The involvement of bulbospinal pathways in fentanyl-induced inhibition of spinal withdrawal reflexes in the decerebrated rabbit

Pain

Volumn 78, Issue 3, 1998, Pages 197-207

  Clarke, Rob W ^a   Parry Baggott, Claire ^a   Houghton, Andrea K ^a   Ogilvie, Jane ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Adrenoceptors; Blood pressure; Descending inhibition; Nociception; Opioid

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR; FENTANYL; MU OPIATE RECEPTOR; NORADRENALIN;

ANIMAL MODEL; BRAIN STEM; CONTROLLED STUDY; DECEREBRATION; DOSE RESPONSE; ELECTROSTIMULATION; FEMALE; GASTROCNEMIUS MUSCLE; INTRACEREBRAL DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; REVIEW; WITHDRAWAL REFLEX;

EID: 0032422034     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(98)00127-4     Document Type: Article

References (83)

1. Advokat C. The role of descending inhibition in morphine-induced analgesia. Trends Pharmacol. Sci. 9:1988;330-334.
2. Advokat C., Burton P. Antinociceptive effect of systemic and intrathecal morphine in spinally transected rats. Eur. J. Pharmacol. 139:1987;335-343.
3. Advokat C., Gulati A. Spinal transection reduces both spinal antinociception and CNS concentration of systemically administered morphine in rats. Brain Res. 555:1991;251-258.
4. 5 (DAMGO) and morphine-induced antinociception in mice. J. Pharmac. Exp. Ther. 256:1991;890-896.
5. Arvidsson U., Riedl M., Chakrabarti S., Lee J.H., Nakano A.H., Dado R.J., Loh H.H., Law P.Y., Wessendorf M.W., Elde R. Distribution and targeting of a mu-opioid receptor (mor1) in brain and spinal-cord. J. Neurosci. 15:1995;3328-3341.
6. Badoer E., Chalmers J. Interactions of endogenous opioid and excitatory amino acid inputs to the caudal ventrolateral medulla of the rat. Neuropharmacology. 31:1992;857-862.
7. Barton C., Basbaum A.I., Fields H.L. Dissociation of supraspinal and spinal actions of morphine: a quantitative evaluation. Brain Res. 188:1980;487-498.
8. Carstens E., Hartung M., Stelzer B., Zimmermann M. Suppression of a hind limb flexion withdrawal reflex by microinjection of glutamate or morphine into the periaqueductal gray in the rat. Pain. 43:1990;105-112.
9. Clark S.L., Edeson R.O., Ryall R.W. The descending control of nociception and the site of action of morphine in the anaesthetized cat. Br. J. Pharmacol. 79:1983;807-818.
10. Clarke R.W., Ford T.W. The contributions of μ-, δ- and κ-opioid receptors to the actions of endogenous opioids on spinal reflexes in the rabbit. Br. J. Pharmacol. 91:1987;579-589.
11. Clarke R.W., Ford T.W., Taylor J.S. Adrenergic and opioidergic modulation of a spinal reflex in the rabbit. J. Physiol. 404:1988;407-417.
12. Clarke R.W., Ford T.W., Taylor J.S. Reflex actions of selective stimulation of sural nerve C fibres in the rabbit. Q. J. Exp. Physiol. 74:1989;681-690.
13. Clarke, R.W., Houghton, A.K., Parry-Baggott, C. and Ogilvie, J., A possible interaction between intravenous fentanyl and endogenous noradrenaline in the spinal cord of the decerebrated rabbit, J. Physiol., 493.P (1996a) 41P.
14. Clarke, R.W., Ogilvie, J., Parry-Baggott, C. and Voce, A., Inhibition of a reflex after intravenous and intraventricular fentanyl in the decerebrated rabbit, J. Physiol., 495.P (1996b) 23P-24P.
15. Crisp T., Stafinsky J.L., Uram M., Perni V.C., Weaver M.F., Spanos L.J. Serotonin contributes to the spinal antinociceptive effects of morphine. Pharmacol. Biochem. Behav. 39:1991;591-595.
16. Dhawan B.N., Cesselin F., Raghubir R., Reisine T., Bradley P.B., Portoghese P., Hamon M. International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol. Rev. 48:1996;567-592.
17. Dickenson A.H. Plasticity: implications for opioid and other pharmacological interventions in specific pain states. Behav. Brain Res. 20:1997;392-403.
18. Dickenson A.H., Le Bars D. Lack of evidence for increased descending inhibition on the dorsal horn of the rat following periaqueductal grey morphine microinjections. Br. J. Pharmacol. 92:1987;271-280.
19. Drolet G., Morilak D.A., Chalmers J. Endogenous opioids tonically inhibit the depressor neurones in the caudal ventrolateral medulla of rabbits - mediation through δ-receptor and κ-receptor. Neuropharmacol. 30:1991;383-390.
20. Duggan A.W., Griersmith B.T., North R.A. Morphine and supraspinal inhibition of spinal neurones: evidence that morphine decreases tonic descending inhibition in the anaesthetized cat. Br. J. Pharmacol. 69:1980;461-466.
21. Duggan A.W., North R.A. Electrophysiology of opioids, Pharmacol. Rev. 35:1984;219-281.
22. Feldman P.D., Parveen N., Sezen S. Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat. Brain Res. 709:1996;331-336.
23. Gao K.M., Chen D.O., Genzen J.R., Mason P. Activation of serotonergic neurons in the raphe magnus is not necessary for morphine analgesia. J. Neurosci. 18:1998;1860-1868.
24. Gebhart G.F., Sandkuhler J., Thalhammer J.G., Zimmerman M. Inhibition of spinal cord antinociceptive information by electrical stimulation and morphine microinjection at identical sites in the midbrain of the cat. J. Neurophysiol. 51:1984;75-89.
25. Gogas K.R., Presley R.W., Levine J.D., Basbaum A.I. The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control - correlation of nociceptive behavior and c-fos expression. Neurosci. 42:1991;617-628.
26. Gogas K.R., Cho H.J., Botchkina G.I., Levine J.D., Basbaum A.I. Inhibition of noxious stimulus-evoked pain behaviors and neuronal fos-like immunoreactivity in the spinal cord of the rat by supraspinal morphine. Pain. 65:1996;9-15.
27. Goodchild C.S., Guo Z., Davies A., Gent J.P. Antinociceptive actions of intrathecal xylazine: Interactions with spinal cord opioid pathways. Br. J. Anaesth. 76:1996;544-551.
28. Gouarderes C., Cros J., Quirion R. Autoradiographic localization of mu, delta and kappa opioid receptor binding sites in rat and guinea pig spinal cord. Neuropeptides. 6:1985;331-342.
29. Gupta U., Pant K.K., Nath R., Sinha J.N. Effect of guanethidine pretreatment of spinal autonomic loci on the cardiovascular effects of intrathecally injected opioidergic agonists in chloralose anaesthetized cats. Asia Pac. J. Pharmacol. 12:1997;25-29.
30. Harris J., Clarke R.W. An analysis of adrenergic influences on the sural gastrocnemius reflex of the decerebrated rabbit. Exp. Brain Res. 92:1992;310-317.
31. 2-adrenoceptor antagonists in the decerebrated rabbit. Eur. J. Pharmacol. 237:1993;323-328.
32. Heinricher M.M., Morgan M.M., Fields H.L. Direct and indirect actions of morphine on medullary neurons that modulate nociception. Neurosci. 48:1992;533-543.
33. Herrero J.F., Headley P.M. The effects of sham and full spinalization on the systemic potency of mu-opioid and kappa-opioids on spinal nociceptive reflexes in rats. Br. J. Pharmacol. 104:1991;166-170.
34. Herz A., Albus K., Metys J., Schubert P., Teschemacher H. On the central sites for the antinociceptive action of morphine and fentanyl. Neuropharmacol. 9:1970;539-551.
35. Honda C.N., Arvidsson U. Immunohistochemical localization of delta- and mu-opioid receptors in primate spinal cord. NeuroReport. 6:1995;1025-1028.
36. 2-adrenoceptor agonist and a μ-opioid agonist influence noxiously evoked C-fos expression in the rat - a pharmacological study. J. Pharmac. exp. Ther. 278:1996;393-403.
37. 2-adrenoceptors in the rat brain. Mol. Neuropharmacol. 1:1992;219-229.
38. Irwin S., Houde R.W., Bennett D.R., Hendershott L.C., Seevers M. The effects of morphine, methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation. J. Pharmacol. Exp. Ther. 101:1951;132-143.
39. Jensen T.S. Opioids in the brain: Supraspinal mechanisms in pain control. Acta Anaesth. Scand. 41:1997;123-132.
40. Jensen T.S., Yaksh T.L. Examination of spinal monoamine receptors through which brainstem opiate-sensitive systems act in the rat. Brain Res. 363:1986;114-127.
41. Jensen T.S., Yaksh T.L. Comparison of the antinociceptive effect of morphine and glutamate at coincidental sites in the periaqueductal gray and medial medulla in rats. Brain Res. 476:1989;1-9.
42. Jung J.S., Song D.K., Suh H.W., Kim Y.H. Effects of intraventricular-injection of morphine and beta-endorphin on serotonin release from the spinal-cord in rats. Pharmacol. Biochem. Behav. 49:1994;1037-1042.
43. Jurna I., Grossman W. The effects of morphine on the activity evoked in ventrolateral tract axons of the cat spinal cord. Exp. Brain Res. 24:1976;473-484.
44. Keay K.A., Crowfoot L.J., Floyd N.S., Henderson L.A., Christie M.J., Bandler R. Cardiovascular effects of microinjections of opioid agonists into the 'Depressor Region' of the ventrolateral periaqueductal gray region. Brain Res. 762:1997;61-71.
45. Kitahata L.M., Collins J.G., Omote K. Analgesic mechanism of opioid analgesics at the spinal level. 2 Interaction of opiate and monoamine systems. Sapporo Med. J. 59:1990;419-426.
46. Le Bars D., Menetrey D., Besson J.-M. Effects of morphine on the lamina V type cells activities in the dorsal horn of the decerebrate cat. Brain Res. 115:1976;293-310.
47. Loomis C.W., Milne B., Cervenko F.W. A study of the interaction between clonidine and morphine on analgesia and blood pressure during continuous intrathecal infusion in the rat. Neuropharmacol. 27:1988;191-199.
48. Mansour, A., Fox, C.A., Burke, S., Meng, F., Thompson, R.C., Akil, H. and Watson, S.J., Mu-opioid, delta-opioid, and kappa-opioid receptor messenger-rna expression in the rat cns - an in-situ hybridization study, J. Comp. Neurol., 350 (1994a) 412-438.
49. Mansour, A., Fox, C.A., Burke, S. and Watson, S.J., Immunohistochemical localization of the mu opioid receptors, Regul. Pept., 54 (1994b) 179-180.
50. McQuay H.J., Sullivan A.F., Smallman K., Dickenson A.H. Intrathecal opioids, potency and lipophilicity. Pain. 36:1989;111-116.
51. 1A receptors in the rat brain. Eur. J. Pharmacol. 312:1996;385-388.
52. Morilak D.A., Drolet G., Chalmers J. Tonic opioid inhibition of the pressor region of the rostral ventrolateral medulla of rabbits is mediated by delta-receptors. J. Pharmacol. Exp. Ther. 254:1990;671-676.
53. Nagasaka H., Yaksh T.L. Effects of intrathecal mu-agonist, delta-agonist and kappa-agonist on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats. Anesthes. Analg. 80:1995;437-443.
54. Nath R., Mukherjee D., Gurtu S., Dhawan K.N., Gupta G.P., Sinha J.N. Characterization of opioid receptors of spinal cord involved in cardiovascular regulation in alpha-chloralose anaesthetized cats. Asia Pac. J. Pharmacol. 7:1992;283-289.
55. Ogilvie J., Bhandari R.N.B., Clarke R.W. Tonic adrenergic descending inhibition in the rabbit is not the product of surgical preparation. Soc. Neurosci. Abs. 23:1997;1539.
56. 1A-receptors in rabbit spinal cord in vivo. Br. J. Pharmcol. 123:1998;1138-1142.
57. Ogutman C., Kaputlu I., Sadan G. Cardiovascular effects of intrathecally injected mu, delta and kappa opioid receptor agonists in rabbits. J. Auton. Pharmacol. 15:1995;443-450.
58. Ossipov, M.H., Harris, S., Lloyd, P. and Messineo, E., An isobolographic analysis of the antinociceptive effect of systemically and intrathecally administered combinations of clonidine and opiates, J. Pharmacol. Exp. Ther., 255 (1990a) 1107-1116.
59. Ossipov, M.H., Harris, S., Lloyd, P., Messineo, E., Lin, B.S. and Bagley, J., Antinociceptive interaction between opioids and medetomidine - systemic additivity and spinal synergy, Anesthesiology, 73 (1990b) 1227-1235.
60. Parsons C.G., West D.C., Headley P.M. Spinal antinociceptive actions and naloxone reversibility of intravenous μ- and k-opioids in spinalized rats: potency mismatch with values reported for spinal administration. Br. J. Pharmacol. 98:1989;533-543.
61. Przesmycki K., Dzieciuch J.A., Czuczwar S.J., Kleinrok Z. Isobolographic analysis of interaction between intrathecal morphine and clonidine in the formalin test in rats. Eur. J. Pharmacol. 337:1997;11-17.
62. Rabkin S.W. D-Ala-2-Me-Phe-4-Met-(O)-ol-enkephalin in the nucleus tractus solitarius of the rat produces cardiorespiratory depression. Gen. Pharmacol. 22:1991;479-484.
63. Satoh M., Tagaki H. Enhancement by morphine of the central descending inhibitory influence on spinal transmission. Eur. J. Pharmacol. 14:1971;60-65.
64. Schouenborg J., Kalliomaki J. Functional organization of the nociceptive withdrawal reflexes. 1. Activation of hindlimb muscles in the rat. Exp. Brain Res. 83:1990;67-78.
65. Spaulding T.C., Fielding S., Venafro J.J., Lal H. Antinociceptive activity of clonidine and its potentiation of morphine analgesia. Eur. J. Pharmacol. 58:1979;19-25.
66. 2 adrenergic controls and spinal morphine potency in inflammation. NeuroReport. 5:1994;469-472.
67. 2 agonists and is necessary for spinal adrenergic-opioid synergy. J. Neurosci. 17:1997;7157-7165.
68. 2 adrenergic antinociception in the rat spinal cord. Neurosci. Lett. 139:1992;65-68.
69. Sun M.K. Pharmacology of reticulospinal vasomotor neurons in cardiovascular regulation. Pharmacol. Rev. 48:1996;465-494.
70. Sun S.Y., Liu Z., Li P., Ingenito A.J. Central effects of opioid agonists and naloxone on blood pressure and heart rate in normotensive and hypertensive rats. Gen. Pharmacol. 27:1996;1187-1194.
71. Taylor, J.S., Opioid and monoamine modulation of spinal reflexes in the rabbit, Ph.D. thesis, University of Nottingham, 1994.
72. 3H]-idazoxan. Neurochem. Int. 17:1990;537-546.
73. Villanueva L., Le Bars D. The activation of bulbo-spinal controls by peripheral nociceptive inputs: Diffuse noxious inhibitory controls. Biol. Res. 28:1995;113-125.
74. Vogt M. The effect of lowering the 5-hydroxytryptamine content of the rat spinal cord on the analgesia produced by morphine. J. Physiol. 236:1974;483-498.
75. von Cube B., Teschemacher H., Herz A., Hess R. Permeation morphinartiger Substanzen an den Ort der antinociceptiven Wirkung bei intravenoser under intravetrikularer Applikation in Abhan gigkeit von ihrer Lipoidloslichkeit. Naunyn-Schmeideberg's Arch. Pharmacol. 265:1970;455-473.
76. Wei Z.Y., Karim F., Roerig S.C. Spinal morphine/clonidine antinociceptive synergism - involvement of G-proteins and N-type voltage-dependent calcium channels. J. Pharmacol. Exp. Ther. 278:1996;1392-1407.
77. Wilcox G.L., Carlsson K.-H., Jochim A., Jurna I. Mutual potentiation of the effects of morphine and clonidine on motor and sensory responses in rat spinal cord. Brain Res. 405:1987;84-93.
78. Yaksh T.L., Yeung J.C., Rudy T.A. Systematic examination in the rat brain of sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray. Brain Res. 114:1976;83-114.
79. Yaksh T.L. Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray. Brain Res. 160:1979;180-185.
80. Yaksh T.L. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol. Scand. 41:1997;94-111.
81. Yaksh, T.L. and Malmberg, A.B., Interaction of spinal modulatory receptor systems. In: H.L. Fields and J.C. Liebeskind (Eds.), Pharmacological approaches to the treatment of chronic pain: new concepts and critical issues, IASP Press, Seattle, WA, 1994, pp. 151-172.
82. Yaksh T.L., Noueihed R. The physiology and pharmacology of spinal opiates. Ann. Rev. Pharmacol. Toxicol. 25:1985;433-462.
83. Yeung J.C., Rudy T.A. Multiplicative interaction between narcotic agonisms expressed at spinal and supraspinal sites of action as revealed by concurrent intrathecal and intracerebroventricular injections of morphine. J. Pharmacol. Exp. Ther. 215:1980;633-642.