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Volumn 4, Issue 4, 1998, Pages 254-263

Animal models of neural tube defects

Author keywords

Anencephaly; Exencephaly; Model; Mouse; Neural tube; Spina bifida

Indexed keywords

RETINOID; TERATOGENIC AGENT; VALPROIC ACID;

EID: 0032438006     PISSN: 10804013     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2779(1998)4:4<254::AID-MRDD4>3.0.CO;2-M     Document Type: Review
Times cited : (6)

References (121)
  • 1
    • 0019802436 scopus 로고
    • The mode of development of an inherited form of anencephaly in the house mouse
    • Anderson JR. The mode of development of an inherited form of anencephaly in the house mouse. Neuropathol Appl Neurobiol 1981;7: 229-235.
    • (1981) Neuropathol Appl Neurobiol , vol.7 , pp. 229-235
    • Anderson, J.R.1
  • 2
    • 0029347164 scopus 로고
    • High-frequency developmental abnormalities in p53-deficient mice
    • Armstrong JF, Kaufman MH, Harrison DJ, et al. High-frequency developmental abnormalities in p53-deficient mice. Curr Biol 1995;5:931-936.
    • (1995) Curr Biol , vol.5 , pp. 931-936
    • Armstrong, J.F.1    Kaufman, M.H.2    Harrison, D.J.3
  • 3
    • 0030585759 scopus 로고    scopus 로고
    • Effects of Pax3 modifier genes on craniofacial morphology, pigmentation, and viability: A murine model of Waardenburg syndrome variation
    • AsherJH Jr, Harrison RW, Morell R, et al. Effects of Pax3 modifier genes on craniofacial morphology, pigmentation, and viability: A murine model of Waardenburg syndrome variation. Genomics 1996;34:285-298.
    • (1996) Genomics , vol.34 , pp. 285-298
    • Asher Jr., J.H.1    Harrison, R.W.2    Morell, R.3
  • 4
    • 84981841769 scopus 로고
    • Analysis of the developmental effects of a lethal mutation in the house mouse
    • Auerbach R. Analysis of the developmental effects of a lethal mutation in the house mouse. J Exp Zool 1954;127:305-329.
    • (1954) J Exp Zool , vol.127 , pp. 305-329
    • Auerbach, R.1
  • 5
    • 0025292906 scopus 로고
    • A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner
    • Dastian H, Gruss P. A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner. EMBOJ 1990;9:1839-1852.
    • (1990) EMBOJ , vol.9 , pp. 1839-1852
    • Dastian, H.1    Gruss, P.2
  • 6
    • 0029278796 scopus 로고
    • Haplotype analysis of intra-specific backcross curly-tail mice confirms the localization of ct to chromosome 4
    • Beier DR, Dushkin H, Telle T. Haplotype analysis of intra-specific backcross curly-tail mice confirms the localization of ct to chromosome 4. Mamm Genome 1995;6:269-272.
    • (1995) Mamm Genome , vol.6 , pp. 269-272
    • Beier, D.R.1    Dushkin, H.2    Telle, T.3
  • 7
    • 0031951710 scopus 로고    scopus 로고
    • Neurulation abnormalities secondary to altered gene expression in neural tube defect susceptible Splotch embryos
    • Bennett GD, An J, Craig JC, et al. Neurulation abnormalities secondary to altered gene expression in neural tube defect susceptible Splotch embryos. Teratology 1998;57:17-29.
    • (1998) Teratology , vol.57 , pp. 17-29
    • Bennett, G.D.1    An, J.2    Craig, J.C.3
  • 8
    • 0030599409 scopus 로고    scopus 로고
    • Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency
    • Blackshear PJ, Lai WS, TuttleJS, et al. Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency. Brain Res Dev Brain Res 1996;96:62-75.
    • (1996) Brain Res Dev Brain Res , vol.96 , pp. 62-75
    • Blackshear, P.J.1    Lai, W.S.2    Tuttle, J.S.3
  • 9
    • 0028205002 scopus 로고
    • Pax-3 is required for the development of limb muscles: A possible role for the migration of dermomyotomal muscle progenitor cells
    • Bober E, Franz T, Arnold H-H, et al. Pax-3 is required for the development of limb muscles: A possible role for the migration of dermomyotomal muscle progenitor cells. Development 1994;120:603-612.
    • (1994) Development , vol.120 , pp. 603-612
    • Bober, E.1    Franz, T.2    Arnold, H.-H.3
  • 10
    • 0025947203 scopus 로고
    • Curvature of the caudal region is responsible for failure of neural tube closure in the curly tail (ct) mouse embryo
    • Brook FA, Shum AS, van Straaten HW, et al. Curvature of the caudal region is responsible for failure of neural tube closure in the curly tail (ct) mouse embryo. Development 1991; 113:671-678.
    • (1991) Development , vol.113 , pp. 671-678
    • Brook, F.A.1    Shum, A.S.2    Van Straaten, H.W.3
  • 11
    • 0028283289 scopus 로고
    • Female predisposition to cranial neural tube defects is not because of a difference between the sexes in the rate of embryonic growth or development during neurulation
    • Brook FA, Estibeiro JP, Copp AJ. Female predisposition to cranial neural tube defects is not because of a difference between the sexes in the rate of embryonic growth or development during neurulation. J Med Genet 1994;31:383387.
    • (1994) J Med Genet , vol.31 , pp. 383387
    • Brook, F.A.1    Estibeiro, J.P.2    Copp, A.J.3
  • 12
    • 0028956944 scopus 로고
    • Absence of linkage between familial neural tube defects and PAX3 gene
    • Chatkupt S, Hol FA, Shugart YY, et al. Absence of linkage between familial neural tube defects and PAX3 gene. J Med Genet 1995;32:200204.
    • (1995) J Med Genet , vol.32 , pp. 200204
    • Chatkupt, S.1    Hol, F.A.2    Shugart, Y.Y.3
  • 13
    • 0029957831 scopus 로고    scopus 로고
    • Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly
    • Chen J, Chang S, Duncan SA, et al. Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly. Proc Natl Acad Sei USA 1996;93:6275-6279.
    • (1996) Proc Natl Acad Sei USA , vol.93 , pp. 6275-6279
    • Chen, J.1    Chang, S.2    Duncan, S.A.3
  • 14
    • 0028206583 scopus 로고
    • Prevention of spinal neural tube defects in the curly tail mouse mutant by a specific effect of retinoic acid
    • Chen WH, Morriss-Kay GM, Copp AJ. Prevention of spinal neural tube defects in the curly tail mouse mutant by a specific effect of retinoic acid. DevDyn 1994;199:93-102.
    • (1994) DevDyn , vol.199 , pp. 93-102
    • Chen, W.H.1    Morriss-Kay, G.M.2    Copp, A.J.3
  • 15
    • 0028954111 scopus 로고
    • Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: Involvement of retinoic acid and its nuclear receptors RARbeta and RAR-gamma
    • Chen WH, Morriss-Kay GM, Copp AJ. Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: Involvement of retinoic acid and its nuclear receptors RARbeta and RAR-gamma. Development 1995; 121:681-691.
    • (1995) Development , vol.121 , pp. 681-691
    • Chen, W.H.1    Morriss-Kay, G.M.2    Copp, A.J.3
  • 17
    • 0025000359 scopus 로고
    • Methionine and neural tube closure in cultured rat embryos: Morphological and biochemical analyses
    • Coelho CND, Klein NW. Methionine and neural tube closure in cultured rat embryos: Morphological and biochemical analyses. Teratology 1990;42:437-451.
    • (1990) Teratology , vol.42 , pp. 437-451
    • Coelho, C.N.D.1    Klein, N.W.2
  • 18
    • 0031258150 scopus 로고    scopus 로고
    • Neural crest is involved in development of abnormal myocardial function
    • Conway SJ, Godt RE, Hatcher CJ, et al. Neural crest is involved in development of abnormal myocardial function. J Mol Cell Cardiol 1997a;29:2675-2685.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 2675-2685
    • Conway, S.J.1    Godt, R.E.2    Hatcher, C.J.3
  • 19
    • 0031040876 scopus 로고    scopus 로고
    • I'ax3 is required for cardiac neural crest migration in the mouse: Evidence from the splotch (Sp2H) mutant
    • Conway SJ, Henderson DJ, Copp AJ. I'ax3 is required for cardiac neural crest migration in the mouse: Evidence from the splotch (Sp2H) mutant. Development 1997b; 124:505-514.
    • (1997) Development , vol.124 , pp. 505-514
    • Conway, S.J.1    Henderson, D.J.2    Copp, A.J.3
  • 20
    • 0024553655 scopus 로고
    • Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation?
    • Copp AJ, Brook FA. Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation? J Med Genet 1989;26: 160-166.
    • (1989) J Med Genet , vol.26 , pp. 160-166
    • Copp, A.J.1    Brook, F.A.2
  • 21
    • 0023736270 scopus 로고
    • Prevention of spinal neural tube defects in the mouse embryo by growth retardation during neurulation
    • Copp AJ, CrollaJA, Brook FA. Prevention of spinal neural tube defects in the mouse embryo by growth retardation during neurulation. Development 1988;104:297-303.
    • (1988) Development , vol.104 , pp. 297-303
    • Copp, A.J.1    Crolla, J.A.2    Brook, F.A.3
  • 22
    • 0024993562 scopus 로고
    • The embryonic development of mammalian neural tube defects
    • Copp AJ, Brook FA, Estibeiro JP, et al. The embryonic development of mammalian neural tube defects. Prog Neurobiol 1990;35:363403.
    • (1990) Prog Neurobiol , vol.35 , pp. 363403
    • Copp, A.J.1    Brook, F.A.2    Estibeiro, J.P.3
  • 23
    • 0028040705 scopus 로고
    • Developmental basis of severe neural tube defects in the loop-tail (Lp) mutant mouse: Use of microsatellite DNA markers to identify embryonic genotype
    • Copp AJ, Checiu I, Henson JN. Developmental basis of severe neural tube defects in the loop-tail (Lp) mutant mouse: Use of microsatellite DNA markers to identify embryonic genotype. DevBiol 1994; 165:20-29.
    • (1994) DevBiol , vol.165 , pp. 20-29
    • Copp, A.J.1    Checiu, I.2    Henson, J.N.3
  • 24
    • 0031239122 scopus 로고    scopus 로고
    • Pax genes and organogenesis
    • Dahl E, Koseki H, Balling R. Pax genes and organogenesis. Bioessays 1997;19:755-765.
    • (1997) Bioessays , vol.19 , pp. 755-765
    • Dahl, E.1    Koseki, H.2    Balling, R.3
  • 25
    • 0016540885 scopus 로고
    • Congenital defects of the nervous system of lambs
    • Dennis SM. Congenital defects of the nervous system of lambs. Aust VetJ 1975;51:385-388.
    • (1975) Aust VetJ , vol.51 , pp. 385-388
    • Dennis, S.M.1
  • 26
    • 0028578195 scopus 로고
    • Developmental expression of the mouse Evx-2 gene: Relationship with the evolution of the HOM/Hox complex
    • Dolle P, Fraulob V, Duboule D. Developmental expression of the mouse Evx-2 gene: Relationship with the evolution of the HOM/Hox complex. Development [Suppl] 1994;143153.
    • (1994) Development [Suppl] , pp. 143153
    • Dolle, P.1    Fraulob, V.2    Duboule, D.3
  • 27
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215-221.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 28
    • 0026556607 scopus 로고
    • Valproic acid-induced spina bifida: A mouse model
    • Ehlers K, Sturje H, Merker HJ, et al. Valproic acid-induced spina bifida: A mouse model. Teratology 1992a;45:145-154.
    • (1992) Teratology , vol.45 , pp. 145-154
    • Ehlers, K.1    Sturje, H.2    Merker, H.J.3
  • 29
    • 0026669144 scopus 로고
    • Spina bifida aperta induced by valproic acid and by all-trans-retinoic acid in the mouse: Distinct differences in morphology and periods of sensitivity
    • Ehlers K, Sturje H, Merker HJ, et al. Spina bifida aperta induced by valproic acid and by all-trans-retinoic acid in the mouse: Distinct differences in morphology and periods of sensitivity. Teratology 1992b;46:l 17-130.
    • (1992) Teratology , vol.46
    • Ehlers, K.1    Sturje, H.2    Merker, H.J.3
  • 31
    • 0025925068 scopus 로고
    • Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3
    • Epstein DJ, Vekemans M, Gros P. Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell 1991:67:767-774.
    • (1991) Cell , vol.67 , pp. 767-774
    • Epstein, D.J.1    Vekemans, M.2    Gros, P.3
  • 32
    • 0027393598 scopus 로고
    • A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant
    • Epstein DJ, Vogan KJ, Trasler DG, et al. A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant. Proc Nad Acad Sei USA 1993;90:532-536.
    • (1993) Proc Nad Acad Sei USA , vol.90 , pp. 532-536
    • Epstein, D.J.1    Vogan, K.J.2    Trasler, D.G.3
  • 33
    • 0026513723 scopus 로고
    • Matemal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants
    • Essien FB. Matemal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants. Teratology 1992:45:205-212.
    • (1992) Teratology , vol.45 , pp. 205-212
    • Essien, F.B.1
  • 34
    • 0027455468 scopus 로고
    • Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice
    • Essien FB, Wannberg SL. Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice. J Nutr 1993;123:27-34.
    • (1993) J Nutr , vol.123 , pp. 27-34
    • Essien, F.B.1    Wannberg, S.L.2
  • 35
    • 0025341313 scopus 로고
    • Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age
    • Essien FB, Haviland MB, Naidoff AE. Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age. Teratology 1990;42:183-194.
    • (1990) Teratology , vol.42 , pp. 183-194
    • Essien, F.B.1    Haviland, M.B.2    Naidoff, A.E.3
  • 36
    • 0028918775 scopus 로고
    • Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in hétérozygotes
    • Farese RV Jr, Ruland SL, Flynn LM, et al. Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in hétérozygotes. Proc Nad Acad Sei USA 1995:92:1774-1778.
    • (1995) Proc Nad Acad Sei USA , vol.92 , pp. 1774-1778
    • Farese Jr., R.V.1    Ruland, S.L.2    Flynn, L.M.3
  • 37
    • 0023691642 scopus 로고
    • Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite
    • Finnell RH, Bennett GD, Karras SB, et al. Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite. Teratology 1988; 38:313-320.
    • (1988) Teratology , vol.38 , pp. 313-320
    • Finnell, R.H.1    Bennett, G.D.2    Karras, S.B.3
  • 38
    • 0032568871 scopus 로고    scopus 로고
    • Embryonic folate metabolism and mouse neural tube defects
    • Fleming A, Copp AJ. Embryonic folate metabolism and mouse neural tube defects. Science 1998;280:2107-2109.
    • (1998) Science , vol.280 , pp. 2107-2109
    • Fleming, A.1    Copp, A.J.2
  • 39
    • 0030854129 scopus 로고    scopus 로고
    • Failure of neural tube closure in the loop-tail (Lp) mutant mouse: Analysis of the embryonic mechanism
    • Gerrelli D, Copp AJ. Failure of neural tube closure in the loop-tail (Lp) mutant mouse: Analysis of the embryonic mechanism. Dev Brain Res 1997;102:217-224.
    • (1997) Dev Brain Res , vol.102 , pp. 217-224
    • Gerrelli, D.1    Copp, A.J.2
  • 40
    • 0028969815 scopus 로고
    • Multiple sites of anterior neural tube closure in humans: Evidence from anterior neural tube defects (anencephaly)
    • Golden JA, ChemoffGF. Multiple sites of anterior neural tube closure in humans: Evidence from anterior neural tube defects (anencephaly). Pediatrics 1995;95:506-510.
    • (1995) Pediatrics , vol.95 , pp. 506-510
    • Golden, J.A.1    Chemoff, G.F.2
  • 41
    • 0025875226 scopus 로고
    • Pax-3, a novel murine DNA binding protein expressed during early neurogenesis
    • Goulding MD, Chalepakis G, Deutsch U, et al. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 1991;10:1135-1147.
    • (1991) EMBO J , vol.10 , pp. 1135-1147
    • Goulding, M.D.1    Chalepakis, G.2    Deutsch, U.3
  • 42
    • 0031033593 scopus 로고    scopus 로고
    • Inositol prevents folateresistant neural tube defects in the mouse [see comments]
    • Greene ND, Copp AJ. Inositol prevents folateresistant neural tube defects in the mouse [see comments]. NatMed 1997;3:60-66.
    • (1997) NatMed , vol.3 , pp. 60-66
    • Greene, N.D.1    Copp, A.J.2
  • 43
    • 33747571571 scopus 로고
    • The Pathology of Development
    • Gruneberg H. The Pathology of Development. Oxford: Blackwell, 1963. pp. 24-32.
    • (1963) Oxford: Blackwell , pp. 24-32
    • Gruneberg, H.1
  • 44
    • 0013690487 scopus 로고    scopus 로고
    • Genetic and developmental studies of abnormal neural tube closure in SELH/Bc mice
    • Gunn TM. Genetic and developmental studies of abnormal neural tube closure in SELH/Bc mice. Ph.D. thesis, University of British Columbia, 1996.
    • (1996) Ph.D. Thesis, University of British Columbia
    • Gunn, T.M.1
  • 45
    • 0026748376 scopus 로고
    • Further genetic studies of the cause of exencephaly in SELH mice
    • Gunn TM, JuriloffDM, Harris MJ. Further genetic studies of the cause of exencephaly in SELH mice. Teratology 1992;45:679-686.
    • (1992) Teratology , vol.45 , pp. 679-686
    • Gunn, T.M.1    Juriloff, D.M.2    Harris, M.J.3
  • 46
    • 0027332855 scopus 로고
    • Histological study of the cranial neural folds of mice genetically liable to exencephaly
    • Gunn TM, JurilofFDM, Vogl W, et al. Histological study of the cranial neural folds of mice genetically liable to exencephaly. Teratology 1993;48:459-471.
    • (1993) Teratology , vol.48 , pp. 459-471
    • Gunn, T.M.1    JurilofF, D.M.2    Vogl, W.3
  • 47
    • 0028844403 scopus 로고
    • Genetically determined absence of an initiation site of cranial neural tube closure is causally related to exencephaly in SELH/Bc mouse embryos
    • Gunn TM, Juriloff DM, Harris MJ. Genetically determined absence of an initiation site of cranial neural tube closure is causally related to exencephaly in SELH/Bc mouse embryos. Teratology 1995;52:101-108.
    • (1995) Teratology , vol.52 , pp. 101-108
    • Gunn, T.M.1    Juriloff, D.M.2    Harris, M.J.3
  • 48
    • 0030464723 scopus 로고    scopus 로고
    • Exencephaly and cleft cerebellum in SELH/Bc mouse embryos are alternative developmental consequences of the same underlying genetic defect
    • Gunn TM, Juriloff DM, Harris MJ. Exencephaly and cleft cerebellum in SELH/Bc mouse embryos are alternative developmental consequences of the same underlying genetic defect. Teratology 1996;54:230-236.
    • (1996) Teratology , vol.54 , pp. 230-236
    • Gunn, T.M.1    Juriloff, D.M.2    Harris, M.J.3
  • 49
    • 0030765760 scopus 로고    scopus 로고
    • Effect of multifactorial genetic liability to exencephaly on the teratogenic effect of valproic acid in mice
    • HallJL, Harris MJ, JurilofFDM. Effect of multifactorial genetic liability to exencephaly on the teratogenic effect of valproic acid in mice. Teratology 1997;55:306-313.
    • (1997) Teratology , vol.55 , pp. 306-313
    • Hall, J.L.1    Harris, M.J.2    Juriloff, D.M.3
  • 50
    • 0030716384 scopus 로고    scopus 로고
    • Genetic landmarks for defects in mouse neural tube closure
    • Harris MJ, Juriloff DM. Genetic landmarks for defects in mouse neural tube closure. Teratology 1997;56:177-187.
    • (1997) Teratology , vol.56 , pp. 177-187
    • Harris, M.J.1    Juriloff, D.M.2
  • 51
    • 0027936938 scopus 로고
    • Development of the cerebellar defect in ataxic SELH/Bc mice
    • Harris MJ, Juriloff DM, Gunn TM, et al. Development of the cerebellar defect in ataxic SELH/Bc mice. Teratology 1994;50:63-73.
    • (1994) Teratology , vol.50 , pp. 63-73
    • Harris, M.J.1    Juriloff, D.M.2    Gunn, T.M.3
  • 52
    • 0025674267 scopus 로고
    • Expression of the Axd (axial defects) mutation in the mouse is insensitive to retinoic acid at low dose
    • Haviland MB, Essien FB. Expression of the Axd (axial defects) mutation in the mouse is insensitive to retinoic acid at low dose. J Exp Zool 1990:256:342-346.
    • (1990) J Exp Zool , vol.256 , pp. 342-346
    • Haviland, M.B.1    Essien, F.B.2
  • 53
    • 0028954840 scopus 로고
    • A frameshift mutation in the gene for PAX3 in a girl with spina bifida and mild signs of Waardenburg syndrome
    • Hoi FA, Hamel BC, Geurds MP, et al. A frameshift mutation in the gene for PAX3 in a girl with spina bifida and mild signs of Waardenburg syndrome. J Med Genet 1995:32:52-56.
    • (1995) J Med Genet , vol.32 , pp. 52-56
    • Hoi, F.A.1    Hamel, B.C.2    Geurds, M.P.3
  • 54
    • 0017113479 scopus 로고
    • Genetic spina bifida occulta in the mouse
    • Hollander WF. Genetic spina bifida occulta in the mouse. AmJ Anat 1976;146:173-179.
    • (1976) AmJ Anat , vol.146 , pp. 173-179
    • Hollander, W.F.1
  • 55
    • 0028249612 scopus 로고
    • Spina bifida: Anticonvulsants and other maternal influences
    • Holmes LB. Spina bifida: Anticonvulsants and other maternal influences. Ciba Found Symp 1994; 181:232-244.
    • (1994) Ciba Found Symp , vol.181 , pp. 232-244
    • Holmes, L.B.1
  • 56
    • 0027478167 scopus 로고
    • Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice
    • Homanics GE, Smith TJ, Zhang SH, et al. Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. Proc Natl AcadSci USA 1993:90:2389-2393.
    • (1993) Proc Natl AcadSci USA , vol.90 , pp. 2389-2393
    • Homanics, G.E.1    Smith, T.J.2    Zhang, S.H.3
  • 57
    • 0028961719 scopus 로고
    • Exencephaly and hydrocephaly in mice with targeted modification of the apolipoprotein B (Apob) gene
    • Homanics GE, Maeda N, Traber MG, et al. Exencephaly and hydrocephaly in mice with targeted modification of the apolipoprotein B (Apob) gene. Teratology 1995;51:1-10.
    • (1995) Teratology , vol.51 , pp. 1-10
    • Homanics, G.E.1    Maeda, N.2    Traber, M.G.3
  • 58
    • 0028800863 scopus 로고
    • Apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in hétérozygotes
    • Huang LS, Voyiaziakis E, Markenson DF, et al. apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in hétérozygotes. J Clin Invest 1995;96:2152-2161.
    • (1995) J Clin Invest , vol.96 , pp. 2152-2161
    • Huang, L.S.1    Voyiaziakis, E.2    Markenson, D.F.3
  • 59
    • 0023283842 scopus 로고
    • Craniorachischisis in a squirrel monkey
    • Jerome CP. Craniorachischisis in a squirrel monkey. LabAnimSci 1987;37:76-79.
    • (1987) LabAnimSci , vol.37 , pp. 76-79
    • Jerome, C.P.1
  • 60
    • 0024422922 scopus 로고
    • Genetic analysis of the cause of exencephaly in the SELH/Bc mouse stock
    • Juriloff DM, Macdonald KB, Harris MJ. Genetic analysis of the cause of exencephaly in the SELH/Bc mouse stock. Teratology 1989;40: 395-405.
    • (1989) Teratology , vol.40 , pp. 395-405
    • Juriloff, D.M.1    Macdonald, K.B.2    Harris, M.J.3
  • 61
    • 0027457494 scopus 로고
    • Ataxia and a cerebellar defect in the exencephalyprone SELH/Bc mouse stock
    • JurilofFDM, Harris MJ, Harrod ML, et al. Ataxia and a cerebellar defect in the exencephalyprone SELH/Bc mouse stock. Teratology 1993;47:333-340.
    • (1993) Teratology , vol.47 , pp. 333-340
    • Juriloff, D.M.1    Harris, M.J.2    Harrod, M.L.3
  • 63
    • 0004348138 scopus 로고
    • Female preponderance for hereditary exencephaly in mice also exists in fetuses
    • Kalter H. Female preponderance for hereditary exencephaly in mice also exists in fetuses. Teratology-1988;37:469 [abstract].
    • (1988) Teratology , vol.37 , pp. 469
    • Kalter, H.1
  • 64
    • 0021218972 scopus 로고
    • Gene-teratogen interaction and its morphological basis in retinoic acid-induced mouse spina bifida
    • Kapron-Bras CM, Trasler DG. Gene-teratogen interaction and its morphological basis in retinoic acid-induced mouse spina bifida. Teratology 1984;30:143-150.
    • (1984) Teratology , vol.30 , pp. 143-150
    • Kapron-Bras, C.M.1    Trasler, D.G.2
  • 65
    • 0021884331 scopus 로고
    • Reduction in the frequency of neural tube defects in splotch mice by retinoic acid
    • Kapron-Bras CM, Trasler DG. Reduction in the frequency of neural tube defects in splotch mice by retinoic acid. Teratology 1985;32:8792.
    • (1985) Teratology , vol.32 , pp. 8792
    • Kapron-Bras, C.M.1    Trasler, D.G.2
  • 66
    • 0023936633 scopus 로고
    • Histological comparison of the effects of the splotch gene and retinoic acid on the closure of the mouse neural tube
    • Kapron-Bras CM, Trasler DG. Histological comparison of the effects of the splotch gene and retinoic acid on the closure of the mouse neural tube. Teratology 1988;37:389-399.
    • (1988) Teratology , vol.37 , pp. 389-399
    • Kapron-Bras, C.M.1    Trasler, D.G.2
  • 68
    • 0028856888 scopus 로고
    • A curly-tail modifier locus, mctl, on mouse chromosome 17
    • Letts VA, Schork NJ, Copp AJ, et al. A curly-tail modifier locus, mctl, on mouse chromosome 17. Genomics 1995;29:719-724.
    • (1995) Genomics , vol.29 , pp. 719-724
    • Letts, V.A.1    Schork, N.J.2    Copp, A.J.3
  • 69
    • 0024539888 scopus 로고
    • Developmental study of neural tube closure in a mouse stock with a high incidence of exencephaly
    • Macdonald KB, Juriloff DM, Harris MJ. Developmental study of neural tube closure in a mouse stock with a high incidence of exencephaly. Teratology 1989;39:195-213.
    • (1989) Teratology , vol.39 , pp. 195-213
    • Macdonald, K.B.1    Juriloff, D.M.2    Harris, M.J.3
  • 70
    • 0029026227 scopus 로고
    • The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages
    • Martin JF, Bradley A, Oison EN. The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev 1995;9:1237-1249.
    • (1995) Genes Dev , vol.9 , pp. 1237-1249
    • Martin, J.F.1    Bradley, A.2    Oison, E.N.3
  • 71
    • 0025122421 scopus 로고
    • Comparison of the incidence of 5-azacytidine-induced exencephaly between MT/Hokldr and Slc:ICR mice
    • Matsuda M. Comparison of the incidence of 5-azacytidine-induced exencephaly between MT/Hokldr and Slc:ICR mice. Teratology 1990;41:147-154.
    • (1990) Teratology , vol.41 , pp. 147-154
    • Matsuda, M.1
  • 72
    • 0023547102 scopus 로고
    • Retinoic acid-induced selective mortality of splotch-delayed mouse neural tube defect mutants
    • Moase CE, Trasler DG. Retinoic acid-induced selective mortality of splotch-delayed mouse neural tube defect mutants. Teratology 1987; 36:335-343.
    • (1987) Teratology , vol.36 , pp. 335-343
    • Moase, C.E.1    Trasler, D.G.2
  • 73
    • 0025297945 scopus 로고
    • Delayed neural crest cell emigration from Sp and Spd mouse neural tube expiants
    • Moase CE, Trasler DG. Delayed neural crest cell emigration from Sp and Spd mouse neural tube expiants. Teratology 1990;42:171-182.
    • (1990) Teratology , vol.42 , pp. 171-182
    • Moase, C.E.1    Trasler, D.G.2
  • 74
    • 0026052275 scopus 로고
    • N-CAM alterations in splotch neural tube defect mouse embryos
    • Moase CE, Trasler DG. N-CAM alterations in splotch neural tube defect mouse embryos. Development 1991;113:1049-1058.
    • (1991) Development , vol.113 , pp. 1049-1058
    • Moase, C.E.1    Trasler, D.G.2
  • 75
    • 0026539239 scopus 로고
    • Splotch locus mouse mutants: Models for neural tube defects and Waardenburg syndrome type I in humans
    • Moase CE, Trasler DG. Splotch locus mouse mutants: Models for neural tube defects and Waardenburg syndrome type I in humans. J Med Genet 1992;29:145-151.
    • (1992) J Med Genet , vol.29 , pp. 145-151
    • Moase, C.E.1    Trasler, D.G.2
  • 76
    • 0031026635 scopus 로고    scopus 로고
    • Effects of methionine on the cytoplasmic distribution of actin and tubulin during neural tube closure in rat embryos
    • Moephuli SR, Klein NW, Baldwin MT, et al. Effects of methionine on the cytoplasmic distribution of actin and tubulin during neural tube closure in rat embryos. Proc Nad Acad Sei USA 1997;94:543-548.
    • (1997) Proc Nad Acad Sei USA , vol.94 , pp. 543-548
    • Moephuli, S.R.1    Klein, N.W.2    Baldwin, M.T.3
  • 77
    • 0018595774 scopus 로고
    • Heritability of cranium bifidum and spina bifida in the golden hamster
    • Moffa AM, White JA. Heritability of cranium bifidum and spina bifida in the golden hamster. Genet Res 1979;34:189-194.
    • (1979) Genet Res , vol.34 , pp. 189-194
    • Moffa, A.M.1    White, J.A.2
  • 79
    • 0029023462 scopus 로고
    • High-resolution linkage map in the vicinity of the Lp locus
    • Mullick A, Trasler D, Gros P. High-resolution linkage map in the vicinity of the Lp locus. Genomics 1995:26:479-488.
    • (1995) Genomics , vol.26 , pp. 479-488
    • Mullick, A.1    Trasler, D.2    Gros, P.3
  • 80
    • 0028313164 scopus 로고
    • Valproic acid-induced neural tube defects
    • Nau H. Valproic acid-induced neural tube defects. Ciba Found Symp 1994;181:144-156.
    • (1994) Ciba Found Symp , vol.181 , pp. 144-156
    • Nau, H.1
  • 81
    • 0028131139 scopus 로고
    • Early sialylation on N-CAM in splotch neural tube defect mouse embryos
    • Neale SA, Trailer DG. Early sialylation on N-CAM in splotch neural tube defect mouse embryos. Teratology 1994;50:118-124.
    • (1994) Teratology , vol.50 , pp. 118-124
    • Neale, S.A.1    Trailer, D.G.2
  • 82
    • 0028244488 scopus 로고
    • Multifactorial inheritance of neural tube defects: Localization of the major gene and recognition of modifiers in ct mutant mice
    • Neumann PE, Frankel WN, Letts VA, et al. Multifactorial inheritance of neural tube defects: localization of the major gene and recognition of modifiers in ct mutant mice. Nat Genet 1994;6:357-362.
    • (1994) Nat Genet , vol.6 , pp. 357-362
    • Neumann, P.E.1    Frankel, W.N.2    Letts, V.A.3
  • 83
    • 0030250887 scopus 로고    scopus 로고
    • Sodium valproate augments spontaneous neural tube defects and axial skeletal malformations in to mouse fetuses
    • Padmanabhan R, Ahmed I. Sodium valproate augments spontaneous neural tube defects and axial skeletal malformations in TO mouse fetuses. Reprod Toxicol 1996; 10:345-363.
    • (1996) Reprod Toxicol , vol.10 , pp. 345-363
    • Padmanabhan, R.1    Ahmed, I.2
  • 84
    • 0028080907 scopus 로고
    • Exencephaly and axial skeletal malformations induced by maternal administration of sodium valproate in the MF1 mouse
    • Padmanabhan R, Hameed MS. Exencephaly and axial skeletal malformations induced by maternal administration of sodium valproate in the MF1 mouse. J Craniofac Genet Dev Biol 1994;14:192-205.
    • (1994) J Craniofac Genet Dev Biol , vol.14 , pp. 192-205
    • Padmanabhan, R.1    Hameed, M.S.2
  • 85
    • 0024574127 scopus 로고
    • A mouse model for neural tube defects: The curtailed (Tc) mutation produces -s'pina bifida occulta in Tc/+ animals and spina bifida with meningomyelocele in Tc/t
    • Park CH, Pruitt JH, Bennett D. A mouse model for neural tube defects: The curtailed (Tc) mutation produces -s'pina bifida occulta in Tc/+ animals and spina bifida with meningomyelocele in Tc/t. Teratology 1989;39:303312.
    • (1989) Teratology , vol.39 , pp. 303312
    • Park, C.H.1    Pruitt, J.H.2    Bennett, D.3
  • 86
    • 0030899177 scopus 로고    scopus 로고
    • Spina bifida occulta in homozygous Patch mouse embryos
    • Payne J, Shibasaki F, Mercola M. Spina bifida occulta in homozygous Patch mouse embryos. Dev Dyn 1997;209:105-116.
    • (1997) Dev Dyn , vol.209 , pp. 105-116
    • Payne, J.1    Shibasaki, F.2    Mercola, M.3
  • 87
    • 0030068399 scopus 로고    scopus 로고
    • Relationship between altered axial curvature and neural tube closure in normal and mutant (curly tail) mouse embryos
    • Peeters MC, Shum AS, Hekking JW, et al. Relationship between altered axial curvature and neural tube closure in normal and mutant (curly tail) mouse embryos. Anat Embiyol (Berl) 1996:193:123-130.
    • (1996) Anat Embiyol (Berl) , vol.193 , pp. 123-130
    • Peeters, M.C.1    Shum, A.S.2    Hekking, J.W.3
  • 88
    • 0030240363 scopus 로고    scopus 로고
    • Cervical meningomyelocele associated with spina bifida in a hydrocéphalie miniature colt
    • Rivas LJ, HinchclifFKW, Robertson JT. Cervical meningomyelocele associated with spina bifida in a hydrocéphalie miniature colt. J Am VetMedAssoc 1996;209:950-953.
    • (1996) J Am VetMedAssoc , vol.209 , pp. 950-953
    • Rivas, L.J.1    HinchclifF, K.W.2    Robertson, J.T.3
  • 90
    • 0020086082 scopus 로고
    • Actin distribution patterns in the mouse neural tube during neurulation
    • Sadler TW, Greenberg D, Coughlin P, et al. Actin distribution patterns in the mouse neural tube during neurulation. Science 1982;215:172174.
    • (1982) Science , vol.215 , pp. 172174
    • Sadler, T.W.1    Greenberg, D.2    Coughlin, P.3
  • 91
    • 0029007405 scopus 로고
    • A subset of p53-deficient embryos exhibit exencephaly
    • Sah VP, Attardi LD, Mulligan GJ, et al. A subset of p53-deficient embryos exhibit exencephaly. Nat Genet 1995:10:175-180.
    • (1995) Nat Genet , vol.10 , pp. 175-180
    • Sah, V.P.1    Attardi, L.D.2    Mulligan, G.J.3
  • 92
    • 0030609894 scopus 로고    scopus 로고
    • TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes
    • Sanford LP, Ormsby I, Gittenberger-de Groot AC, et al. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 1997; 124:2659-2670.
    • (1997) Development , vol.124 , pp. 2659-2670
    • Sanford, L.P.1    Ormsby, I.2    Gittenberger-de Groot, A.C.3
  • 93
    • 0028247567 scopus 로고
    • Vitamins, folic acid and the cause and prevention of neural tube defects
    • Seller MJ. Vitamins, folic acid and the cause and prevention of neural tube defects. Ciba Found Symp 1994:181:161-179.
    • (1994) Ciba Found Symp , vol.181 , pp. 161-179
    • Seller, M.J.1
  • 94
    • 0029057083 scopus 로고
    • Sex, neural tube defects, and multisite closure of the human neural tube
    • Seller MJ. Sex, neural tube defects, and multisite closure of the human neural tube. Am J Med Genet 1995:58:332-336.
    • (1995) Am J Med Genet , vol.58 , pp. 332-336
    • Seller, M.J.1
  • 96
    • 0030914859 scopus 로고    scopus 로고
    • Analysis of neural crest cell migration in Splotch mice using a neural crest-specific LacZ reporter
    • Serbedzija GN, McMahon AP. Analysis of neural crest cell migration in Splotch mice using a neural crest-specific LacZ reporter. Dev Biol 1997;185:139-147.
    • (1997) Dev Biol , vol.185 , pp. 139-147
    • Serbedzija, G.N.1    McMahon, A.P.2
  • 98
    • 0028988719 scopus 로고
    • Genetic basis of neural tube defects: The mouse gene loop-tail maps to a region of Chromosome 1 syntenic with human Iq21-q23
    • Stanier P, Henson JN, Eddleston J, et al. Genetic basis of neural tube defects: The mouse gene loop-tail maps to a region of Chromosome 1 syntenic with human Iq21-q23. Genomics 1995:26:473-478.
    • (1995) Genomics , vol.26 , pp. 473-478
    • Stanier, P.1    Henson, J.N.2    Eddleston, J.3
  • 99
    • 0002539548 scopus 로고
    • Development of mice homozygous for the gene for Looptail
    • Stein KF, Rudin IA. Development of mice homozygous for the gene for Looptail. J Hered 1953;44:59-G9.
    • (1953) J Hered , vol.44
    • Stein, K.F.1    Rudin, I.A.2
  • 101
    • 0028883213 scopus 로고
    • MARCKS deficiency in mice leads to abnormal brain development and perinatal death
    • Stumpo DJ, Bock CD, Tuttle JS, et al. MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc Natl Acad Sei USA 1995;92:944-948.
    • (1995) Proc Natl Acad Sei USA , vol.92 , pp. 944-948
    • Stumpo, D.J.1    Bock, C.D.2    Tuttle, J.S.3
  • 103
    • 0025753068 scopus 로고
    • Studies of the effect of retinoic acid on anterior neural tube closure in mice genetically liable to exencephaly
    • Tom C, Juriloff DM, Harris MJ. Studies of the effect of retinoic acid on anterior neural tube closure in mice genetically liable to exencephaly. Teratology 1991;43:27-tO.
    • (1991) Teratology , vol.43
    • Tom, C.1    Juriloff, D.M.2    Harris, M.J.3
  • 104
    • 0026001235 scopus 로고
    • Immunohistochemical localization of chondroitin and heparan sulfate proteoglycans in pre-spina bifida splotch mouse embryos
    • Trasler DG, Morriss-Kay G. Immunohistochemical localization of chondroitin and heparan sulfate proteoglycans in pre-spina bifida splotch mouse embryos. Teratology 1991;44:571-579.
    • (1991) Teratology , vol.44 , pp. 571-579
    • Trasler, D.G.1    Morriss-Kay, G.2
  • 105
    • 0028784906 scopus 로고
    • A transgenic neuroanatomical marker identifies cranial neural crest deficiencies associated with the Pax3 mutant Splotch
    • Tremblay P, Kessel M, Gruss P. A transgenic neuroanatomical marker identifies cranial neural crest deficiencies associated with the Pax3 mutant Splotch. DevBioI 1995; 171:317-329.
    • (1995) DevBioI , vol.171 , pp. 317-329
    • Tremblay, P.1    Kessel, M.2    Gruss, P.3
  • 106
    • 0025355724 scopus 로고
    • Teratogenic effects on the neuroepithelium of the CD-1 mouse embryo exposed in utero to sodium valproate
    • Turner S, Sucheston ME, De Philip RM, et al. Teratogenic effects on the neuroepithelium of the CD-1 mouse embryo exposed in utero to sodium valproate. Teratology 1990;41:421442.
    • (1990) Teratology , vol.41 , pp. 421442
    • Turner, S.1    Sucheston, M.E.2    De Philip, R.M.3
  • 107
    • 0026781876 scopus 로고
    • Effects of H-2 on neural tube defects in congenic mice
    • Tyan ML. Effects of H-2 on neural tube defects in congenic mice. Proc Soc Exp Biol Med 1992;200:487-489.
    • (1992) Proc Soc Exp Biol Med , vol.200 , pp. 487-489
    • Tyan, M.L.1
  • 108
    • 0027493364 scopus 로고
    • Evidence for multi-site closure of the neural tube in humans
    • Van Alien MI, Kalousek DK, ChemofF GF, et al. Evidence for multi-site closure of the neural tube in humans. Am J Med Genet 1993;47: 723-743.
    • (1993) Am J Med Genet , vol.47 , pp. 723-743
    • Van Alien, M.I.1    Kalousek, D.K.2    Chemoff, G.F.3
  • 110
    • 0027338132 scopus 로고
    • The splotch-delayed (Spd) mouse mutant carries a point mutation within the paired box of the Pax-3 gene
    • Vogan KJ, Epstein DJ, Trasler DG, et al. The splotch-delayed (Spd) mouse mutant carries a point mutation within the paired box of the Pax-3 gene. Genomics 1993;17:364-369.
    • (1993) Genomics , vol.17 , pp. 364-369
    • Vogan, K.J.1    Epstein, D.J.2    Trasler, D.G.3
  • 111
    • 0027398807 scopus 로고
    • New Zealand white mice: An experimental model of exencephaly
    • Vogelweid CM, Vogt DW, Besch-Williford CL, et al. New Zealand white mice: an experimental model of exencephaly. Lab Anim Sei 1993; 43:58-).
    • (1993) Lab Anim Sei , vol.43 , pp. 58
    • Vogelweid, C.M.1    Vogt, D.W.2    Besch-Williford, C.L.3
  • 112
    • 0018242811 scopus 로고
    • Inheritance and morphology of exencephaly, a neonatal lethal recessive with partial penetrance, in the house mouse
    • Wallace ME, Knights PJ, Anderson JR. Inheritance and morphology of exencephaly, a neonatal lethal recessive with partial penetrance, in the house mouse. Genet Res 1978;32:135-149.
    • (1978) Genet Res , vol.32 , pp. 135-149
    • Wallace, M.E.1    Knights, P.J.2    Anderson, J.R.3
  • 113
    • 0018869127 scopus 로고
    • Early development of the brain and spinal cord in dysraphic mice
    • Wilson DB, Finta LA. Early development of the brain and spinal cord in dysraphic mice. Anat Embryol (Berl) 1980;160:315-326.
    • (1980) Anat Embryol (Berl) , vol.160 , pp. 315-326
    • Wilson, D.B.1    Finta, L.A.2
  • 114
    • 0022629758 scopus 로고
    • Pathogenesis of neural dysraphism in the mouse mutant vacuolated lens (vl)
    • Wilson DB, Wyatt DP. Pathogenesis of neural dysraphism in the mouse mutant vacuolated lens (vl). J Neuropathol Exp Neurol 1986;45:43-55.
    • (1986) J Neuropathol Exp Neurol , vol.45 , pp. 43-55
    • Wilson, D.B.1    Wyatt, D.P.2
  • 115
    • 0030434075 scopus 로고    scopus 로고
    • Valproic acid-induced changes in gene expression during neurulation in a mouse model
    • Wlodarczyk BC, Craig JC, Bennett GD, et al. Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 1996;54:284-297.
    • (1996) Teratology , vol.54 , pp. 284-297
    • Wlodarczyk, B.C.1    Craig, J.C.2    Bennett, G.D.3
  • 116
    • 9044254925 scopus 로고    scopus 로고
    • Neural tube defects and abnormal brain development in F52-deficient mice
    • Wu M, Chen DF, Sasaoka T, et al. Neural tube defects and abnormal brain development in F52-deficient mice. Proc Natl Acad Sei USA 1996;93:2110-2115.
    • (1996) Proc Natl Acad Sei USA , vol.93 , pp. 2110-2115
    • Wu, M.1    Chen, D.F.2    Sasaoka, T.3
  • 117
    • 0022888676 scopus 로고
    • Developmental anomalies induced by all-tram retinoic acid in fetal mice: I
    • Yasuda Y, Okamoto M, Konishi H, et al. Developmental anomalies induced by all-tram retinoic acid in fetal mice: I. Macroscopic findings. Teratology 1986;34:37-49.
    • (1986) Macroscopic Findings. Teratology , vol.34 , pp. 37-49
    • Yasuda, Y.1    Okamoto, M.2    Konishi, H.3
  • 119
    • 0027973640 scopus 로고
    • The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development
    • Zhao GQ, Eberspaecher H, Seldin MF, et al. The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. Mech Dev 1994;48:245-254.
    • (1994) Mech Dev , vol.48 , pp. 245-254
    • Zhao, G.Q.1    Eberspaecher, H.2    Seldin, M.F.3
  • 120
    • 0029946542 scopus 로고    scopus 로고
    • Prenatal folk acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cartl homeobox gene
    • Zhao Q, Behringer RR, de Crombrugghe B. Prenatal folk acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cartl homeobox gene. Nat Genet 1996;13: 275-283.
    • (1996) Nat Genet , vol.13 , pp. 275-283
    • Zhao, Q.1    Behringer, R.R.2    De Crombrugghe, B.3
  • 121


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