Drug-induced down-regulation of topoisomerase I in human epidermoid cancer cells resistant to saintopin and camptothecins

Cancer Research

Volumn 56, Issue 10, 1996, Pages 2348-2354

  Taniguchi, Ken ^a   Kohno, Kimitoshi ^a   Kawanami, Kiyoshi ^a   Wada, Morimasa ^a   Kanematsu, Takashi ^b   Kuwano, Michihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CISPLATIN; COMPLEMENTARY DNA; DACTINOMYCIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; IRINOTECAN; MESSENGER RNA; MITOMYCIN C; NIMUSTINE; SAINTOPIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA CLEAVAGE; DNA PROTEIN COMPLEX; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; DRUG RESISTANCE; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; ULTRAVIOLET RADIATION;

ANTIBIOTICS, ANTINEOPLASTIC; BENZ(A)ANTHRACENES; CAMPTOTHECIN; CARCINOMA, SQUAMOUS CELL; DACTINOMYCIN; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE, NEOPLASM; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KB CELLS; NEOPLASM PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; TUMOR CELLS, CULTURED;

EID: 0029889595     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Nittis, J. L. Roles of DNA topoisomerases in chromosomal replication and segregation. In: L. F. Liu (ed), DNA Topoisomerases; Biochemistry and Molecular Biology, pp. 103-134. Boston: Academic Press, 1994.
2. Drolet, M., Wu, H Y , and Liu, L. F Roles of DNA topoisomerases in transcription. In: L. F. Liu (ed.), DNA Topoisomerases; Biochemistry and Molecular Biology, pp 135-146. Boston: Academic Press, 1994.
3. Drlica, K., and Franco, R. J. Inhibitors of DNA topoisomerases. Biochemistry, 27: 2253-2259, 1988.
4. Lynn, R. M , and Wang, J. C. Peptide sequencing and site-directed mutagenesis identify tyrosine-319 as the active site tyrosine of Escherichia coli DNA topoisomerase I. Proteins, 6: 231-239, 1989.
5. Eng, W. K., Pandit, S. D., and Sternglanz, R Mapping of the active site tyrosine of eukaryotic DNA topoisomerase I. J. Biol Chem., 264: 13373-13376, 1989.
6. Liu, L F., Rowe, T C., Yang, L , Tewey, K M., and Chen, G. L. Cleavage of DNA by mammalian DNA topoisomerase II. J. Biol. Chem., 258: 15365-15370, 1983.
7. Bonner, J. A., and Lawrence, T. S. Doxorubicin decreases the repair of radiation-induced DNA damage. Int J. Radiat. Biol., 57: 55-64, 1990.
8. Popanda, O., and Thielmann, H W. The function of DNA topoisomerases in UV-induced DNA excision repair: studies with specific inhibitors in permeabilized human fibroblasts. Carcinogenesis (Lond.), 13: 2321-2328, 1992.
9. Giocanti, N., Hennequin, C., Balosso, J., Mahler, M., and Favaudon, V. DNA repair and cell cycle interactions in radiation sensitization by the topoisomerase II poison etoposide. Cancer Res., 53: 2105-2111, 1993.
10. Thielmann, H. W., Popanda, O., Gersbach, H., and Gilberg, F. Various inhibitors of DNA topoisomerases diminish repair-specific DNA incision in UV-irradiated human fibroblasts. Carcinogenesis, 14. 2341-2351, 1993.
11. Beck, W. T., and Danks, M. K. Resistance of mammalian tumor cells to inhibitors of DNA topoisomerase II. In: L F. Liu (ed.), DNA Topoisomerases; Topoisomerase-Targeting Drugs, pp. 145-169. Boston: Academic Press, 1994.
12. Takano, H., Kohno, K., Matsuo, K , Matsuda, T., and Kuwano, M. DNA topoisomerase-targering antitumor agents and drug resistance. Anticancer Drugs, 3: 323-330, 1992.
13. Cole, S. P. C., Bhardwaj, G , Gerlach, J. H., Mackie, J. E., Grant, C. E , Almquist, K. C., Stewart, A. J , Kurz, E. U., Duncan, A. M., and Deeley, R. G. Overexpression of transporter gene in multidrug resistant human lung-cancer cell line Science (Washington DC), 258: 1650-1654, 1992.
14. Abe, T., Hasegawa, S , Taniguchi, K., Yokomizo, A., Kuwano, T., Ono, M., Mori, T., Hori, S., Kohno, K. and Kuwano, M. Possible involvement of mutidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and Adriamycin in human glioma cells. Int. J. Cancer, 58. 860-864, 1994.
15. Hasegawa, S., Abe, T., Naito, S., Kotoh, S., Kumazawa, J., Hipfner, D. R., Deeley, R. G., Cole, S. P., and Kuwano, M. Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase D in human multidrug-resistant bladder cancer cell lines. Br J. Cancer, 71: 907-913, 1995.
16. Yamashita, Y., Kawada, S., Fujii, N , and Nakano, H. Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus. Biochemistry, 30: 5838-5845, 1991
17. Yamashita, Y., Saitoh, Y., Ando, K., Takahashi, K., Ohno, H., and Nakano, H Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces J Antibiot (Tokyo), 43. 1344-1346, 1990.
18. Leteurtre, F , Fujimori, A , Tanizawa, A., Chhabra, A , Mazumder, A., Kohlhagen, G., Nakano, H and Pommier, Y. Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions. J. Biol Chem., 269: 28702-28707, 1994.
19. Matsuo, K. I., Kohno, K., Takano, H , Sato, S. I., Kiue, A., and Kuwano, M Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cell lines. Cancer Res., 50: 5819-5824, 1990.
20. Takano, H., Kohno, K , Ono, M., Uchida, Y., and Kuwano, M. Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells Cancer Res., 51. 3951-3957, 1991.
21. Matsuo, K., Kohno, K., Sato, S , Uchiumi, T., Tanimura, H., Yamada, Y., and Kuwano, M. Enhanced expression of the DNA topoisomerase II gene in response to heat shock stress in human epidermoid cancer KB cells. Cancer Res., 53: 1085-1090, 1993.
22. Duguet, M , Lavenot, C., Harper, F., Mirambeau, G., and De Recondo, A. M DNA topoisomerases from rat liver: physiological variations Nucleic Acids Res., 11. 1059-1075, 1983.
23. Bradford, M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem., 72: 248-254, 1976.
24. Yokomizo, A., Kohno, K., Wada, M., Ono, M., Morrow, C. S., Cowan, K. H., and Kuwano M. Markedly decreased expression of glutathione S-transferase π gene in human cancer cell lines resistant to buthionine sulfoximine, an inhibitor of cellular glutathione synthesis J Biol Chem , 270: 19451-19457, 1995
25. Yokomizo, A., Ono, M., Nanri, H., Makino, Y , Ohga, T , Wada, M., Okamoto, T , Yodoi, J , Kuwano, M., and Kohno, K. Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxombicin, and etoposide. Cancer Res., 55. 4293-4296, 1995
26. Kubo, T., Kohno, K., Ohga, T , Taniguchi, K., Kawanami, K., Wada, M. and Kuwano, M. DNA topoisomerase IIα gene expression under transcriptional control in etoposide/temposide-resistant human cancer cells. Cancer Res , 55: 3860-3864, 1995.
27. Kubota, N , Kanzawa, F., Nishio, K., Takeda, Y., Ohmori, T., Fujiwara, Y., Terashima, Y , and Saijo, N. Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line Biochem Biophys. Res. Commun., 188: 571-577, 1992.
28. D'Arpa, P , Machlin, P. S., Ratrie, H., III, Rothfield, N. F , Cleveland, D W., and Earnshaw, W. C. cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7 kDa carboxyl-terminal fragment Proc. Natl. Acad. Sci. USA, 85: 2543-2547, 1988.
29. Boothman, D A , Fukunaga, N., and Wang, M. Down-regulation of topoisomerase I in mammalian cells following ionizing radiation Cancer Res., 54: 4618-4626, 1994.
30. Kawato, Y., Aonuma, M., Hirota, Y., Kuga, H., and Sato, K. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res., 51: 4187-4191, 1991.
31. Satoh, T., Hosokawa, M., Atsumi, R., Suzuki, W., Hakusui, H., and Nagai, E Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase. Biol. Pharm. Bull., 17: 662-664, 1994.
32. Chang, J. Y., Dethlefsen, L. A., Barley, L. R., Zhou, B. S., and Cheng, Y. C. Characterization of camptothecin-resistant Chinese hamster lung cells (erratum appears in Biochem. Pharmacol. 45: 787, 1993). Biochem. Pharmacol., 43: 2443-2452, 1992.
33. Sugimoto, Y., Tsukahara, S , Oh, H. T , Isoe, T., and Tsuruo, T. Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody. Cancer Res., 50: 6925-6930, 1990.
34. Andoh, T., Ishii, K., Suzuki, Y., Ikegami, Y., Kusunoki, Y , Takemoto, Y., and Okada, K. Characterization of a mammalian mutant with a camptothecin- resistant DNA topoisomerase I. Proc. Natl. Acad. Sci. USA, 84: 5565-5569, 1987
35. Gupta, R. S., Gupta, R., Eng, B., Lock, R. B., Ross, W. E , Hertzberg, R. P., Caranfa, M J., and Johnson, R. K Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I. Cancer Res., 48: 6404-6410, 1988.
36. Beidler, D. R , and Cheng, Y. Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity Mol. Pharmacol., 47: 907-914, 1995.
37. Amara, F. M., Hurta, R. A. R., Huang, A., and Wright, J. A. Altered regulation of message stability and tumor promoter-responsive cis-trans interactions of ribonucleotide reductase R1 and R2 messenger RNAs in hydroxyurea-resistant cells. Cancer Res., 55: 4503-4506, 1995.
38. Smith, P J., Makinson, T. A , and Watson, J. V. Enhanced sensitivity to camptothecin in ataxia-telangiectasia cells and its relationship with the expression of DNA topoisomerase I. Int J. Radiat. Biol., 55: 217-231, 1989.
39. Thacker, J., and Ganesh, A. N. DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive its mutants: comparisons to ataxia-telangiectasia cells. Mutat. Res , 235: 49-58, 1990.
40. Saito, H., Grompe, M., Neeley, T. L., Jakobs, P. M., and Moses, R. E. Fanconi anemia cells have a normal gene structure for topoisomerase I. Hum Genet., 93. 583-586, 1994
41. Squires, S., Ryan, A J , Strutt, H. L., and Johnson, R. T. Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA. Cancer Res., 53: 2012-2019, 1993
42. Niimi, S., Nakagawa, K., Sugimoto, Y., Nishio, K., Fujiwara, Y., Yokoyama, S., Terashima, Y., and Saijo, N. Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin. Cancer Res., 52: 328-333, 1992.
43. Kotoh, S., Naito, S., Yokomizo, A., Kumazawa, J., Asakuno, K., Kohno, K., and Kuwano, M. Increased expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells. Cancer Res., 54: 3248-3252, 1994.
44. Schwartz, G. N., Teicher, B. A., Eder, J. P., Jr., Korbut, T., Holden, S A., Ara, G., and Herman, T. S. Modulation of antitumor alkylating agents by novobiocin, topotecan, and Ionidamine. Cancer Chemother. Pharmacol., 32: 455-462, 1993.