Mecanismos patogénicos de las vasculitis sistémicas. Nuevos conceptos

Medicina Clinica

Volumn 110, Issue 15, 1998, Pages 587-596

  Cid Xutglà, Maria Cinta ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTROPHIL CYTOPLASMIC ANTIBODY;

ADULT; ANTIGEN ANTIBODY COMPLEX; AORTA ARCH SYNDROME; ARTICLE; BEHCET DISEASE; BLOOD VESSEL; CLINICAL OBSERVATION; CLINICAL STUDY; DIAGNOSIS; FEMALE; HUMAN; IMMUNOLOGY; INFLAMMATION; INTESTINE MUCOSA; MALE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; POLYARTERITIS NODOSA; T LYMPHOCYTE; VASCULITIS; WEGENER GRANULOMATOSIS;

ADULT; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIGEN-ANTIBODY COMPLEX; BEHCET SYNDROME; BLOOD VESSELS; FEMALE; HUMANS; INFLAMMATION; INTESTINAL MUCOSA; MALE; NEOVASCULARIZATION, PATHOLOGIC; POLYARTERITIS NODOSA; T-LYMPHOCYTES; TAKAYASU'S ARTERITIS; VASCULITIS; WEGENER GRANULOMATOSIS;

EID: 0032474040     PISSN: 00257753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (96)

1. Lie JT. Histopathologic specificity of systemic vasculitis. Rheum Dis Clin North Am 1995; 21: 883-909.
2. Fauci As, Haynes BF, Katz P. The spectrum of vasculitis. Clinical, pathologic, immunologic and therapeutic considerations. Ann Intern Med 1978; 89: 660-676.
3. Michel BA, Hunder GG, Bloch DA, Calabrese LH. Hypersensitivity vasculitis and Henoch-Schonlain purpura: a comparison between the 2 disorders. J Rheumatol 1992; 19: 721-728.
4. Calabrese LH, Duna GF. Drug-induced vasculitis. Curr Opin Rheumatol 1996; 8: 34-40.
5. Lie JT. Vasculitis associated with infectious diseases. Curr Opin Rheumatol 1996; 8: 26-29.
6. Sergent JS, Lockshin MD, Christian CL, Gocke DJ. Vasculitis with hepatitis B antigenemia: long-term observations in nine patients. Medicine (Baltimore) 1976; 55: 1-18.
7. Cuellar ML, Garcia C, Molina JF. Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. Curr Opin Rheum 1995: 7: 58-64.
8. Guillevin L, Lhote F, Sauvaget F, Deblois P, Rossi F, Levallois D et al. Treatment of polyarteritis nodosa related to hepatitis B virus with interferon-alpha and plasma exchanges. Ann Rheum Dis 1994; 53: 334-337.
9. Misiani R, Bellavita P, Fenili D, Vicari O, Marchesi D, Sironi PL et al. Interferon alpha-2a therapy in cryoglobulinemia associated with hepatitis C virus. N Engl J Med 1994; 330: 751-756.
10. Guillevin L, Lhote F, Gherardi R. The spectrum and treatment of virus-associated vasculitides. Curr Opin Rheumatol 1997; 9: 31-36.
11. Gherardi RK, Mhiri C, Baudrimont M, Roillet E, Berry JP, Poirier J. Iron patient deposits, small vasael vaseislitis and erythrotagacytosis in the muscle of human immunodeficiency virus-infected patiens. Hum Pathol 1991; 22: 1.187-1.194.
12. Font C, Miró O, Padrol E, Masanás F, Coll-Vinent B, Casademont J et al. Polyarteritis nodnsa in human immunodeficiency virus infection: report of four cases and revisw of the literature. Br J Rheumatol 1996; 35: 796-799.
13. Gherardi R, Balee L, Mhiri C, Gray F, leses MC, Sobel A et al. The spectrum of vasculities in human immunodeficiency virus-infected patients. Arhritis Rheum 1993; 36: 1.164-1.174.
14. Masanás F, Padrol E, Coll-Vinent B, Casademont J, Miró O, Mallolas J et al. Symptomatic myopathies in HIV-I infected patients untreated with antiretroviral agents. A clinicopathological study of 30 consecutive patients. Clin Neuropathol 1995; 15: 221-225.
15. Kissel JT, Riethman JL, Omeiza J, Rammohan KW, Mendell JR. Peripheral nerve vasculitis: immune characterization of the vascular lesons. Ann Neurol 1989; 25: 291-297.
16. Falk RJ, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crsscentic glomerulonephritis. N Engl J Med 1998; 318: 1.651-1.657.
17. Ludeman J, Utecht B, Gross WL. Anti-neutrophil cytoplasm antibodies in Wagener's granulomatusis recognize an elastinclytic enzyme. J Exp Med 1990; 171: 357-362.
18. Van der Woude FJ, Rasmussen N, Lobatto S, Wiik A, Permin H, Van es LA et al. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1985; 1: 425-429.
19. Bosch X, Mirapeix E, Font J, Cervera R, Ingelmo M, Urbano-Ḿrquez A. Anti-myeloperoxidase autoantibodies in patients with necrotizing glomerular and alveolar capillantis. Am J Kidney Dis 1992; 20: 231-239.
20. Gross WL, Csernok E. Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis. Curr Opin Rheumatol 1995; 7: 11-19.
21. Gross WL, Csernok E, Szymkowiak CH. Antineutrophil cytoplasmic autoantibodies with specificity for proteinase 3. En: Peter JB. Schoenfeld Y. editores. Autoantibodies 1996; 61-67.
22. Falk RJ, Terell RS, Charles LA, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro Proc Natl Acad Sci USA 1990; 87: 4.115-4.119.
23. Csernok E, Ernst M, Schmitt W, Bainton DF, Gross WL. Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo, Clin Exp Immunol 1994; 95: 244-250.
24. Keogan MT, Esnault VLM, Green AJ, Lockwood CM, Brown DL. Activation of normal neutrophils by anti-neutrophil cytoplasm antibodies. Clin Exp Immunol 1992; 90: 228-234.
25. Keogan MR, Rifkin I, Ronda N, Lockwood CM, Brown DL. Anti-neutrophil cytoplasm antibodies increase neutrophil adhesion to cultured human endothelium. Adv Exp Med Biol 1993; 336: 115-119.
26. Pall AA, Wilkes M, Adu D, Garner C, Richards NT, Savage CO et al. ANCA induces nitric oxide synthase in human neutrophils. Clin Exp Immunol 1995; 111: 35.
27. Mulder AHL, Heeringe P, Brouwer E, Limburg PC, Kallenberg CGM. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a FcgammaRII-dependent process. Clin Exp Immunol 1994; 98: 270-278.
28. Mulder AHL, Stegeman CA, Kallenberg CGM. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis: a predominant role for the lgG3 subclass of ANCA. Clin Exp Immunol 1995; 101: 227-232.
29. Wainstein E, Edberg J, Csernok E, Sneller M, Hoffman GS, Keystone E et al. Fcy-RIIIB alleles predict renal dysfunction in Wegener's granulomatosis (WG). Arthritis Rheum 1996; 39 (Supl): 210.
30. Braun MG, Csernok E, Gross WL, Muller-Hermelink HK. Proteinase 3: the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis: Immunolocalization in normal and pathologic tissues Am J Pathol 1991; 139: 831-838.
31. Mayel WJ, Csernok E, Szymkowiak C, Gross WL. Meyer Zum Buschenfelde KH. Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis. Blood 1993: 82: 1.221-1.229.
32. Pall AA, Savage COS. Mechanisms of endothelial cell injury in vasculitis. Springer Seminar Immunopathol 1994; 16. 23-37.
33. Brouwer E, Huitema MG, Klok PA, De Weerd H, Cohen Tervaert JW, Weening JJ et al. Antimyeloperoxidase-associated proliferative glomerulonephritis: an animal model. J Exp Med 1993; 177: 905-914.
34. Brouwer E, Klok PA, Huitema MG, Weening JJ, Kallenberg CGM. Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidase-associated proliferative glomerulonephritis. Kidney Int 1995: 47: 1.121-1.129.
35. Foucher P, Heeringa P, Petersen AH, Huitema MG, Brouwer E, Cohen Tervaert JW et al. In vivo lung perfusion of activated neulrophil products in myeloperoxidase immunized rats. Clin Exp Immunol 1995; 111: 40.
36. Kobayashi K, Shibata T, Sugisaki T. Aggravation of rat nephrotoxic serum nephritis by anti-myeloperoxidase antibodies Kidney Int 1995- 47: 454-463.
37. Meroni PL, Del Papa N, Conforti G, Barcellini W, Borghi MO, Gambini D. Antibodies to endothelial cells in systemic vasculitis. En: Cervera R, Khamashta MA. Hughes GRV, edilores. Antibodies to endothelial cells and vascular damage 1994: 121-133.
38. Cervera R, Navarro M, López-Soto A, Cid MC. Font J. Esparza J et al. Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity Ann Rheum Dis 1994: 53: 265-267.
39. Damianovich M, Gilburd B, George J, Del Papa N, Afek A. Goldberg l et al. Pathogenic role of anti-endothelial cell antibodies in vasculitis. An idiotypic experimental model. J Immunol 1996; 156: 4.946-4.951.
40. Cid MC, Campo E, Ercilla G, Palacin A, Vilaseca J, Villalta J el al . Immunohistochemical analysis of lymphoid and macrophage cell subsets and their immunologic activation markers in temporal arteritis. Arthritis Rheum 1989: 32: 884-893.
41. Cid MC, Grau JM, Casademont J, Campo E, Coll-Vinent B, López-Soto A et al. Immunohistochemical characterization of inflammatory cells and immunologic activation markers in muscle and nerve biopsy specimens from patients with systemic polyartentis nodosa. Arthritis Rheum 1994; 37: 1.055-1.061.
42. Seko Y, Minota S, Kawasaki A, Shinkai Y, Maeda K, Yagita H et al. Perforin-secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu's arteritis. J Clin Invest 1994; 93: 750-758.
43. Abe J, Kotzin B, Meissner C, Melish M, Takahshi M, Fulton D et al. Characterization of T cell repertoire changes in acute Kawasaki disease. J Exp Med 1993; 177: 791-796.
44. Martinez-Taboada VM, Goronzy JJ, Weyand CM Clonally expanded CDS T cells in patients with polymyalgia rheumatica and giant cell arteritis. Clin Immunol Immunopathol 1996; 79: 263-270.
45. Giscombe R, Grunewald J, Nityanand S, Lefvert AK. T cell receptor (TCR) V gene usage in patìents with systemic necrotizing vasculitis. Clin Exp Immunol 1995; 101: 213-219.
46. Simpson IJ, Skinner MA, Geursen A, Peake JS. Abbott WG, Fraser JD et al. Peripheral blood T lymphocytes in systemic vasculitis: increased T cell receptor Vbeta 2 gene usage in microscopic polyarteritis. Clin Exp Immunol 1995; 101: 220-226.
47. Weyand CM, Schonberger J, Oppitz U, Hunder NN, Hicok KC, Goronzy JJ Distinct vascular lesions in giant cell arteritis share identical T cell clonotypes. J Exp Med 1994; 179: 951-960.
48. Rasmusen N, Petersen J. Cellular immune responses and pathogenesis in c-ANCA positive vasculitides. J Autoimmunity 1993; 6: 227-236.
49. Nabel E, Plautz G, Nabel GJ. Transduction of a foreign histocompatibility gene into the arterial wall induces vasculitis. Proc Natl Acad Sci USA 1992; 89; 5.157-5.161.
50. Grunewald J, Andersson R, Rydberg L, Gigliotti D, Schaufelberger C, Hansson GK et al. CD4+ and CDS+ T cell expansions using selected TCR V and J gene segments at the onset of giant-cell arteritis. Arthritis Rheum 1994; 37: 1.221-1.227.
51. Weyand CM, Wagner AD, Bjornsson J, Goronzy JJ Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis. J Clin Invest 1996; 98: 1.642-1.649
52. Wagner AD, Goronzy JJ, Weyand CM. Functional profile of tissue infiltrating and circulating CD68+ cells in gant cell arteritis: evidence for two components of the disease. J Clin Invest 1994; 94: 1.134-1.140.
53. Romagnani S. Induction of TH1 and TH2 responses: a key role for the «natural» immune response? Immunol Today 1992; 13: 379-381.
54. Wagner AD, Bjorsson J, Bartley GB, Goronzy JJ, Weyand CM, Interferon γ-producing T cells in giant cell arteritis represent a minority of tissue-infiltrating cells and are located distant from the site of pathology. Am J Pathol 1996; 148: 1.925-1.933.
55. Weyand CM, Hicok KC, Hunder GG, Goronzy JJ. Tissue cytokme patterns in patients with polymyalgia rheumatic and giant-cell arteritis. Ann Intern Med 1994; 121: 484-491.
56. Nikkari ST, Hoyhtya M, Isola J, Nikkari T. Macrophages contain 92-kd gelatinase (MMP-9) at the site of degenerated internal e'aslic lamina intemporal arteritis Am J Pathol 1996; 149: 1.427-1.433.
57. Grau GE, Roux-Lombard P, Gysler C, Lambert C, Lambert PH, Dayer JM et al. Serum cytokine changes in systemic vasculitis. Immunology 1989; 68: 196-198.
58. Roche NE, Fulbright JW, Wagner AD, Hunder GG, Goronzy JJ, Weyand CM. Correlation of interleukm-6 production and disease activity in polymyalgia rheumatica and giant-cell arteritis. Arthritis Rheum 1993; 36: 1.286-1.294.
59. Akira S, Hirano T, Taga T, Kishimoto T. Biology of multifocal cytokines: IL-6 and related molecules (IL-1 and TNF). FASEB J 1990; 4: 2.860-2.867.
60. Kasama T, Strieter RM, Lukacs NW, Lincoln PM, Burdick MD, Kunkel SL. Interferon γ modulates the expression of neutrophil-denved chemokines. J Investigative Med 1995: 43: 58-67.
61. Font C, Cebrián M, Cid MC, Coll-Vment B, Sánchez E. López-Soto A et al. Polymorphonuclear leukocytes (PMN) and E-selectin expression in inflammatory lesions of giant-cell arteritis (GCA). Arthritis Rheum 1996; 39 (Supl): 67.
62. Cid MC, Coll-Vinent B, Grau JM. Moléculas de adhesion en las interacciones entre los leucocitcs, el endotelio y la matriz extracelular. Relevancia en clinica humana y aplicaciones terapéuticas potenciales. Med Clin (Barc) 1997; 108: 503-511.
63. Cid MC, Esparza J, Juan M. Moleculas de adhesión en las interacciones entre los leucocitos, el endotelio y la matriz extracelular. Estructura, distribución y función biolȯgica Med Clin (Barc) 1997: 108: 472-477.
64. Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science 1996: 272: 60-66.
65. Albelda SM, Wayne Smith C. Ward PA. Adhesion molecules and inflammatory injury. FASEB J 1994; 8: 504-512
66. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994: 76: 301-314.
67. Gearing AJH, Newman W. Circulating adhesion molecules in disease, Immunol Today 1993; 14: 506-512.
68. Cid MC. New developments in the pathogenesis of systemic vasculilis. Curr Opin Rheumatol 1996: 8: 1-11.
69. Coll-Vinent B, Cebrian M, Cid MC, Font C, Juan M, Yague J et al. Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classical polyarteritis nodosa. Arthritis Rheum 1998. En prensa.
70. Cohen Tervaert JW, Kallenberg CGM. Cell adhesion molecules in vasculitis. Curr Opin Rheumatol 1997; 9: 16-25.
71. Lozada CJ, Levin RI, Whitlow MS, Cronstein BN. Immune complex vasculitis revisited: C1q receptors promote expression of adhesive molecules on endothelial cells. Arthritis Rheurn 1994; 37 (Supl): 426
72. Mayet WJ, Meyer Zum Buschenfelde KH. Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells. Clin Exp Immunol 1993; 94: 440-446.
73. Janssen BA, Luqmani RA, Gordon C, Hemingway IH, Bacon PA, Gearing AJH et al. Correlation of blood levels of soluble vascular cell adhesion molecule-1 with disease activity in systemic lupus erythematosus and vasculitis. Br J Rheumatol 1994; 33: 1.112-1.116.
74. John S, Neumayer H, Weber M. Serum circulating ICAM-1 levels are not useful to indicate active vasculitis or early renal allograft rejection. Clin Nephrol 1994; 42: 369-375.
75. Pall AA, Adu D, Drayson M, Taylor CM, Richards NT. Michael J. Circulating soluble adhesion molecules in systemic vasculitis. Nephrol Dial Transplant 1994; 9: 770-774.
76. Wang CR, Lin MF, Tsai RT, Chuang CY, Chen CY. Circulating intercellular adhesion molecules-1 and autoanlibodies including anti-endothelial cell, anti-cardiolipin. and anti-neutrophil cytoplasma antibodies in patients with vasculitis. Clin Rheumatol 1993; 12: 375-380.
77. Stegeman CA, Cohen Tervaert JW, Huitema MG, De Jong PE, Kallenberg CGM. Serum levels of soluble adhesion molecules intercellular adhesion molecule 1, vascular cell adhesion molecule 1. and E-selectin in patients with Wegener's granulomatosis. Relationship to disease activity and relevance during follow-up. Arthritis Rheum 1994: 37: 1.228-1235.
78. Coll-Vinent B, Grau JM López-Soto A, Oristrell J, Font C. Bosch X et al. Circulating soluble adhesion moleculesin patients with classical polyarteritis nodosa. Br J Rheumatol 1998. En prensa.
79. Folkman J, Klagsbrun M. Angiogenic factors. Science 1987; 235: 442-447.
80. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Medicine 1995; 1: 27-31.
81. Cid MC, Grant DS, Hoffman GS, Auerbach R, Fauci AS, Kleinman HK. Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis. J Clin Invest 1993; 91: 977-985.
82. Mantovani A, Bussolino F, Dejana E. Cytokine regulation of endothelial cell function. FASEB J. 1992; 6: 2.591-2.599.
83. Mantovani A, Bussolino F, Introna M. Cytokine regulation of endothelial cell function: from molecular level to the bedside, Immunol Today 1997; 18: 231-240.
84. Noronha IL, Kruger C, Andrassy K, Ritz E, Waldherr R. In situ production of TNFalpha. IL-1 beta and IL-2R in ANCA-positive glomerulonephritis. Kidney Int 1993: 43: 682-692.
85. Cid MC, Font C, Oristrell J, López-Soto A, Coll-Vinent B, Vilaseca J et al. A strong inflammatory response is associated with a low risk of developing visual loss and other cranial ischemic events in giant-cell arteritis. Arthritis Rheum 1998. En prensa.
86. Kopp JB, Bruggeman LA, Klotman PE. Extracellular matrix gene expression in experimental glomerulonephritis. Curr Opin Nephrol Hypertension 1993: 2: 609-617.
87. Kovacs EJ, Di Pietro LA. Fibrogenic cytokmes and connective tissue production. FASEB J 1994; 8: 854-861.
88. Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M et al. Takayasu arteritis Ann Intern Med 1994; 120: 919-929.
89. Kim-Schulze S, McGowan KA, Hubchak SC, Cid MC, Martin MB, Kleinman HK et al. Expression of an estrogen receptor by human coronary artery and umbilical vein endothelial cells Circulation 1996; 94: 1.402-1.407.
90. Cid MC, Kleinman HK, Grant DS, Schnaper HW, Fauci AS. Huffman GS. Estradiol enhances leukocyte binding to tumor necrosis factor (TNF]-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin. intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1. J Clin Invest 1994; 93: 17-25.
91. Morales D, McGowan KA, Grant DS, Maheshwari S, Barthiya D. Cid MC et al. Estrogen promotes angiogenic activity in human umbilical vein endothelial cells in vitro and in a murine model Circulation 1995; 91: 755-763.
92. Cid MC, Ercilla MG, Vilaseca J, Sanmarti R, Villalta J, Ingelmo M et al. Polymyalgia rheumatica: a syndrome associated with the HLA-DR4 antigen. Arthritis Rheum 1988; 31: 678-682.
93. Weyand CM, Hicok KC, Hunder GG, Goron zy JJ. The HLA-DRBI locus as a genetic component in giant cell arteritis. J Clin Invest 1992: 90: 2.355-2.361.
94. Shurbaji MS, Kuhajda FP, Pasternack GR. Thurmond TS Expression of oncogenic antigen (OA-519) in prostate cancer is a potential prognostic indicator. Am J Clin Pathol 1991; 97: 686-691.
95. Kuhajda FP, Piantadosi S, Pasternak GR. Haptoglobin-related protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease. N Engl J Med 1989; 321: 636-641.
96. Chapelle JP, Albert JP, Smeets C, Heugshem C, Kulbertus HE. Effect of haptoglobin phenotype on the size of myocardial infarct. N Engl J Med 1982; 307: 457-463.