Angiogenesis inhibitor TNP-470 prevents implanted liver metastases after partial hepatectomy in an experimental model without impairing wound healing

British Journal of Surgery

Volumn 83, Issue 10, 1996, Pages 1444-1447

  Tanaka, H ^a   Taniguchi, H ^a   Mugitani, T ^a   Koishi, Y ^a   Masuyama, M ^a   Koyama, H ^a   Hoshima, M ^a   Takahashi, T ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FUMAGILLOL CHLOROACETYLCARBAMATE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; LIVER METASTASIS; LIVER RESECTION; NONHUMAN; PRIORITY JOURNAL; WOUND HEALING;

ANIMALS; CYCLOHEXANES; HEPATECTOMY; LIVER NEOPLASMS; NEOPLASM SEEDING; RABBITS; SESQUITERPENES; WOUND HEALING;

EID: 0029803590     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1002/bjs.1800831038     Document Type: Article

References (20)

1. Scheele J, Stangl R, Altendorf-Hofmann A. Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history. Br J Surg 1990; 77: 1241-6.
2. Hughes KS, Simon R, Songhorabodi S et al. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence. Surgery 1986; 100: 278-4.
3. Ballantyne GH, Quin J. Surgical treatment of liver metastases in patients with colorectal cancer. Cancer 1993; 71(Suppl): 4252-66.
4. Que FG, Nagorncy DM. Resection of 'recurrent' colorectal metastasis to the liver. Br J Surg 1994; 81: 255-8.
5. Fisher B, Fisher ER. Experimental studies of factors influencing hepatic metastases: II. Effect of partial hepatectomy. Cancer 1959; 12: 929-32.
6. Panis Y, Ribeiro J, Chretien Y, Nordlinger B. Dormant liver metastases: an experimental study. Br J Surg 1992; 79: 221-3.
7. Slooter GD, Marquet RL, Jeekel J, Ijzermans JNM. Tumor growth stimulation after partial hepatectomy can be reduced by treatment with tumour necrosis factor α. Br J Surg 1995; 82: 129-32.
8. Kaneko A, Hayashi N, Tanaka Y et al. Changes in serum human hepatocyte growth factor levels after transcatheter arterial embolization and partial hepatectomy. Am J Gastroenterol 1992; 87: 1014-17.
9. Tsujitani S, Watanabe A, Sugimachi K et al. Hepatic recurrence not prevented with low-dosage long-term intraportal 5-FU infusion after resection of colorectal liver metastasis. Eur J Surg Oncol 1991; 17: 526-9.
10. Safi F, Bittner R, Beger GH et al. Regional chemotherapy for hepatic metastases of colorectal carcinoma (continuous intraarterial versus continuous intraarterial/intravenous therapy): results of a controlled clinical trial. Cancer 1989; 64: 379-87.
11. Ingber D, Fujita T, Kishimoto S et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 1990; 348: 555-7.
12. Kusaka M, Sudo K, Fujita T et al. Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent. Biochem Biophys Res Commun 1991; 174: 1070-6.
13. Toi M, Yamamoto Y, Imazawa T, Takayanagi T, Akutu K, Tominaga T. Antitumor effect of the angiogenesis inhibitor AGM-1470 and its combination effect with tamoxifen in DMBA induced mammary tumors in rats. Int J Oncol 1993; 3: 525-8.
14. Yanase T, Tamura M, Fujita K, Kodama S, Tanaka K. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res 1993; 53; 2566-70.
15. Tanaka H, Taniguchi H, Takahashi T et al. Intra-arterial administration of the angiogenesis inhibitor TNP-470 blocks liver metastasis in a rabbit model. Br J Cancer 1995; 72: 650-3.
16. Yamaoka M, Yamamoto T, Masaki T, Ikeyama S, Sudo K, Fujita T. Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470). Cancer Res 1993; 53: 4262-7.
17. Lautt WW, Greenway CV. Conceptual review of the hepatic vascular bed. Hepatology 1987; 7: 952-63.
18. Taylor I, Bennett R, Sheriff S. The blood supply of colorectal liver metastases. Br J Cancer 1979; 39: 749-56.
19. Folkman J. Tumor angiogenesis. Adv Cancer Res 1985; 43: 175.
20. Muto M. A scanning electron microscopic study on endothelial cells and Kupffer cells in rat liver sinusoids. Archivum Histologicum Japonicum 1975; 37: 369-86.