Inhibitory effect of the angiogenesis inhibitor TNP-470 on tumor growth and metastasis in nude mice bearing human hepatocellular carcinoma

Journal of Cancer Research and Clinical Oncology

Volumn 123, Issue 7, 1997, Pages 383-387

  Xia, Jing Lin ^a   Yang, Bing Hui ^a   Tang, Zhao You ^a   Sun, Fang Xian ^a   Xue, Qiong ^a   Gao, Dong Mei ^a  

^a ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; Metastasis; Nude mice; TNP 470; Tumor growth; Vascular endothelial growth factor

Indexed keywords

ALPHA FETOPROTEIN; FUMAGILLOL CHLOROACETYLCARBAMATE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LUNG METASTASIS; METASTASIS; METASTASIS INHIBITION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR VOLUME;

EID: 0030819803     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01240121     Document Type: Article

References (21)

1. Dvorak HF, Nagy JA, Dvorak JT, Dvorak AM (1988) Identification and characterization of the blood vessels of solid tumors that are leaky to circulation macromolecules. Am J Pathol 133:95-109
2. Egawa SI, Tsutsumi M, Konishi Y, Kobari M, Matsuno S, Nagasahi K, Futami H, Yamaguchi K (1995) The role of angiogenesis in the tumor growth of Syrian hamster pancreatic cancer cell line HPD-NR. Gastroenterology 108:1526-1533
3. Fidler IJ, Ellis LM (1994) The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79:185-188
4. Folkman J (1985) Tumor angiogenesis. Adv Cancer Res 43:175-203
5. Geran RI, Greenberg NH, Mac Donald MM, Schumacher AM, Abbott BJ (1972) Protocols for screening chemical agents and natural products against animal tumors and biological systems. Cancer Chemother Rep 3:1-103
6. Hawkins MJ (1995) Clinical trials of antiangiogenic agents. Curr Opin Oncol 7:90-93
7. Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Berm H, Folkman J (1990) Synthetic analogues of fumgillin that inhibit angiogenesis and suppress tumor growth. Nature 348:555-557
8. Kamei S, Okada H, Inoue Y, Yoshioka T, Ogawa Y, Toguchi H (1993) Antitumor effects of angiogenesis inhibitor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administration of microspheres and solution. J Pharmacol Exp Ther 264:469-474
9. Kusaka M, Sudo K, Fujita T, Marui S, Itoh H, Ingber D, Folkman J (1991) Potent antiangiogenic action of AGM-1470: comparison to the fumgillin parent. Biochem Biophys Res Commum 174:1070-1076
10. Liota L, Kleinerman J, Saidel G (1974) Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastasis following tumor implantation. Cancer Res 34:997-1004
11. Mori S, Ueda T, Kuratsu S, Hosono N, Izawa K, Uchida A (1995) Suppression of pulmonary metastasis by angiogenesis inhibitor TNP-470 in murine osteosarcoma. Int J Cancer 6:148-52
12. Morita T, Shinohara N, Tokue A (1994) Antitumor effect of synthetic analogue of fumagillin on murine renal carcinoma. Br J Urol 74:416-421
13. Srivastava A, Laidler P, Davies RP (1986) The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma: quantitative histologic study. Am J Pathol 13:419-423
14. Sun FX, Tang ZY, Liu KD, Ye SL, Xue Q, Gao DM, Mao ZC (1996) Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues. Int J Cancer 66:239-243
15. Tanaka T, Konno H, Matsuda I, Nakamura S, Baba S (1995) Prevention of hepatic metastasis of colon cancer by angiogenesis inhibitor TNP-470. Cancer Res 55:836-839
16. Tetsuro K, Kazunari S, Hideaki K, Yukihisa M (1994) Enhanced suppression of tumor growth by combination of angiogenesis inhibitor O-(chloroacetyl-carbamoyl) fumagillol (TNP-470) and cytotoxic agents in mice. Cancer Res 54:5143-147
17. Weidner N, Semple JP, Welch WR (1991) Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324:1-8
18. Yamaka M, Yamaoto T, Maski T, Ikeyama S, Sudo K, Fujita T (1993) Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloacetyl-carbamoyl) fumgillin TNP-470; AGM-1470). Cancer Res 53:4262-4267
19. Yamaoka K, Yamamoto T, Ikeyama S, Sudo K, Fujita T (1993) Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibit the tumor growth of hormone-independent human breast and prostate carcinoma cell lines Cancer Res 53:5233-5236
20. Yamaue H, Tanimura K, Noguchi T, Hotta M, Tani T, Tsunoda T, Iwahashi M, Tamai, Iwakura S (1992) Chemosensitivity testing of fresh human gastric cancer with highly purified tumor cells using MTT assay. Br J Cancer 66:794-797
21. Yanase T, Tamura M, Fujita K, Kodama S, Tanaka K (1993) Inhibition effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res 53:2566-2570