion mutations in Drosphila melanogaster
    • Pastink A., Vreeken C., Nivard M.J.M., Searles L.L., Vogel E.W. Sequence analysis of N-ethyl-N-nitrosourea-induced vermilion mutations in Drosphila melanogaster. Genetics. 123:1989;123-129.
    • (1989) Genetics , vol.123 , pp. 123-129
    • Pastink, A.1    Vreeken, C.2    Nivard, M.J.M.3    Searles, L.L.4    Vogel, E.W.5
  • 15
    • 0028286953 scopus 로고
    • Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea
    • Jansen J.G., Mohn G.R., Vreiling H., Teijlingen C.M.M.v., Lohman P.H.M., Zeeland A.A.v. Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. Cancer Res. 54:1994;2478-2485.
    • (1994) Cancer Res. , vol.54 , pp. 2478-2485
    • Jansen, J.G.1    Mohn, G.R.2    Vreiling, H.3    Teijlingen, C.M.M.V.4    Lohman, P.H.M.5    Zeeland, A.A.V.6
  • 17
    • 0026629905 scopus 로고
    • Mutational spectrum at the Hprt locus in spleenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea
    • Skopek T.R., Walker V.E., Cochrane J.E., Craft T.R., Cariello N.F. Mutational spectrum at the Hprt locus in spleenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea. Proc. Natl. Acad. Sci. U.S.A. 89:1992;7866-7870.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 7866-7870
    • Skopek, T.R.1    Walker, V.E.2    Cochrane, J.E.3    Craft, T.R.4    Cariello, N.F.5
  • 18
    • 0026779701 scopus 로고
    • DNA sequence analysis of spontaneous and N-ethyl-N-nitrosourea-induced hprt mutations arising in vivo in cytomologus monkey T-lymphocytes
    • Harbach, Filipunas, Wang C.S., Aaron DNA sequence analysis of spontaneous and N-ethyl-N-nitrosourea-induced hprt mutations arising in vivo in cytomologus monkey T-lymphocytes. Environmental and Molecular Mutagenesis. 20:1992;96-105.
    • (1992) Environmental and Molecular Mutagenesis , vol.20 , pp. 96-105
    • Harbach1    Filipunas2    Wang, C.S.3    Aaron4
  • 19
    • 0025997527 scopus 로고
    • Toxicity, mutagenicity and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes
    • Bronstein S.M., Cochrane J.E., Craft T.R., Swenberg J.A., Skopek T.R. Toxicity, mutagenicity and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes. Cancer Res. 51:1991;5188-5197.
    • (1991) Cancer Res. , vol.51 , pp. 5188-5197
    • Bronstein, S.M.1    Cochrane, J.E.2    Craft, T.R.3    Swenberg, J.A.4    Skopek, T.R.5
  • 20
    • 0024214186 scopus 로고
    • Molecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea
    • Eckert K.A., Ingle C.A., Klinedinst D.K., Drinkwater N.R. Molecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea. Mol. Carcinog. 1:1988;50-56.
    • (1988) Mol. Carcinog. , vol.1 , pp. 50-56
    • Eckert, K.A.1    Ingle, C.A.2    Klinedinst, D.K.3    Drinkwater, N.R.4
  • 21
    • 0019833919 scopus 로고
    • Tissue dependent enzyme-mediated repair or removal of O-ethyl pyrimidines and ethyl purines in carcinogen-treated rats
    • Singer B., Spengler S., Bodell W.J. Tissue dependent enzyme-mediated repair or removal of O-ethyl pyrimidines and ethyl purines in carcinogen-treated rats. Carcinogenesis. 2:1981;1069-1073.
    • (1981) Carcinogenesis , vol.2 , pp. 1069-1073
    • Singer, B.1    Spengler, S.2    Bodell, W.J.3
  • 22
    • 0030818757 scopus 로고    scopus 로고
    • Replication of template-primers containing propanodeoxyguanosine by DNA polymerase β
    • Hashim M.F., Schnetz-Boutaud N., Marnett L.J. Replication of template-primers containing propanodeoxyguanosine by DNA polymerase β J. Biol. Chem. 272:1997;20205-20212.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20205-20212
    • Hashim, M.F.1    Schnetz-Boutaud, N.2    Marnett, L.J.3
  • 23
    • 0027983133 scopus 로고
    • Oxygen radical induced mutagenesis is DNA polymerase specific
    • Feig D.I., Loeb L.A. Oxygen radical induced mutagenesis is DNA polymerase specific. J. Mol. Biol. 235:1994;33-41.
    • (1994) J. Mol. Biol. , vol.235 , pp. 33-41
    • Feig, D.I.1    Loeb, L.A.2
  • 24
    • 0027310726 scopus 로고
    • Specificity of mutations induced by N-methyl-N-nitrosourea in a cDNA of the HPRT gene
    • Akagi T., Hiromatsu K., Iyehara-Ogawa H., Kimura H., Kato T. Specificity of mutations induced by N-methyl-N-nitrosourea in a cDNA of the HPRT gene. Carcinogenesis. 14:1993;725-729.
    • (1993) Carcinogenesis , vol.14 , pp. 725-729
    • Akagi, T.1    Hiromatsu, K.2    Iyehara-Ogawa, H.3    Kimura, H.4    Kato, T.5
  • 25
    • 0026046989 scopus 로고
    • 3-Methyladenine mutagenesis under conditions of SOS induction in Escherichia coli
    • Chaudhuri I.J.M.E. 3-Methyladenine mutagenesis under conditions of SOS induction in Escherichia coli. Carcinogenesis. 12:1991;2283-2289.
    • (1991) Carcinogenesis , vol.12 , pp. 2283-2289
    • Chaudhuri, I.J.M.E.1
  • 26
    • 0028277699 scopus 로고
    • Influence of DNA repair by ada and ogt alkyltransferases on the mutational specificity of alkylating agents
    • Roldan-Arjona T., Luque-Romero F.L., Ariza R.R., Jurado J., Pueyo C. Influence of DNA repair by ada and ogt alkyltransferases on the mutational specificity of alkylating agents. Mol. Carcinog. 9:1994;200-209.
    • (1994) Mol. Carcinog. , vol.9 , pp. 200-209
    • Roldan-Arjona, T.1    Luque-Romero, F.L.2    Ariza, R.R.3    Jurado, J.4    Pueyo, C.5
  • 27
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau S.N., Bren G., Schaid D. Microsatellite instability in cancer of the proximal colon. Science. 260:1993;816.
    • (1993) Science , vol.260 , pp. 816
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 30
    • 0022363977 scopus 로고
    • Methylation-induced blocks to in vitro DNA replication
    • Larson K., Sahm J., Shenkar R., Strauss B. Methylation-induced blocks to in vitro DNA replication. Mutat. Res. 150:1985;77-84.
    • (1985) Mutat. Res. , vol.150 , pp. 77-84
    • Larson, K.1    Sahm, J.2    Shenkar, R.3    Strauss, B.4
  • 31
    • 0022399410 scopus 로고
    • Mechanisms of carcinogenesis induced by alkylating agents
    • Saffhill R., Margison G., O'Connor P. Mechanisms of carcinogenesis induced by alkylating agents. Biochim. Biophys. Acta. 823:1985;111-145.
    • (1985) Biochim. Biophys. Acta , vol.823 , pp. 111-145
    • Saffhill, R.1    Margison, G.2    O'Connor, P.3
  • 32
    • 0023275843 scopus 로고
    • RecA-Dependent and recA-independent N-ethyl-N-nitrosourea mutagenesis at a plasmid-encoded herpes simplex virus thymidine kinase gene in Escherichia coli
    • Eckert K.A., Drinkwater N.R. recA-Dependent and recA-independent N-ethyl-N-nitrosourea mutagenesis at a plasmid-encoded herpes simplex virus thymidine kinase gene in Escherichia coli. Mutat. Res. 178:1987;1-10.
    • (1987) Mutat. Res. , vol.178 , pp. 1-10
    • Eckert, K.A.1    Drinkwater, N.R.2
  • 33
    • 0029817866 scopus 로고    scopus 로고
    • Crystal structure of human DNA polymerase β complexed with DNA: Implications for catalytic mechanism, processivity and fidelity
    • Pelletier H., Sawaya M.R., Wolfle W., Kraut J. Crystal structure of human DNA polymerase β complexed with DNA: implications for catalytic mechanism, processivity and fidelity. Biochemistry. 35:1996;12742-12761.
    • (1996) Biochemistry , vol.35 , pp. 12742-12761
    • Pelletier, H.1    Sawaya, M.R.2    Wolfle, W.3    Kraut, J.4
  • 34
    • 0020491949 scopus 로고
    • Synthesis and template properties of an ethylphosphotriester modified decadeoxyribonucleotide
    • Miller P.S., Chandrasegaran S., Dow D.L., Pulford S.M., Kan L.S. Synthesis and template properties of an ethylphosphotriester modified decadeoxyribonucleotide. Biochemistry. 21:1982;5468-5474.
    • (1982) Biochemistry , vol.21 , pp. 5468-5474
    • Miller, P.S.1    Chandrasegaran, S.2    Dow, D.L.3    Pulford, S.M.4    Kan, L.S.5
  • 35
    • 0025288239 scopus 로고
    • Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents
    • Beranek D.T. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res. 231:1990;11-30.
    • (1990) Mutat. Res. , vol.231 , pp. 11-30
    • Beranek, D.T.1
  • 36
    • 0027340355 scopus 로고
    • 4-ethylthymine preferentially form alkyl T·G pairs that do not block in vitro replication in a defined sequence
    • 4-ethylthymine preferentially form alkyl T·G pairs that do not block in vitro replication in a defined sequence. Carcinogenesis. 14:1993;1915-1919.
    • (1993) Carcinogenesis , vol.14 , pp. 1915-1919
    • Dosanjh, M.K.1    Menichini, P.2    Eritja, R.3    Singer, B.4
  • 37
    • 0030462405 scopus 로고    scopus 로고
    • Miscoding properties of 3,N4-etheno-2′-deoxycytidine in reactions catalyzed by mammalian DNA polymerases
    • Shibutani S., Suzuki N., Matsumoto Y., Grollman A.P. Miscoding properties of 3,N4-etheno-2′-deoxycytidine in reactions catalyzed by mammalian DNA polymerases. Biochemistry. 35:1996;14992-14998.
    • (1996) Biochemistry , vol.35 , pp. 14992-14998
    • Shibutani, S.1    Suzuki, N.2    Matsumoto, Y.3    Grollman, A.P.4
  • 38
    • 0029014360 scopus 로고
    • In vitro replication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide adducts
    • Chary P., Lloyd R.S. In vitro replication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide adducts. Nucleic Acids Res. 23:1995;1398-1405.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 1398-1405
    • Chary, P.1    Lloyd, R.S.2
  • 39
    • 0031038053 scopus 로고    scopus 로고
    • Abasic translesion synthesis by DNA polymerase β violates the 'A-rule'
    • Efrati E., Tocco G., Eritja R., Wilson S., Goodman M. Abasic translesion synthesis by DNA polymerase β violates the 'A-rule'. J. Biol. Chem. 272:1997;2559-2569.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2559-2569
    • Efrati, E.1    Tocco, G.2    Eritja, R.3    Wilson, S.4    Goodman, M.5
  • 40
    • 0027196408 scopus 로고
    • On the mechanism of frameshift (deletion) mutagenesis in vitro
    • Shibutani S., Grollman A. On the mechanism of frameshift (deletion) mutagenesis in vitro. J. Biol. Chem. 268:1993;11703-11710.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11703-11710
    • Shibutani, S.1    Grollman, A.2
  • 41
    • 0010325831 scopus 로고    scopus 로고
    • DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions
    • in press
    • K.A. Eckert, P.L. Opresko, DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions, Mutat. Res., in press (1998).
    • (1998) Mutat. Res.
    • Eckert, K.A.1    Opresko, P.L.2
  • 42
    • 0031815214 scopus 로고    scopus 로고
    • Spectrum of point muations in the coding region of the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene in human T-lymphocytes
    • Podlutsky A., Osterholm A.-M., Hou S.-M., Hofmaier A., Lambert B. Spectrum of point muations in the coding region of the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene in human T-lymphocytes. Carcinogenesis. 19:1998;557-566.
    • (1998) Carcinogenesis , vol.19 , pp. 557-566
    • Podlutsky, A.1    Osterholm, A.-M.2    Hou, S.-M.3    Hofmaier, A.4    Lambert, B.5
  • 46
    • 0010945939 scopus 로고    scopus 로고
    • APC Mutations in colorectal tumors with mismatch repair deficiency
    • Huang H.et al. APC Mutations in colorectal tumors with mismatch repair deficiency. Proc. Natl. Acad. Sci. U.S.A. 93:1996;9049-9054.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 9049-9054
    • Huang, H.1
  • 47
    • 0030817162 scopus 로고    scopus 로고
    • Conditional mutator phenotype in hMSH2-deficient tumor cell lines
    • Richards B., Zhang H., Phear G., Meuth M. Conditional mutator phenotype in hMSH2-deficient tumor cell lines. Science. 277:1997;1523-1526.
    • (1997) Science , vol.277 , pp. 1523-1526
    • Richards, B.1    Zhang, H.2    Phear, G.3    Meuth, M.4
  • 49
    • 0027292234 scopus 로고
    • An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
    • Kat A., Thilly W.G., Fang W., Longley M.J., Li G., Modrich P. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl. Acad. Sci. U.S.A. 90:1993;6424-6428.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6424-6428
    • Kat, A.1    Thilly, W.G.2    Fang, W.3    Longley, M.J.4    Li, G.5    Modrich, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.