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Volumn 41, Issue 11, 1998, Pages 1327-1336

Evidence for direct action of alloxan to induce insulin resistance at the cellular level

Author keywords

Experimental diabetes; Insulin action; Insulin transport

Indexed keywords

ALLOXAN; INSULIN;

EID: 0031739947     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051073     Document Type: Article
Times cited : (14)

References (40)
  • 1
    • 0019988894 scopus 로고
    • Insulin resistance is a prominent feature of insulin-dependent diabetes
    • DeFronzo RA, Hendler R, Simonson D (1982) Insulin resistance is a prominent feature of insulin-dependent diabetes. Diabetes 31: 795-801
    • (1982) Diabetes , vol.31 , pp. 795-801
    • DeFronzo, R.A.1    Hendler, R.2    Simonson, D.3
  • 2
    • 0025138242 scopus 로고
    • Localization of rate-limiting defect for glucose diposal in skeletal muscle of insulin-resistant type I diabetic patients
    • Yki-Jarvinen H, Sahlin K, Ren JM, Koivisto VA (1990) Localization of rate-limiting defect for glucose diposal in skeletal muscle of insulin-resistant type I diabetic patients. Diabetes 39: 157-167
    • (1990) Diabetes , vol.39 , pp. 157-167
    • Yki-Jarvinen, H.1    Sahlin, K.2    Ren, J.M.3    Koivisto, V.A.4
  • 3
    • 0020516750 scopus 로고
    • Insulin resistance in alloxan-diabetic dogs: Evidence for reversal following insulin therapy
    • Caruso G, Proietto J, Calenti A, Alford F (1983) Insulin resistance in alloxan-diabetic dogs: evidence for reversal following insulin therapy. Diabetologia 5: 273-279
    • (1983) Diabetologia , vol.5 , pp. 273-279
    • Caruso, G.1    Proietto, J.2    Calenti, A.3    Alford, F.4
  • 4
    • 0017715943 scopus 로고
    • Development of insulin resistance in normal dogs following alloxan-induced insulin deficiency
    • Reaven GM, Sageman WS, Swenson RS (1977) Development of insulin resistance in normal dogs following alloxan-induced insulin deficiency. Diabetologia 13: 459-462
    • (1977) Diabetologia , vol.13 , pp. 459-462
    • Reaven, G.M.1    Sageman, W.S.2    Swenson, R.S.3
  • 5
    • 0030292743 scopus 로고    scopus 로고
    • Glucose transport: Pivotal step in insulin action (Lilly Lecture)
    • Kahn BB (1996) Glucose transport: pivotal step in insulin action (Lilly Lecture). Diabetes 45: 1644-1654
    • (1996) Diabetes , vol.45 , pp. 1644-1654
    • Kahn, B.B.1
  • 6
    • 0024352305 scopus 로고
    • Differential regulation of two glucose transporters in adipose cells from diabetic and insulin treated diabetic rats
    • Kahn BB, Charron MJ, Lodish HF, Cushman SW, Flier JS (1989) Differential regulation of two glucose transporters in adipose cells from diabetic and insulin treated diabetic rats. J Clin Invest 84: 404-411
    • (1989) J Clin Invest , vol.84 , pp. 404-411
    • Kahn, B.B.1    Charron, M.J.2    Lodish, H.F.3    Cushman, S.W.4    Flier, J.S.5
  • 7
    • 0026033325 scopus 로고
    • Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin resistant glucose transport in adipose cells without restoring glucose transporter gene expression
    • Kahn BB, Shulman GI, DeFronzo RA, Cushman SW, Rossetti L (1991) Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest 87: 561-570
    • (1991) J Clin Invest , vol.87 , pp. 561-570
    • Kahn, B.B.1    Shulman, G.I.2    DeFronzo, R.A.3    Cushman, S.W.4    Rossetti, L.5
  • 8
    • 0025954408 scopus 로고
    • Mechanism of insulin resistance in insulin-dependent diabetes mellitus: A major role for reduced skeletal muscle blood flow
    • Baron AD, Laakso M, Brechtel G, Edelman SV (1991) Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. J Clin Endocrinol Metab 73: 637-643
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 637-643
    • Baron, A.D.1    Laakso, M.2    Brechtel, G.3    Edelman, S.V.4
  • 9
    • 0024423823 scopus 로고
    • Insulin transport across capillaries is rate limiting for insulin action in dogs
    • Yang YJ, Hope ID, Ader M, Bergman RN (1989) Insulin transport across capillaries is rate limiting for insulin action in dogs. J Clin Invest 84: 1620-1628
    • (1989) J Clin Invest , vol.84 , pp. 1620-1628
    • Yang, Y.J.1    Hope, I.D.2    Ader, M.3    Bergman, R.N.4
  • 10
    • 0026584423 scopus 로고
    • Dose response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues
    • Yang YJ, Hope ID, Ader M, Poulin RA, Bergman RN (1992) Dose response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues. Diabetes 41: 241-253
    • (1992) Diabetes , vol.41 , pp. 241-253
    • Yang, Y.J.1    Hope, I.D.2    Ader, M.3    Poulin, R.A.4    Bergman, R.N.5
  • 11
    • 0028153563 scopus 로고
    • Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men
    • Castillo C, Bogardus C, Bergman R, Thuillez P, Lillioja S (1994) Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men. J Clin Invest 93: 10-16
    • (1994) J Clin Invest , vol.93 , pp. 10-16
    • Castillo, C.1    Bogardus, C.2    Bergman, R.3    Thuillez, P.4    Lillioja, S.5
  • 12
    • 0030669621 scopus 로고    scopus 로고
    • Interstitial muscle insulin and glucose levels in normal and insulin-resistant Zucker rats
    • Holmäng A, Mimura K, Bjorntorp P, Lonnroth P (1997) Interstitial muscle insulin and glucose levels in normal and insulin-resistant Zucker rats. Diabetes 46: 1799-1804
    • (1997) Diabetes , vol.46 , pp. 1799-1804
    • Holmäng, A.1    Mimura, K.2    Bjorntorp, P.3    Lonnroth, P.4
  • 13
    • 0003153046 scopus 로고
    • Vascular endothelium and diabetes mellitus
    • Simionescu N, Simionescu M (eds) Plenum Press, New York
    • Bar RS (1992) Vascular endothelium and diabetes mellitus. In: Simionescu N, Simionescu M (eds) Endothelial Cell Dysfunctions. Plenum Press, New York, pp 363-381
    • (1992) Endothelial Cell Dysfunctions , pp. 363-381
    • Bar, R.S.1
  • 14
    • 0024585240 scopus 로고
    • Identification of persistent defects in insulin receptor structure and function in capillary endothelial cells from diabetic rats
    • Kwok CF, Goldstein BJ, Muller-Wieland D, Lee TS, Kahn CR, King GL (1989) Identification of persistent defects in insulin receptor structure and function in capillary endothelial cells from diabetic rats. J Clin Invest 83: 127-136
    • (1989) J Clin Invest , vol.83 , pp. 127-136
    • Kwok, C.F.1    Goldstein, B.J.2    Muller-Wieland, D.3    Lee, T.S.4    Kahn, C.R.5    King, G.L.6
  • 15
    • 0021907605 scopus 로고
    • Receptor-mediated transport of insulin across endothelial cells
    • King GL, Johnson SM (1985) Receptor-mediated transport of insulin across endothelial cells. Science 227: 1583-1586
    • (1985) Science , vol.227 , pp. 1583-1586
    • King, G.L.1    Johnson, S.M.2
  • 16
    • 0029871377 scopus 로고    scopus 로고
    • Transendothelial insulin transport is not saturable in vivo: No evidence for a receptor-mediated process
    • Steil GM, Ader M, Moore DM, Rebrin K, Bergman RN (1996) Transendothelial insulin transport is not saturable in vivo: no evidence for a receptor-mediated process. J Clin Invest 97: 1497-1503
    • (1996) J Clin Invest , vol.97 , pp. 1497-1503
    • Steil, G.M.1    Ader, M.2    Moore, D.M.3    Rebrin, K.4    Bergman, R.N.5
  • 17
    • 0017259545 scopus 로고
    • The essentiality of insulin and the role of glucagon in regulating glucose utilization and production during strenuous exercise in dogs
    • Vranic M, Kawamori R, Pek S, Kovacevic N, Wrenshall GA (1976) The essentiality of insulin and the role of glucagon in regulating glucose utilization and production during strenuous exercise in dogs. J Clin Invest 57: 245-255
    • (1976) J Clin Invest , vol.57 , pp. 245-255
    • Vranic, M.1    Kawamori, R.2    Pek, S.3    Kovacevic, N.4    Wrenshall, G.A.5
  • 18
    • 0030901308 scopus 로고    scopus 로고
    • Glucose effectiveness assessed under dynamic and steady state conditions: Comparability of uptake versus production components
    • Ader M, Ni T-C, Bergman RN (1997) Glucose effectiveness assessed under dynamic and steady state conditions: comparability of uptake versus production components. J Clin Invest 99: 1187-1199
    • (1997) J Clin Invest , vol.99 , pp. 1187-1199
    • Ader, M.1    Ni, T.-C.2    Bergman, R.N.3
  • 19
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: Comparison of unlabeled and labeled exogenous glucose infusates
    • Finegood DT, Bergman RN, Vranic M (1987) Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36: 914-924
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 20
    • 0024311323 scopus 로고
    • Assessment of insulin sensitivity in vivo: A critical review
    • Bergman RN, Hope ID, Yang YJ et al. (1989) Assessment of insulin sensitivity in vivo: a critical review. Diabetes Metab Rev 5: 411-429
    • (1989) Diabetes Metab Rev , vol.5 , pp. 411-429
    • Bergman, R.N.1    Hope, I.D.2    Yang, Y.J.3
  • 22
    • 0026723827 scopus 로고
    • Diurnal variation in glucose tolerance: Cyclic suppression of insulin action and insulin secretion in normal weight, but not obese subjects
    • Lee A, Ader M, Bray GA, Bergman RN (1992) Diurnal variation in glucose tolerance: cyclic suppression of insulin action and insulin secretion in normal weight, but not obese subjects. Diabetes 41: 750-759
    • (1992) Diabetes , vol.41 , pp. 750-759
    • Lee, A.1    Ader, M.2    Bray, G.A.3    Bergman, R.N.4
  • 23
    • 0020757484 scopus 로고
    • Optimal segments: A method for smoothing tracer data to calculate metabolic fluxes
    • Finegood DT, Bergman RN (1983) Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes. Am J Physiol 244: E472-E479
    • (1983) Am J Physiol , vol.244
    • Finegood, D.T.1    Bergman, R.N.2
  • 24
    • 0027223164 scopus 로고
    • Quantitation of measurement error with Optimal Segments: Basis for adaptive time course smoothing
    • Bradley DC, Steil GM, Bergman RN (1993) Quantitation of measurement error with Optimal Segments: basis for adaptive time course smoothing. Am J Physiol 264: E902-E911
    • (1993) Am J Physiol , vol.264
    • Bradley, D.C.1    Steil, G.M.2    Bergman, R.N.3
  • 25
    • 0023120630 scopus 로고
    • Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
    • Bergman RN, Prager R, Volund A, Olefsky JM (1987) Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest 79: 790-800
    • (1987) J Clin Invest , vol.79 , pp. 790-800
    • Bergman, R.N.1    Prager, R.2    Volund, A.3    Olefsky, J.M.4
  • 26
    • 0023577736 scopus 로고
    • Insulin sensitivity in the intact organism
    • Alberti KGMM, Home PD, Taylor R (eds) Bailliere Tindall, London
    • Ader M, Bergman RN (1987) Insulin sensitivity in the intact organism. In: Alberti KGMM, Home PD, Taylor R (eds) Bailliere's Clinics in Endocrinology and Metabolism. Bailliere Tindall, London, pp 879-910
    • (1987) Bailliere's Clinics in Endocrinology and Metabolism , pp. 879-910
    • Ader, M.1    Bergman, R.N.2
  • 27
    • 0028097682 scopus 로고
    • Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph
    • Poulin RA, Steil GM, Moore DM, Ader M, Bergman RN (1994) Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Diabetes 43: 180-190
    • (1994) Diabetes , vol.43 , pp. 180-190
    • Poulin, R.A.1    Steil, G.M.2    Moore, D.M.3    Ader, M.4    Bergman, R.N.5
  • 28
    • 0018127929 scopus 로고
    • Insulin receptors in human endothelial cells: Identification and characterization
    • Bar RS, Hoak JC, Peacock ML (1978) Insulin receptors in human endothelial cells: identification and characterization. J Clin Endocrinol Metab 47: 699-702
    • (1978) J Clin Endocrinol Metab , vol.47 , pp. 699-702
    • Bar, R.S.1    Hoak, J.C.2    Peacock, M.L.3
  • 29
    • 0027203144 scopus 로고
    • Altered distribution of insulin between intravascular and interstitial compartments in STZ-induced diabetic rats
    • Bryer-Ash M (1993) Altered distribution of insulin between intravascular and interstitial compartments in STZ-induced diabetic rats. Diabetes 42: 1528-1535
    • (1993) Diabetes , vol.42 , pp. 1528-1535
    • Bryer-Ash, M.1
  • 30
    • 0027475912 scopus 로고
    • Effect of hyperglycemia per se on glucose turnover rates in patients with insulin-dependent diabetes
    • Hother-Nielsen O, Vaag A, Skott P, Beck-Nielsen H (1993) Effect of hyperglycemia per se on glucose turnover rates in patients with insulin-dependent diabetes. Metabolism 42: 86-93
    • (1993) Metabolism , vol.42 , pp. 86-93
    • Hother-Nielsen, O.1    Vaag, A.2    Skott, P.3    Beck-Nielsen, H.4
  • 31
    • 0029819733 scopus 로고    scopus 로고
    • Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus
    • Makimattila S, Virkamaki A, Groop PH et al. (1996) Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus. Circulation 94: 1276-1282
    • (1996) Circulation , vol.94 , pp. 1276-1282
    • Makimattila, S.1    Virkamaki, A.2    Groop, P.H.3
  • 34
    • 0022361971 scopus 로고
    • Assessment of insulin sensitivity in vivo
    • Bergman RN, Finegood DT, Ader M (1985) Assessment of insulin sensitivity in vivo. Endocr Rev 6: 45-86
    • (1985) Endocr Rev , vol.6 , pp. 45-86
    • Bergman, R.N.1    Finegood, D.T.2    Ader, M.3
  • 35
    • 0021419369 scopus 로고
    • Hepatic extraction of exogenous insulin in depancreatized conscious dogs
    • Ishida T, Chap Z, Chou J et al. (1984) Hepatic extraction of exogenous insulin in depancreatized conscious dogs. Am J Physiol 246: E369-E379
    • (1984) Am J Physiol , vol.246
    • Ishida, T.1    Chap, Z.2    Chou, J.3
  • 36
    • 0020724747 scopus 로고
    • Comparison of hepatic extraction of insulin and glucagon in conscious and anesthetized dogs
    • Ishida T, Lewis RM, Hartley CJ, Entman ML, Field JB (1983) Comparison of hepatic extraction of insulin and glucagon in conscious and anesthetized dogs. Endocrinology 112: 1098-1109
    • (1983) Endocrinology , vol.112 , pp. 1098-1109
    • Ishida, T.1    Lewis, R.M.2    Hartley, C.J.3    Entman, M.L.4    Field, J.B.5
  • 37
    • 0025125773 scopus 로고
    • In vivo relationship between insulin clearance and action in healthy subjects and IDDM patients
    • Nijs HGT, Radder JK, Frolich M, Krans HMJ (1990) In vivo relationship between insulin clearance and action in healthy subjects and IDDM patients. Diabetes 39: 333-339
    • (1990) Diabetes , vol.39 , pp. 333-339
    • Nijs, H.G.T.1    Radder, J.K.2    Frolich, M.3    Krans, H.M.J.4
  • 38
    • 0000977149 scopus 로고
    • Quantitative aspects of reaction between insulin and insulin-binding antibody
    • Berson SA, Yalow RS (1959) Quantitative aspects of reaction between insulin and insulin-binding antibody. J Clin Invest 38: 1996-2016
    • (1959) J Clin Invest , vol.38 , pp. 1996-2016
    • Berson, S.A.1    Yalow, R.S.2
  • 39
    • 0018862484 scopus 로고
    • Chemically induced (streptozotocin-alloxan) diabetes mellitus in the dog
    • Black HE, Rosenblum IY, Capen CC (1980) Chemically induced (streptozotocin-alloxan) diabetes mellitus in the dog. Am J Pathol 98: 295-310
    • (1980) Am J Pathol , vol.98 , pp. 295-310
    • Black, H.E.1    Rosenblum, I.Y.2    Capen, C.C.3
  • 40
    • 0023253280 scopus 로고
    • Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes: Prevention by aldose reductase inhibitors and castration
    • Williamson JR, Chang K, Tilton RG et al. (1987) Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes: prevention by aldose reductase inhibitors and castration. Diabetes 36: 813-821
    • (1987) Diabetes , vol.36 , pp. 813-821
    • Williamson, J.R.1    Chang, K.2    Tilton, R.G.3


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