Therapeutic potential of the anti-angiogenesis drug TNP-470

International Journal of Experimental Pathology

Volumn 79, Issue 6, 1998, Pages 359-362

  Gervaz, Pascal ^a   Fontolliet, C ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Angiogenesis; Applications; Cancer; Clinical testing

Indexed keywords

FUMAGILLOL CHLOROACETYLCARBAMATE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL COMPARTMENTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DRUG EFFECT; ENDOTHELIUM CELL; GROWTH INHIBITION; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; REVIEW; TARGET CELL; TUMOR GROWTH;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CYCLOHEXANES; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; SESQUITERPENES;

EID: 0032436426     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.1998.00087.x     Document Type: Review

References (30)

1. ABE J., ZHOU W., TAKUWA N. ET AL. (1994) A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product. Cancer Res. 54, 3407-3412.
2. AHMED M.H., KONNO H., NAHAR L. ET AL. (1996) The angiogenesis inhibitor TNP-470 improves long-term survival of rats with liver metastases. J. Surg. Res. 64, 35-41.
3. FIGG W.D., PLUDA J.M., LUSH R.M. ET AL. (1997) The pharmakokinetics of TNP-470, a new angiogenesis inhibitor. Pharmacotherapy 17, 91-97.
4. FOLKMAN J. (1971) Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-118.
5. FOLKMAN J. (1995) Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nature Med. 1, 27-31.
6. HOLMGREN L., O'REILLY M.S. & FOLKMAN J. (1995) Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med. 1, 149-154.
7. INGBER D., FUJITA T., KISHIMOTO S. ET AL. (1990) Synthetic analogues of fumagilin that inhibit angiogenesis and suppress tumor growth. Nature 348, 555-557.
8. KAKEJI Y. & TEICHER B.A. (1997) Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents. Inv New Drugs 15, 39-48.
9. KLAUBER N., ROMAN R.M., FLYNN E. & D'AMATO R.J. (1997) Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470. Nature Medicine. 3, 443-446.
10. KONNO H., TANAKA T., MAKUDA I. ET AL. (1995) Comparison of the inhibitory effect of the angiogenesis inhibitor TNP-470, and mitomycin C on the growth and liver metastasis of human colon cancer. Int. J. Cancer 61, 268-71.
11. KUDELKA A.P., VERSCHRAGEN C.F. & LOYER E. (1998) Complete remission of metastatic cervical cancer with the angiogenesis inhibitor TNP-470. New Eng. J. Med. 338, 991-992.
12. KUSAKA M., SUDO K., NATSUTANI E. ET AL. (1994) Cystostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470. Br. J. Cancer 69, 212-216.
13. LEVEY T., KUDELKA A., VERSCHRAGEN C.F. ET AL (1996) A Phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix (abstract). Proc. Am. Assoc. Cancer Res. 37, 166.
14. MOLLER P.M., IVARSSON K., ROOS G. ET AL. (1997) Angiogenesis inhibitor TNP-470 augments the effect of repeated arterial ischemia on growth but does not affect take in a rat liver tumor model. Anticancer Res. 17, 2401-2406.
15. MCLESKEY S.W., ZHANG L., TROCK B.J. ET AL. (1996) Effects of AGM-1470 and pentosan polysulphate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells. Br. J. Cancer 73, 1053-1062.
16. MORI S., VEDA T., KURATSU S. ET AL. (1995) Suppression of pulmonary metastases by antiangiogenesis inhibitor TNP-470 in murine osteosarcoma. Int. J. Cancer 61, 148-152.
17. MORITA T., SHINOHARA N. & TOKUE A. (1994) Antitumor effect of a synthetic analogue of fumagillin on murine renal carcinoma. Br. J. Urology 74, 416-421.
18. MURATA R., MISHIMURA Y. & HIRAOKA M. (1997) An antiangiogenic agent inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma. Int. J. Rad. Oncol. Biol. Phys. 37, 1107-1113.
19. PLUDA J.M., WYVILL K., FIGG W.D. ET AL. (1994) A phase I study of an angiogenesis inhibitor, TNP-470 (AGM-1470), administered to patients with HIV-associated Kaposi's sarcoma. Proc. Am. Soc. Clin. Oncol. 13, 51 (abstract).
20. SIN M., MENG M.Q., WEN J.J. ET AL. (1997) The antiangiogenic agent fumagillin covalently binds and inhibits the methionone aminopeptidase, metAP-2. Proc. Nat. Acad. Sc. 94, 6099-6103.
21. TAKAMYIA Y., BREM H., OJEIFO J. ET AL. (1994) AGM-1470 inhibits the growth of human glioblastoma cells in vitro and in vivo. Neurosurgery 34, 869-875.
22. TANAKA H., TANIGUCHI H., MUGITANI T. ET AL. (1996) Angiogenesis inhibitor TNP-470 prevents implanted liver metastases after partial hepatectomy in an experimental model without impairing wound healing. Br. J. Surg. 83, 1444-1447.
23. TANAKA T., KONNO H., MATSUDA I. ET AL. (1995) Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470. Cancer Res. 55, 836-839.
24. TEICHER B.A., HOLDEN S.A.., ARA G. ET AL. (1994) Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int. J. Cancer. 57, 920-925.
25. XIA J.L., YANG B.H., TANG Z.Y. ET AL. (1997) Inhibitory effect of the angiogenesis inhibitor TNP-470 on tumor growth and metastasis in nude mice bearing human hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 123, 383-387.
26. YAMAOKA M., YAMAMOTO T., IKEYAMA S. ET AL. (1993a) Angiogenesis inhibitor TNP-470 potently inhibits the tumor growth of hormone independent human breast and prostate carcinoma cell lines. Cancer Res. 53, 5233-5236.
27. YAMAOKA M., YAMAMOTO M., MASAKI T. ET AL. (1993b) Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor TNP-470. Cancer Res. 53, 4262-4267.
28. YANASE T., TAMURA M., FUJITA K. ET AL. (1993) Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res. 53, 2566-2570.
29. YANO T., TANASE M., WATANABLE A. ET AL. (1995) Enhancement effect of an antiangiogenic agent TNP-470, on hyperthermia-induced growth suppression of human esophageal and gastric cancers transplantable to nude mice. Anticancer Res. 15, 1355-1358.
30. ZUKIWSKI J., GUTTERMAN J., BUL C. ET AL. (1994) Phase I trial of the angiogenesis inhibitor TNP-470 in patients with androgen independent prostate cancer. Proc. Am. Soc. Clin. Oncol. 13, 252.