Thrombopoietin: Its role in platelet disorders and as a new drug in clinical medicine

Bailliere's Clinical Haematology

Volumn 11, Issue 2, 1998, Pages 427-445

  Von dem Borne, A E G Kr ^a   Folman, C ^a   Linthorst, G E ^a   Porcelijn, L ^a   Van den Oudenrijn, ^a   Van der Schoot, E ^a   De Haas, M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Assay; Myeloproliferative disorders; Therapy; Thrombocytopenia; Thrombocytosis; Thrombopoietin

Indexed keywords

MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; RECOMBINANT THROMBOPOIETIN; THROMBOPOIETIN;

BABOON; BONE MARROW; BONE MARROW CANCER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG HALF LIFE; HUMAN; MAJOR CLINICAL STUDY; MOLECULAR CLONING; MULTICENTER STUDY; MYELOPROLIFERATIVE DISORDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; STEM CELL TRANSPLANTATION; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTE COUNT; THROMBOCYTE DISORDER; THROMBOCYTHEMIA; THROMBOCYTOPENIA; THROMBOCYTOSIS; THROMBOEMBOLISM;

EID: 0032446103     PISSN: 09503536     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0950-3536(98)80059-0     Document Type: Review

References (66)

1. Basser RL Rasko JEJ Clarke K Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer Lancet 348 1996 1279 1281
2. Basser RL Rasko JE Clarke K Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer Blood 89 1997 3118 3128
3. Bertolini F Battaglia M Pedrazzoli P Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progenitor cell transplant recipients Blood 89 1997 2679 2688
4. (abstract) Bloedow D Vadhan-Raj S Paton V Pharmacokinetics of recombinant human thrombopoietin (rhTPO) after intravenous administration in cancer patients Blood 88 supplement 1 1996 351a
5. Bouscary D Preudhomme C Ribrag V Prognostic value of c-mpl expression in myelodysplastic syndromes Leukemia 9 1995 783 788
6. Bouscary D Prudhomme C Quesnel B c- mpl expression in hematologic disorders Leukemia and Lymphoma 17 1995 19 26
7. Briere J Kiladjian JJ Peynaud-Debayle E Megakaryocytes and platelets in myeloproliferative disorders (review) Baillières Clinical Haematology 10 1997 65 88
8. Cerutti A Custodi P Duranti M Thrombopoietin levels in patients with primary and reactive thrombocytosis British Journal of Haematology 99 1997 281 284
9. (abstract) Chang M Fielder PJ Fernandez G Thrombopoietin (TPO) uptake within the spleen is primarily responsible for lowering circulating TPO levels in immune thrombocytopenic hosts Blood 88 supplement 1 1996 468a
10. Cwirla SE Balasubramanian P Duffin DJ Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine Science 276 1997 1696 1699
11. Dale DC Nichol JL Rich DA Chronic thrombocytopenia is induced in dogs by development of cross-reacting antibodies to the MpL ligand Blood 90 1997 3456 3461
12. Daw NC Arnold JT Abushullaih BA A single intravenous dose of murine megakaryocyte growth and development factor potently stimulates platelet production, challenging the necessity for daily administration Blood 91 1998 466 474
13. (abstract) Debili N Le Couedic JP Ternisien C Autonomous growth of megakaryocyte progenitors in essential thrombocythemia is is not due to a mutation of C-MPL Blood 88 supplement 1 1996 98a
14. Emmons RVB Reid DM Cohen RL Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction Blood 87 1996 4068 4071
15. Fanucchi M Glaspy J Crawford J Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer [see comments] New England Journal of Medicine 336 1997 404 409
16. Folman CC von dem Borne AEGK Rensink IHJAM Sensitive measurement of thrombopoietin by a monoclonal antibody based sandwich enzyme-linked immunosorbent assay Thrombosis and Haemostasis 78 1997 1262 1267
17. + progenitor cells from bone marrow and G-CSF-mobilized peripheral blood Experimental Hematology 25 1997 1125 1139
18. Gordon MS McCaskill-Stevens WJ Battiato LA A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy Blood 87 1996 3615 3624
19. Harker LA Hunt P Marzec UM Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates Blood 87 1996 1833 1844
20. Harker LA Marzec UM Hunt P Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates Blood 88 1996 511 521
21. Hirai H Shimazaki C Yamagata N Effects of thrombopoietin (c- mpl ligand) on growth of blast cells from patients with transient abnormal myelopoiesis and acute myeloblastic leukemia European Journal of Haematology 59 1997 38 46
22. Hiyoyama K Wada H Shimura M Increased serum levels of thrombopoietin in patients with thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, or disseminated intravascular coagulation Blood Coagulation and Fibrinolysis 8 1997 345 349
23. Horikawa Y Matsumura I Hashimoto K Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia Blood 90 1997 4031 4038
24. Isaacs C Robert NJ Bailey FA Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin Journal of Clinical Oncology 15 1997 3368 3377
25. El-Kassar N Hetet G Briere J Grandchamp B Clonality analysis of hematopoiesis in essential thrombocythemia: advantages of studying T lymphocytes and platelets Blood 89 1997 128 134
26. Kiladjian JJ Elkassar N Hetet G Study of the thrombopoietin receptor in essential thrombocythemia Leukemia 11 1997 1821 1826
27. Kimura T Kaburaki H Miyamoto S Discovery of a novel thrombopoietin mimic agonist peptide Journal of Biochemistry 122 1997 1046 1051
28. Komura-Naito E Matsumura T Sawada T Thrombopoietin in patients with hepatoblastoma (letter) Blood 90 1997 2849 2850
29. (abstract) Kondo T Okabe M Sanada M Identification of TPO gene mutation in familial essential thrombocythemia Blood 90 supplement 1 1997 54a
30. Kosugi S Kurata Y Tomiyama Y Circulating thrombopoietin level in chronic immune thrombocytopenic purpura British Journal of Haematology 93 1996 704 706
31. Kuter DJ Rosenberg RD The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit Blood 85 1995 2720 2730
32. Li Y Hetet G Kiladjian JJ Proto-oncogene c- mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders British Journal of Haematology 92 1996 60 66
33. (abstract) Linthorst GE Levi M de Jonge E Increased plasma Tpo levels in septic patients with DIC Blood 90 supplement 1 1997 86b
34. McCarty JM Sprugel KH Fox NE Murine thrombopoietin mRNA levels are modulated by platelet count Blood 86 1995 3668 3675
35. (abstract) Martin JM Gandhi YK Jackson WR Dessypris EN Hypersensitivity of polycythemia vera megakaryocytic progenitors to thrombopoietin Blood 88 supplement 1 1996 94a
36. Matsumura I Kanakura Y Kato T Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin Blood 86 1995 703 709
37. Matsumura I Kanakura Y Ikeda H Coexpression of thrombopoietin and c-mpl genes in human acute myeloblastic leukemia cells Leukemia 10 1996 91 94
38. Michiels JJ Juvonen E Proposal for revised diagnostic criteria of essential thrombocythemia and polycythemia vera by the Thrombocythemia Vera Study Group Seminars in Thrombosis and Hemostasis 23 1997 339 347
39. Moliterno AR Hankins WD Spivak JL Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera New England Journal of Medicine 338 1998 572 580
40. + cell subsets into peripheral blood and expands multilineage progenitors in bone marrow of cancer patients with normal hematopoiesis Experimental Hematology 26 1998 207 216
41. Negrin RS Stein R Doherty K Maintenance treatment of the anemia of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor and erythropoietin: evidence for in vivo synergy Blood 87 1996 4076 4081
42. Nichol JL Hokom MM Hornkohl A Megakaryocyte growth and development factor. Analysis of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia Journal of Clinical Investigation 95 1995 2973 2978
43. O'Malley CJ Rasko JEJ Basser RL Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation Blood 88 1996 3288 3298
44. Oh H Nakamura H Yokota A Serum thrombopoietin levels in cyclic thrombocytopenia (letter) Blood 87 1996 4918
45. Piacibello W Sanavio F Brizzi MF Megakaryocyte growth and development factor (MGDF)-induced acute leukemia cell proliferation and clonal growth is associated with functional c-mpl Leukemia 11 1997 531 540
46. Pitcher L Taylor K Nichol J Thrombopoietin measurement in thrombocytosis: dysregulation and lack of feedback inhibition in essential thrombocythaemia British Journal of Haematology 99 1997 929 932
47. Porcelijn L Folman CC Bossers B The diagnostic value of thrombopoietin level measurements in thrombocytopenia Thrombosis and Haemostasis 79 1998 1101 1105
48. Quentmeier H Zaborski M Graf G Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells Leukemia 10 1996 297 310
49. Rasko JE Basser RL Boyd J Multilineage mobilization of peripheral blood progenitor cells in humans following administration of PEG-rHuMGDF British Journal of Haematology 97 1997 871 880
50. Sasaki A Katoh O Kawaishi K Expression of c-Mpl and c-Mpl ligand gene in hematopoietic cells of individuals with and without myeloproliferative disorders and leukemia cell lines International Journal of Hematology 62 1995 217 223
51. Schrezenmeier H Griesshammer M Hornkohl A Thrombopoietin serum levels in patients with aplastic anaemia: correlation with platelet count and persistent elevation in remission British Journal of Haematology 100 1998 571 576
52. Shibuya K Akahori H Takahashi K Multilineage hematopoietic recovery by a single injection of pegylated recombinant human megakaryocyte growth and development factor in myelosuppressed mice Blood 91 1998 37 45
53. Silva M Richard C Benito A Expression of Bcl-x in erythroid precursors from patients with polycythemia vera New England Journal of Medicine 338 1998 564 571
54. Sungaran R Markovic B Chong BH Localization and regulation of thrombopoietin mRNa expression in human kidney, liver, bone marrow, and spleen using in situ hybridization Blood 89 1997 101 107
55. Tahara T Usuki K Sato H A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders British Journal of Haematology 93 1996 783 788
56. Takeshita A Shinjo K Izumi M Quantitative expression of thrombopoietin receptor on leukaemia cells from patients with acute myeloid leukaemia and acute lymphoblastic leukaemia British Journal of Haematology 100 1998 283 290
57. Vadhan-Raj S Murray LJ Bueso-Ramos C Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer (see comments) Annals of Internal Medicine 126 1997 673 681
58. Villeval JL Cohen-Solal K Tulliez M High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice Blood 90 1997 4369 4383
59. Wang JC Chen C Lou LH Mora M Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia Leukemia 11 1997 1827 1832
60. Westwood NB Pearson TC Diagnostic applications of haemopoietic progenitor culture techniques in polycythaemias and thrombocythaemias Leukemia and Lymphoma 22 supplement 1 1996 95 103
61. Wetzler M Baer MR Bernstein SH Expression of c-mpl mRNA, the receptor for thrombopoietin, in acute myeloid leukemia blasts identifies a group of patients with poor response to intensive chemotherapy Journal of Clinical Oncology 15 1997 2262 2268
62. Wiestner A Schlemper RJ van der Maas APC Skoda RC An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia Nature Genetics 18 1998 49 52
63. Yan L Elkassar N Gardin C Briere J Clonality assays and megakaryocyte culture techniques in essential thrombocythemia (review) Leukemia and Lymphoma 22 supplement 1 1996 31 40
64. Yanagida M Ide Y Imai A The role of transforming growth factor-beta in PEG-rHuMGDF-induced reversible myelofibrosis in rats British Journal of Haematology 99 1997 739 745
65. (abstract) Young G Loechelt B Luban NLC Nichol J Thrombopoietin levels in children with HIV-associated thrombocytopenia Blood 90 supplement 1 1997 142a
66. Zwierzina H Rollinger-Holzinger I Nuessler V Endogenous serum thrombopoietin concentrations in patients with myelodysplastic syndromes Leukemia 12 1998 59 64