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Readers interested in recent information pertaining to structure-toxicity relationships may also want to check either of the following non-profit organizations: School of Chemistry at the University of Leeds (http://Chem.leeds.AC.UK/Luk); or The European Center for Ecotoxicology and Toxicology of Chemicals (ECETOC).
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Also in this regard, interested readers may want to consider the somewhat analogous metabolic surveys that are being conducted in plant tissues, e.g. i) R. O. Mumma and R. H. Hamilton, Xenobiotic Metabolism In Higher Plants: In Vitro Tissue And Cell Culture Techniques, ACS Symp Ser., 97, 35-76 (1979); ii) R. H. Shimabukuro and W. C. Walsh, Xenobiotic Metabolism In Plants: In Vitro Tissue, Organ, And Isolated Cell Techniques, ACS Symp. Ser., 97 3-34 (1979), along with iii) The AGRO-version of Metabol Expert which is also available from ARSoftware Corp.
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Also in this regard, interested readers may want to consider the somewhat analogous metabolic surveys that are being conducted in plant tissues, e.g. i) R. O. Mumma and R. H. Hamilton, Xenobiotic Metabolism In Higher Plants: In Vitro Tissue And Cell Culture Techniques, ACS Symp Ser., 97, 35-76 (1979); ii) R. H. Shimabukuro and W. C. Walsh, Xenobiotic Metabolism In Plants: In Vitro Tissue, Organ, And Isolated Cell Techniques, ACS Symp. Ser., 97 3-34 (1979), along with iii) The AGRO-version of Metabol Expert which is also available from ARSoftware Corp.
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Molecular modelling of cytochrome CYP1A1: A putative access channel explains differences in induction potency between the isomers benzo(a)pyrene and benzo(e)pyrene, and 2- and 4- acetylaminofluorene
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D. F. Lewis, C. Ioannides and D. V. Parke, Molecular Modelling Of Cytochrome CYP1A1: A Putative Access Channel Explains Differences In Induction Potency Between The Isomers Benzo(a)pyrene and Benzo(e)pyrene, And 2- And 4- Acetylaminofluorene, Tox. Lett., 71, 235-243 (1994).
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D. F. Lewis, B. G. Lake and D. V. Parke, Molecular Orbital-Generated QSARs In A Homologous Series Of Alkoxyresorufins And Studies Of Their Interactive Docking With P450s, Xenobiotica, 25, 1355-1369 (1995).
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D. F. Lewis, C. Ioannides and D. V. Parke, A Quantitative Structure-Activity Relationship Study On A Series Of 10 Para-Substituted Toluenes Binding To Cytochrome P4502B4 (CYP2B4), And Their Hydroxylation Rates, Biochem. Pharm., 50, 619-625 (1995).
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