-
1
-
-
0029914693
-
Phase I and pharmacology study of intoplicine (RP 60475; NSC 645008), novel topoisomerase I and II inhibitor, in cancer patients
-
Abigerges D, Armand JP, Chabot GG, Bruno R, Bissery MC, Bayssas M, Klink-Alakl M, Clavel M and Catimel G (1996) Phase I and pharmacology study of intoplicine (RP 60475; NSC 645008), novel topoisomerase I and II inhibitor, in cancer patients. Anticancer Drugs 7: 166-74.
-
(1996)
Anticancer Drugs
, vol.7
, pp. 166-174
-
-
Abigerges, D.1
Armand, J.P.2
Chabot, G.G.3
Bruno, R.4
Bissery, M.C.5
Bayssas, M.6
Klink-Alakl, M.7
Clavel, M.8
Catimel, G.9
-
2
-
-
0023395222
-
Characterization of a mammalian mutant with camptothecin resistant DNA topoisomerase I
-
Andoh T, Ishii K, Suzuki Y, Ikegami Y, Kuzunoki Y, Takemoto Y and Okada K (1987) Characterization of a mammalian mutant with camptothecin resistant DNA topoisomerase I. Proc Natl Acad Sci USA 84: 5565-69.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 5565-5569
-
-
Andoh, T.1
Ishii, K.2
Suzuki, Y.3
Ikegami, Y.4
Kuzunoki, Y.5
Takemoto, Y.6
Okada, K.7
-
3
-
-
0027129071
-
Gene expression-dialogue with the cell cycle
-
Andrews BJ (1992) Gene expression-dialogue with the cell cycle. Nature 355: 393-1
-
(1992)
Nature
, vol.355
, pp. 393-401
-
-
Andrews, B.J.1
-
4
-
-
0025236684
-
Design of DNAintercalators to overcome topoisomerase II-mediated multidrug resistance
-
Baguley BC, Holdway KM and Fray LM (1990) Design of DNAintercalators to overcome topoisomerase II-mediated multidrug resistance. J Natl Cancer Inst 82: 398-302.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 398-302
-
-
Baguley, B.C.1
Holdway, K.M.2
Fray, L.M.3
-
5
-
-
0028795337
-
Cell cycle analysis of amount and distribution of nuclear DNA topoisomerase I as determined by fluorescence digital imaging microscopy
-
Baker SD, Wadkins RM, Stewart CF, Beck WT and Danks MK (1995) Cell cycle analysis of amount and distribution of nuclear DNA topoisomerase I as determined by fluorescence digital imaging microscopy. Cytometry 19: 134-45.
-
(1995)
Cytometry
, vol.19
, pp. 134-145
-
-
Baker, S.D.1
Wadkins, R.M.2
Stewart, C.F.3
Beck, W.T.4
Danks, M.K.5
-
7
-
-
0021173495
-
Cellular and molecular effects of Adriamycin on dividing and non dividing cells
-
Barronco SC (1984) Cellular and molecular effects of Adriamycin on dividing and non dividing cells. Pharmac Ther 24: 303-319.
-
(1984)
Pharmac Ther
, vol.24
, pp. 303-319
-
-
Barronco, S.C.1
-
8
-
-
0023205811
-
The cell biology of multiple drug resistance
-
Beck WT (1987) The cell biology of multiple drug resistance. Biochem Pharmacol 36: 2879-88.
-
(1987)
Biochem Pharmacol
, vol.36
, pp. 2879-2888
-
-
Beck, W.T.1
-
9
-
-
0026210179
-
Mechanisms of resistance to drugs that inhibit DNA topoisomerases
-
Beck WT and Danks MK (1991) Mechanisms of resistance to drugs that inhibit DNA topoisomerases. Semin Cancer Biol 2: 235-44.
-
(1991)
Semin Cancer Biol
, vol.2
, pp. 235-244
-
-
Beck, W.T.1
Danks, M.K.2
-
10
-
-
0023201236
-
Pharmacological molecular and cytogenetic analysis of 'atypical' multidrug-resistant human leukemic lines
-
Beck WY Cirtain MC, Danks MK, Felsted RL, Safa AR, Wolverton JS, Suttle DP and Trent JM (1987) Pharmacological molecular and cytogenetic analysis of 'atypical' multidrug-resistant human leukemic lines. Cancer Res 47: 5455-60.
-
(1987)
Cancer Res
, vol.47
, pp. 5455-5460
-
-
Beck, W.Y.1
Cirtain, M.C.2
Danks, M.K.3
Felsted, R.L.4
Safa, A.R.5
Wolverton, J.S.6
Suttle, D.P.7
Trent, J.M.8
-
11
-
-
0029072716
-
Camptothecin induction of a time- And concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity
-
Beidler DR and Cheng YC (1995) Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity. Mol Pharmacol 47: 907-14.
-
(1995)
Mol Pharmacol
, vol.47
, pp. 907-914
-
-
Beidler, D.R.1
Cheng, Y.C.2
-
12
-
-
0030481076
-
Topoisomerase I inhibition by the camptothecin analog Gil47211C. from the laboratory to the clinic
-
Besterman JM (1996) Topoisomerase I inhibition by the camptothecin analog Gil47211C. From the laboratory to the clinic. Ann N Y Acad Sci 803: 202-9.
-
(1996)
Ann N Y Acad Sci
, vol.803
, pp. 202-209
-
-
Besterman, J.M.1
-
13
-
-
0030031184
-
Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I
-
Boege F, Straub T, Kehr A, Boesenberg C, Christiansen K, Andersen A, Jakob F and Kohrle J (1996) Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. J Biol Chem 271: 2262-70.
-
(1996)
J Biol Chem
, vol.271
, pp. 2262-2270
-
-
Boege, F.1
Straub, T.2
Kehr, A.3
Boesenberg, C.4
Christiansen, K.5
Andersen, A.6
Jakob, F.7
Kohrle, J.8
-
14
-
-
0029922970
-
Elevations of DNA topoisomerase I catalytic activity and immunoprotein in human malignancies
-
Bronstein IB, Vorobyev S, Timofeev A, Jolies CJ, Alder SL and Holden JA (1996) Elevations of DNA topoisomerase I catalytic activity and immunoprotein in human malignancies. One Res 8: 17-25.
-
(1996)
One Res
, vol.8
, pp. 17-25
-
-
Bronstein, I.B.1
Vorobyev, S.2
Timofeev, A.3
Jolies, C.J.4
Alder, S.L.5
Holden, J.A.6
-
15
-
-
0029883835
-
RNA synthesis inhibitors alter the subnuclear distribution of DNA topoisomerase I
-
Buckwalter CA, Lin AH and Tanizawa A et al. (1996) RNA synthesis inhibitors alter the subnuclear distribution of DNA topoisomerase I. Cancer Res 6: 1674-81.
-
(1996)
Cancer Res
, vol.6
, pp. 1674-1681
-
-
Buckwalter, C.A.1
Lin, A.H.2
Tanizawa, A.3
-
16
-
-
0027201885
-
Preferential binding of carboxylate form of camptothecin by human serum albumin
-
Burke TG and Mi Z (1993) Preferential binding of carboxylate form of camptothecin by human serum albumin. Analytical Biochem 21: 285-87.
-
(1993)
Analytical Biochem
, vol.21
, pp. 285-287
-
-
Burke, T.G.1
Mi, Z.2
-
17
-
-
0028012774
-
The structural basis of camptothecin interactions with human serum albumin: Impact on drug stability
-
Burke TG and Mi Z (1994) The structural basis of camptothecin interactions with human serum albumin: Impact on drug stability. JMedChem37:401-6.
-
(1994)
JMedChem
, vol.37
, pp. 401-406
-
-
Burke, T.G.1
Mi, Z.2
-
18
-
-
0030636777
-
Comparative molecular field analysis and molecular modeling studies of 20-(S)-camptothecin analogs as inhibitors of DNA topoisomerase I and anticancer/antitumor agents
-
Carrigan SW, Fox PC, Wall ME, Wani MC and Bowen JP (1997) Comparative molecular field analysis and molecular modeling studies of 20-(S)-camptothecin analogs as inhibitors of DNA topoisomerase I and anticancer/antitumor agents. J Comput Aided Mol Des 11: 71-8.
-
(1997)
J Comput Aided Mol Des
, vol.11
, pp. 71-78
-
-
Carrigan, S.W.1
Fox, P.C.2
Wall, M.E.3
Wani, M.C.4
Bowen, J.P.5
-
19
-
-
0019888076
-
DNA is linked to the rat liver nicking-closing enzyme by a phosphodiester bond to tyrosine
-
Champoux JJ (1981) DNA is linked to the rat liver nicking-closing enzyme by a phosphodiester bond to tyrosine. J Biol Chem 256: 4805-09.
-
(1981)
J Biol Chem
, vol.256
, pp. 4805-4809
-
-
Champoux, J.J.1
-
20
-
-
0026339352
-
Camptothecin overcomes MDRl-mediated resistance in human KB carcinoma cells
-
Chen AY, Yu C, Potmesil M, Wall ME, Wani MC and Liu LF (1991) Camptothecin overcomes MDRl-mediated resistance in human KB carcinoma cells. Cancer Res 51: 6039-6044.
-
(1991)
Cancer Res
, vol.51
, pp. 6039-6044
-
-
Chen, A.Y.1
Yu C2
Potmesil, M.3
Wall, M.E.4
Wani, M.C.5
Liu, L.F.6
-
21
-
-
0027411980
-
A new mammalian DNA topoisomerase I poison Hoechst 33342: Cytotoxicity and drug resistance in human cell cultures
-
Chen AY, Yu C, Bodley A, Peng LF and Liu LF (1993) A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures. Cancer Res 53: 1332-37.
-
(1993)
Cancer Res
, vol.53
, pp. 1332-1337
-
-
Chen, A.Y.1
Yu C2
Bodley, A.3
Peng, L.F.4
Liu, L.F.5
-
22
-
-
0027345632
-
Function and regulation of the human multidrug resistance gene
-
Chin KV, Pastan I and Gottesman MM (1993) Function and regulation of the human multidrug resistance gene. Adv. Cancer Res 60: 157-80.
-
(1993)
Adv. Cancer Res
, vol.60
, pp. 157-180
-
-
Chin, K.V.1
Pastan, I.2
Gottesman, M.M.3
-
23
-
-
0026555717
-
Modulation of activity of the promoter of the human MDR1 gene by ras and p53
-
Chin KV, Ueda K, Pastan I and Gottesman MM (1992) Modulation of activity of the promoter of the human MDR1 gene by ras and p53. Science 255: 459-62.
-
(1992)
Science
, vol.255
, pp. 459-462
-
-
Chin, K.V.1
Ueda, K.2
Pastan, I.3
Gottesman, M.M.4
-
24
-
-
0027167527
-
Cellular models for multiple drug resistance in cancer
-
Clynes M (1993) Cellular models for multiple drug resistance in cancer. In Vitro Cell. Dev Biol 29A: 171-79.
-
(1993)
In Vitro Cell. Dev Biol
, vol.29 A
, pp. 171-179
-
-
Clynes, M.1
-
25
-
-
0025115237
-
Recent developments in research on multiple drug-resistance in cancer cells
-
Clynes M, Redmond A and Heenan M (1990) Recent developments in research on multiple drug-resistance in cancer cells. Cancer J 3: 34-39.
-
(1990)
Cancer J
, vol.3
, pp. 34-39
-
-
Clynes, M.1
Redmond, A.2
Heenan, M.3
-
26
-
-
0030980443
-
Analysis of expression and function of topoisomerase I and II during meiosis in male mice
-
Cobb J, Reddy RK, Park C and Handel MA (1997) Analysis of expression and function of topoisomerase I and II during meiosis in male mice. Mol Reprod Develop 46: 489-98.
-
(1997)
Mol Reprod Develop
, vol.46
, pp. 489-498
-
-
Cobb, J.1
Reddy, R.K.2
Park, C.3
Handel, M.A.4
-
28
-
-
0030580063
-
Development of anthracenyl-amino acid conjugates as topoisomerase I and II inhibitors that circumvent drug resistance
-
Cummings J, Macpherson JS, Meikle I and Smyth JF (1996) Development of anthracenyl-amino acid conjugates as topoisomerase I and II inhibitors that circumvent drug resistance. Biochem Pharmacol 52: 979-90.
-
(1996)
Biochem Pharmacol
, vol.52
, pp. 979-990
-
-
Cummings, J.1
Macpherson, J.S.2
Meikle, I.3
Smyth, J.F.4
-
29
-
-
0343703236
-
A phase I trial of 9-aminocamptothecin (9-AC) in adult patients with solid tumors
-
Dahut W, Brillhart N, Takimoto C, Allegra C, Hamilton JM, Sorensen JM, Arbuck S, Chen A and Grem J (1994) A phase I trial of 9-aminocamptothecin (9-AC) in adult patients with solid tumors. Proc Am Soc Clin Oncol 13: A345.
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
-
-
Dahut, W.1
Brillhart, N.2
Takimoto, C.3
Allegra, C.4
Hamilton, J.M.5
Sorensen, J.M.6
Arbuck, S.7
Chen, A.8
Grem, J.9
-
30
-
-
0029862963
-
Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan
-
Danks MK, Garret KE and Marion RC et al. (1996) Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan. Cancer Res 56: 1664-73.
-
(1996)
Cancer Res
, vol.56
, pp. 1664-1673
-
-
Danks, M.K.1
Garret, K.E.2
Marion, R.C.3
-
31
-
-
0024853052
-
Topoisomerase-targeting antitumor-drugs
-
D'arpa P and Liu FL (1989) Topoisomerase-targeting antitumor-drugs. Biochim Biophis Acta 989: 163-77.
-
(1989)
Biochim Biophis Acta
, vol.989
, pp. 163-177
-
-
D'Arpa, P.1
Liu, F.L.2
-
32
-
-
0030968181
-
Synthesis and antitumor properties of N-[2(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: A new class of putative topoisomerase inhibitors
-
Deady LW, Kaye AJ, Finlay GJ, Baguley BC and Denny WA (1997) Synthesis and antitumor properties of N-[2(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors. J Med Chem 40: 2040-6.
-
(1997)
J Med Chem
, vol.40
, pp. 2040-2046
-
-
Deady, L.W.1
Kaye, A.J.2
Finlay, G.J.3
Baguley, B.C.4
Denny, W.A.5
-
33
-
-
0023693947
-
Multifactorialresistance to Adriamycin: Relationship of DNA repair, glutathione transferase activity drug efflux, and P-glycoprotein in cloned cell lines of Adriamycin-sensitive and resistant P388 leukemia
-
Deffie AM, Alam T, Seneviratne C, Beenken SW, Batra JK, SheaTC, Henner WD and Geldenberg GJ (1988) Multifactorialresistance to Adriamycin: relationship of DNA repair, glutathione transferase activity drug efflux, and P-glycoprotein in cloned cell lines of Adriamycin-sensitive and resistant P388 leukemia. Cancer Res 48: 3595-602.
-
(1988)
Cancer Res
, vol.48
, pp. 3595-3602
-
-
Deffie, A.M.1
Alam, T.2
Seneviratne, C.3
Beenken, S.W.4
Batra, J.K.5
Shea, T.C.6
Henner, W.D.7
Geldenberg, G.J.8
-
34
-
-
0024329881
-
The biochemistry of P-glycoproteinmediated multridrug resistance
-
Endicott JA and Ling V (1989) The biochemistry of P-glycoproteinmediated multridrug resistance Annu Rev Biochem 58: 351-375.
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 351-375
-
-
Endicott, J.A.1
Ling, V.2
-
35
-
-
0024229066
-
Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin
-
Eng WK, Faucette L, Johnson RK and Sternglanz R (1988) Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol Pharmacol 34: 755-60.
-
(1988)
Mol Pharmacol
, vol.34
, pp. 755-760
-
-
Eng, W.K.1
Faucette, L.2
Johnson, R.K.3
Sternglanz, R.4
-
36
-
-
0025115965
-
Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content
-
Eng WK, McCabe FL, Tan KB, Mattern MR, Hofmann GA, Woessner RD, Hertzberg RP and Johnson RK (1990) Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content. Mol Pharmacol 38: 471-80.
-
(1990)
Mol Pharmacol
, vol.38
, pp. 471-480
-
-
Eng, W.K.1
McCabe, F.L.2
Tan, K.B.3
Mattern, M.R.4
Hofmann, G.A.5
Woessner, R.D.6
Hertzberg, R.P.7
Johnson, R.K.8
-
37
-
-
33847492247
-
Reports on Topoisomerase I Inhibitors from the 7th NCI-EORTC Symposium on New Drugs in Cancer Therapy
-
EORTC (1992) Reports on Topoisomerase I Inhibitors from the 7th NCI-EORTC Symposium on New Drugs in Cancer Therapy. Amsterdam, March 17-20.
-
(1992)
Amsterdam, March
, pp. 17-20
-
-
-
38
-
-
0031054593
-
Differential toxicity of camptothecin, topotecan, and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro
-
Erickson-Miller CL, May RD, Tomaszewski JE, Osborn B, Murphy MJ, Page JG and Parchment RE (1997) Differential toxicity of camptothecin, topotecan, and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro. Can Chem Pharmacol 39: 467-72.
-
(1997)
Can Chem Pharmacol
, vol.39
, pp. 467-472
-
-
Erickson-Miller, C.L.1
May, R.D.2
Tomaszewski, J.E.3
Osborn, B.4
Murphy, M.J.5
Page, J.G.6
Parchment, R.E.7
-
39
-
-
0023792382
-
Combined modalities of resistance in etoposide-resistant human KB cell lines
-
Ferguson PJ, Fisher MH, Stephenson J, Li D-H, Zhou B-S and Cheng Y-C (1988) Combined modalities of resistance in etoposide-resistant human KB cell lines. Cancer Res 48: 5956
-
(1988)
Cancer Res
, vol.48
, pp. 5956
-
-
Ferguson, P.J.1
Fisher, M.H.2
Stephenson, J.3
Li, D.-H.4
Zhou, B.-S.5
Cheng, Y.-C.6
-
40
-
-
0042132423
-
Expression of a multidrug-resistance gene in human tumors and tissues
-
Fojo AT, Ueda K, Slamon DJ, Poplank DG, Gottesman MM and Pastan I (1987) Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 84: 265-269.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 265-269
-
-
Fojo, A.T.1
Ueda, K.2
Slamon, D.J.3
Poplank, D.G.4
Gottesman, M.M.5
Pastan, I.6
-
41
-
-
0028206027
-
Activity of 9-dimethlyaminomethyl-10hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts
-
Friedman HS, Houghton PJ, Schold SC, Keir S and Bigner DD (1994) Activity of 9-dimethlyaminomethyl-10hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol 34: 171-74.
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, pp. 171-174
-
-
Friedman, H.S.1
Houghton, P.J.2
Schold, S.C.3
Keir, S.4
Bigner, D.D.5
-
42
-
-
0030476665
-
Acquired camptothecin resistance of human breast cancer MCF-7/C4 cells with normal topoisomerase I and elevated DNA repair
-
Fujimori A, Gupta M, Hoki Y and Pommier Y (1996) Acquired camptothecin resistance of human breast cancer MCF-7/C4 cells with normal topoisomerase I and elevated DNA repair. Mol Pharmacol 50: 1472-8.
-
(1996)
Mol Pharmacol
, vol.50
, pp. 1472-1478
-
-
Fujimori, A.1
Gupta, M.2
Hoki, Y.3
Pommier, Y.4
-
43
-
-
0030068657
-
Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells
-
Fukuda M, Nishio K, Kanzawa F, Ogasawara H, Ishida T, Arioka H, Bojanowski K, Oka M and Saijo N (1996) Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells. Cancer Res 56: 789-93.
-
(1996)
Cancer Res
, vol.56
, pp. 789-793
-
-
Fukuda, M.1
Nishio, K.2
Kanzawa, F.3
Ogasawara, H.4
Ishida, T.5
Arioka, H.6
Bojanowski, K.7
Oka, M.8
Saijo, N.9
-
44
-
-
0028171012
-
TAN-1496 A, C and E, diketopiperazine antibiotics with inhibitory activity against mammalian DNA topoisomerase I
-
Funabashi Y, Horiguchi T, linuma S, Tanida S and Harada S (1994) TAN-1496 A, C and E, diketopiperazine antibiotics with inhibitory activity against mammalian DNA topoisomerase I. J Antibiot47: 1202-18.
-
(1994)
J Antibiot
, vol.47
, pp. 1202-1218
-
-
Funabashi, Y.1
Horiguchi, T.2
Linuma, S.3
Tanida, S.4
Harada, S.5
-
45
-
-
0029670813
-
Effects of beta- And gammacarboline derivatives of DNA topoisomerase activities
-
Funayama Y Nishio K, Wakabayashi K, Nagao M, Shimoi K, Ohira T, Hasegawa S and Saijo N (1996) Effects of beta- and gammacarboline derivatives of DNA topoisomerase activities. Mutat Res 349: 183-91.
-
(1996)
Mutat Res
, vol.349
, pp. 183-191
-
-
Funayama, Y.1
Nishio, K.2
Wakabayashi, K.3
Nagao, M.4
Shimoi, K.5
Ohira, T.6
Hasegawa, S.7
Saijo, N.8
-
46
-
-
0019376425
-
DNA topoisomerases
-
Geliert M (1981) DNA topoisomerases. Annu Rev Biochem 50: 879-910.
-
(1981)
Annu Rev Biochem
, vol.50
, pp. 879-910
-
-
Geliert, M.1
-
47
-
-
0029954843
-
P-glycoprotein- A mediator of multidrug resistance in tumor cells
-
Germann UA (1996) P-glycoprotein- A mediator of multidrug resistance in tumor cells. Eur J Cancer 6: 927-944.
-
(1996)
Eur J Cancer
, vol.6
, pp. 927-944
-
-
Germann, U.A.1
-
48
-
-
0029928849
-
Phase I and pharmacological study of the new topoisomerase I inhibitor GI147211, using a daily x 5 intravenous administration
-
Gerrits CJ, Creemers GJ, Schellens JH, Wissel P, Planting AS, Kunka R, Selinger K, de Boer-Dennert M, Marijnen Y, Harteveld M and Verweij J (1996) Phase I and pharmacological study of the new topoisomerase I inhibitor GI147211, using a daily x 5 intravenous administration. Br J Cancer 73: 744-50.
-
(1996)
Br J Cancer
, vol.73
, pp. 744-750
-
-
Gerrits, C.J.1
Creemers, G.J.2
Schellens, J.H.3
Wissel, P.4
Planting, A.S.5
Kunka, R.6
Selinger, K.7
De Boer-Dennert, M.8
Marijnen, Y.9
Harteveld, M.10
Verweij, J.11
-
49
-
-
0024358188
-
DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts
-
Giovanella BC, Stehlin JS, Wall ME, Wani MC, Nicholas AW, Liu LF, Silber R and Potmesil M (1989) DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science 246: 1046-48.
-
(1989)
Science
, vol.246
, pp. 1046-1048
-
-
Giovanella, B.C.1
Stehlin, J.S.2
Wall, M.E.3
Wani, M.C.4
Nicholas, A.W.5
Liu, L.F.6
Silber, R.7
Potmesil, M.8
-
50
-
-
0025912553
-
Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin
-
Giovanella BC, Hinz HR, Kozielski AJ, Stehlin JS, Silber R and Potmesil M (1991) Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin. Cancer Res 51: 3052-55.
-
(1991)
Cancer Res
, vol.51
, pp. 3052-3055
-
-
Giovanella, B.C.1
Hinz, H.R.2
Kozielski, A.J.3
Stehlin, J.S.4
Silber, R.5
Potmesil, M.6
-
51
-
-
0029971854
-
Modulation of DNA topoisomerase I activity by p53
-
Gobert C, Bracco L, Rossi F, Olivier M, Tazi J, Lavelle, Larsen AK and Riou JF (1996) Modulation of DNA topoisomerase I activity by p53. Biochem 35: 5778-86.
-
(1996)
Biochem
, vol.35
, pp. 5778-5786
-
-
Gobert, C.1
Bracco, L.2
Rossi, F.3
Olivier, M.4
Tazi, J.5
Lavelle6
Larsen, A.K.7
Riou, J.F.8
-
52
-
-
0014895176
-
Preliminary pharmacologie and clinical evaluation of camptothecin sodium (NSC-100880)
-
Gottlieb JA, Guarino AM, Call JB, Oliverio VT and Block JB (1970) Preliminary pharmacologie and clinical evaluation of camptothecin sodium (NSC-100880). Cancer Chemother Reports 54: 461-70.
-
(1970)
Cancer Chemother Reports
, vol.54
, pp. 461-470
-
-
Gottlieb, J.A.1
Guarino, A.M.2
Call, J.B.3
Oliverio, V.T.4
Block, J.B.5
-
53
-
-
0026646768
-
Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer
-
Grochow LB, Rowinsky EK, Johnson R, Ludeman S, Kaufmann SH, McCabe FL, Smith BR, Hurowitz L, DeLisa A, Donehower RC and Noe DA (1992) Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer. Drug Metab Disp 20: 706-13.
-
(1992)
Drug Metab Disp
, vol.20
, pp. 706-713
-
-
Grochow, L.B.1
Rowinsky, E.K.2
Johnson, R.3
Ludeman, S.4
Kaufmann, S.H.5
McCabe, F.L.6
Smith, B.R.7
Hurowitz, L.8
Delisa, A.9
Donehower, R.C.10
Noe, D.A.11
-
54
-
-
0027238539
-
Characterization of an altered DNA catalysis of a camptothecin resistant eukaryotic topoisomerase I
-
Gromova II, Kjeldsen E, Svejstrup JQ, Aisner J, Christiansen K and Westergaard O (1993) Characterization of an altered DNA catalysis of a camptothecin resistant eukaryotic topoisomerase I. Nucleic Acid Res 21: 593-600.
-
(1993)
Nucleic Acid Res
, vol.21
, pp. 593-600
-
-
Gromova, H.1
Kjeldsen, E.2
Svejstrup, J.Q.3
Aisner, J.4
Christiansen, K.5
Westergaard, O.6
-
55
-
-
0028022585
-
Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
-
Gupta E, Lestingi TM, Mick R, Ramirez J, Yokes EE and Ratain Ml (1994) Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. Cancer Res 54: 3723-5.
-
(1994)
Cancer Res
, vol.54
, pp. 3723-3725
-
-
Gupta, E.1
Lestingi, T.M.2
Mick, R.3
Ramirez, J.4
Yokes, E.E.5
Ml, R.6
-
56
-
-
0028784873
-
Eukaryotic DNA topoisomerases mediated DNA cleavage induced by a new inhibitor: NSC 665517
-
Gupta M, Abdel-Megeed M, Hoki Y, Kohlhagen G, Paull K, and Pommier Y (1995) Eukaryotic DNA topoisomerases mediated DNA cleavage induced by a new inhibitor: NSC 665517. Mol Pharmacol 48: 658-65.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 658-665
-
-
Gupta, M.1
Abdel-Megeed, M.2
Hoki, Y.3
Kohlhagen, G.4
Paull, K.5
Pommier, Y.6
-
57
-
-
0023739308
-
Camptothecin resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I
-
Gupta RS, Gupta R, Eng B, Lock RB, Ross WE, Hertzberg RP, Caranfa MI and Johnson RK (1988) Camptothecin resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I. Cancer Res 48: 6404-10.
-
(1988)
Cancer Res
, vol.48
, pp. 6404-6410
-
-
Gupta, R.S.1
Gupta, R.2
Eng, B.3
Lock, R.B.4
Ross, W.E.5
Hertzberg, R.P.6
Caranfa, M.I.7
Johnson, R.K.8
-
58
-
-
0026512425
-
Rational design and preclinical pharmacology of drugs for reversing multidrug resistance
-
Hait WN and Aftab DT (1992) Rational design and preclinical pharmacology of drugs for reversing multidrug resistance. Biochem Pharmacol 43: 103-7.
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 103-107
-
-
Hait, W.N.1
Aftab, D.T.2
-
59
-
-
0000266944
-
Differentialexpression of DNA topoisomerases I and II during the eukaryotic cell cycle
-
Heck MMS, Hittelman WN and Earnshaw WC (1988) Differentialexpression of DNA topoisomerases I and II during the eukaryotic cell cycle. Proc Natl Acad Sci USA 85: 1086-90.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 1086-1090
-
-
Heck, M.M.S.1
Hittelman, W.N.2
Earnshaw, W.C.3
-
60
-
-
0026772298
-
Effect of p-glycoprotein expression of the accumulation and cytotoxicity of topotecan (SK&f 104864) a new camptothecin analogue
-
Hendricks CB, Rowinsky EK, Grochow LB, Donehower RC and Kaufmann SH (1992)Effect of p-glycoprotein expression of the accumulation and cytotoxicity of topotecan (SK&f 104864) a new camptothecin analogue. Cancer Res 52: 2268-70.
-
(1992)
Cancer Res
, vol.52
, pp. 2268-2270
-
-
Hendricks, C.B.1
Rowinsky, E.K.2
Grochow, L.B.3
Donehower, R.C.4
Kaufmann, S.H.5
-
61
-
-
0028357995
-
Phase I trial of low-dose continuous topotecan infusion in patients with cancer: An active and well-tolerated regimen
-
Hochster H, Liebes L, Speyer J, Sorich J, Taubes B, Oratz R, Wernz J, Chachoua A, Raphael B, Vinci RZ and Blum RH (1994) Phase I trial of low-dose continuous topotecan infusion in patients with cancer: an active and well-tolerated regimen. J Clin Oncol 12: 553-59.
-
(1994)
J Clin Oncol
, vol.12
, pp. 553-559
-
-
Hochster, H.1
Liebes, L.2
Speyer, J.3
Sorich, J.4
Taubes, B.5
Oratz, R.6
Wernz, J.7
Chachoua, A.8
Raphael, B.9
Vinci, R.Z.10
Blum, R.H.11
-
62
-
-
0030738095
-
Differential cytotoxicity of clinically important camptothecin derivatives in Pglycoprotein-overexpressing cell lines
-
Hoki Y, Fujimori A and Pommier Y (1997) Differential cytotoxicity of clinically important camptothecin derivatives in Pglycoprotein-overexpressing cell lines. Cancer Chemother Pharmacol 40: 433-8.
-
(1997)
Cancer Chemother Pharmacol
, vol.40
, pp. 433-438
-
-
Hoki, Y.1
Fujimori, A.2
Pommier, Y.3
-
64
-
-
0015692519
-
Effects of camptothecin on the breakage and repair of DNA during the cell cycle
-
Horwitz SB and Horwitz MS (1973) Effects of camptothecin on the breakage and repair of DNA during the cell cycle. Cancer Res 33: 2834-36.
-
(1973)
Cancer Res
, vol.33
, pp. 2834-2836
-
-
Horwitz, S.B.1
Horwitz, M.S.2
-
65
-
-
0026487210
-
Evaluation of 9-dimethylaminomethyl10-hydroxycamptothecin against xenografts derived from adult and chidhood solid tumors
-
Houghton PJ, Cheshire PJ, Myers I, Stewart CF, Synold TW and Oughton JA (1992) Evaluation of 9-dimethylaminomethyl10-hydroxycamptothecin against xenografts derived from adult and chidhood solid tumors. Cancer Chemother Pharmacol 31: 229-59.
-
(1992)
Cancer Chemother Pharmacol
, vol.31
, pp. 229-259
-
-
Houghton, P.J.1
Cheshire, P.J.2
Myers, I.3
Stewart, C.F.4
Synold, T.W.5
Oughton, J.A.6
-
66
-
-
0024356003
-
DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues
-
Hsiang H, Liu LF, Wall ME, Wani MC, Nicholas AW, Manikumar G, Kirschenbaum S, Silber R and Potmesil M (1989) DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. Cancer Res 49: 4385-89.
-
(1989)
Cancer Res
, vol.49
, pp. 4385-4389
-
-
Hsiang, H.1
Liu, L.F.2
Wall, M.E.3
Wani, M.C.4
Nicholas, A.W.5
Manikumar, G.6
Kirschenbaum, S.7
Silber, R.8
Potmesil, M.9
-
68
-
-
0022340594
-
Camptothecin induces protein linked DNA breaks via mammalian DNA topoisomerases
-
Hsiang YH, Herzberg R, Hecht S and Liu LF (1985) Camptothecin induces protein linked DNA breaks via mammalian DNA topoisomerases J Biol Chem 260: 14873-78.
-
(1985)
J Biol Chem
, vol.260
, pp. 14873-14878
-
-
Hsiang, Y.H.1
Herzberg, R.2
Hecht, S.3
Liu, L.F.4
-
69
-
-
0024420685
-
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
-
Hsiang YH, Lihou MG and Liu LF (1989a) Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res 49: 5077-82.
-
(1989)
Cancer Res
, vol.49
, pp. 5077-5082
-
-
Hsiang, Y.H.1
Lihou, M.G.2
Liu, L.F.3
-
70
-
-
0023927993
-
Proliferation dependent regulation of DNA topoisomerase II in cultured human cells
-
Hsiang YH, Wu HY and Liu FL (1988) Proliferation dependent regulation of DNA topoisomerase II in cultured human cells. Cancer Res 48: 3230-35.
-
(1988)
Cancer Res
, vol.48
, pp. 3230-3235
-
-
Hsiang, Y.H.1
Wu, H.Y.2
Liu, F.L.3
-
71
-
-
0028006314
-
Elevation topoisomerase I messenger RNA, protein and catalytic activity in human tumors: Demonstration of tumor-type specificity and implications for cancer chemotherapy
-
Husain I, Mohler JL, Seigler HF and Besterman JM (1994) Elevation topoisomerase I messenger RNA, protein and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. Cancer Res 54: 539-46.
-
(1994)
Cancer Res
, vol.54
, pp. 539-546
-
-
Husain, I.1
Mohler, J.L.2
Seigler, H.F.3
Besterman, J.M.4
-
72
-
-
0022538665
-
Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase α primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts
-
Hussy P, Maass G, Tümmler B, Grosse F and Schomburg U (1986) Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase α primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother 29: 1073-78.
-
(1986)
Antimicrob Agents Chemother
, vol.29
, pp. 1073-1078
-
-
Hussy, P.1
Maass, G.2
Tümmler, B.3
Grosse, F.4
Schomburg, U.5
-
73
-
-
0028832819
-
Irinotecan (CPT11) and characteristic mucosal changes in the mouse ileum and cecum (see comments)
-
Ikuno N, Soda H, Watanabe M and Oka M (1995) Irinotecan (CPT11) and characteristic mucosal changes in the mouse ileum and cecum (see comments). J Natl Cancer Inst 87: 1876-83.
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 1876-1883
-
-
Ikuno, N.1
Soda, H.2
Watanabe, M.3
Oka, M.4
-
74
-
-
0023122935
-
Mechanism of inhibition of mammalian DNA topoisomerase I by heparin
-
Ishii K, Futaki S, Uchiyama H, Nagasawa K and Andoh T (1987) Mechanism of inhibition of mammalian DNA topoisomerase I by heparin. Biochem J 241: 111-16.
-
(1987)
Biochem J
, vol.241
, pp. 111-116
-
-
Ishii, K.1
Futaki, S.2
Uchiyama, H.3
Nagasawa, K.4
Andoh, T.5
-
75
-
-
0026316262
-
Characterization of a camptothecin-resistant human DNA topoisomerase I in an in vitro system for Simian virus 40 DNA replication
-
Ishimi Y Nishizawa M and Andoh T (1991) Characterization of a camptothecin-resistant human DNA topoisomerase I in an in vitro system for Simian virus 40 DNA replication. Eur J Biochem 202: 835-39.
-
(1991)
Eur J Biochem
, vol.202
, pp. 835-839
-
-
Ishimi, Y.1
Nishizawa, M.2
Andoh, T.3
-
76
-
-
0029931599
-
Major vault protein LRP-related multidrug resistance
-
Izquierdo MA, Scheffer GL, Flens MI, Schroeijers AB, van der Valk P and Scheper RJ (1996) Major vault protein LRP-related multidrug resistance. Eur J Cancer 6: 976-84.
-
(1996)
Eur J Cancer
, vol.6
, pp. 976-984
-
-
Izquierdo, M.A.1
Scheffer, G.L.2
Flens, M.I.3
Schroeijers, A.B.4
Van Der Valk, P.5
Scheper, R.J.6
-
77
-
-
0024560495
-
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and a relation to antitumor activity
-
Jaxel C, Kohn KW, Wani MC, Wall ME and Pommier Y (1989) Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity. Cancer Res 49: 1465-69.
-
(1989)
Cancer Res
, vol.49
, pp. 1465-1469
-
-
Jaxel, C.1
Kohn, K.W.2
Wani, M.C.3
Wall, M.E.4
Pommier, Y.5
-
78
-
-
0344211563
-
-
Potmesil M and Kohn KW (eds) DNA topoisomerases in cancer. Oxford University Press, New York
-
Jaxel C, Capranico G, Wasserman K, Kerrigan D, Kohn KW and Pommier Y (1991) DNA sequence at sites of topoisomerase I cleavage induced by Camptothecin in SV40 DNA. In: Potmesil M and Kohn KW (eds) DNA topoisomerases in cancer. Oxford University Press, New York, pp. 182-195.
-
(1991)
DNA Sequence at Sites of Topoisomerase I Cleavage Induced by Camptothecin in SV40 DNA.
, pp. 182-195
-
-
Jaxel, C.1
Capranico, G.2
Wasserman, K.3
Kerrigan, D.4
Kohn, K.W.5
Pommier, Y.6
-
79
-
-
0031039517
-
In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: Preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin
-
Jensen PB, Holm B, Sorensen M, Christensen IJ and Sehested M (1997) In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin. Br J Cancer 75: 869-77.
-
(1997)
Br J Cancer
, vol.75
, pp. 869-877
-
-
Jensen, P.B.1
Holm, B.2
Sorensen, M.3
Christensen, I.J.4
Sehested, M.5
-
80
-
-
0000482574
-
Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20ql2-13.2
-
Juan CC, Hwang J, Liu AA, Whang-Peng J, Knutsen T, Huebner K, Croce CM, Zhang H, Wang JC and Liu LF (1988) Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20ql2-13.2. Proc Natl Acad Sci USA 85: 8910-17.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 8910-8917
-
-
Juan, C.C.1
Hwang, J.2
Liu, A.A.3
Whang-Peng, J.4
Knutsen, T.5
Huebner, K.6
Croce, C.M.7
Zhang, H.8
Wang, J.C.9
Liu, L.F.10
-
82
-
-
0027501999
-
Phase I study of topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia
-
Kantaijian HM, Beran M, Ellis A, Zwelling L, O'Brien S, Cazenave L, Koller C, Rios MB, Plunkett W, Keating Ml and Estey EH (1993) Phase I study of topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia. Blood 81: 1146-51.
-
(1993)
Blood
, vol.81
, pp. 1146-1151
-
-
Kantaijian, H.M.1
Beran, M.2
Ellis, A.3
Zwelling, L.4
O'Brien, S.5
Cazenave, L.6
Koller, C.7
Rios, M.B.8
Plunkett, W.9
Ml, K.10
Estey, E.H.11
-
83
-
-
0019991171
-
A fluorescence enhancement assay for cellular DNA damage
-
Kanter PM and Schwartz HS (1982) A fluorescence enhancement assay for cellular DNA damage. Mol Pharmacol 22: 145-51.
-
(1982)
Mol Pharmacol
, vol.22
, pp. 145-151
-
-
Kanter, P.M.1
Schwartz, H.S.2
-
84
-
-
0025084410
-
Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small-cell lung cancer: Characterization and mechanism of resistance
-
Kanzawa F, Sugimoto Y and Minato K, et al. (1990) Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small-cell lung cancer: Characterization and mechanism of resistance. Cancer Res 50: 5919-24.
-
(1990)
Cancer Res
, vol.50
, pp. 5919-5924
-
-
Kanzawa, F.1
Sugimoto, Y.2
Minato, K.3
-
85
-
-
0000883719
-
Measurement of strand breaks and cross links by alkaline elution
-
Friedberg EC and Hanawalt PC (eds) Marcel Dekker, Inc. New York
-
Khon KW, Ewig RAG, Erickson LC and Zwelling LA (1981)Measurement of strand breaks and cross links by alkaline elution. In: Friedberg EC and Hanawalt PC (eds) DNA repair: a laboratory manual of research procedures, (pp. 379-401) Marcel Dekker, Inc. New York.
-
(1981)
DNA Repair: a Laboratory Manual of Research Procedures
, pp. 379-401
-
-
Khon, K.W.1
Ewig, R.A.G.2
Erickson, L.C.3
Zwelling, L.A.4
-
86
-
-
0001325629
-
Substituted 2, S'-Bi-lH-benzimidazoles: Topoisomerase I inhibition and cytotoxicity
-
Kirn JS, Gatto B, Yu C, Liu A, Liu LF, and La Voie EJ (1996) Substituted 2, S'-Bi-lH-benzimidazoles: topoisomerase I inhibition and cytotoxicity. J Med Chem 39: 992-8.
-
(1996)
J Med Chem
, vol.39
, pp. 992-998
-
-
Kirn, J.S.1
Gatto, B.2
Yu C3
Liu, A.4
Liu, L.F.5
La Voie, E.J.6
-
87
-
-
0026099599
-
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: Inhibition of topoisomerase I and antitumor activity
-
Kingsbury WD, Boehm JC, Jakas DR, Holden KG, Hecht SM, Gallagher G, Caranfa MJ, McCabe FL, Faucette LF, Johnson RK and Hertzberg RP (1991) Synthesis of water-soluble (aminoalkyl)camptothecin analogues: Inhibition of topoisomerase I and antitumor activity. J Med Chem 34: 98-107.
-
(1991)
J Med Chem
, vol.34
, pp. 98-107
-
-
Kingsbury, W.D.1
Boehm, J.C.2
Jakas, D.R.3
Holden, K.G.4
Hecht, S.M.5
Gallagher, G.6
Caranfa, M.J.7
McCabe, F.L.8
Faucette, L.F.9
Johnson, R.K.10
Hertzberg, R.P.11
-
88
-
-
0023873933
-
Characterization of a camptothec in resistant human DNA topoisomerase I
-
Kjeldsen E, Bonven BJ, Andoh T, Ishii K, Okada K, Bolund L and Westergaard O (1988) Characterization of a camptothec in resistant human DNA topoisomerase I. J Biol Chem 263: 3912-16.
-
(1988)
J Biol Chem
, vol.263
, pp. 3912-3916
-
-
Kjeldsen, E.1
Bonven, B.J.2
Andoh, T.3
Ishii, K.4
Okada, K.5
Bolund, L.6
Westergaard, O.7
-
89
-
-
0027381388
-
Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants
-
Knab AM, Fertala J and Bjornsti MA (1993) Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants. J Biol Chem 268: 22322-30.
-
(1993)
J Biol Chem
, vol.268
, pp. 22322-22330
-
-
Knab, A.M.1
Fertala, J.2
Bjornsti, M.A.3
-
90
-
-
0026497895
-
Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line
-
Kubota N, Kanzawa F, Nishio K, Takeda Y, Ohmori T, Fujiwara Y Terashima Y and Saijo N (1992) Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line. Biochem Biophys Res Commun 188: 571-7.
-
(1992)
Biochem Biophys Res Commun
, vol.188
, pp. 571-577
-
-
Kubota, N.1
Kanzawa, F.2
Nishio, K.3
Takeda, Y.4
Ohmori, T.5
Fujiwara, Y.6
Terashima, Y.7
Saijo, N.8
-
91
-
-
0025793634
-
Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line. Decrease of topoisomerase II and increase of both topoisomerase I and the acidic glutathione S transferase
-
Lefevre D, Riou J-F and Ahomadegbe JC et al. (1991) Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line. Decrease of topoisomerase II and increase of both topoisomerase I and the acidic glutathione S transferase. Biochem Pharmacol 41: 1967-79.
-
(1991)
Biochem Pharmacol
, vol.41
, pp. 1967-1979
-
-
Lefevre, D.1
Riou, J.-F.2
Ahomadegbe, J.C.3
-
92
-
-
0015451631
-
Action of camptothecin on mammalian cells in culture
-
Li HL, Fraser TJ, Olin EJ and Bhuyan BK (1972) Action of camptothecin on mammalian cells in culture. Cancer Res 32: 2643-50.
-
(1972)
Cancer Res
, vol.32
, pp. 2643-2650
-
-
Li, H.L.1
Fraser, T.J.2
Olin, E.J.3
Bhuyan, B.K.4
-
93
-
-
0029586590
-
Response of purified mitochondrial DNA topoisomerase I from bovine liver to camptothecin and mAMSA
-
Lin JH and Castora FJ (1995) Response of purified mitochondrial DNA topoisomerase I from bovine liver to camptothecin and mAMSA. Arch Biochem Biophys 324: 293-9.
-
(1995)
Arch Biochem Biophys
, vol.324
, pp. 293-299
-
-
Lin, J.H.1
Castora, F.J.2
-
94
-
-
0021012019
-
DNA topoisomerase-enzymes that catalyse thebreacking and rejoining of DNA
-
Liu LF (1983) DNA topoisomerase-enzymes that catalyse thebreacking and rejoining of DNA. Crit Rev Biochem 15: 1-24.
-
(1983)
Crit Rev Biochem
, vol.15
, pp. 1-24
-
-
Liu, L.F.1
-
95
-
-
0024316466
-
DNA topoisomerase poisons as antitumor drugs
-
Liu LF (1989) DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 58: 351-75.
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 351-375
-
-
Liu, L.F.1
-
96
-
-
33847497386
-
DNA topoisomerases in drug resistance and cancer chemotherapy
-
Oct 15-18, New York
-
Liu LF (1990) DNA topoisomerases in drug resistance and cancer chemotherapy. The third Conference on DNA Topoisomerase in therapy. Oct 15-18, New York, p. 25.
-
(1990)
The Third Conference on DNA Topoisomerase in Therapy.
, pp. 25
-
-
Liu, L.F.1
-
97
-
-
0021112878
-
Cleavage of DNA by mammalian DNA topoisomerase II
-
Liu LF, Rowe TC, Yang L, Tewey KM and Chen GL (1983) Cleavage of DNA by mammalian DNA topoisomerase II. J Biol Chem 258: 15365-70.
-
(1983)
J Biol Chem
, vol.258
, pp. 15365-15370
-
-
Liu, L.F.1
Rowe, T.C.2
Yang, L.3
Tewey, K.M.4
Chen, G.L.5
-
98
-
-
0029954845
-
Biology of the multidrug resistance-associated protein, MRP
-
Loe DW, Deeley RG and Cole SPC (1996) Biology of the multidrug resistance-associated protein, MRP. Eur J Cancer 6: 945-57.
-
(1996)
Eur J Cancer
, vol.6
, pp. 945-957
-
-
Loe, D.W.1
Deeley, R.G.2
Spc, C.3
-
99
-
-
0025946775
-
Rapid functional assay for the detection of multidrugresistant cells using the fluorescent dye rhodamine-123
-
Ludescher C, Gattringer C, Drach J, Hofmann J and Grunicke H (1991) Rapid functional assay for the detection of multidrugresistant cells using the fluorescent dye rhodamine-123. Blood 78: 1385-87.
-
(1991)
Blood
, vol.78
, pp. 1385-1387
-
-
Ludescher, C.1
Gattringer, C.2
Drach, J.3
Hofmann, J.4
Grunicke, H.5
-
100
-
-
0028787255
-
Preferential binding of human topoisomerase I to superhelical DNA
-
Madden KR, Stewart L and Champoux JJ (1995) Preferential binding of human topoisomerase I to superhelical DNA. EMBO J 14: 5399-109.
-
(1995)
EMBO J
, vol.14
, pp. 5399-6109
-
-
Madden, K.R.1
Stewart, L.2
Champoux, J.J.3
-
101
-
-
0029998477
-
Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons
-
Makhey D, Gatto B, Yu C, Liu A, Liu LF and La Voie EJ (1996) Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem 4: 781-91.
-
(1996)
Bioorg Med Chem
, vol.4
, pp. 781-791
-
-
Makhey, D.1
Gatto, B.2
Yu C3
Liu, A.4
Liu, L.F.5
La Voie, E.J.6
-
102
-
-
0026602982
-
Microculture-based chemosensitivity testing: A feasibility study camparting freshly explanted human melanoma cells with human melanoma cell lines
-
Marshall ES, Finlay GJ, Matthews JHL, Shaw JHF, Nixon J and Baguley BC (1992) Microculture-based chemosensitivity testing: a feasibility study camparting freshly explanted human melanoma cells with human melanoma cell lines. J Natl Cancer Inst84: 341-44.
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 341-344
-
-
Marshall, E.S.1
Finlay, G.J.2
Jhl, M.3
Jhf, S.4
Nixon, J.5
Baguley, B.C.6
-
103
-
-
0028862978
-
Topoisomerase I activity in squamous cell carcinoma of the head and neck
-
Masin JS, Berger SJ, Setrakian S, Stepnik DW and Berger NA (1995) Topoisomerase I activity in squamous cell carcinoma of the head and neck. Laring 105: 1191-6.
-
(1995)
Laring
, vol.105
, pp. 1191-1196
-
-
Masin, J.S.1
Berger, S.J.2
Setrakian, S.3
Stepnik, D.W.4
Berger, N.A.5
-
104
-
-
0028075751
-
Topoisomerase I and II activity in human breast, cervix, lung and colon cancer
-
McLeod HL, Douglas F, Oates M, Symonds RP, Prakash D, van der Zee AGJ, Kaye SB, Brown R and Keith WN (1994) Topoisomerase I and II activity in human breast, cervix, lung and colon cancer. Int J Cancer 59: 607-611.
-
(1994)
Int J Cancer
, vol.59
, pp. 607-611
-
-
McLeod, H.L.1
Douglas, F.2
Oates, M.3
Symonds, R.P.4
Prakash, D.5
Van Agj, D.Z.6
Kaye, S.B.7
Brown, R.8
Keith, W.N.9
-
105
-
-
0028818643
-
Identification of anthracenyl-dipeptide conjugates as novel topoisomerase I and II inhibitors and their evaluation as potential anticancer drugs
-
Meikle I, Cummings J, Macpherson JS and Smyth JF (1995) Identification of anthracenyl-dipeptide conjugates as novel topoisomerase I and II inhibitors and their evaluation as potential anticancer drugs. Anticancer Drug Des 10: 515-27.
-
(1995)
Anticancer Drug Des
, vol.10
, pp. 515-527
-
-
Meikle, I.1
Cummings, J.2
Macpherson, J.S.3
Smyth, J.F.4
-
106
-
-
0027930186
-
Differential interaction of camptothecin lactone and carboxylate forms with human blood components
-
Mi Z and Burke TG ( 1994a) Differential interaction of camptothecin lactone and carboxylate forms with human blood components. Biochemistry 33: 10325-36.
-
(1994)
Biochemistry
, vol.33
, pp. 10325-10336
-
-
Mi, Z.1
Burke, T.G.2
-
107
-
-
0028150946
-
Marked interspecies variations concerning the interaction of camptothecin with serum albumin: A frequency-domain fluorescence spectroscopic study
-
Mi Z and Burke TG (1994b) Marked interspecies variations concerning the interaction of camptothecin with serum albumin: a frequency-domain fluorescence spectroscopic study. Biochemistry 33: 12540-45.
-
(1994)
Biochemistry
, vol.33
, pp. 12540-12545
-
-
Mi, Z.1
Burke, T.G.2
-
108
-
-
0015378084
-
Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): Correlation with preclinical studies
-
Muggia FM, Creaven PJ, Hansen H, Cohen MH and Selawry OS (1972) Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): Correlation with preclinical studies. Cancer Chemother Reports 56: 515-21.
-
(1972)
Cancer Chemother Reports
, vol.56
, pp. 515-521
-
-
Muggia, F.M.1
Creaven, P.J.2
Hansen, H.3
Cohen, M.H.4
Selawry, O.S.5
-
109
-
-
0022067647
-
Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA
-
Muller MT, Pfund WP and Mehta VB et al. (1985) Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA. EMBO J 4: 1237-43.
-
(1985)
EMBO J
, vol.4
, pp. 1237-1243
-
-
Muller, M.T.1
Pfund, W.P.2
Mehta, V.B.3
-
110
-
-
0030464036
-
Camptothecin resistance related to drug-induced down-regulation of topoisomerase I and to steps occurring after the formation of protein-linked DNA breaks
-
Murren JR, Beidler DR and Cheng YC (1996) Camptothecin resistance related to drug-induced down-regulation of topoisomerase I and to steps occurring after the formation of protein-linked DNA breaks. Ann N Y Acad Sci 803: 74-92.
-
(1996)
Ann N Y Acad Sci
, vol.803
, pp. 74-92
-
-
Murren, J.R.1
Beidler, D.R.2
Cheng, Y.C.3
-
111
-
-
8044231335
-
Induction of apoptosis in multi-drug resistant (MDR) human glioblastoma cells by SN-38, a metabolite of the camptothecin derivative CPT-11
-
Nakatsu S, Kondo S, Kondo Y, Yin D, Peterson JW, Kaakaji R, Morimura T, Kikuchi H, Takeuchi J and Barnett GH (1997) Induction of apoptosis in multi-drug resistant (MDR) human glioblastoma cells by SN-38, a metabolite of the camptothecin derivative CPT-11. Cancer Chemother Pharmacol 39: 417-23.
-
(1997)
Cancer Chemother Pharmacol
, vol.39
, pp. 417-423
-
-
Nakatsu, S.1
Kondo, S.2
Kondo, Y.3
Yin, D.4
Peterson, J.W.5
Kaakaji, R.6
Morimura, T.7
Kikuchi, H.8
Takeuchi, J.9
Barnett, G.H.10
-
112
-
-
0026595541
-
Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin
-
Niimi S, Nakagawa K, Sugimoto Y Nishio K, Fujiwara Y Yokoyama S, Terashima Y and Saijo N (1992) Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin. Cancer Res 52: 328-33.
-
(1992)
Cancer Res
, vol.52
, pp. 328-333
-
-
Niimi, S.1
Nakagawa, K.2
Sugimoto, Y.3
Nishio, K.4
Fujiwara, Y.5
Yokoyama, S.6
Terashima, Y.7
Saijo, N.8
-
113
-
-
0029944106
-
Antitopoisomerase drug action and resistance
-
Nitiss JL and Beck WT (1996) Antitopoisomerase drug action and resistance. Eur J Cancer 6: 958-66.
-
(1996)
Eur J Cancer
, vol.6
, pp. 958-966
-
-
Nitiss, J.L.1
Beck, W.T.2
-
114
-
-
0025828251
-
Multidrug resistance (mdr)genes in human cancer
-
Nooter K and Herweijer H (1991) Multidrug resistance (mdr)genes in human cancer. Br J Cancer 63: 663-9.
-
(1991)
Br J Cancer
, vol.63
, pp. 663-669
-
-
Nooter, K.1
Herweijer, H.2
-
115
-
-
0025153516
-
Collateral drug sensitivity induced in CPT-11 (a novel derivative of camptothecin)resistant cell lines
-
Oguro M, Seki Y Okada K and Andoh T (1990) Collateral drug sensitivity induced in CPT-11 (a novel derivative of camptothecin)resistant cell lines. Biomed Pharmacother 44: 209-216.
-
(1990)
Biomed Pharmacother
, vol.44
, pp. 209-216
-
-
Oguro, M.1
Seki, Y.2
Okada, K.3
Andoh, T.4
-
116
-
-
0028127960
-
Cytotoxic efficacy of 9-nitrocamptothecin in the treatment of human malignant melanoma cells in vitro
-
Pantazis P, Early JA, Mendoza JT, DeJesus AR and Giovanella BC (1994a) Cytotoxic efficacy of 9-nitrocamptothecin in the treatment of human malignant melanoma cells in vitro. Cancer Res 54: 771-6.
-
(1994)
Cancer Res
, vol.54
, pp. 771-776
-
-
Pantazis, P.1
Early, J.A.2
Mendoza, J.T.3
Dejesus, A.R.4
Giovanella, B.C.5
-
117
-
-
0028032929
-
Conversion of 9-nitro-camptothecin to 9-amino-camptothecin by human blood cells in vitro (letter)
-
Pantazis P, Harris N, Mendoza J and Giovanella B (1994b) Conversion of 9-nitro-camptothecin to 9-amino-camptothecin by human blood cells in vitro (letter). Eur J Haematol 53: 246-8.
-
(1994)
Eur J Haematol
, vol.53
, pp. 246-248
-
-
Pantazis, P.1
Harris, N.2
Mendoza, J.3
Giovanella, B.4
-
118
-
-
0026694680
-
Complete inhibition of growth followed by death of human malignant melanoma cells in vitro and regression of human melanoma Xenografts in immunodeficient mice induced by camptothecin
-
Pantazis P, Hinz HR, Mendoza JT, Kozielski AJ, Williams LJ Jr, Stehlin JS Jr and Giovanella BC (1992) Complete inhibition of growth followed by death of human malignant melanoma cells in vitro and regression of human melanoma Xenografts in immunodeficient mice induced by camptothecin. Cancer Res 52: 3980-87.
-
(1992)
Cancer Res
, vol.52
, pp. 3980-3987
-
-
Pantazis, P.1
Hinz, H.R.2
Mendoza, J.T.3
Kozielski, A.J.4
Williams Jr., L.J.5
Stehlin Jr., J.S.6
Giovanella, B.C.7
-
119
-
-
0028000917
-
Development of resistance to 9-nitro-camptothecin by human leukemia U-937 cells in vitro correlates with altered sensitivities to several anticancer drugs
-
Pantazis P, Mendoza J, DeJesus A, Early J, Shaw M and Giovanella BC (1994c) Development of resistance to 9-nitro-camptothecin by human leukemia U-937 cells in vitro correlates with altered sensitivities to several anticancer drugs. Anticancer Drugs 5: 473-9.
-
(1994)
Anticancer Drugs
, vol.5
, pp. 473-479
-
-
Pantazis, P.1
Mendoza, J.2
Dejesus, A.3
Early, J.4
Shaw, M.5
Giovanella, B.C.6
-
120
-
-
0023774273
-
Enrichment and depletion of Hela topoisomerase I recognition sites among specific types of DNA elements
-
Perez-Stable C, Shen CC and Shen CKJ (1988) Enrichment and depletion of Hela topoisomerase I recognition sites among specific types of DNA elements. Nucl Acids Res 16: 7975-93.
-
(1988)
Nucl Acids Res
, vol.16
, pp. 7975-7993
-
-
Perez-Stable, C.1
Shen, C.C.2
Shen, C.K.J.3
-
121
-
-
0027721618
-
Topoisomerase I in multiple drug resistance
-
Pessina A (1993) Topoisomerase I in multiple drug resistance. Cytotechnology 12: 127-135.
-
(1993)
Cytotechnology
, vol.12
, pp. 127-135
-
-
Pessina, A.1
-
122
-
-
0025297468
-
Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C
-
Pommier Y, Kerrigan D and Hartman KD et al. (1990) Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C. J Biol Chem 265: 9418-22.
-
(1990)
J Biol Chem
, vol.265
, pp. 9418-9422
-
-
Pommier, Y.1
Kerrigan, D.2
Hartman, K.D.3
-
123
-
-
0021792433
-
Correlation between intercalator induced DNA strand breaks and sister chromatid exchanges mutations and cytotoxicity in Chinese hamster cells
-
Pommier Y, Zwelling LA, Kao-Shan CS, Whang-Peng J and Bradley MO (1985) Correlation between intercalator induced DNA strand breaks and sister chromatid exchanges mutations and cytotoxicity in Chinese hamster cells. Cancer Res 45: 314348.
-
(1985)
Cancer Res
, vol.45
, pp. 314348
-
-
Pommier, Y.1
Zwelling, L.A.2
Kao-Shan, C.S.3
Whang-Peng, J.4
Bradley, M.O.5
-
124
-
-
0002195718
-
Cellular resistance to camptothecins
-
Pantazis P, Giovanella BC and Rothenberg ML (eds) New York: Annals NY Acad Sci
-
Pommier Y, Gupta M, Valenti and Nieves-Neira W (1996) Cellular resistance to camptothecins. In Pantazis P, Giovanella BC and Rothenberg ML (eds) The Camptothecin: From Discovery to the Patient. New York: Annals NY Acad Sci 52: 2268-78.
-
(1996)
The Camptothecin: from Discovery to the Patient
, vol.52
, pp. 2268-2278
-
-
Pommier, Y.1
Gupta, M.2
Valenti3
Nieves-Neira, W.4
-
125
-
-
0023897804
-
Resistance of human leukemic and normal lynphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II
-
Potmesil M, Hsiang Y-H, Liu LF, Bank B, Grossberg H, Kirschenbaum S, Forlenza TJ, Penziner A, Kanganis D, Knowles D, Traganos F and Silber R (1988) Resistance of human leukemic and normal lynphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. Cancer Res 48: 3537-3533.
-
(1988)
Cancer Res
, vol.48
, pp. 3537-3533
-
-
Potmesil, M.1
Hsiang, Y.-H.2
Liu, L.F.3
Bank, B.4
Grossberg, H.5
Kirschenbaum, S.6
Forlenza, T.J.7
Penziner, A.8
Kanganis, D.9
Knowles, D.10
Traganos, F.11
Silber, R.12
-
126
-
-
0028357993
-
Phase I study of topotecan for pediatric patients with malignant solid tumors
-
Pratt CB, Stewart C, Santana VM, Bowman L, Furman W, Ochs J, Marina N, Kuttesch JF, Heideman R, Sandlund JT, Avery L and Meyer WH (1994) Phase I study of topotecan for pediatric patients with malignant solid tumors. J Clin Oncol 12: 539-43.
-
(1994)
J Clin Oncol
, vol.12
, pp. 539-543
-
-
Pratt, C.B.1
Stewart, C.2
Santana, V.M.3
Bowman, L.4
Furman, W.5
Ochs, J.6
Marina, N.7
Kuttesch, J.F.8
Heideman, R.9
Sandlund, J.T.10
Avery, L.11
Meyer, W.H.12
-
127
-
-
0026082794
-
Inhibition of humanimmunodeficiency virus (HIV-1) replication in vitro by non cytotoxic doses of camptothecin, a topoisomerase I inhibitor
-
Priel E, Showalter SD and Blair DG (1991) Inhibition of humanimmunodeficiency virus (HIV-1) replication in vitro by non cytotoxic doses of camptothecin, a topoisomerase I inhibitor. AIDS Res Hum Retrovirus 7: 65-72.
-
(1991)
AIDS Res Hum Retrovirus
, vol.7
, pp. 65-72
-
-
Priel, E.1
Showalter, S.D.2
Blair, D.G.3
-
128
-
-
0029586426
-
Mechanisms of resistance to topoisomerases poisons
-
Prost S (1995) Mechanisms of resistance to topoisomerases poisons. Gen Pharmacol 26: 1673-84.
-
(1995)
Gen Pharmacol
, vol.26
, pp. 1673-1684
-
-
Prost, S.1
-
129
-
-
0025092166
-
Binding of an optically pure photoaffinity analogue of verapamil LU-49888 to P-glycoprotein from multidrug resistant human leukemic cell lines
-
Qian X and Beck WT (1990) Binding of an optically pure photoaffinity analogue of verapamil LU-49888 to P-glycoprotein from multidrug resistant human leukemic cell lines. Cancer Res 50: 1132-1137.
-
(1990)
Cancer Res
, vol.50
, pp. 1132-1137
-
-
Qian, X.1
Beck, W.T.2
-
130
-
-
0030465293
-
Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani
-
Ray S, Majumder HK, Chakravarty AK, Mukhopadhyay S, Gil RR, and Cordell GA (1996) Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani. J Nat Prod 59: 27-9.
-
(1996)
J Nat Prod
, vol.59
, pp. 27-29
-
-
Ray, S.1
Majumder, H.K.2
Chakravarty, A.K.3
Mukhopadhyay, S.4
Gil, R.R.5
Cordell, G.A.6
-
131
-
-
0031550251
-
Dual inhibition of DNA topoisomerases of Leishmania donovani by novel indolyl quinolines
-
Ray S, Sadhukhan PK, Mandai NB, Mahato SB and Majumder HK (1997) Dual inhibition of DNA topoisomerases of Leishmania donovani by novel indolyl quinolines. Biochem Biophys Res Commun 230: 171-5.
-
(1997)
Biochem Biophys Res Commun
, vol.230
, pp. 171-175
-
-
Ray, S.1
Sadhukhan, P.K.2
Mandai, N.B.3
Mahato, S.B.4
Majumder, H.K.5
-
132
-
-
0029148053
-
Effects of two distamycin-ellipticine hybrid molecules on topoisomerase I and II mediated DNA cleavage: Relation to cytotoxicity
-
Riou JF, Grondard L, Naudin A and Bailly C (1995) Effects of two distamycin-ellipticine hybrid molecules on topoisomerase I and II mediated DNA cleavage: relation to cytotoxicity. Biochem Pharmacol 50: 424-8.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 424-428
-
-
Riou, J.F.1
Grondard, L.2
Naudin, A.3
Bailly, C.4
-
133
-
-
0029780443
-
Influence of elsamicin a on the activity of mammalian topoisomerase I
-
Rodriguez-Campos A, Azorin F and Portugal J (1996) Influence of elsamicin A on the activity of mammalian topoisomerase I. Biochemistry 35: 11177-82.
-
(1996)
Biochemistry
, vol.35
, pp. 11177-11182
-
-
Rodriguez-Campos, A.1
Azorin, F.2
Portugal, J.3
-
134
-
-
0026570652
-
The role of the MDR1 (P-glycoprotein)gene in multidrug resistance in vitro and in vivo
-
Roninson IB (1992) The role of the MDR1 (P-glycoprotein)gene in multidrug resistance in vitro and in vivo. Biochem Pharmacol 43: 95-102.
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 95-102
-
-
Roninson, I.B.1
-
135
-
-
0023805882
-
Association of DNA topoisomerase and RNA polymerase I: A possible role for topoisomerase I in ribosomal gene transcription
-
Rose KM, Szopa J, Han FS, Cheng YC, Richter A and Scheer U (1988) Association of DNA topoisomerase and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription. Chromosoma 96: 411-416.
-
(1988)
Chromosoma
, vol.96
, pp. 411-416
-
-
Rose, K.M.1
Szopa, J.2
Han, F.S.3
Cheng, Y.C.4
Richter, A.5
Scheer, U.6
-
136
-
-
15844415445
-
Specific phosphorylation of S R proteins by mammalian DNA topoisomerase I
-
Rossi F, Labourier E, Forne T, Divita G, Derancourt J, Riou JF, Antoine E, Cathala G, Brunei C and Tazi J (1996) Specific phosphorylation of S R proteins by mammalian DNA topoisomerase I. Nature 381: 80-2.
-
(1996)
Nature
, vol.381
, pp. 80-82
-
-
Rossi, F.1
Labourier, E.2
Forne, T.3
Divita, G.4
Derancourt, J.5
Riou, J.F.6
Antoine, E.7
Cathala, G.8
Brunei, C.9
Tazi, J.10
-
137
-
-
0030826929
-
Topoisomerase I inhibitors
-
Rothenberg ML (1997) Topoisomerase I inhibitors. Annu Oncol 8: 837-55.
-
(1997)
Annu Oncol
, vol.8
, pp. 837-855
-
-
Rothenberg, M.L.1
-
138
-
-
0026537874
-
Phase I and pharmacological study of topotecan: A novel topoisomerase inhibitor
-
Rowinsky EK, Grochow LB, Hendricks CB, Ettinger DS, Forastiere AA, Hurowitz LA, McGuire WP, Sartorius SE, Lubejko BG, Kaufmann SH and Donehower RC (1992) Phase I and pharmacological study of topotecan: A novel topoisomerase inhibitor. J Clin Oncol 10: 647-56.
-
(1992)
J Clin Oncol
, vol.10
, pp. 647-656
-
-
Rowinsky, E.K.1
Grochow, L.B.2
Hendricks, C.B.3
Ettinger, D.S.4
Forastiere, A.A.5
Hurowitz, L.A.6
McGuire, W.P.7
Sartorius, S.E.8
Lubejko, B.G.9
Kaufmann, S.H.10
Donehower, R.C.11
-
139
-
-
0028030721
-
Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-Nitro-camptothecin
-
Rubin E, Pantazis P, Bharti A, Toppmeyer D, Giovanella B and Kufe D (1994) Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-Nitro-camptothecin. J Biol Chem 269: 2433-39.
-
(1994)
J Biol Chem
, vol.269
, pp. 2433-2439
-
-
Rubin, E.1
Pantazis, P.2
Bharti, A.3
Toppmeyer, D.4
Giovanella, B.5
Kufe, D.6
-
140
-
-
0027323646
-
Phase I clinical and pharmacology study of topotecan given daily for 5 consecutive days to patients with advanced solid tumors with attempt at dose-intensification using recombinant granulocyte colony-stimulating factor
-
Saltz L, Sirott M, Young C, Tong W, Niedzwiecki D, Tzy-Jyun Y, Tao Y, Trochanowski B, Wright P, Barbosa K, Toomasi F and Kelsen D (1993) Phase I clinical and pharmacology study of topotecan given daily for 5 consecutive days to patients with advanced solid tumors with attempt at dose-intensification using recombinant granulocyte colony-stimulating factor. J Natl Cancer Inst 85: 1499-507.
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 1499-1507
-
-
Saltz, L.1
Sirott, M.2
Young, C.3
Tong, W.4
Niedzwiecki, D.5
Tzy-Jyun, Y.6
Tao, Y.7
Trochanowski, B.8
Wright, P.9
Barbosa, K.10
Toomasi, F.11
Kelsen, D.12
-
141
-
-
0027466646
-
Overexpression of a Mr 110 000 vesicular protein in nonP-glycoprotein-mediated multidrug resistance
-
Scheper RJ, Broxterman HJ, Scheffer GL, Kaaijk P, DaltonWS, Heijningen van THM, van Kalken CK, Slovak ML, de Vries EGE, van der Valk P, Meijer CJLM and Pinedo HM (1993) Overexpression of a Mr 110 000 vesicular protein in nonP-glycoprotein-mediated multidrug resistance. Cancer Res 53: 1475-79.
-
(1993)
Cancer Res
, vol.53
, pp. 1475-1479
-
-
Scheper, R.J.1
Broxterman, H.J.2
Scheffer, G.L.3
Kaaijk, P.4
Dalton, W.S.5
Van Heijningen, T.H.M.6
Van Kalken, C.K.7
Slovak, M.L.8
De Vries, E.G.E.9
Van Der Valk, P.10
Cjlm, M.11
Pinedo, H.M.12
-
142
-
-
0025307835
-
Specificity and flexibility of therecognition of DNA helical structure by eukaryotic topoisomerase I
-
Shen CC and Shen CKJ (1990) Specificity and flexibility of therecognition of DNA helical structure by eukaryotic topoisomerase I. J Mol Biol 212: 67-78.
-
(1990)
J Mol Biol
, vol.212
, pp. 67-78
-
-
Shen, C.C.1
Shen, C.K.J.2
-
143
-
-
0030218978
-
DNA fragmentation induced by protease activation in p53-null human leukemia cells undergoing apoptosis following treatment with the topoisomerase I inhibitor camptothecin: Cell-free system studies
-
Shimizu T and Pommier Y (1996) DNA fragmentation induced by protease activation in p53-null human leukemia cells undergoing apoptosis following treatment with the topoisomerase I inhibitor camptothecin: Cell-free system studies. Exp Cell Res 226: 292301.
-
(1996)
Exp Cell Res
, vol.226
, pp. 292301
-
-
Shimizu, T.1
Pommier, Y.2
-
145
-
-
0025407684
-
DNA topoisomerase dysfunction: A new goal for antitumor chemotherapy
-
Smith PJ (1990) DNA topoisomerase dysfunction: a new goal for antitumor chemotherapy. Bioassay 12: 1657-72.
-
(1990)
Bioassay
, vol.12
, pp. 1657-1672
-
-
Smith, P.J.1
-
146
-
-
0026022732
-
Characterization of adriamycin resistant and amsacrine-resistant human leukaemic T-cell lines
-
Snow K and Judd W (1991) Characterization of adriamycin resistant and amsacrine-resistant human leukaemic T-cell lines. Br J Cancer 63: 17-28.
-
(1991)
Br J Cancer
, vol.63
, pp. 17-28
-
-
Snow, K.1
Judd, W.2
-
147
-
-
0031004973
-
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
-
Spicer JA, Carriage SA, Atwell GJ, Finlay GJ, Baguley BC and Denny WA (1997) Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide. J Med Chem 40: 1919-29.
-
(1997)
J Med Chem
, vol.40
, pp. 1919-1929
-
-
Spicer, J.A.1
Carriage, S.A.2
Atwell, G.J.3
Finlay, G.J.4
Baguley, B.C.5
Denny, W.A.6
-
148
-
-
0029873920
-
Lipid-complexed camptothecin: Formulation and initial biodistribution and antitumor activity studies
-
Sugarman SM, Zou Y, Wasan K, Poirot K, Kumi R, Reddy S and Perez-Soler R (1996) Lipid-complexed camptothecin: formulation and initial biodistribution and antitumor activity studies. Cancer Chem Pharmacol 37: 531-8.
-
(1996)
Cancer Chem Pharmacol
, vol.37
, pp. 531-538
-
-
Sugarman, S.M.1
Zou, Y.2
Wasan, K.3
Poirot, K.4
Kumi, R.5
Reddy, S.6
Perez-Soler, R.7
-
149
-
-
0025151823
-
Decreased expression of DNA topoisomerase I in camptothecinresistant tumor cell lines as determined by a monoclonal antibody
-
Sugimoto Y, Tsukahara S, Oh-Hara T, Isoe T and Tsuruo T (1990) Decreased expression of DNA topoisomerase I in camptothecinresistant tumor cell lines as determined by a monoclonal antibody. Cancer Res 50: 6925-30.
-
(1990)
Cancer Res
, vol.50
, pp. 6925-6930
-
-
Sugimoto, Y.1
Tsukahara, S.2
Oh-Hara, T.3
Isoe, T.4
Tsuruo, T.5
-
150
-
-
0029816571
-
Modulation of melphalan cytotoxic activity in human melanoma cell lines
-
Supino R, Caserini C, Orlandi L, Zaffaroni N, Silvestrini R, Vaglini M and Zunino F (1996) Modulation of melphalan cytotoxic activity in human melanoma cell lines. Anticancer Drugs 7: 604-12.
-
(1996)
Anticancer Drugs
, vol.7
, pp. 604-612
-
-
Supino, R.1
Caserini, C.2
Orlandi, L.3
Zaffaroni, N.4
Silvestrini, R.5
Vaglini, M.6
Zunino, F.7
-
151
-
-
0029889595
-
Drug-induced down-regulation of topoisomerase I in human epidermoid cancer cells resistant to saintopin and camptothecins
-
Taniguchi K, Kohno K, Kawanami K, Wada M, Kanematsu T and Kuwano M (1996) Drug-induced down-regulation of topoisomerase I in human epidermoid cancer cells resistant to saintopin and camptothecins. Cancer Res 56: 2348-54.
-
(1996)
Cancer Res
, vol.56
, pp. 2348-2354
-
-
Taniguchi, K.1
Kohno, K.2
Kawanami, K.3
Wada, M.4
Kanematsu, T.5
Kuwano, M.6
-
152
-
-
0026694495
-
Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture
-
Tanizawa A and Pommier Y (1992) Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture. Cancer Res 52: 1848-54.
-
(1992)
Cancer Res
, vol.52
, pp. 1848-1854
-
-
Tanizawa, A.1
Pommier, Y.2
-
153
-
-
0027368901
-
Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance
-
Tanizawa A, Beitrand R, Kohlhagen G, Tabuchi A, Jenkins J and Pommier Y (1993) Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance. J Biol Chem 268: 25463-8.
-
(1993)
J Biol Chem
, vol.268
, pp. 25463-25468
-
-
Tanizawa, A.1
Beitrand, R.2
Kohlhagen, G.3
Tabuchi, A.4
Jenkins, J.5
Pommier, Y.6
-
154
-
-
0023447098
-
Cellular localization of the multidrugresistance gene product P-glycoprotein in normal human tissues
-
Thiebaut T, Tsuruo T, Hamada H, Gottesman MM, Pastan I and Willingham MC (1987) Cellular localization of the multidrugresistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 84: 7735-38.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7735-7738
-
-
Thiebaut, T.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
155
-
-
0023971164
-
Stabilization of type I topoisomerase DNA covalent complexes by actinomycin D
-
Trask DK and Muller MT (1988) Stabilization of type I topoisomerase DNA covalent complexes by actinomycin D. Proc Natl Acad Sci USA 85: 1417-25.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 1417-1425
-
-
Trask, D.K.1
Muller, M.T.2
-
156
-
-
0021397622
-
Rapid detection and isolation of covalent DNA protein complexes: Application to topoisomerase I and II
-
Trask DK, DiDonato JA and Muller MT (1984) Rapid detection and isolation of covalent DNA protein complexes: application to topoisomerase I and II. EMBO J 3: 671-676.
-
(1984)
EMBO J
, vol.3
, pp. 671-676
-
-
Trask, D.K.1
Didonato, J.A.2
Muller, M.T.3
-
157
-
-
0023864510
-
Antitumor effect of CPT-11 a new derivative of camptothecin against pleiotropic drug resistant tumors in vitro and in vivo
-
Tsuruo T, Matsuzaki T, Matsushita M, Saito H and Yokokura T (1988) Antitumor effect of CPT-11 a new derivative of camptothecin against pleiotropic drug resistant tumors in vitro and in vivo. Cancer Chemother Pharmac 21: 71-74.
-
(1988)
Cancer Chemother Pharmac
, vol.21
, pp. 71-74
-
-
Tsuruo, T.1
Matsuzaki, T.2
Matsushita, M.3
Saito, H.4
Yokokura, T.5
-
158
-
-
0027437792
-
A Casein Kinase type II (CKII) like nuclear protein kinase associates with, phosphorylates and activates topoisomerase I
-
Turman MA and Douvas A (1993) A Casein Kinase type II (CKII) like nuclear protein kinase associates with, phosphorylates and activates topoisomerase I. Biochem Med Metab Biol 50: 210225.
-
(1993)
Biochem Med Metab Biol
, vol.50
, pp. 210225
-
-
Turman, M.A.1
Douvas, A.2
-
159
-
-
0030756223
-
Novel 7-alkyl methylenedioxycamptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells
-
Valent! M, Nieves-Neira W, Kohlhagen G, Kohn KW, Wall ME, Wani MC and Pommier Y (1997) Novel 7-alkyl methylenedioxycamptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells. Mol Pharmacol 52: 82-7.
-
(1997)
Mol Pharmacol
, vol.52
, pp. 82-87
-
-
Valent, M.1
Nieves-Neira, W.2
Kohlhagen, G.3
Kohn, K.W.4
Wall, M.E.5
Wani, M.C.6
Pommier, Y.7
-
160
-
-
0026326003
-
P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in maglignant tumors of the ovary, before and after platinium/cyclophosphamide chemotherapy
-
van der Zee AG, Hollema H, de Jong S, Boonstra H, Gouw A, Willemse PH, Zijlstra JG and de Vries EG (1991) P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in maglignant tumors of the ovary, before and after platinium/cyclophosphamide chemotherapy. Cancer Res 51: 5915-20.
-
(1991)
Cancer Res
, vol.51
, pp. 5915-5920
-
-
Van Der Zee, A.G.1
Hollema, H.2
De Jong, S.3
Boonstra, H.4
Gouw, A.5
Ph Willemse6
Zijlstra, J.G.7
De Vries, E.G.8
-
161
-
-
0030465009
-
Cisplatin, camptothecin, andtaxol sensitivities of cells withp53associated multidrug resistance
-
Vasey PA, Jones NA, Jenkins S, Dive C and Brown R (1996) Cisplatin, camptothecin, andtaxol sensitivities of cells withp53associated multidrug resistance. Mol Pharmacol 50: 1536-40.
-
(1996)
Mol Pharmacol
, vol.50
, pp. 1536-1540
-
-
Vasey, P.A.1
Jones, N.A.2
Jenkins, S.3
Dive, C.4
Brown, R.5
-
162
-
-
0027454410
-
Phase I and pharmacokinetic study of topotecan, a new topoisomerase I inhibitor
-
Verweij J, Lund B, Beijnen J, Planting A, de Boer-Dennert M, Koier I, Rosing H and Hansen H (1993) Phase I and pharmacokinetic study of topotecan, a new topoisomerase I inhibitor. Ann Oncol 4: 673.
-
(1993)
Ann Oncol
, vol.4
, pp. 673
-
-
Verweij, J.1
Lund, B.2
Beijnen, J.3
Planting, A.4
De Boer-Dennert, M.5
Koier, I.6
Rosing, H.7
Hansen, H.8
-
163
-
-
0013780715
-
The twisted circular form of polyoma viral DNA
-
Vinograd J, Lebowtiz J, Radloff R, Waron R and Laipis P (1965) The twisted circular form of polyoma viral DNA. Proc Natl Acad Sci USA 53: 1104-1111.
-
(1965)
Proc Natl Acad Sci USA
, vol.53
, pp. 1104-1111
-
-
Vinograd, J.1
Lebowtiz, J.2
Radloff, R.3
Waron, R.4
Laipis, P.5
-
164
-
-
7144248725
-
Plant antitumor agents. 1. the isolation and structure of camptothecin, a novel alkyloidal leukemia and tumor inhibitor from Camptotheca acuminata
-
Wall ME, Wani NC, Cook CE, Palmer KH, McPhail AT and Sim GA (1966) Plant antitumor agents. 1. The isolation and structure of camptothecin, a novel alkyloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc 94: 3888.
-
(1966)
J Am Chem Soc
, vol.94
, pp. 3888
-
-
Wall, M.E.1
Wani, N.C.2
Cook, C.E.3
Palmer, K.H.4
McPhail, A.T.5
Sim, G.A.6
-
165
-
-
0028685454
-
Synthesis of novel water-soluble 7-(aminoacylhydrazono)-formyl camptothecins with potent inhibition of DNA topoisomerase I
-
Wang HK, Liu SY, Hwang KM, Taylor G and Lee KH (1994) Synthesis of novel water-soluble 7-(aminoacylhydrazono)-formyl camptothecins with potent inhibition of DNA topoisomerase I. Bioorg Med Chem 2: 1397-402.
-
(1994)
Bioorg Med Chem
, vol.2
, pp. 1397-1402
-
-
Wang, H.K.1
Liu, S.Y.2
Hwang, K.M.3
Taylor, G.4
Lee, K.H.5
-
166
-
-
0025873579
-
Topoisomerase I-mediated integration of hepadnavirus DNA in vitro
-
Wang HP and Rogler CE (1991) Topoisomerase I-mediated integration of hepadnavirus DNA in vitro. J Virol 65: 2381-92.
-
(1991)
J Virol
, vol.65
, pp. 2381-2392
-
-
Wang, H.P.1
Rogler, C.E.2
-
167
-
-
0021891888
-
DNA topoisomerases
-
Wang JC (1985) DNA topoisomerases. Annu Rev Biochem 54: 665-697.
-
(1985)
Annu Rev Biochem
, vol.54
, pp. 665-697
-
-
Wang, J.C.1
-
168
-
-
0030014783
-
DNA topoisomerases
-
Wang JC (1996) DNA topoisomerases. Annu Rev Biochem 65: 636-92.
-
(1996)
Annu Rev Biochem
, vol.65
, pp. 636-692
-
-
Wang, J.C.1
-
169
-
-
0015222656
-
Interaction between DNA and Escherichia coli omega protein
-
Wang JC (1971) Interaction between DNA and Escherichia coli omega protein. J Mol Biol 55: 523-533.
-
(1971)
J Mol Biol
, vol.55
, pp. 523-533
-
-
Wang, J.C.1
-
170
-
-
0027433723
-
Inhibition of topoisomerase I function by nitidine and fagaronine
-
Wang LK, Johnson RK and Hecht SM (1993) Inhibition of topoisomerase I function by nitidine and fagaronine. Chem Res Toxicol 6: 813-8.
-
(1993)
Chem Res Toxicol
, vol.6
, pp. 813-818
-
-
Wang, L.K.1
Johnson, R.K.2
Hecht, S.M.3
-
171
-
-
0030054013
-
Inhibition of topoisomerase I function by coralyne and 5,6-dihidrocoralyne
-
Wang LK, Rogers BD and Hecht SM (1996) Inhibition of topoisomerase I function by coralyne and 5,6-dihidrocoralyne. Chem Res Toxicol 9: 75-83.
-
(1996)
Chem Res Toxicol
, vol.9
, pp. 75-83
-
-
Wang, L.K.1
Rogers, B.D.2
Hecht, S.M.3
-
172
-
-
0018901322
-
Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues
-
Wani MC, Ronman PE, Lindley JT and Wall ME (1980) Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. J Med Chem 23: 554-60.
-
(1980)
J Med Chem
, vol.23
, pp. 554-560
-
-
Wani, M.C.1
Ronman, P.E.2
Lindley, J.T.3
Wall, M.E.4
-
173
-
-
0029974583
-
Bisindolylmaleimides linked to DNA minor groove binding lexitropsins. synthesis, inhibitory activity against topoisomerase I, and biological evaluation
-
Xie G, Gupta R, Atchison K and Lown JW (1996) Bisindolylmaleimides linked to DNA minor groove binding lexitropsins. synthesis, inhibitory activity against topoisomerase I, and biological evaluation. J Med Chem 39: 1049-55.
-
(1996)
J Med Chem
, vol.39
, pp. 1049-1055
-
-
Xie, G.1
Gupta, R.2
Atchison, K.3
Lown, J.W.4
-
174
-
-
33847528820
-
Quantitative PCR for DNA topoisomerase I, II alpha, II beta and mdrl in cell lines and tumor samples
-
Yang CHJ, Cowan KH and Schneider E (1993) Quantitative PCR for DNA topoisomerase I, II alpha, II beta and mdrl in cell lines and tumor samples. Proc Annu Meet Am Assoc Cancer Res 34:A56.
-
(1993)
Proc Annu Meet Am Assoc Cancer Res
, vol.34
-
-
Yang, C.H.J.1
Cowan, K.H.2
Schneider, E.3
-
175
-
-
0029091756
-
Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations
-
Yang CHJ, Horton JK, Cowan KH and Schneider E (1995) Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations. Cancer Res 55: 4004-9.
-
(1995)
Cancer Res
, vol.55
, pp. 4004-4009
-
-
Yang, C.H.J.1
Horton, J.K.2
Cowan, K.H.3
Schneider, E.4
-
176
-
-
0023958908
-
Involvement of DNAtopoisomerase I in transcription of human ribosomal RNA genes
-
Zhang H, Wang JC and Liu LF (1988) Involvement of DNAtopoisomerase I in transcription of human ribosomal RNA genes. Proc Natl Acad Sci USA 85: 1060-1064.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 1060-1064
-
-
Zhang, H.1
Wang, J.C.2
Liu, L.F.3
-
177
-
-
0025276858
-
A model tumor cell killing by topoisomerase poisons
-
Zhang H, D'Arpa P and Liu LF (1990) A model tumor cell killing by topoisomerase poisons. Cancer Cells 2: 23-27.
-
(1990)
Cancer Cells
, vol.2
, pp. 23-27
-
-
Zhang, H.1
D'Arpa, P.2
Liu, L.F.3
-
178
-
-
0031033311
-
Camptothecin and minor-groove binder hybrid molecules: Synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro
-
Zhao R, Al-Said NH, Sternbach DL and Lown JW (1997) Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro. J Med Chem 40: 216-25.
-
(1997)
J Med Chem
, vol.40
, pp. 216-225
-
-
Zhao, R.1
Al-Said, N.H.2
Sternbach, D.L.3
Lown, J.W.4
-
179
-
-
0024383401
-
Characterization of 3′-region of the human DNA topoisomerase I gene
-
Zhou BS, Bastow KF and Cheng YC (1989) Characterization of 3′-region of the human DNA topoisomerase I gene. Cancer Res 49: 3922-3927.
-
(1989)
Cancer Res
, vol.49
, pp. 3922-3927
-
-
Zhou, B.S.1
Bastow, K.F.2
Cheng, Y.C.3
-
180
-
-
0025272246
-
Topoisomerases, new targets in cancer chemotherapy
-
Zijlstra JG, De Jong S, De Vries EGE and Mulder NH (1990) Topoisomerases, new targets in cancer chemotherapy. Med Oncol Tumor Pharmacother 7: 11-18.
-
(1990)
Med Oncol Tumor Pharmacother
, vol.7
, pp. 11-18
-
-
Zijlstra, J.G.1
De Jong, S.2
De Ege, V.3
Mulder, N.H.4
|