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Volumn 76, Issue 4, 1996, Pages 544-551

Antinociceptive actions of intrathecal xylazine: Interactions with spinal cord opioid pathways

Author keywords

Analgesics opioid, fentanyl; Pain, mechanism; Spinal cord; Sympathetic nervous system, adrenergic block; Sympathetic nervous system, xylazine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; FENTANYL; IDAZOXAN; OPIATE AGONIST; XYLAZINE;

EID: 13344259983     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/76.4.544     Document Type: Article
Times cited : (14)

References (27)
  • 1
    • 0025297711 scopus 로고
    • Antinociceptive effects of intrathecal adrenoceptor agonists in a rat model of visceral nociception
    • Danzebrink RM, Gebhart GF. Antinociceptive effects of intrathecal adrenoceptor agonists in a rat model of visceral nociception. Journal of Pharmacology and Experimental Therapeutics 1990; 253: 698-705.
    • (1990) Journal of Pharmacology and Experimental Therapeutics , vol.253 , pp. 698-705
    • Danzebrink, R.M.1    Gebhart, G.F.2
  • 2
    • 0023188075 scopus 로고
    • Prolonged spinal analgesia in the rat with the alpha-adrenoceptor agonist oxymetazoline
    • Sherman S, Loomis C, Milne B, Cervenko F. Prolonged spinal analgesia in the rat with the alpha-adrenoceptor agonist oxymetazoline. European Journal of Pharmacology 1987; 140: 25-32.
    • (1987) European Journal of Pharmacology , vol.140 , pp. 25-32
    • Sherman, S.1    Loomis, C.2    Milne, B.3    Cervenko, F.4
  • 4
    • 0026773466 scopus 로고
    • Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats
    • Takano Y, Yaksh TL. Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. Journal of Pharmacology and Experimental Therapeutics 1992; 261: 764-772.
    • (1992) Journal of Pharmacology and Experimental Therapeutics , vol.261 , pp. 764-772
    • Takano, Y.1    Yaksh, T.L.2
  • 5
    • 0025895414 scopus 로고
    • Spinally mediated antinociception after intrathecal chlordiazepoxide further evidence for a benzodiazepine spinal analgesic effect
    • Boulter N, Serrao JM, Gent JP, Goodchild CS. Spinally mediated antinociception after intrathecal chlordiazepoxide further evidence for a benzodiazepine spinal analgesic effect. European Journal of Anaesthesiology 1991; 8: 407-411.
    • (1991) European Journal of Anaesthesiology , vol.8 , pp. 407-411
    • Boulter, N.1    Serrao, J.M.2    Gent, J.P.3    Goodchild, C.S.4
  • 6
    • 0025124957 scopus 로고
    • On the mechanism by which midazolam causes spinally mediated analgesia
    • Edwards M, Serrao JM, Gent JP, Goodchild CS. On the mechanism by which midazolam causes spinally mediated analgesia. Anesthesiology 1990; 73: 273-277.
    • (1990) Anesthesiology , vol.73 , pp. 273-277
    • Edwards, M.1    Serrao, J.M.2    Gent, J.P.3    Goodchild, C.S.4
  • 8
    • 0023492912 scopus 로고
    • Intrathecal midazolam in the rat: Evidence for spinally-mediated analgesia
    • Goodchild CS, Serrao JM. Intrathecal midazolam in the rat: evidence for spinally-mediated analgesia. British Journal of Anaesthesia 1987; 59: 1563-1570.
    • (1987) British Journal of Anaesthesia , vol.59 , pp. 1563-1570
    • Goodchild, C.S.1    Serrao, J.M.2
  • 9
    • 0024669170 scopus 로고
    • Intrathecal midazolam and fentanyl in the rat: Evidence for different spinal antinociceptive effects
    • published erratum appears in Anesthesiology 1989; 71: 482
    • Serrao JM, Stubbs SC, Goodchild CS, Gent JP. Intrathecal midazolam and fentanyl in the rat: evidence for different spinal antinociceptive effects (published erratum appears in Anesthesiology 1989; 71: 482). Anesthesiology 1989; 70: 780-786.
    • (1989) Anesthesiology , vol.70 , pp. 780-786
    • Serrao, J.M.1    Stubbs, S.C.2    Goodchild, C.S.3    Gent, J.P.4
  • 10
    • 13344289224 scopus 로고
    • Spinally-mediated antinociceptive effects of xylazine, an alpha adrenoceptor agonist: Interaction with spinal cord opioid pathways
    • Goodchild CS, Guo Z, Gent JP. Spinally-mediated antinociceptive effects of xylazine, an alpha adrenoceptor agonist: interaction with spinal cord opioid pathways. British Journal of Anaesthesia 1991; 67: 201P.
    • (1991) British Journal of Anaesthesia , vol.67
    • Goodchild, C.S.1    Guo, Z.2    Gent, J.P.3
  • 11
    • 0009165238 scopus 로고
    • Intrathecal 5-hydroxytryptamine produces analgesia by activating spinal cord opioid pathways
    • Guo Z, Gent JP, Goodchild CS. Intrathecal 5-hydroxytryptamine produces analgesia by activating spinal cord opioid pathways. Pain 1990; (Suppl 5): S103.
    • (1990) Pain , Issue.5 SUPPL.
    • Guo, Z.1    Gent, J.P.2    Goodchild, C.S.3
  • 12
    • 3142530490 scopus 로고
    • Two GABA mechanisms for spinally-mediated antinociception: Evidence from antagonism of 5-hydroxytryptamine (5HT) by bicuculline
    • Guo Z, Gent JP, Goodchild CS. Two GABA mechanisms for spinally-mediated antinociception: evidence from antagonism of 5-hydroxytryptamine (5HT) by bicuculline. British Journal of Anaesthesia 1990; 64: 589-590P.
    • (1990) British Journal of Anaesthesia , vol.64
    • Guo, Z.1    Gent, J.P.2    Goodchild, C.S.3
  • 13
    • 0023886195 scopus 로고
    • Tolerance to intrathecal oxymetazoline-induced analgesia, with paradigm-dependent cross-tolerance to intrathecal morphine
    • Sherman SE, Loomis CW, Milne B, Cervenko FW. Tolerance to intrathecal oxymetazoline-induced analgesia, with paradigm-dependent cross-tolerance to intrathecal morphine. Journal of Pharmacology and Experimental Therapeutics 1988; 245: 319-326.
    • (1988) Journal of Pharmacology and Experimental Therapeutics , vol.245 , pp. 319-326
    • Sherman, S.E.1    Loomis, C.W.2    Milne, B.3    Cervenko, F.W.4
  • 14
    • 0023900253 scopus 로고
    • Intrathecal oxymetazoline produces analgesia via spinal alpha-adrenoceptors and potentiates spinal morphine
    • published erratum appears in European Journal of Pharmacology 1988; 154: 345-348
    • Sherman SE, Loomis CW, Milne B, Cervenko FW. Intrathecal oxymetazoline produces analgesia via spinal alpha-adrenoceptors and potentiates spinal morphine (published erratum appears in European Journal of Pharmacology 1988; 154: 345-348). European Journal of Pharmacology 1988; 148: 371-380.
    • (1988) European Journal of Pharmacology , vol.148 , pp. 371-380
    • Sherman, S.E.1    Loomis, C.W.2    Milne, B.3    Cervenko, F.W.4
  • 15
    • 0023898826 scopus 로고
    • Intrathecal morphine and clonidine: Antinociceptive tolerance and cross-tolerance and effects on arterial pressure
    • Solomon RE, Gebhart GF. Intrathecal morphine and clonidine: antinociceptive tolerance and cross-tolerance and effects on arterial pressure. Journal of Pharmacology and Experimental Therapeutics 1988; 245: 444-454.
    • (1988) Journal of Pharmacology and Experimental Therapeutics , vol.245 , pp. 444-454
    • Solomon, R.E.1    Gebhart, G.F.2
  • 16
    • 0020525719 scopus 로고
    • Ethical guidelines for investigation of experimental pain on conscious animals
    • Zimmerman M. Ethical guidelines for investigation of experimental pain on conscious animals. Pain 1983; 16: 109-110.
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmerman, M.1
  • 17
    • 0025900430 scopus 로고
    • Reversal by naloxone of spinal antinociceptive effects of fentanyl, ketocyclazocine, and midazolam
    • Serrao JM, Goodchild CS, Gent JP. Reversal by naloxone of spinal antinociceptive effects of fentanyl, ketocyclazocine, and midazolam. European Journal of Anesthesiology 1991; 8: 401-406.
    • (1991) European Journal of Anesthesiology , vol.8 , pp. 401-406
    • Serrao, J.M.1    Goodchild, C.S.2    Gent, J.P.3
  • 18
    • 0023196178 scopus 로고
    • Spinal kappa-opioid receptor-mediated antino- Ciceprion is stimulus-specific
    • Schmauss C. Spinal kappa-opioid receptor-mediated antino-ciceprion is stimulus-specific. European Journal of Pharmacology 1987; 137: 197-205.
    • (1987) European Journal of Pharmacology , vol.137 , pp. 197-205
    • Schmauss, C.1
  • 19
    • 0021360975 scopus 로고
    • In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat
    • Schmauss C, Yaksh TL. In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat. Journal of Pharmacology and Experimental Therapeutics 1984; 228: 1-12.
    • (1984) Journal of Pharmacology and Experimental Therapeutics , vol.228 , pp. 1-12
    • Schmauss, C.1    Yaksh, T.L.2
  • 21
    • 0018835073 scopus 로고
    • Spinal noradrenergic terminal system mediates antinociception
    • Reddy SV, Yaksh TL. Spinal noradrenergic terminal system mediates antinociception. Brain Research 1980; 189: 391-401.
    • (1980) Brain Research , vol.189 , pp. 391-401
    • Reddy, S.V.1    Yaksh, T.L.2
  • 22
    • 0023949639 scopus 로고
    • Analgesic effects of intrathecally-applied alpha 2-adrenoceptor agonists in conscious, unrestrained sheep
    • Waterman A, Livingston A, Bouchenafa O. Analgesic effects of intrathecally-applied alpha 2-adrenoceptor agonists in conscious, unrestrained sheep. Neuropharmacology 1988; 27: 213-216.
    • (1988) Neuropharmacology , vol.27 , pp. 213-216
    • Waterman, A.1    Livingston, A.2    Bouchenafa, O.3
  • 23
    • 0019449982 scopus 로고
    • Studies in the primate on the analgesic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen
    • Yaksh TL, Reddy SV. Studies in the primate on the analgesic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen. Anesthesiology 1981; 54: 451-467.
    • (1981) Anesthesiology , vol.54 , pp. 451-467
    • Yaksh, T.L.1    Reddy, S.V.2
  • 24
    • 0020418629 scopus 로고
    • Anrinociceptive activity of clonidine in the mouse, rat and dog
    • Skingle M, Hayes AG, Tyers MB. Anrinociceptive activity of clonidine in the mouse, rat and dog. Life Sciences 1982; 31: 1123-1132.
    • (1982) Life Sciences , vol.31 , pp. 1123-1132
    • Skingle, M.1    Hayes, A.G.2    Tyers, M.B.3
  • 26
    • 0016301797 scopus 로고
    • Morphine analgesia and the bulbospinal noradrenergic system: Increase in the concentration of normetanephrine in the spinal cord of the rat caused by analgesics
    • Shiomi H, Takagi H. Morphine analgesia and the bulbospinal noradrenergic system: increase in the concentration of normetanephrine in the spinal cord of the rat caused by analgesics. British Journal of Pharmacology 1974; 52: 519-526.
    • (1974) British Journal of Pharmacology , vol.52 , pp. 519-526
    • Shiomi, H.1    Takagi, H.2
  • 27
    • 84886623988 scopus 로고
    • Pain and the bulbospinal noradrenergic system: Pain-induced increase in normetanephrine content in the spinal cord and its modification by morphine
    • Takagi H, Shiomi H, Kuraishi Y, Fukui K, Ueda H. Pain and the bulbospinal noradrenergic system: pain-induced increase in normetanephrine content in the spinal cord and its modification by morphine. European Journal of Pharmacology 1979; 54: 99-107.
    • (1979) European Journal of Pharmacology , vol.54 , pp. 99-107
    • Takagi, H.1    Shiomi, H.2    Kuraishi, Y.3    Fukui, K.4    Ueda, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.